CN101284097A - Plaster for curing the protrusion of lumbar intervertebral discs, hyperosteogeny and rheumatoid and preparation method thereof - Google Patents

Abstract

A plaster for treating lumbar intervertebral disc protrusion, hyperosteogeny and rheumatoid diseases is provided. The plaster contains a base drug prepared from four groups of drugs and a dusted powder drug. The base drug is prepared from rosin and mung bean; sesame oil, angelica, cochinchina momordica seed, common anemarrhena, dahurian angelica root, croton, hard clam, indian iphigenia bulb, corymbose knoxia and teasel root; frankincense, myrrh, dragon's blood, catechu, calomel, verdigris, realgar, salammoniac, arsenic trioxide, gamboge, natural indigo, mercuric oxide, calcined plaster, camphor, kansui root and borneol; and castor seed, almond, hydnocapus seed, cochinchina momordica seed and croton. The dusted powder drug is prepared from ephedra root, Chinese wild ginger, cinnamon, honey locust, raw pinellia tuber, cloven, raw arisaema and borneol. The plaster has the advantages of precise and scientifi formulation, wide raw material source, simple process, low cost, good skin permeation for the affected part, good therapeutic effect, short treatment period and quick effect, and is used for treating lumbar intervertebral disc protrusion, hyperosteogeny and rheumatoid diseases with a cure rate of 63% or higher and a total effective rate of 96% or higher.

Description

Treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster and preparation method thereof

Technical field

The present invention relates to treat the Chinese medicine of rheumatic and rheumatoid one class disease, particularly a kind of treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster and preparation method thereof.

Background technology

Prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid arthritis etc. all are commonly encountered diseases, difficult treatment, and the patient increases day by day, affects people's orthobiosis and work to some extent.

Generally in treatment, adopt the method for internal and external application for prolapse of lumbar intervertebral disc, hyperosteogeny, promoting blood circulation to remove obstruction in the collateral for oral administration and antalgica are executed massage, acupuncture outward, or are adopted special medical apparatus and instruments traction therapeutic etc.Existing external curing medicament, treatment effect is not ideal, and cure rate is not high, and retransmission rate is higher, and needs strict the rest during the treatment.Operative treatment can not be left the bed in tens days especially, and expense is bigger.

The traditional Chinese medical science, prevention and treatment in Chinese and western rheumatoid arthritis have obtained gratifying progress in recent years.But still some patient with rheumatoid arthritis at first uses after being ill at present, even the prolonged application hormone therapy, and side effect is big, causes the dependency to hormone, and the relapse rate height is difficult to cure.

Summary of the invention

The objective of the invention is at above-mentioned deficiency, provide a kind of and treat conveniently, the medicine source is extensive, processing and manufacturing is easy, price is low, economic security, treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster that therapeutic effect is good.

The technical scheme that realizes the object of the invention is:

This treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster, by A group, B group, C group and D group the plaster principal agent formed of totally 4 groups of pharmaceutical compositions and D organize the dusting powder drug that pharmaceutical composition forms and constitute, each is organized pharmaceutical composition and is made by the raw material of following weight parts respectively:

A group: Colophonium 500-1500, Semen phaseoli radiati 50-150;

B group: Oleum sesami 200-600, Radix Angelicae Sinensis 20-60, Semen Momordicae 20-60, Rhizoma Anemarrhenae 20-60, Radix Angelicae Dahuricae 20-60, Fructus Crotonis 20-60, Conch Meretricis seu Cyclinae 20-60, Pseudobulbus Cremastrae seu Pleiones 20-60, Knoxia valerianoides 20-60, Radix Dipsaci 20-60;

C group: Olibanum 7.5-22.5, Myrrha 7.5-22.5, Sanguis Draxonis 7.5-22.5, catechu 7.52-2.5, Calomelas 5-15, Aerugo 10-30, Realgar 5-15, Sal Ammoniacus 2.5-7.5, arsenicum sablimatum 2.5-7.5, Resina garciniae 2.5-7.5, Indigo Naturalis 5-15, Hydrargyri Oxydum Rubrum 2.5-7.5, Gypsum Fibrosum Preparatum 7.5-22.5, Camphora 7.5-22.5, Radix Kansui 7.5-22.5, Borneolum Syntheticum 7.5-22.5;

D group: Semen Ricini 50-150, Semen Armeniacae Amarum 7.5-22.5, Semen Hydnocarpi 12.5-37.5, Semen Momordicae 7.5-22.5, Fructus Crotonis 1-3;

E group: Radix Ephedrae 12.5-37.5, Herba Asari 12.5-37.5, Cortex Cinnamomi 25-75, Fructus Gleditsia 7.5-22.5, Rhizoma Pinelliae 20-60, Flos Caryophylli 25-75, Rhizoma Arisaematis 20-60, Borneolum Syntheticum 1-3.

The Sal Ammoniacus of described C group is by weight rice vinegar: Sal Ammoniacus=1: 10-15, Sal Ammoniacus is added in the rice vinegar, and after mixing moistening thoroughly and treating that vinegar is exhausted, put into the parch container and fry the Sal Ammoniacus of processing after dried.

The arsenicum sablimatum of described C group, be Removing Kernel for Date after, arsenicum sablimatum is filled in the Fructus Jujubae, burn Fructus Jujubae to the charcoal shape and make the arsenicum sablimatum of processing of arsenicum sablimatum sustainability with slow fire.

The Radix Kansui of described C group is by weight rice vinegar: Radix Kansui=1: 10-15, Radix Kansui is added in the rice vinegar, and after mixing moistening thoroughly and treating that vinegar is exhausted, put into the parch container and fry to the charcoal shape and make the Radix Kansui of processing of Radix Kansui sustainability.

The Fructus Crotonis of described D group is that Fructus Crotonis is fried the Fructus Crotonis of processing to the charcoal shape and after making the Fructus Crotonis sustainability.

Another object of the present invention provides the preparation method of this treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster.

Raw material in above-mentioned each group is made the preparation method of plaster of the present invention, comprise the steps:

(1) get the Semen phaseoli radiati that A organizes described weight portion, add the water of 20-25 times of weight, heating gets mung bean water with the well-done back elimination of Semen phaseoli radiati Semen phaseoli radiati, get the Colophonium of described weight portion and put into mung bean water, be stirred to the Colophonium off-bottom, the cooling after-filtration removes mung bean water, with porphyrize behind the Colophonium airing, must make Colophonium, standby;

(2) get Radix Angelicae Sinensis, Semen Momordicae, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Fructus Crotonis, Conch Meretricis seu Cyclinae, Pseudobulbus Cremastrae seu Pleiones, Knoxia valerianoides and the Radix Dipsaci that B organizes described weight portion, be immersed in and soak in the Oleum sesami of described weight portion fully, then fry in shallow oil under the 280-320 ℃ of temperature withered after, the elimination medicinal residues, get pharmacy oil, standby;

(3) get Olibanum, Myrrha, Sanguis Draxonis, catechu, Calomelas, Aerugo, Realgar, Sal Ammoniacus, arsenicum sablimatum, Resina garciniae, Indigo Naturalis, Hydrargyri Oxydum Rubrum, Gypsum Fibrosum Preparatum, Camphora and the Radix Kansui that C organizes described weight portion, be ground into fine powder after the mixing, add Borneolum Syntheticum again, porphyrize gets the fines medicine, and is standby;

(4) get Semen Ricini, Semen Armeniacae Amarum, Semen Hydnocarpi, Semen Momordicae and the Fructus Crotonis that D organizes described weight portion, smash into the mud shape after the mixing, get the seed medicine, standby;

(5) get (2) gained pharmacy oil, be heated to 180-230 ℃, pour (1) gained system Colophonium into, the limit bevelling stirs with Ramulus Salicis Babylonicae, treat the Colophonium off-bottom after, add (3) gained fines medicine and (4) gained seed medicine from fire, continue to stir, after the cooling cream drug, cold water soaks 24-48 hour releasing fire-toxin, the stand be coated with the plaster principal agent;

(6) get Radix Ephedrae, Herba Asari, Cortex Cinnamomi, Fructus Gleditsia, Rhizoma Pinelliae, Flos Caryophylli and the Rhizoma Arisaematis that E organizes described weight portion, be ground into fine powder after the mixing, add Borneolum Syntheticum again, the porphyrize packing gets dusting powder drug.

Step is soaked adequate time with drug immersion described in (2) in Oleum sesami, press soak time conventional in the Chinese medicine preparation and grasp, be i.e. 5 days spring, 3 days summers, 7 days autumns, 10 days winters.

The consumption of each raw material in the plaster of the present invention all can be done suitably to adjust, to make the series of products that adapt to different syndromes according to the difference of disease.Generally be coated with the plaster principal agent by every subsides 5 gram stand, the dusting powder drug about 0.7 gram, packing are respectively joined in every subsides.

Using method: plaster of the present invention is the Colophonium plaster, and smooth in appearance is glossy, and is very easy to use.The treatment prolapse of lumbar intervertebral disc, during diseases such as bone matrix hyperplasia, rheumatoid arthritis, according to a conventional method with plaster principal agent molten after the plaster surface evenly sprinkles dusting powder drug, be affixed on pain spot or acupuncture point point gets final product.Every subsides are for 1 time 1 course of treatment, paste 7-10 days for 1 time, and general disease patient pastes can heal 1 course of treatment entirely, and the patient with severe symptoms pastes rest a period of time after 2 courses of treatment.After plaster sticked on the affected part, viscosity very much not moved freely, does not trickle, is difficult for pollution clothes, and allergic phenomena is few.

Plaster of the present invention, prescription is rigorous, science, select medicine to suit the medicine to the illness invariably, and medication is meticulous comprehensive, makes full use of the active ingredient of medicine, makes the medicine diseased region that goes directly, and reaches the ideal effect for the treatment of both the principal and secondary aspects of a disease; The medicine source is extensive, technology is simple, processing and manufacturing is easy, cheap; Paste with back medicine and under the help of body temperature, dissolve, help soaking into and very easily being drawn by skin to ill position, so good effect, short treating period, instant effect, determined curative effect is reliable, and toxic and side effects is little, no contraindication.The inventor proves that through 14 years, nearly 7000 many cases clinical practices plaster of the present invention is to diseases such as prolapse of lumbar intervertebral disc, bone matrix hyperplasia and rheumatoid arthritiss, and cure rate is all more than 63%, and total effective rate reaches more than 96%.

Simultaneously, this plaster also all has better curative effect to associated conditions such as rheumatic arthritis, scapulohumeral periarthritis, sciatica, traumatic injury sequelas, and range of application is very extensive.

The specific embodiment

Below in conjunction with embodiments of the invention and test example the present invention is further described, but the present invention is not limited to embodiment, those of ordinary skills do some modification with technical solution of the present invention, still in protection domain of the present invention.

Embodiment 1-5: the preparation of plaster of the present invention (inventor is called: " Jiang Shi big plaster ")

(the unit: gram) see Table 1 of the consumption of each crude drug among each embodiment.Raw materials used, all select commercially available medical material for use, each raw material all should meet the specification requirement of a regulation of Pharmacopoeia of the People's Republic of China version in 2005.

Table 1

Continuous table 1

Its preparation method is (with embodiment 3 is example, and other embodiment is except that raw material consumption difference, and preparation method is substantially the same manner as Example 3):

(1) get 1000 Semen phaseoli radiatis that restrain, add the water of 20000 grams, heating gets mung bean water with the well-done back elimination of Semen phaseoli radiati Semen phaseoli radiati, get the Colophonium of 10000 grams and put into mung bean water, be stirred to the Colophonium off-bottom, the cooling after-filtration removes mung bean water, with porphyrize behind the Colophonium airing, must make Colophonium, standby.

(2) get Radix Angelicae Sinensis, Semen Momordicae, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Fructus Crotonis, Conch Meretricis seu Cyclinae, Pseudobulbus Cremastrae seu Pleiones, Knoxia valerianoides and Radix Dipsacis of each 400 gram, add in the Oleum sesami of 4000 grams and soak fully, then heating under the 280-320 ℃ of temperature fry in shallow oil withered after, the elimination medicinal residues, pharmacy oil, standby.

(3) get each 150 the gram Olibanum, Myrrha, Sanguis Draxonis, catechu, Gypsum Fibrosum Preparatum, Camphoras and process Radix Kansui, the Aerugo of 200 grams, Calomelas, Realgar and the Indigo Naturalis of each 100 gram, the processing Sal Ammoniacus, process arsenicum sablimatum of each 50 gram, Resina garciniae and Hydrargyri Oxydum Rubrum, be developed into 120 order fine powders after all mixing, add the Borneolum Syntheticum of 150 grams again, porphyrize, get the fines medicine, standby.

(4) get the Semen Ricini of 1000 grams, the Semen Hydnocarpi of 250 grams, Semen Armeniacae Amarum and Semen Momordicaes of each 150 gram, 20 grams process Fructus Crotonis, smash into the mud shape after all mixing, the seed medicine, standby.

(5) get (2) gained pharmacy oil, be heated to 180-230 ℃, pour (1) gained system Colophonium into, the limit bevelling stirs with Ramulus Salicis Babylonicae, treat the Colophonium off-bottom after, add (3) gained fine powder material medicine and (4) gained seed medicine from fire, continue to stir, after the cooling cream drug, after cold water soaks 24 hours releasing fire-toxin, be coated with by every subsides 5 gram stand, amount to pack finished product plaster principal agent.

(6) get each 250 Radix Ephedrae and Herba Asari that restrain, Cortex Cinnamomi and Flos Caryophyllis of each 500 gram, the Fructus Gleditsias of 150 grams, each 400 Rhizoma Pinelliae and Rhizoma Arisaematis that restrain, be ground into 120 order fine powders after the mixing, add the Borneolum Syntheticum of 20 grams again, get dusting powder drug behind the porphyrize, the dusting powder drug of joining 0.7 gram by whenever forcing on is in incapsulating.

(7) with the plaster principal agent and the dusting powder drug packing that make, promptly get " Jiang Shi big plaster ".

Test example 1: use plaster of the present invention, the clinical observation on the therapeutic effect of treatment prolapse of lumbar intervertebral disc

The inventor selects patients with lumbar disc herniation 120 examples, is divided into treatment group and matched group at random, every group 60 example.The treatment group sticks plaster of the present invention in the affected part, change 11 course of treatment (10 days), treated for 2 courses of treatment.Matched group sticks " just strange logical subsides " (Shaanxi just very Medicines and Health Product Co., Ltd produces, and Shan food medicine prison is good for and is used No. 04010192, word).Treat 20 days post-evaluation curative effects.Two groups of cases are all learned by statistics aspect age, sex, the state of an illness and are handled P＞0.05, no significant difference.

Curative effect judging standard: cure: the symptom and sign complete obiteration; Produce effects: big disappearance of symptom, the patient still has tenderness; Effectively: symptom and sign before alleviates; Invalid: symptom and sign improves with the preceding nothing of treatment.

The curative effect of treatment group and matched group relatively sees Table 2.

Table 2

Group	The example number	Cure	％	Produce effects	％	Effectively	％	Invalid	％
										The treatment group	60	43	71.7	10	16.7	7	11.6	0	0
Matched group	60	21	35.0	18	30.0	19	31.7	2	3.3

By clinical observation on the therapeutic effect as can be seen, use plaster treatment prolapse of lumbar intervertebral disc of the present invention healing account for 71.7%, produce effects account for 16.7%, effectively account for 11.6%, total effective rate reaches 100%, shows that fully plaster of the present invention has very obvious treatment effect for the treatment prolapse of lumbar intervertebral disc.

Test example 2: use plaster of the present invention, the clinical observation on the therapeutic effect of treatment bone matrix hyperplasia

The inventor selects bone matrix hyperplasia patient 1047 examples, all cases all have tangible arthralgia, joint function disturbance or nerve compression symptom, and through X film making or the diagnosis of CT sheet, existing only with complete data, and have the clinical observation on the therapeutic effect result of 778 examples of Follow-up results to add up.

Curative effect judging standard: cure: local pain disappears, and the osteoarthrosis functional rehabilitation is followed up a case by regular visits to and do not had recurrence in 6 months to 1 year; Produce effects: local pain disappears substantially, and the osteoarthrosis funtion part is recovered, and follows up a case by regular visits to 6 months to 1 year effect stabilities; Effectively: with not the treatment before pain weaken; Invalid: with indifference before the treatment.

Therapeutic effect statistical result sees Table 3.

Table 3

By clinical observation on the therapeutic effect as can be seen, use plaster treatment bone matrix hyperplasia of the present invention, healing account for 63.4%, produce effects account for 20.3%, effectively account for 12.9%, total effective rate reaches 96.6%, shows that fully plaster of the present invention has the obvious treatment effect for the treatment bone matrix hyperplasia.

Test example 3: use plaster of the present invention, the clinical observation on the therapeutic effect of treatment rheumatoid arthritis

The inventor selects rheumatoid patient 162 examples of complete data, wherein, and male 68 people, women 94 people; 8 people below 20 years old, 20-30 year 32 people, 30-40 year 39 people, 40-50 year 61 people, 22 people more than 50 years old.The patient is in the majority with the middle age, the shortest person of the course of disease 2 months, and elder 20 years, all cases all have arthralgia, redness, swelling and moving obstacle, have 32% patient once to use hormone medicine, discretely reach 11 years with hormone medicine.Press disease degree, early stage have 98 people, promptly most of arthralgia and limitation of activity, rarely seen soft tissue of X-ray examination and an osteoporosis; Mid-term 39 people are arranged, i.e. part redness and swelling of joints activity is obviously limited, the visible joint space of X-ray examination narrows down; Late period 25 people are arranged, promptly most joints severe deformities is stiff, movable difficulty, X-ray examination visible joint heavy damage.

Therapeutic Method: general rheumatoid patient, every subsides are for 1 time 1 course of treatment, and 1 course of treatment is treated in 1 subsides 7-10 days, and the patient with severe symptoms adds up therapeutic outcome after pasting 2 courses of treatment.

Curative effect judging standard: cure: symptom all disappears, and functional activity is normal, and the main test index is normal; Produce effects: symptomatology disappears or cardinal symptom is eliminated or obviously progress, can participate in operate as normal, and test rating is normal substantially; Produce effects: cardinal symptom disappears, and main function of joint is recovered substantially or be obviously progressive, and can't take care of oneself becomes substantially and can take care of oneself, and laboratory indexes does not have significant change; Invalid: no significant change before various symptoms and laboratory indexes and the treatment.

Therapeutic effect statistical result sees Table 4.

Table 4

By clinical observation on the therapeutic effect as can be seen, use plaster treatment rheumatoid patient of the present invention, healing account for 69.8%, produce effects account for 14.2%, effectively account for 11.7%, total effective rate reaches 95.7%, shows that fully plaster of the present invention has the obvious treatment effect for the treatment rheumatoid patient.

For investigating the therapeutic effect at a specified future date of plaster of the present invention, the patient of the inventor after to the treatment of the example of 137 among the above-mentioned patient carried out the follow-up investigation in 3 years, and follow-up investigation the results are shown in Table 5.

Table 5

Through above follow-up investigation data as seen, behind plaster treatment of the present invention, 131 routine patients are arranged in 1 year in 137 routine patients, efficacy consolidation or basic the consolidation were consolidated rate and reach 95.6% in 1 year.120 routine patients are arranged in 3 years in 137 routine patients, efficacy consolidation or basic the consolidation, 3 years consolidate rate is 87.6%.Follow-up results confirms that plaster of the present invention has very satisfied curative effect and consolidates rate.

Claims (6)

1, a kind of treatment prolapse of lumbar intervertebral disc, hyperosteogeny, rheumatoid plaster, by A group, B group, C group and D group the plaster principal agent formed of totally 4 groups of pharmaceutical compositions and D organize the dusting powder drug that pharmaceutical composition forms and constitute, it is characterized in that respectively organizing pharmaceutical composition and make by the raw material of following weight parts respectively:

A group: Colophonium 500-1500, Semen phaseoli radiati 50-150;

B group: Oleum sesami 200-600, Radix Angelicae Sinensis 20-60, Semen Momordicae 20-60, Rhizoma Anemarrhenae 20-60, Radix Angelicae Dahuricae 20-60, Fructus Crotonis 20-60, Conch Meretricis seu Cyclinae 20-60, Pseudobulbus Cremastrae seu Pleiones 20-60, Knoxia valerianoides 20-60, Radix Dipsaci 20-60;

C group: Olibanum 7.5-22.5, Myrrha 7.5-22.5, Sanguis Draxonis 7.5-22.5, catechu 7.5-22.5, Calomelas 5-15, Aerugo 10-30, Realgar 5-15, Sal Ammoniacus 2.5-7.5, arsenicum sablimatum 2.5-7.5, Resina garciniae 2.5-7.5, Indigo Naturalis 5-15, Hydrargyri Oxydum Rubrum 2.5-7.5, Gypsum Fibrosum Preparatum 7.5-22.5, Camphora 7.5-22.5, Radix Kansui 7.5-22.5, Borneolum Syntheticum 7.5-22.5;

D group: Semen Ricini 50-150, Semen Armeniacae Amarum 7.5-22.5, Semen Hydnocarpi 12.5-37.5, Semen Momordicae 7.5-22.5, Fructus Crotonis 1-3;

E group: Radix Ephedrae 12.5-37.5, Herba Asari 12.5-37.5, Cortex Cinnamomi 25-75, Fructus Gleditsia 7.5-22.5, Rhizoma Pinelliae 20-60, Flos Caryophylli 25-75, Rhizoma Arisaematis 20-60, Borneolum Syntheticum 1-3.

2, treatment prolapse of lumbar intervertebral disc according to claim 1, hyperosteogeny, rheumatoid plaster, it is characterized in that the Sal Ammoniacus in the C group, it is by weight rice vinegar: Sal Ammoniacus=1: 10-15, Sal Ammoniacus is added in the rice vinegar, after mixing moistening thoroughly and treating that vinegar is exhausted, put into the parch container and fry the Sal Ammoniacus of processing after doing.

3, treatment prolapse of lumbar intervertebral disc according to claim 1, hyperosteogeny, rheumatoid plaster is characterized in that the arsenicum sablimatum in the C group, be Removing Kernel for Date after, arsenicum sablimatum is filled in the Fructus Jujubae, burn Fructus Jujubae to the charcoal shape and make the arsenicum sablimatum of processing of arsenicum sablimatum sustainability with slow fire.

4, treatment prolapse of lumbar intervertebral disc according to claim 1, hyperosteogeny, rheumatoid plaster, it is characterized in that the Radix Kansui in the C group, it is by weight rice vinegar: Radix Kansui=1: 10-15, Radix Kansui is added in the rice vinegar, after mixing moistening thoroughly and treating that vinegar is exhausted, put into the parch container and fry to the charcoal shape and make the Radix Kansui of processing of Radix Kansui sustainability.

5, treatment prolapse of lumbar intervertebral disc according to claim 1, hyperosteogeny, rheumatoid plaster is characterized in that the Fructus Crotonis in the D group, are Fructus Crotonis is fried the Fructus Crotonis of processing to the charcoal shape and after making the Fructus Crotonis sustainability.

6, the preparation method of treatment prolapse of lumbar intervertebral disc as claimed in claim 1, hyperosteogeny, rheumatoid plaster is characterized in that preparation method comprises the steps:

(1) get the Semen phaseoli radiati that A organizes described weight portion, add the water of 20-25 times of weight, heating gets mung bean water with the well-done back elimination of Semen phaseoli radiati Semen phaseoli radiati, get the Colophonium of described weight portion and put into mung bean water, be stirred to the Colophonium off-bottom, the cooling after-filtration removes mung bean water, with porphyrize behind the Colophonium airing, must make Colophonium, standby;

(2) get Radix Angelicae Sinensis, Semen Momordicae, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Fructus Crotonis, Conch Meretricis seu Cyclinae, Pseudobulbus Cremastrae seu Pleiones, Knoxia valerianoides and the Radix Dipsaci that B organizes described weight portion, be immersed in and soak in the Oleum sesami of described weight portion fully, then fry in shallow oil under the 280-320 ℃ of temperature withered after, the elimination medicinal residues, get pharmacy oil, standby;

(3) get Olibanum, Myrrha, Sanguis Draxonis, catechu, Calomelas, Aerugo, Realgar, Sal Ammoniacus, arsenicum sablimatum, Resina garciniae, Indigo Naturalis, Hydrargyri Oxydum Rubrum, Gypsum Fibrosum Preparatum, Camphora and the Radix Kansui that C organizes described weight portion, be ground into fine powder after the mixing, add Borneolum Syntheticum again, porphyrize gets the fines medicine, and is standby;

(4) get Semen Ricini, Semen Armeniacae Amarum, Semen Hydnocarpi, Semen Momordicae and the Fructus Crotonis that D organizes described weight portion, smash into the mud shape after the mixing, get the seed medicine, standby;

(5) get (2) gained pharmacy oil, be heated to 180-230 ℃, pour (1) gained system Colophonium into, the limit bevelling stirs with Ramulus Salicis Babylonicae, treat the Colophonium off-bottom after, add (3) gained fines medicine and (4) gained seed medicine from fire, continue to stir, after the cooling cream drug, cold water soaks 24-48 hour releasing fire-toxin, the stand be coated with the plaster principal agent;

(6) get Radix Ephedrae, Herba Asari, Cortex Cinnamomi, Fructus Gleditsia, Rhizoma Pinelliae, Flos Caryophylli and the Rhizoma Arisaematis that E organizes described weight portion, be ground into fine powder after the mixing, add Borneolum Syntheticum again, the porphyrize packing gets dusting powder drug.