CN101259228B

CN101259228B - Compound changning mixture

Info

Publication number: CN101259228B
Application number: CN2008100149561A
Authority: CN
Inventors: 刘爱玲; 姜云霞; 马玉芹
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-04-03
Filing date: 2008-04-03
Publication date: 2011-01-12
Anticipated expiration: 2028-04-03
Also published as: CN101259228A

Abstract

The present invention relates to the art of drug formulation, in particular to a Compound Chang-Ning Mixture, which is made from milk veteh, largehead atractylode, coptis root, Patrinia villosa, coix seed, ballonflower root, india madder root, pangolin and angelica. Milk veteh, largehead atractylode, coptis root, Patrinia villosa, coix seed, ballonflower root, india madder root, pangolin and angelica are cleaned and soaked with water, then decocted and filtered to get the filtrate, finally disinfected and refined to get the mixture. The technical characteristic is that the weight portions of the raw materials are as follows: 12 to 22 percent of milk veteh, 8 to 10 percent of largehead atractylode, 4 to 6 percent of coptis root, 12 to 16 percent of Patrinia villosa, 12 to 23 percent of coix seed, 10 to 14 percent of ballonflower root, 10 to 12 percent of india madder root, 8 to 10 percent of pangolin and 4 to 6 percent of angelica, and the total percent of the raw materials is 100 percent. The Compound Chang-Ning Mixture has the characters of low cost of raw materials, good compliance, and no toxic side effect, thus improving the body immunity and curing ulcerative clotis effectively.

Description

Compound changning mixture

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of compound changning mixture that is used for the treatment of ulcerative colitis.

Background technology

Ulcerative colitis belongs to autoimmune disease, be the colon inflammatory diseases that a kind of cause of disease is still not exclusively understood, may be relevant with infection, immunity, heredity, spirit, neural factor and diet etc., often be chronic process, the course of disease reaches surplus year of several years to ten, and stage of attack and paracmastic replacing are often arranged.Severe patient can have complication such as massive hemorrhage of gastrointestinal tract, intestinal perforation, canceration.Modern medicine mainly adopts Drug therapys such as aminosallcylic acid class, adrenocortical hormone and immunosuppressant.But above-mentioned class medicine can cause hepatic and renal function injure, bone marrow depression, erythra and prolonged application hormone and can cause many untoward reaction such as osteoporosis, secondary hypertension, diabetes, superinfection, spirit change, electrolyte disturbance, drug side effect is big, the state of an illness recurs easily, has seriously influenced their use.Chinese medicine has its uniqueness and superiority in the treatment of ulcerative colitis, play an important role.

Summary of the invention

The technical problem that will solve required for the present invention is in order to overcome above-mentioned the deficiencies in the prior art, a kind of clinical symptoms of improving ulcerative colitis to be provided, and determined curative effect is with low cost, the Chinese medicine preparation that has no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of compound changning mixture, adopt the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Herba Patriniae, Semen Coicis, Radix Platycodonis, Radix Rubiae, Squama Manis, form when being classified as feedstock production, with the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Herba Patriniae, Semen Coicis, Radix Platycodonis, Radix Rubiae, Squama Manis, after Radix Angelicae Sinensis is cleaned, be soaked in water, decoct then, remove slag filtrate, sterilization, after refining, make mixture, its technical characterictic is, raw material is formed: Radix Astragali 12-22%, Rhizoma Atractylodis Macrocephalae 8-10%, Rhizoma Coptidis 4-6%, Herba Patriniae 12-16%, Semen Coicis 12-23%, Radix Platycodonis 10-14%, Radix Rubiae 10-12%, Squama Manis 8-10%, Radix Angelicae Sinensis 4-6%, each raw material components percentage ratio sum equals absolutely.

The invention has the beneficial effects as follows: cost of material is low, and compliance is good, have no side effect, but enhancing human body immunity power can effectively be treated ulcerative colitis.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1:

Present embodiment adopts the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Herba Patriniae, Semen Coicis, Radix Platycodonis, Radix Rubiae, Squama Manis, forms when being classified as feedstock production.Its component (weight %) is the Radix Astragali 16, the Rhizoma Atractylodis Macrocephalae 8, Rhizoma Coptidis 6, Herba Patriniae 16, Semen Coicis 20, Radix Platycodonis 11, Radix Rubiae 10, Squama Manis 9, Radix Angelicae Sinensis 4.Get 54 kilograms of above-mentioned nine kinds of raw material gross weights, after selected the cleaning, medicine is soaked in water decocted earlier in 20 minutes then.Head is fried in shallow oil and is added water 12000ml, is not advisable to have the powder one-inch, with high heat earlier, changes slow fire into after being fried boiling, and decocts 30 minutes extracting juice 4500ml; Two fry in shallow oil and add water 8000ml, change slow fire into after being fried boiling with high heat, decoct 20 minutes extracting juice 4500ml.Two fry in shallow oil mixing, and after routine removed slag filtration, high pressure, sterilization process, gained filtrate is 9000ml altogether, splitting vacuum packaging, every bag of 150ml.Lucifuge, room temperature are preserved.

Therapeutic Principle of the present invention: ulcerative colitis belongs to Chinese medicine " dysentery " " spouting bleeding from anus " sick categories such as " large intestine are let out " of " having loose bowels ".Its pathological change is mainly at taste and intestine and small intestine, and mistake that endogenous cause of ill is insufficiency of the spleen is transported, endogenous damp formation, and the damp and hot evil poison of exopathogenic factor, impairing the spleen and stomach, the intestinal qi depression to blood stasis then runs through the course of disease all the time.So treatment is a rule with invigorating the spleen to clear away damp pathogen, heat-clearing and toxic substances removing, promoting flow of QI and blood, detumescence and promoting granulation.In the component of the present invention: the Radix Astragali is a principal agent, has the spleen invigorating QI invigorating, the merit of promoting pus discharge and tissue regeneration strengthening, modern pharmacological research has to be adjusted immunologic function and promotes ulcer surface healing effect, join Rhizoma Atractylodis Macrocephalae spleen invigorating and in, dampness removing and diarrhea-relieving; Rhizoma Coptidis has heat clearing and damp drying, eliminating fire and detoxication effect, puts down in writing according to " herbal classic ": Rhizoma Coptidis " main spouting bleeding from anus stomachache dysentery "; " not Lu " claims: " main for a long time under let out the addiction pus and blood ".The modern pharmacological research Rhizoma Coptidis has antimicrobial and protozoacidal effect, its has a broad antifungal spectrum, various pathogens such as dysentery bacterium are had inhibitory action, can also strengthen leukocyte and liver reticuloendothelial system phagocytic activity, the dysbolismus that produces because of infection is recovered to some extent.Herba Patriniae returns large intestine channel, is longer than heat-clearing and toxic substances removing, and the eliminating carbuncle eliminating stagnation is for controlling the key medicine of acute appendicitis; Reuse Semen Coicis invigorating the spleen to clear away damp pathogen antidiarrheal, the clearing away heat and discharging pus eliminating carbuncle of holding concurrently, cooperate Radix Platycodonis to strengthen the merit of removing pus and relieving carbuncle, Radix Platycodonis has lung qi dispersing gas again simultaneously, the respectful merit of falling of lung again helps the machine of large intestine conduction.The Radix Rubiae bitter cold, cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, this product can blood circulation promoting and blood stasis dispelling, can stop blooding again, does not stay stasis of blood characteristics so hemostasis is arranged; Be equipped with the Squama Manis blood circulation promoting and blood stasis dispelling, detumescence and apocenosis, the person is disappeared to make carbuncle not become pus, and person's speed is burst to have become pus.The two has hemostasia and dissipation blood stasis, the effect of antiinflammatory wound healing, can promote vascular endothelial cell and fibroblastic generation, thereby quickens angiogenic growth, quickens the epithelial tissue reparation, improves local blood circulation, promotes wound healing.Assistant is with Radix Angelicae Sinensis, and this product is enriched blood, invigorated blood circulation, and kind hemostasis void, blood stasis be pain, and the cold expelling function is arranged, and can play the merit of reducing swelling and alleviating pain, evacuation of pus granulation promoting.All medicines share, and spleen must be good for fortune, wetization, and pyretic toxicity gets clearly, and blood fortune passes unimpeded, and the stasis of blood goes carbuncle to disappear.The present invention has enhancing human body immunity power, promotes chronic inflammatory disease to absorb, repair mucosal ulcer and have analgesic effect.Clinical practice treatment ulcerative colitis has obtained good efficacy.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (percentage by weight) is realized.Its processing technique is identical with embodiment 1.

Embodiment	The Radix Astragali	The Rhizoma Atractylodis Macrocephalae	Rhizoma Coptidis	Herba Patriniae	Semen Coicis	Radix Platycodonis	Radix Rubiae	Squama Manis	Radix Angelicae Sinensis
										Embodiment 1	15	10	4	12	23	10	12	8	6
Embodiment 2	12	9	5	13	23	14	10	10	4
										Embodiment 3	22	8	6	15	12	12	11	9	5
Embodiment 4	19	9	5	14	18	11	11	8	5

Below in conjunction with my institute, i.e. the clinical trial carried out of Shandong Province Wendeng Central Hospital, Weihai City is done further, is described in detail the present invention:

1, case is selected: this organizes 60 examples, male 32 examples, women 28 examples, age 21-64 year, 40 years old mean age; The course of disease 2 months.

2, diagnostic criteria: write 1. chronic diarrhea of diagnostic criteria that " practical internal medicine " 2005 formulate with reference to Chen Haozhu, blood, pus and mucus just, stomachache, General Symptoms in various degree (comprises heating, anemia, water, electrolyte disturbance, acid base imbalance, physically-draining, malnutrition); 2. stool is cultivated does not have the pathogen of discovery more than 3 times; 3. the visible pathological changes of colonoscopy mainly is positioned at rectum and sigmoid colon, may extend into descending colon even whole colon, mucosa is fine particulate, and diffusivity hyperemia, edema, crisp easily hemorrhage arranged, rotten to the corn and most out-of-shapes, the ulcer that the big or small depth is different are coated with yellow or blood effusion.Become situation person and do not classify the object of observation as for massive hemorrhage of gastrointestinal tract, intestinal obstruction, intestinal perforation, intestinal cancer occurring.

3, criterion of therapeutical effect: formulate with reference to relevant criterion in " disease of tcm diagnosis criterion of therapeutical effect " and " new Chinese medicine clinical research guideline (trying) ".Cure: clinical symptoms, sign disappear, and times of defecation, character are normal, and the colonoscopy colonic mucosa is normal.Effectively: clinical symptoms, sign disappear, and times of defecation, character are normal, and the colonoscopy colonic mucosa still has mile abnormality.Invalid: symptom does not have obvious improvement, or during treating the recurrence in addition increase the weight of.

4, Therapeutic Method: take compound changning mixture 150mL at every turn, morning every day, late twice empty stomach decoction being taken warmly, taking ten days is a course of treatment, takes three courses of treatment of the present invention continuously.

5, therapeutic outcome: the present invention treats 60 examples, takes medicine three courses of treatment, cures 14 examples, effective 42 examples, invalid 4 examples, cure rate 23%, effective percentage 70%, inefficiency 7%, total effective rate 93%.

Claims

1. compound changning mixture, its technical characterictic is: adopt the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Herba Patriniae, Semen Coicis, Radix Platycodonis, Radix Rubiae, Squama Manis, form when being classified as feedstock production, with the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Herba Patriniae, Semen Coicis, Radix Platycodonis, Radix Rubiae, Squama Manis, after Radix Angelicae Sinensis is cleaned, be soaked in water, decoct then, remove slag filtrate, sterilization, after refining, make mixture, raw material is formed: Radix Astragali 12-22%, Rhizoma Atractylodis Macrocephalae 8-10%, Rhizoma Coptidis 4-6%, Herba Patriniae 12-16%, Semen Coicis 12-23%, Radix Platycodonis 10-14%, Radix Rubiae 10-12%, Squama Manis 8-10%, Radix Angelicae Sinensis 4-6%, each raw material components percentage ratio sum equals absolutely.