CN101264152A - Medicinal composition for treating anorexia and monophagia and preparation thereof - Google Patents
Medicinal composition for treating anorexia and monophagia and preparation thereof Download PDFInfo
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- CN101264152A CN101264152A CNA2008101058358A CN200810105835A CN101264152A CN 101264152 A CN101264152 A CN 101264152A CN A2008101058358 A CNA2008101058358 A CN A2008101058358A CN 200810105835 A CN200810105835 A CN 200810105835A CN 101264152 A CN101264152 A CN 101264152A
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Abstract
The invention discloses a drug combination treating anorexia and monophagia and the preparation method, which comprises following active pharmaceutical ingredients with weight proportion: Largehead Atractylodes Rhizome 5 to 30, ginseng 5 to 20, orange peel 3 to 20, poria cocos 5 to 20, crab apple 10 to 60. The drug combination can strengthen the spleen and stomach, promote digestion and relieve stasis, improve immunity of body, promote growth and development and can be used for treating anorexia, loss of appetite, indigestion and disorders of digestive function caused by hypofunctioning of spleen and stomach with exact effect. The drug combination has a plurality of formulations such as oral liquid, syrup, pelletized granule, buccal tablets, chewable tablets and tablets through adopting modern preparing technology. The drug combination has the advantages of simple technology, stable quality and convenient use without any poison and side effect and be suitable for long-term administration.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of pharmaceutical composition for the treatment of anorexia, monophagia and preparation method thereof, belong to the novel technique field.
Background technology
The traditional Chinese medical science thinks, the reason of anorexia, monophagia and accumulation of food in the stomach and intes tine due to indigestion, dysfunction of spleen and stomach are relevant.
Along with improving constantly of human living standard, great variety is taking place in people's dietary habit and dietary structure, long-term monophagia and habitual feed fried food, puffed food, meat product etc., and the absorption of minimizing vegetable, fruits food, make dysfunction of spleen and stomach, digestive functional disturbance, cause anorexia and dyspepsia, secular anorexia, monophagia, to have a strong impact on child and teen-age healthy, clinical manifestation is emaciation and sallow complexion, inappetence, lethargy, appetite minimizing, even causes serious consequences such as anemia, dysplasia.
At present, because of anorexia, dyspepsia are that patient's prescription on individual diagnosis rate of main clinic symptoms improves constantly, and urbanization trend is obvious.Though and clinical treatment aspect method is many, but poor effect, for this kind treatment of diseases, need to change Bad Eating Habit on the one hand, need the function of spleen and stomach regulating function on the one hand, and need to replenish the deficiency because of anorexia caused various nutrients, the exploitation of this type of medicine has good social meaning and economic interests.
Summary of the invention
One of the object of the invention is to provide a kind of pharmaceutical composition for the treatment of anorexia, monophagia, this product has invigorating the spleen and regulating the stomach, the effect of promoting digestion and removing stagnation, but and human body immunity improving power, promote functions such as growth promoter, be used for the treatment of apositia, inappetence that weakness of the spleen and stomach causes, accumulation of food in the stomach and intes tine due to indigestion, digestive functional disturbance.
Two of the object of the invention is to provide this preparation of drug combination method.
The present invention selects for use has invigorating the spleen and regulating the stomach, and the pure Chinese medicine of promoting digestion and removing stagnation through the science compatibility, adopts modern preparation technique to process, and it is simple to have technology, steady quality, and taking convenience, without any side effects, the characteristics that are suitable for taking for a long time.
The Rhizoma Atractylodis Macrocephalae has the effect of air making-up and spleen enlivening among the present invention, returns spleen, stomach warp, and " book on Chinese herbal medicine converges and says " is loaded with: " Rhizoma Atractylodis Macrocephalae is to foster taste, and the wet dissipation eliminating impediment helps digestion except that the key medicine of painful abdominal mass.Insufficiency of the spleen unstrong, art can be mended it; Insufficiency of stomach is not received, and art can help it." modern pharmacological research shows that strong, liver-protective effect that the Rhizoma Atractylodis Macrocephalae has is the monarch drug in the side; Be equipped with regulate the flow of vital energy, spleen reinforcing, dampness removing, the Radix Ginseng of sedative action, Pericarpium Citri tangerinae, Poria, to reach the merit of QI invigorating spleen reinforcing, be the ministerial drug in the side; Fructus Crataegi has the effect of relieving dyspepsia, in the Compendium of Material Medica Fructus Crataegi is had and carries: " dissipating fluid-retention food.The meat Ji ， WEIJIA that disappears phlegm retention, the feeling of fullness acid regurgitation, the blood pain with distension stagnates." for digesting the key medicine of greasy meat stagnation; Modern pharmacological research proves that Fructus Crataegi can increase the secretion of digestive enzyme in the stomach, facilitating digestion; The contained lipase composition of Fructus Crataegi can promote the decomposition of fat, and multiple organic acid composition can improve protease activities, makes meat be easy to digestion, is the adjuvant drug in the side.
The present invention is made by following raw materials by weight proportions:
The Rhizoma Atractylodis Macrocephalae 5～30 weight portion Radix Ginsengs 5～20 weight portions
Pericarpium Citri tangerinae 3～20 weight portion Poria 5～20 weight portions
Fructus Crataegi 10～60 weight portions
Further, on the basis that the above-mentioned raw materials medicine is formed, the weight proportion of the active drug composition of pharmaceutical composition of the present invention can be adopted as especially:
The Rhizoma Atractylodis Macrocephalae 10 weight portion Radix Ginsengs 8 weight portions
Pericarpium Citri tangerinae 8 weight portion Poria 5 weight portions
Fructus Crataegi 15 weight portions
The present invention adopts modern preparation technique can be processed into acceptable clinically oral liquid, syrup, granule, buccal tablet, chewable tablet, the arbitrary dosage form of tablet.
The present invention realizes by following preparation method:
1, get Pericarpium Citri tangerinae, fragmentation adopts steam distillation to propose volatile oil, collects volatile oil, and low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;
2, get Radix Ginseng, fragmentation, with 6～10 times of amount 50%～80% alcohol reflux 2～4 times, each 1～3 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10～1.35 (50～70 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;
3, get the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Crataegi, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, merging filtrate, add step (1) gained filtrate, be evaporated to relative density and be the clear paste of 1.10～1.35 (50～70 ℃), standby;
4, get above-mentioned clear paste and volatile oil, formulation method adds the suitable formulations adjuvant routinely, molding, and packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Rhizoma Atractylodis Macrocephalae 20g Radix Ginseng 16g Pericarpium Citri tangerinae 16g
Poria 10g Fructus Crataegi 30g sucrose 100g
Flavoring orange essence 1ml sodium benzoate 1.2g
Make 1000ml altogether
Preparation method:
1, get Pericarpium Citri tangerinae, fragmentation adopts steam distillation to propose volatile oil, collects volatile oil, puts in the sealed container, and low temperature is placed under 4 ℃ of conditions, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;
2, get Radix Ginseng, fragmentation with 10 times of amount 75% alcohol reflux 3 hours, is extracted pure liquid and is filtered; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 1 hour again, extract pure liquid and filter; Filtrate merges, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.15 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;
3, get the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Crataegi, be ground into coarse powder, add Pericarpium Citri tangerinae, Radix Ginseng extraction back gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate merges with step (1) gained filtrate, is evaporated to relative density and is the clear paste of 1.15 (60 ℃), and is standby;
4, get above-mentioned clear paste, merge, filter, add sucrose, flavoring orange essence, sodium benzoate, dissolving filters;
5, get step (1) gained volatile oil, with the small amount of ethanol dissolving, standby;
6, get step (4) gained solution, add step (5) gained volatile oil alcoholic solution, mix homogeneously adds water to ormal weight, filter, and embedding, sterilization, packing, check, promptly.
Embodiment 2
Prescription is formed:
Rhizoma Atractylodis Macrocephalae 40g Radix Ginseng 32g Pericarpium Citri tangerinae 32g
Poria 20g Fructus Crataegi 60g Mel (refining) 40g
Sucrose 935g
Make 1000g altogether
Preparation method:
1, get Pericarpium Citri tangerinae, fragmentation adopts steam distillation to propose volatile oil, collects volatile oil, puts in the sealed container, and low temperature is placed under 4 ℃ of conditions, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;
2, get Radix Ginseng, fragmentation with 10 times of amount 75% alcohol reflux 3 hours, is extracted pure liquid and is filtered; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 1 hour again, extract pure liquid and filter; Filtrate merges, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;
3, get the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Crataegi, be ground into coarse powder, add Pericarpium Citri tangerinae, Radix Ginseng extraction back gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate merges with step (1) gained filtrate, is evaporated to relative density and is the clear paste of 1.10 (60 ℃), and is standby;
4, get step (1) gained volatile oil, with the small amount of ethanol dissolving, standby;
5, with above-mentioned clear paste, merge, add Mel (refining), mix homogeneously adds sucrose, and mix homogeneously is made granule, drying, granulate;
6, get step (5) gained granule, spray into step (4) gained volatile oil alcoholic solution, packing, check, promptly.
Embodiment 3
Prescription is formed:
Rhizoma Atractylodis Macrocephalae 40g Radix Ginseng 32g Pericarpium Citri tangerinae 32g
Poria 20g Fructus Crataegi 60g sucrose 470g
Cyclamate 0.5g citric acid 6g
Make 1000 altogether
Preparation method:
1, get Pericarpium Citri tangerinae, fragmentation adopts steam distillation to propose volatile oil, collects volatile oil, puts in the sealed container, and low temperature is placed under 4 ℃ of conditions, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;
2, get Radix Ginseng, fragmentation with 10 times of amount 75% alcohol reflux 3 hours, is extracted pure liquid and is filtered; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 1 hour again, extract pure liquid and filter; Filtrate merges, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.30 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;
3, get the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Crataegi, be ground into coarse powder, add Pericarpium Citri tangerinae, Radix Ginseng extraction back gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate merges with step (1) gained filtrate, is evaporated to relative density and is the clear paste of 1.10 (60 ℃), and is standby;
4, get step (1) gained volatile oil, with the small amount of ethanol dissolving, standby;
5, get above-mentioned clear paste, merge, add cyclamate, citric acid, sucrose, mix homogeneously is made granule, drying, and granulate sprays into step (4) gained volatile oil alcoholic solution, tabletting, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of anorexia, monophagia is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
The Rhizoma Atractylodis Macrocephalae 5～30 weight portion Radix Ginsengs 5～20 weight portions
Pericarpium Citri tangerinae 3～20 weight portion Poria 5～20 weight portions
Fructus Crataegi 10～60 weight portions
2, a kind of pharmaceutical composition for the treatment of anorexia, monophagia as claimed in claim 1 is characterized in that the weight proportion of the active drug composition of this pharmaceutical composition can be adopted as especially:
The Rhizoma Atractylodis Macrocephalae 10 weight portion Radix Ginsengs 8 weight portions
Pericarpium Citri tangerinae 8 weight portion Poria 5 weight portions
Fructus Crataegi 15 weight portions
3, a kind of pharmaceutical composition for the treatment of anorexia, monophagia as claimed in claim 1 or 2 can be processed into acceptable clinically oral liquid, syrup, granule, buccal tablet, chewable tablet, the arbitrary dosage form of tablet.
4, a kind of as claimed in claim 1 or 2 preparation of drug combination method for the treatment of anorexia, monophagia is as follows:
(1) get Pericarpium Citri tangerinae, fragmentation adopts steam distillation to propose volatile oil, collects volatile oil, and low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;
(2) get Radix Ginseng, fragmentation, with 6～10 times of amount 50%～80% alcohol reflux 2～4 times, each 1～3 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10～1.35 (50～70 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;
(3) get the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Crataegi, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, merging filtrate, add step (1) gained filtrate, be evaporated to relative density and be the clear paste of 1.10～1.35 (50～70 ℃), standby;
(4) get above-mentioned clear paste and volatile oil, formulation method adds the suitable formulations adjuvant routinely, molding, and packing, check, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101058358A CN101264152A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating anorexia and monophagia and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101058358A CN101264152A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating anorexia and monophagia and preparation thereof |
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| Publication Number | Publication Date |
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| CN101264152A true CN101264152A (en) | 2008-09-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101058358A Pending CN101264152A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating anorexia and monophagia and preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171121A (en) * | 2014-07-29 | 2014-12-03 | 宁国中科生物科技有限公司 | Health care tea drink |
| CN104547867A (en) * | 2015-01-16 | 2015-04-29 | 袁金海 | Traditional Chinese medicine composition capable of appetizing and promoting digestion as well as strengthening physique |
| CN106912947A (en) * | 2017-03-02 | 2017-07-04 | 芜湖张恒春药业有限公司 | The compound cream and preparation method thereof that takes care of health of one kind |
| CN114452357A (en) * | 2022-01-17 | 2022-05-10 | 广西健铧健康产业有限公司 | Liupao tea-containing preparation with blood fat and blood sugar reducing effects and preparation method thereof |
-
2008
- 2008-05-04 CN CNA2008101058358A patent/CN101264152A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171121A (en) * | 2014-07-29 | 2014-12-03 | 宁国中科生物科技有限公司 | Health care tea drink |
| CN104547867A (en) * | 2015-01-16 | 2015-04-29 | 袁金海 | Traditional Chinese medicine composition capable of appetizing and promoting digestion as well as strengthening physique |
| CN106912947A (en) * | 2017-03-02 | 2017-07-04 | 芜湖张恒春药业有限公司 | The compound cream and preparation method thereof that takes care of health of one kind |
| CN114452357A (en) * | 2022-01-17 | 2022-05-10 | 广西健铧健康产业有限公司 | Liupao tea-containing preparation with blood fat and blood sugar reducing effects and preparation method thereof |
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Open date: 20080917 |