CN101259234B - Medicinal composition for treating senile dementia and preparation thereof - Google Patents
Medicinal composition for treating senile dementia and preparation thereof Download PDFInfo
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Abstract
The present invention discloses a medicine compound for curing senile dementia and a preparation method thereof. The medicine compound is made from conic gymnadenia and gastrodia tuber. Siberian solomoseal rhizome, glossy privet fruit and Himalayan Mirabilis jalapa can also be added in the medicine compound. The preparation method of the compound adopts decoction, extraction, condensation, abstersion, analytics and other processes. According to regular process, the medicine compound for curing senile dementia is manufactured into clinically-acceptable preparation, including but not limited to condensed pill, capsule, drop pill, granule, tablet, soft capsule, sustained release preparation, oral liquid or freeze-dried injection. The clinical research proves that the medicine compound has comparatively good curing effect for senile dementia.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly a kind of pharmaceutical composition for the treatment of senile dementia and preparation method thereof.
Background technology
Dementia is the acquired and persistence disturbance of intelligence syndrome that produces owing to disordered brain function, disturbance of intelligence comprises that in various degree memory, language, visual space function, abnormality of personality and cognitive ability reduce, and dementia mainly comprises degenerative brain disorder, vascular dementia etc.Senile dementia has another name called Alzheimer, and Alzheimer is a kind of chronic former, carrying out property brain degenerative disease, belongs to the presenile dementia of improper aging state; The comprehensive obstacle and the cognitive function that show as the acquired Premium Features of cerebral cortex are obviously impaired, cerebral functional deterioration decline, and with the change of behavior or personality aspect.Vascular dementia is to be caused by cerebrovascular, mainly is ischemia.Studies show that in recent years, alzheimer disease also have vascular factor to participate in, and brain hemoperfusion quantity not sufficient is an important risk.
Rhizoma Gymnadeniae is the dry tuber of orchid Rhizoma Gymnadeniae Gymnadenia conopsea (L.) R.Br..Autumn end excavates, and cleans earth, dries.Have and tonify Qi of the kidney, the spermatogenesis lung moistening.Be used for pneumonopathy, cough and asthma due to lung deficiency, meat poison, seminal emission sexual impotence.See " Chinese ministry standard Tibetan medicine volume ", standard numbering: WS3-BC-0015-95.
Orchid Rhizoma Gastrodiae (Gastrodia elata B1) is the valuable Chinese medicine of China.Rhizoma Gastrodiae has the effect of suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion; Be mainly used in that treatment headache is dizzy, numb limbs and tense tendons, infantile convulsion, epilepsy clonus; The pharmacological action of Rhizoma Gastrodiae mainly contains: to the protective effect of neural cell injury, to central nervous system's effect, to the effect of cardiovascular system.
But still there is not the synergistic report of the two treatment senile dementia at present.
Summary of the invention
One object of the present invention is to disclose a kind of pharmaceutical composition for the treatment of senile dementia; Another object of the present invention is to disclose this kind treatment medicine for senile dementia preparation of compositions method.
The present invention seeks to be achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Rhizoma Gymnadeniae 10～90 weight portion Rhizoma Gastrodiaes 10～80 weight portions.
The crude drug preferred group of pharmaceutical composition of the present invention becomes:
Rhizoma Gymnadeniae 15 weight portion Rhizoma Gastrodiaes 75 weight portions.
The crude drug preferred group of pharmaceutical composition of the present invention becomes:
Rhizoma Gymnadeniae 80 weight portion Rhizoma Gastrodiaes 20 weight portions.
The crude drug preferred group of pharmaceutical composition of the present invention becomes:
Rhizoma Gymnadeniae 50 weight portion Rhizoma Gastrodiaes 45 weight portions.
The invention described above pharmaceutical composition also can increase one or more in the following crude drug:
Rhizoma Polygonati 5～20 weight portion Fructus Ligustri Lucidi 5～20 weight portion Radix Mirabilis himalaicaes 5～20 weight portions.
The invention described above pharmaceutical composition also can increase one or more in the following crude drug:
Rhizoma Polygonati 6 weight portion Fructus Ligustri Lucidi 17 weight portion Radix Mirabilis himalaicaes 6 weight portions.
The invention described above pharmaceutical composition also can increase one or more in the following crude drug:
Rhizoma Polygonati 18 weight portion Fructus Ligustri Lucidi 17 weight portion Radix Mirabilis himalaicaes 9 weight portions.
The invention described above pharmaceutical composition also can increase one or more in the following crude drug:
Rhizoma Polygonati 6 weight portion Fructus Ligustri Lucidi 6 weight portion Radix Mirabilis himalaicaes 18 weight portions.
Get the above-mentioned composition crude drug, be ground into fine powder, add conventional adjuvant, according to common process, make the dosage form of clinical acceptance, include but not limited to concentrated pill, capsule, drop pill, granule, tablet, soft capsule, slow releasing agent, oral liquid or lyophilized injectable powder.
Preparation of drug combination method of the present invention is:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 150 μ m～200 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 0.1 μ m～50 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 5～20 times of amounts of medical material weight 1～3 time, and relative density is 1.01～1.30 extractum when extracting solution is concentrated into 30 ℃～80 ℃, with the water dilution of 1～10 times of amount of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 10%～30% washing with alcohol, resolve with 40%～80% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
Maybe will clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 150 μ m～200 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 0.1 μ m～50 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 5～20 times of amounts of medical material weight 1～3 time, and relative density is 1.01～1.30 extractum when extracting solution is concentrated into 30 ℃～80 ℃, with the dilution of the water of 1～10 times of amount of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 10%～30% washing with alcohol, resolve with 40%～80% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
Preparation of drug combination method of the present invention is preferably:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 10 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 12 times of amounts of medical material weight 2 times, and relative density is 1.15 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 5 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 60% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
Maybe will clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 20 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 10 times of amounts of medical material weight 2 times, and relative density is 1.10 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 6 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
Preparation of drug combination method of the present invention is preferably:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 190 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 15 times of amounts of medical material weight 2 times, and relative density is 1.20 extractum when extracting solution is concentrated into 60 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
Maybe will clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 180 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation.
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 15 times of amounts of medical material weight 3 times, and relative density is 1.20 extractum when extracting solution is concentrated into 70 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
The present invention is with Rhizoma Gymnadeniae and Rhizoma Gastrodiae combination, and there is curative effect preferably treatment senile dementia aspect.Be processed into micropowders or solvent extraction, be prepared into different dosage forms.Make patient's taking convenience, and reduced medicine gastrointestinal is stimulated, be more conducive to the dissolving and the absorption of medicine, improve bioavailability.In addition, the extract toxicity of Rhizoma Gastrodiae and Rhizoma Gymnadeniae is low, safe, aspect the natural drug treatment senile dementia wide prospect is being arranged.
Experiment and embodiment are used to further specify but are not limited to the present invention below.
Experimental example 1 pair of senile dementia rat AchE and Na
+-K
+-ATP, Ca
2+The influence of-atpase activity
1. animal divides into groups and medication
Select 70 of Wistar male rats for use, body weight 280～320g, be divided into 7 groups at random, every group each 10, be respectively blank group, model group gives modeling merely, do not give any medicine, matched group I gives TIANZHI KELI 6g/Kg, control Group II is given Rhizoma Gastrodiae superfine powder (10 μ m～50 μ m) 0.6g/Kg, and control Group II I gives Rhizoma Gymnadeniae superfine powder (10 μ m～50 μ m) 0.6g/Kg, and medicament composing prescription Rhizoma Gastrodiae of the present invention mixes superfine powder (10 μ m～50 μ m) with Rhizoma Gymnadeniae at 1: 1, get high dose group 1g/Kg, get low dose group 0.5g/Kg; Below respectively organize the equal gastric infusion of medicine, capacity is 0.5ml/100g, successive administration 14 days.
2. modeling method
The blood clot of the aseptic natural drying of Wistar rat was pulverized the 100-200 mesh sieve, was dissolved in the normal saline, made the thromboembolism liquid of 2mg/ml; Urethane intraperitoneal injection of anesthesia rat with 20%, cut skin in the neck, exposure left carotid and neck are interior, external carotid artery, close common carotid artery with the temporary transient folder of bulldog clamp, inject 0.3ml thromboembolism liquid from external carotid artery retrograde puncture intubate, the normal control group is given isometric normal saline, the ligation external carotid artery, relieving common carotid artery folder makes embolus enter intracranial to each tremulous pulse of brain by internal carotid artery, causes many kitchen ranges property cerebral infarction.
3. experimental technique
Postoperative grouping in the 2nd day, successive administration was got brain after 7 days, got tissues such as Hippocampus, thalamus, cortex, and the back of weighing makes 1 with cold saline: the homogenate of 10w/v, the centrifuging and taking supernatant is measured albumen, AchE, Na
+-K
+-ATP, Ca
2+The content of-ATP enzyme.
The experimental data statistical procedures, data are used
Expression is relatively checked with t between group.
4. experimental result
Medicament composing prescription is to senile dementia experimental rat AchE, Na
+-K
+-ATP, Ca
2+The influence of-atpase activity the results are shown in Table 1.
Table 1 the present invention is to senile dementia rat AchE, Ca
2+-ATP, Na
+-K
+The influence of-atpase activity
Remarks: compare with the blank group: * * P＜0.01; Compare △ P＜0.05, △ △ P＜0.01 with model group.
Result from table 1; Model group and blank group contrast after the modeling, acetylcholine esterase content obviously raises, and ATP content reduces, and there were significant differences; Can reduce acetylcholine esterase content after using low dosage, high dose, TIANZHI KELI, ATP content raises, and there were significant differences; Application Rhizoma Gastrodiae, Rhizoma Gymnadeniae group do not have significant difference.
The facilitation of 2 pairs of senile dementia learning and memory of little mouse of experimental example
1. animal grouping
Select 70 of mices for use, body weight 34～42g is divided into 7 groups at random, and every group each 10, be respectively blank group, model group, model group add medicament composing prescription high dose group 1.4g/Kg of the present invention, are called for short matched group I; Model group adds medicament composing prescription low dose group 0.8g/Kg of the present invention, hereinafter to be referred as control Group II; Model group adds Rhizoma Gastrodiae superfine powder (10 μ m～50 μ m) 1g/Kg, hereinafter to be referred as control Group II I; Model group adds to Rhizoma Gymnadeniae superfine powder (10 μ m～50 μ m) 1g/Kg, hereinafter to be referred as matched group IV.
2. experimental apparatus
Ultrasonator, self-control water maze device: the round pool diameter is 100cm, high 60cm, podium level 50cm, diameter 10cm, platform is lower than water surface 1cm, and an end is the sintering in the pond, and the left and right sides is respectively the water channel of wide 20cm, in the middle of the water channel is dead space, and the left side water channel end is established the safety island of a 9cm * 9cm * 21cm.
3. experimental technique
3.1 medication
Below respectively organize the equal gastric infusion of medicine, capacity is 0.5ml/100g, successive administration 14 days.
3.2 the depth of water is 23cm during water maze laboratory, 24～26 ℃ of water temperatures, and every continuous swimming instruction of mice 5 days, all stops 20min after each swimming at every day 12 times on safety island; Towards putting into the sintering, going up safety island with the beeline trip serve as correctly with mouse tail, as to swim 1/2 distance of returning or swimming to safety island offside water channel in the way of safety island be wrong reaction.
3.3 evaluation index
Swimming time: every mice is from putting into the time that the sintering begins to finish to operation, can judge correct or wrong reaction is as the criterion.
Positive exact figures: the peak of every continuously correct number of times of mice swimming every day.
Continuously positive exact figures: the peak of every continuously correct number of times of mice swimming every day.
3.4 statistical analysis: swimming time, positive exact figures, continuously positive exact figures are checked with t.The results are shown in Table 2～6.
First day each index changes after table 2 modeling
Compare * P＜0.05, △ P＜0.01 with model group; Compare * * P＜0.05 with the blank group
Second day each index changes after table 3 modeling
Compare * P＜0.05 with model group; Compare △ P＜0.05 with the blank group
The 3rd day each index changes after table 4 modeling
Compare * P＜0.05 with model group; Compare * * P＜0.05 with the blank group
The 4th day each index changes after table 5 modeling
The 5th day each index changes after table 6 modeling
Compare * P＜0.05, △ P＜0.01 with model group; Compare * * P＜0.05 with the blank group
4. experimental result
By table 2-6 as seen, model group obviously prolongs at the 1st, 2,3,5 day swimming time, shows that learning memory disorder has appearred in model mice; After the modeling the 1st day, each medicine all can significantly shorten the mice swimming time, can not improve the reduction of continuously positive exact figures; Matched group I, control Group II, control Group II I can significantly shorten swimming time in the 2nd day, and matched group IV does not have this effect, and each medicine all can not improve the reduction of continuously positive exact figures; Matched group I, control Group II, control Group II I all can significantly improve the swimming time of mice in the 3rd day, and matched group IV does not have this effect, and matched group I, control Group II can significantly be improved the reduction of continuously positive exact figures; The 4th day each medicine all can not shorten swimming time and improve the reduction of positive exact figures; Matched group I, control Group II all can shorten swimming time and improve positive exact figures and the reduction of continuously positive exact figures in the 5th day.
Experimental example 3 clinical trials
Administrated method: treatment group 1: with Rhizoma Gastrodiae 500g, Rhizoma Gymnadeniae 500g is raw material, and raw medicinal material is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 150～200 μ m then, incapsulates, and every 0.5g gets final product.Dose: a 2-3 grain, 3 times on the one.
Treatment group 2: with Rhizoma Gastrodiae 500g, Rhizoma Gymnadeniae 500g, Rhizoma Polygonati 500g, Fructus Ligustri Lucidi 500g, Radix Mirabilis himalaicae 500g is raw material, and raw medicinal material is carried out remove impurity, cleaning, drying respectively, mixed powder is broken into the fine powder that particle diameter is 150～200 μ m then, incapsulate, every 0.5g gets final product.Dose: a 2-3 grain, 3 times on the one.
Matched group 1: with Rhizoma Gastrodiae 500g is raw material, with its remove impurity, cleaning, drying, is ground into the fine powder that particle diameter is 150～200 μ m then, incapsulates, and every 0.5g gets final product.Dose: a 2-3 grain, 3 times on the one.
Matched group 2: with Rhizoma Gymnadeniae 500g is raw material, with its remove impurity, cleaning, drying, is ground into the fine powder that particle diameter is 150～200 μ m then, incapsulates, and every 0.5g gets final product.Dose: a 2-3 grain, 3 times on the one.
The course of treatment: two groups was a course of treatment with 30 days all, can repeat 1--2 the course of treatment in case of necessity.
Treatment group and matched group data situation: each organizes the sex distribution situation, wherein treatment group 1: senile dementia 63 examples; Treatment group 2: senile dementia 62 examples; Matched group 1 senile dementia 60 examples; Matched group 2 senile dementias 60 examples; Sex when each organizes patient admission, the course of disease distribute see Table 7, table 8; Following clinical data shows that treatment group, matched group are isostatic at aspects such as sex, the courses of disease substantially, and through X 2 test, each group compares with matched group, and P＞0.05 has comparability.
Table 7 is respectively organized case sex distribution situation
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Table 8 is respectively organized course of disease distribution situation
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Through X
2Check, P＞0.05, two group comparison there was no significant difference.
Treatment group and treatment of control group effect relatively see Table 9-table 12.
Each group of table 9 compares the curative effect of senile dementia
As shown in Table 9, through Ridit check, group there is significant difference P＜0.05, two.Then treatment is organized 1 curative effect and is higher than matched group 1.
Each group of table 10 compares the curative effect of senile dementia
As shown in Table 10, through Ridit check, group there is significant difference P＜0.05, two.Then treatment is organized 1 curative effect and is higher than matched group 2.
Each group of table 11 compares the curative effect of senile dementia
As shown in Table 11, through Ridit check, group there is significant difference P＜0.05, two.Then treatment is organized 2 curative effects and is higher than matched group 1.
Each group of table 12 compares the curative effect of senile dementia
As shown in Table 12, through Ridit check, group there is significant difference P＜0.05, two.Then treatment is organized 2 curative effects and is higher than matched group 2.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1:
With Rhizoma Gastrodiae 100g, Rhizoma Gymnadeniae 900g is raw material, and raw medicinal material is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 150～200 μ m then, incapsulates, and gets final product.
Embodiment 2:
With Rhizoma Gastrodiae 900g, Rhizoma Gymnadeniae 100g is raw material, and raw medicinal material is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 200～250 μ m then, and is standby; Fine powder is added the 10g magnesium stearate, and tabletting behind the mix homogeneously gets final product.
Embodiment 3:
With Rhizoma Gastrodiae 500g, Rhizoma Gymnadeniae 500g is raw material, and crude drug is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 150～200 μ m then, and is standby; With the fine powder water pill, make the 0.2g pill.
Embodiment 4:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g is raw material, and crude drug is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 200～250 μ m then, and is standby; Place super micron mill to be ground into the micropowders that particle diameter is 0.1～10 μ m fine powder, make powder and get final product.
Embodiment 5:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g is raw material, and crude drug is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 150～200 μ m then, and is standby; Place super micron mill to be ground into the micropowders that particle diameter is 10～25 μ m fine powder, make soft capsule and get final product.
Embodiment 6:
With Rhizoma Gastrodiae 500g, Rhizoma Gymnadeniae 500g is raw material, and crude drug is carried out remove impurity, cleaning, drying respectively, and mixed powder is broken into the fine powder that particle diameter is 200～250 μ m then, and is standby; Place super micron mill to be ground into the micropowders that particle diameter is 25～50 μ m fine powder, standby; The gained micropowders is added 70% ethanol, make the granule that particle diameter is 1500～2000 μ m, drying, granulate is made granule.
Embodiment 7:
With Rhizoma Gastrodiae 100g, Rhizoma Gymnadeniae 900g is raw material, to carry out remove impurity, clean, exsiccant crude drug mixes, with 95% ethanol extraction of 15 times of amounts of medical material weight 2 hours, and extracting solution is concentrated into relative density is 1.30 extractum, the dilution of the water of 10 times of amounts of reuse extractum volume, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 80% ethanol at last again with 30% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, granulates, and in incapsulating, gets final product.
Embodiment 8:
With Rhizoma Gastrodiae 900g, Rhizoma Gymnadeniae 100g is raw material, to carry out remove impurity, clean, exsiccant crude drug mixes, use 30% ethanol extraction 2 times of medical material weight 12 and 6 times of amounts respectively, each 1 hour, and extracting solution is concentrated into relative density is 1.01 extractum, and reuse extractum is with the water dilution of volume, filter the clarification extracting solution; To clarify extracting solution and feed macroporous adsorptive resins, wash with water earlier,, resolve with 40% ethanol at last again with 10% washing with alcohol; Desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes tablet, gets final product.
Embodiment 9:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g is raw material, to carry out remove impurity, clean, exsiccant crude drug mixes, use 70% ethanol extraction 3 times of 9,6 and 3 times of amounts of medical material weight respectively, each 0.5 hour, and extracting solution is concentrated into relative density is 1.15 extractum, the water dilution of 6 times of amounts of reuse extractum volume, filter the clarification extracting solution; Gained clarification extracting solution feeds macroporous adsorptive resins, washes with water earlier, again with 20% washing with alcohol, resolves with 60% ethanol at last; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes powder, gets final product.
Embodiment 10:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g is raw material, to carry out remove impurity, clean, exsiccant crude drug mixes, use 50% ethanol extraction 3 times of 10,8 and 6 times of amounts of medical material weight respectively, each 1 hour, and extracting solution is concentrated into relative density is 1.20 extractum, the water dilution of 4 times of amounts of reuse extractum volume, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 70% ethanol at last again with 15% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes pill, gets final product.
Embodiment 11:
With Rhizoma Gastrodiae 300g, Rhizoma Gymnadeniae 700g is raw material, to carry out remove impurity, clean, exsiccant crude drug mixes, use 40% ethanol extraction 2 times of medical material weight 10 and 5 times of amounts respectively, each 1.5 hours, and extracting solution is concentrated into relative density is 1.12 extractum, the water dilution of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 50% ethanol at last again with 25% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes tablet, gets final product.
Embodiment 12:
With Rhizoma Gastrodiae 700g, Rhizoma Gymnadeniae 300g is raw material, and the crude drug that will carry out remove impurity, cleaning, drying mixes, and with the water boiling and extraction of 5 times of amounts of medical material weight 3 hours, and extracting solution is concentrated into relative density was 1.30 extractum; With the dilution of the water of 10 times of amounts of extractum volume, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 40% ethanol at last again with 30% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, and extract obtained dry powder is added Icing Sugar, and mixing is made granule, and drying is made granule, gets final product.
Embodiment 13:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g is raw material, and the crude drug that will carry out remove impurity, cleaning, drying mixes, and uses the water boiling and extraction 2 times of medical material weight 20 and 15 times of amounts respectively, each 1 hour, and extracting solution is concentrated into relative density is 1.01 extractum; With extractum with the dilution of the water of volume, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 80% ethanol at last again with 10% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes powder, gets final product.
Embodiment 14:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g is raw material, and the crude drug that will carry out remove impurity, cleaning, drying mixes, with the water boiling and extraction of 10,8 and 6 times of amounts of medical material weight 3 times, and each 0.5 hour, and extracting solution is concentrated into relative density is 1.15 extractum; With the dilution of the water of 6 times of amounts of extractum, filter the clarification extracting solution; Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 60% ethanol at last again with 20% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes pill, gets final product.
Embodiment 15:
With Rhizoma Gastrodiae 500g, Rhizoma Gymnadeniae 500g is raw material, and the crude drug that will carry out remove impurity, cleaning, drying mixes, with the water boiling and extraction of medical material weight 12 and 6 times of amounts 2 times, and each 0.5 hour, and extracting solution is concentrated into relative density is 1.15 extractum; With the dilution of the water of 6 times of amounts of extractum, filter the clarification extracting solution;
Gained is clarified extracting solution feed macroporous adsorptive resins, wash with water earlier,, resolve with 60% ethanol at last again with 20% washing with alcohol; The gained desorbed solution reclaims ethanol, concentrates, and gets extract dry powder after the spray drying, makes capsule, gets final product.
Embodiment 16:
With Rhizoma Gymnadeniae 200g, Rhizoma Gastrodiae 800g, Rhizoma Polygonati 6g, Fructus Ligustri Lucidi 18g, Radix Mirabilis himalaicae 6g is raw material, is ground into fine powder, and particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, and particle diameter is 20 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes pill, gets final product.
Embodiment 17:
With Rhizoma Gymnadeniae 800g, Rhizoma Gastrodiae 200g, Rhizoma Polygonati 18g, Fructus Ligustri Lucidi 17g, Radix Mirabilis himalaicae 9g is raw material, is ground into fine powder, and particle diameter is 180 μ m, places micronizing equipment to be ground into micropowders again, and particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes tablet, gets final product.
Embodiment 18:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g, Rhizoma Polygonati 6g, Fructus Ligustri Lucidi 6g, Radix Mirabilis himalaicae 18g is raw material, with the water boiling and extraction of 15 times of amounts of medical material weight 3 times, and relative density is 1.20 extractum when extracting solution is concentrated into 70 ℃, with the dilution of the water of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make powder, get final product by the routine techniques of galenic pharmacy.
Embodiment 19:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g, Rhizoma Polygonati 18g, Fructus Ligustri Lucidi 17g, Radix Mirabilis himalaicae 9g is raw material, with the water boiling and extraction of 10 times of amounts of medical material weight 2 times, and relative density is 1.10 extractum when extracting solution is concentrated into 50 ℃, with the dilution of the water of 6 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make granule, get final product by the routine techniques of galenic pharmacy.
Embodiment 20:
With Rhizoma Gymnadeniae 200g, Rhizoma Gastrodiae 800g, Rhizoma Polygonati 5g is raw material, is ground into fine powder, and particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, and particle diameter is 10 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes pill, gets final product.
Embodiment 21:
With Rhizoma Gymnadeniae 200g, Rhizoma Gastrodiae 800g, Fructus Ligustri Lucidi 10g, be raw material, be ground into fine powder, particle diameter is 190 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes granule, gets final product.
Embodiment 22:
With Rhizoma Gymnadeniae 800g, Rhizoma Gastrodiae 200g, Radix Mirabilis himalaicae 10g is raw material, is ground into fine powder, and particle diameter is 180 μ m, places micronizing equipment to be ground into micropowders again, and particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes capsule, gets final product.
Embodiment 23:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g, Rhizoma Polygonati 10g, Fructus Ligustri Lucidi 15g is raw material, with the water boiling and extraction of 15 times of amounts of medical material weight 3 times, and relative density is 1.20 extractum when extracting solution is concentrated into 70 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make powder, get final product by the routine techniques of galenic pharmacy.
Embodiment 24:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g, Rhizoma Polygonati 20g, Radix Mirabilis himalaicae 15g is raw material, with the water boiling and extraction of 10 times of amounts of medical material weight 2 times, and relative density is 1.10 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 6 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make tablet, get final product by the routine techniques of galenic pharmacy.
Embodiment 25:
With Rhizoma Gastrodiae 400g, Rhizoma Gymnadeniae 600g, Fructus Ligustri Lucidi 15g, Radix Mirabilis himalaicae 5g is raw material, with the water boiling and extraction of 15 times of amounts of medical material weight 3 times, and relative density is 1.20 extractum when extracting solution is concentrated into 70 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make powder, get final product by the routine techniques of galenic pharmacy.
Embodiment 26:
With Rhizoma Gastrodiae 600g, Rhizoma Gymnadeniae 400g, Fructus Ligustri Lucidi 15g, Radix Mirabilis himalaicae 10g is raw material, with the water boiling and extraction of 10 times of amounts of medical material weight 2 times, and relative density is 1.10 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 6 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make granule, get final product by the routine techniques of galenic pharmacy.
Claims (18)
1. a pharmaceutical composition for the treatment of senile dementia is characterized in that the crude drug of this pharmaceutical composition consists of: Rhizoma Gymnadeniae 10～90 weight portion Rhizoma Gastrodiaes 10～80 weight portions.
2. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of: Rhizoma Gymnadeniae 15 weight portion Rhizoma Gastrodiaes 75 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of: Rhizoma Gymnadeniae 80 weight portion Rhizoma Gastrodiaes 20 weight portions.
4. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of: Rhizoma Gymnadeniae 50 weight portion Rhizoma Gastrodiaes 45 weight portions.
5. pharmaceutical composition for the treatment of senile dementia, the crude drug that it is characterized in that this pharmaceutical composition is made up of one or more and Rhizoma Gymnadeniae 10～90 weight portions in Rhizoma Polygonati 5～20 weight portions, Fructus Ligustri Lucidi 5～20 weight portions and Radix Mirabilis himalaicae 5～20 weight portions and Rhizoma Gastrodiae 10～80 weight portions.
6. pharmaceutical composition as claimed in claim 5, the crude drug that it is characterized in that this pharmaceutical composition is made up of one or more and Rhizoma Gymnadeniae 15 weight portions in Rhizoma Polygonati 6 weight portions, Fructus Ligustri Lucidi 17 weight portions and Radix Mirabilis himalaicae 6 weight portions and Rhizoma Gastrodiae 75 weight portions.
7. pharmaceutical composition as claimed in claim 5, the crude drug that it is characterized in that this pharmaceutical composition is made up of one or more and Rhizoma Gymnadeniae 80 weight portions in Rhizoma Polygonati 18 weight portions, Fructus Ligustri Lucidi 17 weight portions and Radix Mirabilis himalaicae 9 weight portions and Rhizoma Gastrodiae 20 weight portions.
8. pharmaceutical composition as claimed in claim 5, the crude drug that it is characterized in that this pharmaceutical composition is made up of one or more and Rhizoma Gymnadeniae 50 weight portions in Rhizoma Polygonati 6 weight portions, Fructus Ligustri Lucidi 6 weight portions and Radix Mirabilis himalaicae 18 weight portions and Rhizoma Gastrodiae 45 weight portions.
9. as the arbitrary described pharmaceutical composition of claim 1-8, it is characterized in that getting the above-mentioned composition crude drug, be ground into fine powder, add conventional adjuvant,, make the dosage form of clinical acceptance according to common process.
10. pharmaceutical composition as claimed in claim 9 is characterized in that described dosage form is concentrated pill, capsule, drop pill, granule, tablet, slow releasing agent, oral liquid or lyophilized injectable powder.
11. pharmaceutical composition as claimed in claim 9 is characterized in that described dosage form is a soft capsule.
12., it is characterized in that this method comprises a kind of in the following method as the arbitrary described preparation of drug combination method of claim 1-4:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 150 μ m～200 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 0.1 μ m～50 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 5～20 times of amounts of medical material weight 1～3 time, and relative density is 1.01～1.30 extractum when extracting solution is concentrated into 30 ℃～80 ℃, with the water dilution of 1～10 times of amount of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 10%～30% washing with alcohol, resolve with 40%～80% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
13., it is characterized in that this method comprises a kind of in the following method as the arbitrary described preparation of drug combination method of claim 5-8:
To clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 150 μ m～200 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 0.1 μ m～50 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 5～20 times of amounts of medical material weight 1～3 time, and relative density is 1.01～1.30 extractum when extracting solution is concentrated into 30 ℃～80 ℃, with the dilution of the water of 1～10 times of amount of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 10%～30% washing with alcohol, resolve with 40%～80% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
14. preparation of pharmaceutical compositions method as claimed in claim 12 is characterized in that this method comprises a kind of in the following method:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 10 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 12 times of amounts of medical material weight 2 times, and relative density is 1.15 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 5 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 60% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
15. preparation of pharmaceutical compositions method as claimed in claim 13 is characterized in that this method comprises a kind of in the following method:
Maybe will clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 160 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 20 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 10 times of amounts of medical material weight 2 times, and relative density is 1.10 extractum when extracting solution is concentrated into 50 ℃, with the water dilution of 6 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
16. preparation of pharmaceutical compositions method as claimed in claim 12 is characterized in that this method comprises a kind of in the following method:
To clean earlier, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae mix, and is ground into fine powder, particle diameter is 190 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae medical material mix, with the water boiling and extraction of 15 times of amounts of medical material weight 2 times, and relative density is 1.20 extractum when extracting solution is concentrated into 60 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 0.1～10 times of bed volume/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
17. preparation of pharmaceutical compositions method as claimed in claim 13 is characterized in that this method comprises a kind of in the following method:
To clean, exsiccant Rhizoma Gymnadeniae, Rhizoma Gastrodiae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, and is ground into fine powder, particle diameter is 180 μ m, places micronizing equipment to be ground into micropowders again, particle diameter is 40 μ m; With this micropowders is the active component of medicine of the present invention, adds conventional adjuvant and makes clinical acceptable oral preparation;
Maybe will clean, exsiccant Rhizoma Gastrodiae, Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Ligustri Lucidi, Radix Mirabilis himalaicae mix, with the water boiling and extraction of 15 times of amounts of medical material weight 3 times, and relative density is 1.20 extractum when extracting solution is concentrated into 70 ℃, with the water dilution of 8 times of amounts of extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 70% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, drying, the active part component of medicine of the present invention; Pharmaceutically active part component is combined with the pharmaceutics acceptable auxiliary, and make oral drug preparation by the routine techniques of galenic pharmacy.
18. as the application of the arbitrary described pharmaceutical composition of claim 1-8 in the medicine of preparation treatment senile dementia.
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| CN115227779B (en) * | 2021-04-25 | 2024-04-26 | 重庆伊士腾生物科技有限公司 | Composition for preventing senile dementia and improving memory |
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Non-Patent Citations (2)
| Title |
|---|
| 张建军.《传统藏药"旺拉"防治老年性痴呆的研究》.《第十次中国生物物理学术大会论文摘要集,2006年》.2006,130. |
| 鞠桂春.《天麻及其制剂的药理作用和临床应用研究进展》.《中国药业》.2007,第17卷(第1期),64,I,II. * |
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