CN101264238B - Preparation of Chinese medicine for treating iron deficiency anemia - Google Patents

Abstract

The invention relates to a Chinese herbal medicine preparation method for curing iron deficiency anemia, belonging to the technical field of Chinese herbal medicine preparation methods, aiming at solving the problems that: oral iron is generally adopted for curing iron deficiency anemia, such as ferrous sulfate; the application of ferrous sulfate can easily cause gastrointestinal discomfort, pyrosis, constipation or diarrhea. The invention adopts the technical proposal that: donkey hide gelatin, radix polygoni multiflori preparata, angelica sinensis, root of herbaceous peony, prepared rhizomeof rehmanniae, laurel garden pulp, mulberry, coppetas, lanceolata, astragalus, radix pseudostell, bidens tripartite L, cotton root, white hyacinth bean, jujube, rhizome pollgonati, rhizoma ligustici wallichii, danshen root and radix glycyrrhizae are used; the donkey hide gelatin is grinded into powder and melted by heat for infusing with water; then the following 18 medicines are put into 1100 mlwater, immersed for 30 minutes and then boiled with mild fire; the boiled medicine liquid is filtered using gauge for removing slag, and the Chinese herbal medicine for curing iron deficiency anemia is at last made. The Chinese herbal medicine has the advantages of simple manufacture, small side effects, long and stable therapeutic effects when the medicine is taken orally, recurrence eliminatingand good medicine absorption in digestive tract.

Description

A kind of Chinese medicinal preparation method for the treatment of iron deficiency anemia

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method for the treatment of iron deficiency anemia more specifically.

Background technology

Treat iron deficiency anemia at present, generally adopt oral chalybeate: as ferrous sulfate, each 0.3～0.6 gram, 3 times on the 1st; Ferrous carbonate, each 1 gram, every day 3 times; 10% ferric ammonium citrate, each 20ml, every day 3 times.Using sulfated ferrous, cause gastrointestinal upset easily, heartburn sense, constipation or diarrhoea.Can cause acute poisoning, acute necrotizing enteritis when heavy dose of, nauseating, vomiting, digestive tract hemorrhage be arranged, and can increase absorbtivity, cause hepatic necrosis.Individual patients has allergy.Take ferric ammonium citrate, can dye tongue, tooth black.As dark intramuscular injection iron dextran: can cause local pain, medicinal liquid is spilled over to the subcutaneous skin dyeing that causes; Allergy is flush, dizziness, uncomfortable in chest, nauseating, vomiting, shiver with cold, heating then, and even anaphylactic shock, cardiac arrest etc.; Inject the excessive hemosiderosis that causes, involve liver, the heart, pancreas function.As use Iron Sorbitex, the patient who has irritated shock and dissociation to occur.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of iron deficiency anemia.The cause of disease of iron deficiency anemia: 1, Deficiency of Intake and need ferrum amount increase; The malabsorption of ferrum; Chronic blood loss.Etiopathogenesis: ferrum combines with protoporphyrin and forms haemachrome.When iron deficiency, hemoglobin is synthetic to be reduced, and causes hypochrosis.The shortage of iron content enzyme causes a plurality of cells of organs mitochondrial swellings such as the heart, liver, nerve in the body, occurs dysfunctions such as circulation and digestive system clinically.The clinical manifestation of iron deficiency anemia: dizzy, weak, easily tired, tinnitus, dim eyesight, anemia can occur dizzy or faint etc.Because ferruginous oxidoreductase activity reduces and causes that the variation of mucosal tissue and organ function go down in the cell, as stomatitis, glossitis, atrophy of tongue papillae, cheilitis, bicker chap, chronic gastritis, achlorhydria etc.The appearance xerosis cutis that has, wrinkle and atrophy, trichoxerosis does not have the pool and comes off; The flat not polishing of fingernail, thin and brittle easily splitting and coelonychia.Auxiliary examination: one, hemogram: typical hemogram is minicell, hypochrosis, and hemoglobin is more more obvious than erythrocytopenia.Peripheral blood film mature erythrocyte volume is generally little, and form is not of uniform size, and central pale district enlarges.The depression broadening of scanning electron microscope show cell centre is and obvious, and profile is irregular.Leukocyte and platelet count do not have special variation.Mean corpuscular volume (MCV)＜80 cubic millimeter, the little milligram of the average hemoglobin of erythrocyte (MCH)＜28, mean corpuscular hemoglobin (MCHC) is lower than 30%.Two, bone marrow smear: the normoblastic series active proliferation, based in, the normoblast hypertrophy.The normoblast division sees easily that mutually volume is less, and slurry is few, and the edge is irregular.Granulocyte and megalokaryocyte do not have significant change more.Three, ferrum chromoscopy: check bone marrow hemosiderin and sideroblast with prussian blue staining.But ferrum storage case in the antimer is the hide sensitivity of ferrum in early stage and a method reliably of diagnosis.After the normal marrow smear was dyed, hemosiderin is common to be moderate (+～++), during iron deficiency anemia, then negative; The normal marrow normoblast contains the ferrum granule, claims sideroblast.During iron deficiency, owing to too much irony is utilized, so seldom find sideroblast.Four, serum levels of iron: iron deficiency anemia is lower than 50 microgram % often; Total iron binding capacity is up to 400～450 microgram %; Transferritin saturation significantly reduces (＜15%).When hemoglobin reduces when not obvious, serum levels of iron lowers the foundation of diagnosing for early iron deficiency anemia.

Its technical scheme is: this preparation method was divided into for two steps, the first step is that the smalls molten is used for getting Colla Corii Asini 12 weight portions stone roller, second step was, get Radix Polygoni Multiflori Preparata 12 weight portions, Radix Angelicae Sinensis 15 weight portions, the Radix Paeoniae Alba 15 weight portions, Radix Rehmanniae Preparata 12 weight portions, Arillus Longan 15 weight portions, Fructus Mori 12 weight portions, Melanteritum 9 weight portions, Radix Codonopsis 12 weight portions, the Radix Astragali 15 weight portions, Radix Pseudostellariae 9 weight portions, Herba Bidentis Tripartitae 9 weight portions, Radix Gossypii 9 weight portions, Semen Lablab Album 12 weight portions, Fructus Jujubae 15 weight portions, Rhizoma Polygonati 12 weight portions, Rhizoma Chuanxiong 9 weight portions, Radix Salviae Miltiorrhizae 12 weight portions and Radix Glycyrrhizae 9 weight portions, 18 flavor medicines are put into 1100 ml waters, soaked 30 minutes, slow fire is fried then, fried medicinal liquid removes slag with filtered through gauze, makes the Chinese medicine of treatment iron deficiency anemia.The advantage of this invention is: make simple, the Chinese medicine side effect of making is little, with this medicine oral after, the curative effect lasting stability, be difficult for bounce-back, medicine is in the digestive tract good absorbing, the gastrointestinal upset of having avoided Western medicine such as using sulfated ferrous, 10% ferric ammonium citrate to cause, untoward reaction such as that nausea,vomiting,diarrhea or constipation, tongue, tooth dye is black, glossitis, cheilitis.Taking this Chinese medicine can make iron deficiency anemia cure.Colla Corii Asini, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Arillus Longan, Fructus Mori, Melanteritum, this 8 flavor medicine can be gone into liver, kidney, the heart, spleen channel, all can enrich blood, and can be nourshing Yin and drynsessmoistening prescription, benefit is smart, promoting blood circulation and stopping pain.In the process of treatment iron deficiency anemia, play a major role, so be monarch drug.Wherein: Colla Corii Asini is sweet flat, and matter is sticking, is the in love product of flesh and blood, energy tonifying liver blood kidney nourishing water, and lung moistening is dry.The main component of Colla Corii Asini contains and produces soft propylhomoserin, arginine after gelatin unit, bone collagen, the hydrolysis, histidine and cystine, and calcic, sulfur etc.Colla Corii Asini has certain help to RBC number and the hemoglobin content that increases blood.Its principle may be the Nutrition by materials such as aminoacid, improves the whole body function, comprises hemopoietic function.Radix Polygoni Multiflori: pained tepor, sweet in the mouth are held concurrently and are mended, invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening, and the effect of convergence vital essence is arranged.Experimentation: the composition of Radix Polygoni Multiflori contains lecithin, methoxyl group anthraquinone derivative etc., and its contained lecithin is one of main component that constitutes nervous tissue, also is the necessary raw material of hemocyte and cell membrane.Radix Angelicae Sinensis: sweet benefit is hot looses, and it is logical that hardship is let out temperature, can enrich blood, can invigorate blood circulation again, but and promoting the circulation of QI to relieve pain.Go into the heart, liver, spleen three warps.Heart master blood, blood stored in the liver, The spleen governs the blood, thus can cure mainly all mass formed by blood stasis, for disorders of blood will product because the hot perfume (or spice) of Radix Angelicae Sinensis is apt to away, the title of " gas medicine in the blood " is arranged again.Radix Codonopsis, the Radix Astragali, Radix Pseudostellariae, Herba Bidentis Tripartitae, Radix Gossypii, Semen Lablab Album, Fructus Jujubae, Rhizoma Polygonati, this 8 flavor medicine multi-flavor is sweet, can QI invigorating, again can yang invigorating, nourishing blood to promote the production of body fluid, strengthening superficial resistance to stop perspiration, calm the nerves, in the treatment iron deficiency anemia, help out, so be ministerial drug.Ancients' cloud: " the capable then blood of gas is capable, and the stagnation of QI is blood clotting then.Qi being the governor of blood, blood being the material foundation of QI." gas can carry blood, so this 8 flavor medicine has good assosting effect in treatment iron deficiency anemia process.Rhizoma Chuanxiong: acrid in the mouth is warm in nature, goes into liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping, the hot Wen Xiang of its property scurries, walks and do not keep.Radix Salviae Miltiorrhizae: can blood circulation promoting and blood stasis dispelling.Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae two medicines can prevent QI invigorating, enrich blood too, so be adjuvant drug because of the energy promoting flow of QI and blood.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can correct the bias of medicine, the toxicity of cushion is so be messenger drug.More than this 19 the flavor medicine share, play benefiting vital QI and blood, beneficial smart yang invigorating jointly, the merit of Yin-nourishing and body fluid promoting, be the treatment iron deficiency anemia optimum formula.Colla Corii Asini: sweet, flat.Go into liver, lung, kidney channel.Tonifying blood and arresting bleeding is nourshing Yin and drynsessmoistening prescription.Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, tepor.Go into liver, kidney channel.Invigorating the liver and kidney, benefiting essence-blood.Skin ulcer is controlled in relieving constipation, preventing the attack (or recurrence) of malaria.Radix Angelicae Sinensis: sweet, hot, bitter, temperature.Go into liver, the heart, spleen channel.Enriching blood, it is smart to transfer, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.The Radix Paeoniae Alba: bitter, sour, be slightly cold, go into liver, spleen channel.The yin fluid astringing of enriching blood, easing the affected liver to relieve pain, yin nourishing suppressing the hyperactive liver.Radix Rehmanniae Preparata: hardship, tepor.Go into the heart, liver, kidney channel.Tonifying blood and regulating menstruation, the nourishing kidney nourishing YIN.Arillus Longan: sweet, flat.Go into the heart, spleen channel.Nourishing blood to tranquillize the mind.Fructus Mori: sweet, sour, cold.Go into the heart, liver, kidney channel.Nourishing YIN and supplementing blood.Melanteritum: acid, cold.Go into liver, spleen channel.Enrich blood, detumescence removes expands, the eliminating mass jaundice eliminating, and drying dampness to eliminate phlegm, parasite killing is treated skin ulcer, promoting digestion and removing stagnation.Radix Codonopsis: sweet, flat.Go into spleen, lung meridian.Invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid.The Radix Astragali: sweet, temperature.Go into spleen, lung meridian.Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, holder skin ulcer granulation promoting, inducing diuresis to remove edema.Radix Pseudostellariae: sweet, little hardship, tepor.Go into spleen, lung meridian.QI invigorating rises Tianjin.Herba Bidentis Tripartitae: hardship, flat.Go into spleen, lung, large intestine channel.QI invigorating, heat clearing away disappears stagnant.Radix Gossypii: sweet, temperature.Go into spleen, liver, lung meridian.Inrigorating qi and promoting blood circulation.Semen Lablab Album: sweet, tepor.Go into spleen, stomach warp.Invigorating the spleen for eliminating dampness, spleen reinforcing antidiarrheal, eliminating dampness and arresting leucorrhea.Fructus Jujubae: hardship, temperature.Go into spleen, stomach warp.The spleen reinforcing stomach function regulating, benefiting vital QI for tranquillizing.Rhizoma Polygonati: sweet, flat.Go into spleen, lung, kidney channel.Invigorating the spleen and replenishing QI, nourishing YIN and moistening the lung.Rhizoma Chuanxiong: suffering, temperature.Go into liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Radix Salviae Miltiorrhizae: hardship is slightly cold.Go into the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, relieving restlessness is calmed the nerves, reducing swelling and alleviating pain.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

This preparation method was divided into for two steps, and the first step is that the smalls molten is used for getting Colla Corii Asini 12g stone roller, once-a-day; Second step was, get Radix Polygoni Multiflori Preparata 12g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae Preparata 12g, Arillus Longan 15g, Fructus Mori 12g, Melanteritum 9g, Radix Codonopsis 12g, Radix Astragali 15g, Radix Pseudostellariae 9g, Herba Bidentis Tripartitae 9g, Radix Gossypii 9g, Semen Lablab Album 12g, Fructus Jujubae 15g, Rhizoma Polygonati 12g, Rhizoma Chuanxiong 9g, Radix Salviae Miltiorrhizae 12g and Radix Glycyrrhizae 9g, above 18 flavor medicines are put into 1100 ml waters, soaked 30 minutes, slow fire is fried then, fried medicinal liquid is 300 milliliters after with filtered through gauze, divides early, late secondary is oral.By this prescription, potion on the one, 3 weeks were a course of treatment, if symptom is still deposited, obeyed for the 2nd course of treatment again, until recovery from illness.When patient's hemogram, bone marrow smear, ferrum chromoscopy, serum levels of iron inspection are just often, be recovery from illness.

Table one, 215 routine iron deficiency anemia people age scopes

Age	11～16	17～28	29～38	39～68
					The example number	32	81	67	35
Percentage ratio	14.88％	37.68％	31.16％	16.28

Table two, 215 routine iron deficiency anemia patient's curative effect tables

	Cure	Take a turn for the better	Invalid
				The example number	213	2	0
Percentage ratio	99.07％	0.93％	0

Table three, 215 routine iron deficiency anemia patients show the course of treatment

The treatment natural law	21～42	43～63	64～75	76～97
					The example number	5	189	20	1
Percentage ratio	2.33％	87.91％	9.3％	0.46％

Claims (1)

1. Chinese medicinal preparation method for the treatment of iron deficiency anemia, it is characterized in that: this preparation method was divided into for two steps, the first step is that the smalls molten is used for getting Colla Corii Asini 12 weight portions stone roller, second step was, get Radix Polygoni Multiflori Preparata 12 weight portions, Radix Angelicae Sinensis 15 weight portions, the Radix Paeoniae Alba 15 weight portions, Radix Rehmanniae Preparata 12 weight portions, Arillus Longan 15 weight portions, Fructus Mori 12 weight portions, Melanteritum 9 weight portions, Radix Codonopsis 12 weight portions, the Radix Astragali 15 weight portions, Radix Pseudostellariae 9 weight portions, Herba Bidentis Tripartitae 9 weight portions, Radix Gossypii 9 weight portions, Semen Lablab Album 12 weight portions, Fructus Jujubae 15 weight portions, Rhizoma Polygonati 12 weight portions, Rhizoma Chuanxiong 9 weight portions, Radix Salviae Miltiorrhizae 12 weight portions and Radix Glycyrrhizae 9 weight portions, 18 flavor medicines are put into 1100 ml waters, soaked 30 minutes, slow fire is fried then, fried medicinal liquid removes slag with filtered through gauze, makes the Chinese medicine of treatment iron deficiency anemia.