CN101273123B - 标记物是Eph型标记物的细胞/配体标记系统,包含所述系统的细胞材料,其制备方法,和促血管生成的用途 - Google Patents

标记物是Eph型标记物的细胞/配体标记系统,包含所述系统的细胞材料,其制备方法,和促血管生成的用途 Download PDF

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CN101273123B
CN101273123B CN2006800358867A CN200680035886A CN101273123B CN 101273123 B CN101273123 B CN 101273123B CN 2006800358867 A CN2006800358867 A CN 2006800358867A CN 200680035886 A CN200680035886 A CN 200680035886A CN 101273123 B CN101273123 B CN 101273123B
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cell
epc
ephb4
marker
ephrin
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CN101273123A (zh
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菲利普·福伯特
让-塞巴斯蒂安·西尔韦斯特里
索菲·勒里库西-鲁桑尼
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Universite Paris Diderot Paris 7
IVS Institut des Vaisseaux et du Sang
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Universite Paris Diderot Paris 7
IVS Institut des Vaisseaux et du Sang
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2006800358867A 2005-07-27 2006-07-27 标记物是Eph型标记物的细胞/配体标记系统,包含所述系统的细胞材料,其制备方法,和促血管生成的用途 Expired - Fee Related CN101273123B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0508029 2005-07-27
FR0508029A FR2889200B1 (fr) 2005-07-27 2005-07-27 Systeme marqueur cellulaire/ligand, ou le marqueur est du type eph, materiau cellulaire comprenant ce systeme, procede de preparation et utilisation proangiogenique
PCT/FR2006/001837 WO2007012764A2 (fr) 2005-07-27 2006-07-27 Système marqueur cellulaire/ligand, où le marqueur est du type eph, matériau cellulaire comprenant ce système, procédé de préparation et utilisation proangiogénique

Publications (2)

Publication Number Publication Date
CN101273123A CN101273123A (zh) 2008-09-24
CN101273123B true CN101273123B (zh) 2013-06-26

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CN2006800358867A Expired - Fee Related CN101273123B (zh) 2005-07-27 2006-07-27 标记物是Eph型标记物的细胞/配体标记系统,包含所述系统的细胞材料,其制备方法,和促血管生成的用途

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US (1) US8338169B2 (enExample)
EP (1) EP1913130B1 (enExample)
JP (4) JP5755829B2 (enExample)
CN (1) CN101273123B (enExample)
AU (1) AU2006273928B2 (enExample)
CA (1) CA2616712C (enExample)
DK (1) DK1913130T3 (enExample)
ES (1) ES2565675T3 (enExample)
FR (1) FR2889200B1 (enExample)
IL (1) IL188938A (enExample)
WO (1) WO2007012764A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2909559B1 (fr) * 2006-12-06 2012-09-07 Inst Vaisseaux Et Du Sang Preparations cellulaires pour une utilisation comme agent stimulant la revascularisation
AU2008223817A1 (en) 2007-03-02 2008-09-12 National University Of Ireland, Galway Osteopontin for the prediction and treatment of cardiovascular diseases
FR2957799B1 (fr) * 2010-03-26 2012-08-17 Inst Des Vaisseaux Et Du Sang Compositions proangiogeniques, leur procede de preparation et leurs utilisations

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DE4240635C2 (de) * 1992-12-03 1997-07-10 Lothar Prof Dr Kanz Vermehrung hämatopoetischer Vorläuferzellen ex vivo sowieZusammensetzungen hämatopoetischer Wachstumsfaktoren
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
US6864227B1 (en) 1998-04-13 2005-03-08 California Institute Of Technology Artery-and vein-specific proteins and uses therefor
WO2000031124A2 (en) 1998-11-20 2000-06-02 Mount Sinai Hospital Peptides that modulate the interaction of b class ephrins and pdz domains
US6610534B2 (en) 2000-10-05 2003-08-26 Novartis Ag Induction of blood vessel formation through administration of polynucleotides encoding sphingosine kinases
AU2002243623A1 (en) 2001-01-26 2002-08-06 Regeneron Pharmaceuticals, Inc. Methods of imaging and targeting vasculature
AU2002311792A1 (en) 2001-03-30 2002-10-15 President And Fellows Of Harvard College B-ephrin regulation of g-protein coupled chemoattraction; compositions and methods of use
US20050049194A1 (en) 2001-11-09 2005-03-03 Jonas Frisen Use of ephrins and related molecules to regulate cellular proliferation
AU2003232457A1 (en) 2002-05-29 2003-12-19 Curagen Corporation Compositions and methods of use for an ephrin rreceptor
US20040110150A1 (en) 2002-12-10 2004-06-10 Isis Pharmaceuticals Inc. Modulation of Ephrin-B2 expression
US7576074B2 (en) 2002-07-15 2009-08-18 Rice Kenneth D Receptor-type kinase modulators and methods of use
AU2003900541A0 (en) 2003-02-07 2003-02-20 Ludwig Institute For Cancer Research Modulation of cell adhesion and tumour cell metastasis
AU2004220459B2 (en) 2003-03-12 2010-08-05 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth

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Title
.2003,第9卷(第6期),653-660. *
DZAU V.J.等.Angiogenesisi in health and disease.《NATURE MEDICINE&gt *
DZAU V.J.等.Angiogenesisi in health and disease.《NATURE MEDICINE>.2003,第9卷(第6期),653-660.
LE RICOUSSE-ROUSSANNE SOPHIE等.Ex vivo differentiated endothelial and smooth muscle cells from human cord blood progenitors home to the angiogenic tumor vasculature.《CARIDOVASCULAR RESEARCH》.2004,第62卷(第1期),176-184. *
MAEKAWA HIROMITSU等.Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesisi in adult vasculature.《ARTERIOSCLEROSIS THROMBOSIS AND VASCULATURE BIOLOGY》.2003,第23卷(第11期),2008-2014. *
Wang H U等.Molecular distinction and angiogenic interaction betueen embryonic atreries and veins revealed by ephrin-82 and its receptor Eph-B4.《CELL》.1998,第93卷(第5期),741-753. *

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Publication number Publication date
WO2007012764A2 (fr) 2007-02-01
JP6235639B2 (ja) 2017-11-22
ES2565675T3 (es) 2016-04-06
CN101273123A (zh) 2008-09-24
IL188938A0 (en) 2008-04-13
EP1913130B1 (fr) 2015-12-23
JP2017169590A (ja) 2017-09-28
JP5755829B2 (ja) 2015-07-29
AU2006273928B2 (en) 2012-02-16
IL188938A (en) 2014-09-30
AU2006273928A1 (en) 2007-02-01
JP2009505638A (ja) 2009-02-12
DK1913130T3 (en) 2016-03-29
US8338169B2 (en) 2012-12-25
FR2889200B1 (fr) 2008-01-04
JP5981525B2 (ja) 2016-08-31
FR2889200A1 (fr) 2007-02-02
EP1913130A2 (fr) 2008-04-23
CA2616712A1 (fr) 2007-02-01
JP2016127863A (ja) 2016-07-14
CA2616712C (fr) 2015-11-17
WO2007012764A3 (fr) 2007-05-31
US20090123431A1 (en) 2009-05-14
JP2015061536A (ja) 2015-04-02

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