CN101279085A - Chinese medicinal composition for treating hypersomnia and method of preparing the same - Google Patents

Abstract

The invention relates to a traditional Chinese medicine combination for curing lethargy. The traditional Chinese medicine combination is prepared by cortex magnoliae officinalis, coix seed, aconite root, codonopsis pilosula, astragalus hoangtchy, dried orange peel, bupleurum chinense, tuckahoe, talcum, dried ginger, plantain, caladium and/or medically acceptable carrier. The invention also relates to a preparation method of the traditional Chinese medicine combination. The traditional Chinese medicine combination of the invention has the functions of resolving turbidity with drugs of fragrant flavor, eliminating dampness and refreshing the spleen and clearing away heat from the gallbladder and is used for curing dizziness, somatic heaviness, nausea and vomiting, lassitude and bitter taste of mouth and dry mouth, and other symptoms caused by lethargy.

Description

A kind of drowsiness Chinese medicine composition and preparation method thereof for the treatment of

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of drowsiness Chinese medicine composition and preparation method thereof for the treatment of.

Background technology

Drowsiness is a kind of nervous system disease, it can cause can not inhibition the generation of sleep.These Sleep stages can often take place, and incident time contretemps, for example when speaking, having a meal or driving.Although any time that can take place of sleep, the most normal generation is at inertia or dullness, repeated operational phase.

The drowsiness age bracket that occurs in 15 ~ 30 years old usually at first, but also the somebody time ratio of drowsiness phenomenon occurs than morning or than later.In case drowsiness phenomenon occurs, it can follow you lifelong.The affected degree of men and women is the same.Drowsiness initial symptom is normally felt very serious sleepiness during daytime.Yet, may need several years just can make a definite diagnosis patient and suffer from this disease really, in addition much can both produce this symptom in addition because cause the too much reason of sleepiness on daytime.

Medical science defines four kinds of cardinal symptoms of drowsiness usefulness, and these four kinds of symptoms are called as drowsiness tetrad:

Daytime, sleepiness was too much: this symptom exists all the time, and the most obvious usually.

Damping off: dampinging off is meant the unexpected or temporary disappearance of meat quality, and this has caused that head or health paralyse under the situation of loss of consciousness not having.It can continue several seconds or a few minutes.Light symptoms shows as unclean language or stutter, eyelid is sagging or weak fingers is taken incessantly thing.Serious dampinging off can cause the knee bending, and the people is collapsed.Laugh, excitement or anger are to cause the typicality reason of dampinging off.Loosening suddenly of meat quality may be the result that brain enters the REM sleep suddenly.Have have among disorders of excessive sleepiness's the patient phenomenon of dampinging off less than half.

The sleep paralysis: so-called sleep paralysis is exactly temporarily can not move in the time of maybe will waking up when the people is sleeping.It only continues a few minutes.With damping off similar, sleep paralysis may be also with REM sleep and waking state between transition insufficient relevant.The sleep paralysis is relevant with hallucination.

Hypnoagogic hallucination: be meant the image as spirit, the dreamland, very terrified usually, before being common in when sleeping or the sleep paralysis taking place.Nearly 90% is diagnosed as the people who suffers from drowsiness disease does not exist a kind of in the above symptom at least.People with these four kinds of symptoms is less than half.

Usually these symptoms there is no case before this concerning teenager or the people that is only just of age.Suffering from the Rip van Winkle can complain and feel performing poor of fatigue, work, study and social networks.The sleepiness of excessive daytime can make people's incapacitation, reduces quality of life greatly.Hypomnesis, visual disorder may particularly make the people feel uneasy.

Over half suffer from the Rip van Winkle all can hypomnesis or memory takes place interrupt, waking state " microsleep dormancy " causes by swarming into for this.They can be at a loss when walking or driving in these stages, talk nonsense or write recklessly, misplace thing or knock thing.Representational is their behavior off one's feet in these stages, and does not remember the thing of generation clearly afterwards.

The traditional Chinese medical science is thought categories such as drowsiness genus " drowsirness ", " somnolence ".Be characterized in: sleepy constantly no matter round the clock, that calls out can wake up, and sleeps again after awake.Be that cloudy gas is contained very much, due to the cause of disease such as deficiency of YANG QI is weak and insufficiency of the spleen.Traditional Chinese medical science ancient book is early on the books, the void of taste, tiredness with somnolence.Summer is drowsiness, because the summer-heat consumption is hindered vigour, diminishes spirit; If winter is often drowsiness, expression health YANG QI deficiency or insufficiency of the spleen damp and hot.

Often ponder over manyly, beat one's brains well or people that diet control is improper, often the impairment of the spleen influences spleen fortuneization ability.When spleen and stomach function is not good enough, easy insufficiency of vital energy and blood, the result of QI and blood deficiency is, the brain oxygen supply deficiency, it is drowsiness easily to lose consciousness Shen.

The traditional Chinese medical science is divided into two types with this disease:

Insufficiency of the spleen weight in wet base type: main symptom is body obesity, and is uncomfortable in chest, and heavy sensation of the body is weak, inappetence, and the food back is sleepy easily sleeps, or soft stool and abundant expectoration, white and greasy fur.

Type of decline of YANG QI: after the old or prolonged illness, spiritlessness and weakness, inappetence, cold limb cold is feared in the hyperhidrosis of lazy speech, and tongue fur is white and moist.

Traditional Chinese medical science employing eliminating turbid pathogen with aromatics, this disease of decoction for the treatment that dampness is amusing, clearing gallbladder purges heat.

Summary of the invention

The purpose of this invention is to provide a kind of drowsiness Chinese medicine composition for the treatment of.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of drowsiness Chinese medicine composition for the treatment of, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Cortex Magnoliae Officinalis 10-20 part Semen Coicis 5-15 part Radix Aconiti Lateralis Preparata 15-20 part

Radix Codonopsis 5-10 part Radix Astragali 20-30 part Pericarpium Citri Reticulatae 15-20 part

Radix Bupleuri 10-20 part Poria 5-10 part Talcum 10-20 part

Rhizoma Zingiberis 10-25 part Herba Plantaginis 5-10 part Bulbus Fritillariae Uninbracteatae 20-30 part

Effective ingredient is preferably made by weight by following raw materials according:

18 parts of 11 parts of Radix Aconiti Lateralis Preparatas of 16 parts of Semen Coiciss of Cortex Magnoliae Officinalis

18 parts of 26 parts of Pericarpium Citri Reticulataes of 8 parts of Radixs Astragali of Radix Codonopsis

16 parts in 8 parts of Talcums of 16 parts of Poria of Radix Bupleuri

26 parts of 8 portions of Bulbus Fritillariae Uninbracteataes of 20 portions of Herba Plantaginiss of Rhizoma Zingiberis

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) to be broken into impalpable powder standby for Pulvis Talci;

(2) Cortex Magnoliae Officinalis, Radix Codonopsis, Rhizoma Zingiberis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Semen Coicis, Radix Aconiti Lateralis Preparata, the Radix Astragali, Pericarpium Citri Reticulatae, Radix Bupleuri, Poria, Herba Plantaginis, Bulbus Fritillariae Uninbracteatae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has eliminating turbid pathogen with aromatics, dampness is amusing, clearing gallbladder purges heat effect, is used for drowsiness institute to diseases such as dizzy heavy sensation of the body, the tending to vomit of feeling sick, refreshing tired not well, bitter taste xerostomias.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Talcum 160g;

(2) Cortex Magnoliae Officinalis 160g, Radix Codonopsis 80g, Rhizoma Zingiberis 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Semen Coicis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 260g, Pericarpium Citri Reticulatae 180g, Radix Bupleuri 160g, Poria 80g, Herba Plantaginis 80g, Bulbus Fritillariae Uninbracteatae 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 1200g, lactose 800g, mixing, with 75% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Talcum 160g;

(2) Cortex Magnoliae Officinalis 160g, Radix Codonopsis 80g, Rhizoma Zingiberis 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Semen Coicis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 260g, Pericarpium Citri Reticulatae 180g, Radix Bupleuri 160g, Poria 80g, Herba Plantaginis 80g, Bulbus Fritillariae Uninbracteatae 260g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Talcum 160g;

(2) Cortex Magnoliae Officinalis 160g, Radix Codonopsis 80g, Rhizoma Zingiberis 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Semen Coicis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 260g, Pericarpium Citri Reticulatae 180g, Radix Bupleuri 160g, Poria 80g, Herba Plantaginis 80g, Bulbus Fritillariae Uninbracteatae 260g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, and tabletting, coating are promptly.

Claims (4)

1, a kind ofly treating drowsiness Chinese medicine composition, is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Cortex Magnoliae Officinalis 10-20 part Semen Coicis 5-15 part Radix Aconiti Lateralis Preparata 15-20 part

Radix Codonopsis 5-10 part Radix Astragali 20-30 part Pericarpium Citri Reticulatae 15-20 part

Radix Bupleuri 10-20 part Poria 5-10 part Talcum 10-20 part

Rhizoma Zingiberis 10-25 part Herba Plantaginis 5-10 part Bulbus Fritillariae Uninbracteatae 20-30 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

18 parts of 11 parts of Radix Aconiti Lateralis Preparatas of 16 parts of Semen Coiciss of Cortex Magnoliae Officinalis

18 parts of 26 parts of Pericarpium Citri Reticulataes of 8 parts of Radixs Astragali of Radix Codonopsis

16 parts in 8 parts of Talcums of 16 parts of Poria of Radix Bupleuri

26 parts of 8 portions of Bulbus Fritillariae Uninbracteataes of 20 portions of Herba Plantaginiss of Rhizoma Zingiberis.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) to be broken into impalpable powder standby for Pulvis Talci;

(2) Cortex Magnoliae Officinalis, Radix Codonopsis, Rhizoma Zingiberis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Semen Coicis, Radix Aconiti Lateralis Preparata, the Radix Astragali, Pericarpium Citri Reticulatae, Radix Bupleuri, Poria, Herba Plantaginis, Bulbus Fritillariae Uninbracteatae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.