CN101249242A - Traditional Chinese medicine preparation for broad-spectrum curing gastropathy and method of preparing the same - Google Patents
Traditional Chinese medicine preparation for broad-spectrum curing gastropathy and method of preparing the same Download PDFInfo
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Abstract
The invention relates to a Chinese medicine preparation, in particular to a broad spectrum Chinese medicine preparation for the treatment of gastric disease and a preparation method thereof. The broad spectrum Chinese medicine preparation for the treatment of gastric disease is based on the traditional Chinese medicine theory, which is prepared by decocting, filtering, concentrating, dying, baking and mixing eleven species of Chinese herbal medicines of amomum fruit, radish seed, hedge thorn, clove, cape jasmine, dried old orange peel, euonymus tengyuehensis, rhizoma dioscoreae, chickens gizzard-membrane, bulb of long stamen onion and dahurian angelica. After taking the colloid liquid of the inventive Chinese medicine preparation which is dissolved in water, a protecting mucosa is formed on the surface of the intestines and stomachs, the colloid liquid has the functions of absorbing the secreta on the ulcer surface and removing the mechanical frictions on the ulcer surface to ensure the mucosa to form a regenerative environment on the ulcer surface; the colloid liquid can also perform the repairing effect of removing blood stasis, nourishing and promoting tissue regeneration to the mucosa nerve tissue on the ulcer surface, thereby promoting the cicatrization of the ulcer surface.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to pure Chinese medicinal preparation of a kind of broad-spectrum curing gastropathy and preparation method thereof.
Background technology
Peptic ulcer is a global frequently-occurring disease.The sickness rate of peptic ulcer accounts for whole crowd's 23% according to statistics, and men and women's ratio is about 2.6-6.5 than 1.Chronic gastritis is also very common, accounts for the 80%-90% that accepts the gastroscopy patient,, the male increases the merchant more than the women gradually with the age growth sickness rate. and middle medical chronic gastritis curative effect is rather good, and effective percentage can reach 40%-73%.Chinese medicine thinks that chronic gastritis belongs to " stomach painful abdominal mass disease " category, and " interior warp " is referred to as " painful abdominal mass " " feeling of fullness " " painful abdominal mass plug " etc. with stomach painful abdominal mass disease.Say as " element asks 5 constant virtues political affairs big opinion ": " turning to discipline fully ... its sick painful abdominal mass ", " discipline of inferior prison ... its disease is stayed full painful abdominal mass plug ".The treatise on Febrile Diseases that Zhang Zhongjing is shown claims then that the stomach painful abdominal mass is sick and is " epigastric oppression ", and this sick principle-method-recipe-medicines has been carried out detailed argumentation, day: " but feeling fullness but no pain person, draw be painful abdominal mass ", " diseases occurring in YIN meridians or ZANG FU-organs and anti-purgation, because of making painful abdominal mass also ".Next position that spells out the painful abdominal mass location is gastral cavilty portion under the heart, and its primary symptom has the sense of blocking up vexed painful abdominal mass plug, the softness of pressing for gastral cavilty portion.Stomach is a reservoir of food and drink, main being received,, logical diet water paddy falls, be energy and blood of human body the source of vital function spring, the vital organs of the human body all are bullied in stomach, so stomach be the vital organs of the human body this.Gastropathy then influences human body to be received, digestion diet water paddy, and QI and bloodization is given birth to not enough and is become living all diseases.Symptom difference to some extent between the atrophic gastritis individuality, not outer fullness and oppression in the stomach distending pain, indigestion and loss of appetite lack of appetite, heating installation noisy, weak digestive system and General Symptoms such as tired.
Treat chronic gastritis at present, the medicine of gastric and duodenal ulcers is various.Doctor trained in Western medicine at present because the cause of disease of primary disease and essence thereof are not still had thoroughly clear, does not particularly have definite efficacy assessment standard, so there not be the generally acknowledged specific short that can effect a radical cure.The treatment measure of Western medicine mainly contains antacid, suppresses the medicine of helicobacter pylori etc., and these medicines all belong to symptomatic treatment, can not effectively eradicate disease, can only relief of symptoms.
Summary of the invention
Purpose of the present invention overcomes the deficiencies in the prior art exactly, and a kind of active ingredient height is provided, and the pure botanical herbs preparation of broad-spectrum curing gastropathy evident in efficacy makes it to be fit to clinical practice.
An object of the present invention is to provide a kind of Chinese medicine preparation of broad-spectrum curing gastropathy.
Another object of the present invention provides the preparation method of the Chinese medicine preparation of described broad-spectrum curing gastropathy.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine preparation of broad-spectrum curing gastropathy is prepared from by the crude drug of following parts by weight;
Crude drug A 25-40 crude drug B 60-80
Wherein said raw material A is prepared from by the crude drug of following parts by weight;
Fructus Amomi 15-25 Semen Raphani 20-30
Fructus Crataegi 20-30 Flos Caryophylli 3-8
Fructus Gardeniae 10-20 Pericarpium Citri Reticulatae 7-15
Wherein said raw material B is prepared from by the crude drug of following parts by weight;
Rhizoma Euonymus 30-50 Rhizoma Dioscoreae 30-50
Endothelium Corneum Gigeriae Galli 7-15 Bulbus Allii Macrostemonis 3-7
Radix Angelicae Dahuricae 3-8
Preferably, a kind of Chinese medicine preparation of broad-spectrum curing gastropathy is prepared from by the crude drug of following parts by weight:
Crude drug A 30 crude drug B 70
Wherein said raw material A is prepared from by the crude drug of following parts by weight;
Fructus Amomi 20 Semen Raphanis 25
Fructus Crataegi 25 Flos Caryophyllis 5
Fructus Gardeniae 15 Pericarpium Citri Reticulataes 10
Wherein said raw material B is prepared from by the crude drug of following parts by weight;
Rhizoma Euonymus 40 Rhizoma Dioscoreaes 40
Endothelium Corneum Gigeriae Galli 10 Bulbus Allii Macrostemonis 5
The Radix Angelicae Dahuricae 5
The preparation method of the Chinese medicine preparation of a kind of broad-spectrum curing gastropathy of the present invention, it may further comprise the steps;
(1) preparation of crude drug A: take by weighing each raw material by formula ratio, decoct with water after the mixing 3 times, add water weight for the 1st time and be 10 times of raw material A gross weight, decocted 120 minutes, and added water weight for the 2nd time and be 8 times of raw material A gross weight, decocted 90 minutes, add water weight for the 3rd time and be 6 times of raw material A gross weight, decocted 60 minutes, and merged the filtrate that decocts for 3 times, be concentrated into that relative density is 1.17 in the time of 70 ℃, concentrated solution 200 orders filter, collect filtrate, the filtrate spray drying, standby;
(2) preparation of crude drug B: take by weighing each raw material by formula ratio, rinsing, oven dry mixes, and the vacuum air blast is crushed to the 80-100 order, inserts the blowing-type constant temperature roaster, and temperature control is at 82 ℃-86 ℃, 4200 minutes-4800 minutes time, be little yellow to material, take out standby;
(3) with crude drug A and crude drug B, press the abundant mix homogeneously of formula proportion after, and obtain the Chinese medicine preparation that the present invention treats gastropathy.
The Chinese medicine preparation of broad-spectrum curing gastropathy of the present invention, dosage form: electuary, usage: oral one time 6 gram, 2 times on the one.
After the Chinese medicine preparation water (water temperature is not limit) of broad-spectrum curing gastropathy of the present invention is washed open, i.e. agglutination fluid, Chan pool degree reaches 4500-6000 after testing, PH5.5-7.8.
The Chinese medicine preparation of broad-spectrum curing gastropathy of the present invention is based on traditional theory of Chinese medical science, adopts the development mode of modern medicine and pharmacology, a kind of pure botanical herbs preparation of developing.The most important theories characteristics of tradition philosophy of Chinese medicine are exactly " human body integral sight, ecological moving Heng Guan ".Emphasize people's organism balance, i.e. the balance of the inside and outside ecological environment of body will be sick as imbalance.Think that with this theory disease such as gastroenteritic ulcer is exactly due to the human body integral digestive function dynamic balancing imbalance.The Chinese medicine preparation of broad-spectrum curing gastropathy of the present invention is according to Chinese medicine food homologous theory, from various plants, extract, form through complex configuration, be intended to fundamentally the human consumption function is nursed one's health, recuperates, recovered to the ecological balance of human body, thereby play effective treatment.After colloidal liquid after the Chinese medicine preparation of broad-spectrum curing gastropathy of the present invention is water-soluble is oral, the intestines and stomach surface is formed the protection mucosa, secretions with absorption ulcer surface can make the mucosa of ulcer wound surface form a regenerated environment separately to the mechanical friction of ulcer wound surface; Also can play the repair of blood stasis dispelling, nutrition, tissue regeneration promoting to the mucosal tissue nerve of ulcer wound surface breakage, promote the healing of ulcer skin ulcer face.Colloidal substance after the present invention is water-soluble is entered in the process of duodenum (alkalescence) by stomach (acidity), because the change of environment, viscosity increases, stimulated the intestinal wall peripheral nerve with stodgy illusion, promote Digestive system and biliary secretion, thereby provide material base for digestion, absorption, the drainage of food.Experimental results show that these product have the effect of remarkable enhancing gastric motility, its colloidal substance can play positive two-way accent threshold values effect at little intestinal segment, the ascending the clear and descending the turbid function of small intestinal is further activated, make and cause many latencies of ulcer to disappear, thereby cure gastroenteritic ulcer.
The specific embodiment
Following examples are in order further to describe the present invention for example, rather than limit the present invention by any way.
Embodiment 1
Raw material A is prepared from by following crude drug; (unit: kilogram)
Fructus Amomi 20 Semen Raphanis 25
Fructus Crataegi 25 Flos Caryophyllis 5
Fructus Gardeniae 15 Pericarpium Citri Reticulataes 10
Raw material B is prepared from by following crude drug; (unit: kilogram)
Rhizoma Euonymus 40 Rhizoma Dioscoreaes 40
Endothelium Corneum Gigeriae Galli 10 Bulbus Allii Macrostemonis 5
The Radix Angelicae Dahuricae 5
Its preparation method is as follows:
(1) preparation of crude drug A: take by weighing each raw material by formula ratio, decoct with water after the mixing 3 times, add water weight for the 1st time and be 10 times of raw material A gross weight, decocted 120 minutes, and added water weight for the 2nd time and be 8 times of raw material A gross weight, decocted 90 minutes, add water weight for the 3rd time and be 6 times of raw material A gross weight, decocted 60 minutes, and merged the filtrate that decocts for 3 times, be concentrated into that relative density is 1.17 in the time of 70 ℃, concentrated solution 200 orders filter, collect filtrate, the filtrate spray drying, standby;
(2) preparation of crude drug B: take by weighing each raw material by formula ratio, rinsing, oven dry mixes, and the vacuum air blast is crushed to 100 orders, inserts the blowing-type constant temperature roaster, and temperature control is at 85 ℃, 4600 minutes time, be little yellow to material, take out standby;
(3) crude drug A and crude drug B are pressed 3: 7 weight ratios, fully behind the mix homogeneously, reach the Chinese medicine preparation that obtains broad-spectrum curing gastropathy of the present invention
Embodiment 2
Raw material A is prepared from by following crude drug; (unit: kilogram)
Fructus Amomi 25 Semen Raphanis 20
Fructus Crataegi 30 Flos Caryophyllis 4
Fructus Gardeniae 18 Pericarpium Citri Reticulataes 15
Raw material B is prepared from by following crude drug; (unit: kilogram)
Rhizoma Euonymus 45 Rhizoma Dioscoreaes 35
Endothelium Corneum Gigeriae Galli 13 Bulbus Allii Macrostemonis 6
The Radix Angelicae Dahuricae 4
Its preparation method is as follows:
(1) preparation of crude drug A: take by weighing each raw material by formula ratio, decoct with water after the mixing 3 times, add water weight for the 1st time and be 10 times of raw material A gross weight, decocted 120 minutes, and added water weight for the 2nd time and be 8 times of raw material A gross weight, decocted 90 minutes, add water weight for the 3rd time and be 6 times of raw material A gross weight, decocted 60 minutes, and merged the filtrate that decocts for 3 times, be concentrated into that relative density is 1.17 in the time of 70 ℃, concentrated solution 200 orders filter, collect filtrate, the filtrate spray drying, standby;
(2) preparation of crude drug B: take by weighing each raw material by formula ratio, rinsing, oven dry mixes, and the vacuum air blast is crushed to 90 orders, inserts the blowing-type constant temperature roaster, and temperature control is at 86 ℃, 4500 minutes time, be little yellow to material, take out standby;
(3) crude drug A and crude drug B are pressed 4: 8 weight ratios, fully behind the mix homogeneously, reach the Chinese medicine preparation that obtains broad-spectrum curing gastropathy of the present invention.
Embodiment 3
Raw material A is prepared from by following crude drug; (unit: kilogram)
Fructus Amomi 18 Semen Raphanis 20
Fructus Crataegi 20 Flos Caryophyllis 3
Fructus Gardeniae 15 Pericarpium Citri Reticulataes 8
Raw material B is prepared from by following crude drug; (unit: kilogram)
Rhizoma Euonymus 38 Rhizoma Dioscoreaes 35
Endothelium Corneum Gigeriae Galli 9 Bulbus Allii Macrostemonis 4
The Radix Angelicae Dahuricae 3
Its preparation method is as follows:
(1) preparation of crude drug A: take by weighing each raw material by formula ratio, decoct with water after the mixing 3 times, add water weight for the 1st time and be 10 times of raw material A gross weight, decocted 120 minutes, and added water weight for the 2nd time and be 8 times of raw material A gross weight, decocted 90 minutes, add water weight for the 3rd time and be 6 times of raw material A gross weight, decocted 60 minutes, and merged the filtrate that decocts for 3 times, be concentrated into that relative density is 1.17 in the time of 70 ℃, concentrated solution 200 orders filter, collect filtrate, the filtrate spray drying, standby;
(2) preparation of crude drug B: take by weighing each raw material by formula ratio, rinsing, oven dry mixes, and the vacuum air blast is crushed to 100 orders, inserts the blowing-type constant temperature roaster, and temperature control is at 85 ℃, 4600 minutes time, be little yellow to material, take out standby;
(3) crude drug A and crude drug B are pressed 2.5: 6.5 weight ratios, fully behind the mix homogeneously, reach the Chinese medicine preparation that obtains broad-spectrum curing gastropathy of the present invention.
Below be the clinical observation report of the 307 hospital of the Chinese People's Liberation Army to the embodiment of the invention 1;
1. materials and methods
1.1 sample: the Chinese medicine preparation of 1 one kinds of broad-spectrum curing gastropathies of the embodiment of the invention.
1.2 study subject: 51 examples are examined through gastroscope or barium meal examination and are chronic superficial gastritis, chronic atrophic gastritis, peptic ulcer, acute gastritis belongs to traditional Chinese medical science gastric abscess patient, age is in 18-65 year, complication patients such as no severe cardiac Liver and kidney are divided into treatment group and matched group at random, control design between each group employing self and group.
1.3 instructions of taking: the treatment group is taken the Chinese medicine preparation of the embodiment of the invention 1 and is obeyed 2 times every day, sooner or later respectively one wrap (6/g) before the meal, water is once towards 200-300ml, after under elder generation's stirred for several, static 2-3 minute, fully stir again the paste shape fluid took fasting bean curd and Semen phaseoli radiati during taking in 20 minutes before the meal; Matched group is taken gastropine and SANJIU WEITAI, takes continuously 2 months.
2. observation index
Every index begins and finishes each test once in experiment.
2.1 effect observation
2.1.1 observation of symptoms
Detailed medical history-taking is understood patient's diet situation, observes main clinic symptoms: gastric abscess, abdominal distention, return symptom variation such as acid is unable.
2.1.2 blood and routine urinalysis routine examination
Red blood cell count(RBC).Hemoglobin, numeration of leukocyte is urinated eight.
2.2.2 biochemical indicator is measured
Serum albumin ALB.Total protein TB, conscience kidney (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, blood urea nitrogen BUN, inosine Cre).
2.2.3 Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line.
2.2.4 part patient's test-meal finishes back check gastroscope.
3. effect criterion:＜new Chinese medicine treatment gastric abscess clinical research guideline " formulate.
3.1 produce effects: fundamental symptoms disappears, and gastroscopy is almost recovered.
3.2 effectively: fundamental symptoms obviously improves, gastroscopy takes a turn for the better.
3.3 invalid: fundamental symptoms does not have obvious improvement, the gastroscopy no change.
4. result
4.1 physical data:
Observe 51 examples altogether, 36 examples are organized in treatment of the present invention, matched group 15 examples.Be traditional Chinese medical science gastric abscess patient.
4.2 two groups of basic conditions relatively.
4.3 doing well,improving situation:
Treatment is organized among 36 people, the 20 routine check persons 14 routine patient's readmes back clinical symptoms of taking medicine and is obviously alleviated or disappear, wherein to stomachache, abdominal distention, to return symptom such as acid evident in efficacy.14 example check gastroscopes, wherein 1 example is almost recovered in chronic superficial gastritis 9 examples, and 3 routine Mei Countys alleviate, and 6 examples take a turn for the better; 1 routine ulcer recovery from illness in peptic ulcer 3 examples, 2 examples are dwindled, and the matched group 15 routine readmes venter posterior alleviation of pain of taking medicine is light, phenomenon that check gastroscope 6 examples do not see that gastritis alleviates or ulcer is dwindled, healed.
4.4 treatment back gastroscope check situation
4.5 21 routine gastric abscess patients test the back routine blood test, routine urinalysis and conscience kidney blood biochemical analysis measured value are normal range, B ultrasonic, electrocardiogram, the no abnormal change of Chest X-rays.
5. sum up
5.1 the Chinese medicine preparation of the embodiment of the invention 1 broad-spectrum curing gastropathy has comparatively obvious therapeutic action to gastric abscess (upper digestive disease).
5.2 after taking, routine blood test, each blood biochemistry index of routine urinalysis conscience kidney are all in normal range, B ultrasonic, electrocardiogram, the no abnormal change of Chest X-rays illustrate that this product has no adverse effects to health.
5.3 in the process of taking, do not observe allergy and other untoward reaction.
The 307 hospital of the Chinese People's Liberation Army
Interior two sections
Wang Hanbin etc.
It below is the survey report of the Chinese medicine preparation of the embodiment of the invention 2 broad-spectrum curing gastropathies
Ministry of Public Health Food Hygiene Surveillance check institute
Xiyuan Hospital, Chinese Medicine Academy of China
Survey report
Inspection product numbering: 97118
Censorship personnel: Chen Zhijun
Date of manufacture: 2700 bags of 1997.3.15 sample size: embodiment 2 Chinese medicine preparation
2700 bags of the auspicious instant granule for curing of stomach
Inspection product title: the Chinese medicine preparation of the embodiment of the invention 2 broad-spectrum curing gastropathies
Test item: protection gastric mucosa effect human experiment experiment
Date received; The 15 Days report dates of March in 1997: on November 20th, 1997
Test basis: " the health food function assessment assessment process and the method for inspection "
Result and judgement:
Adopt counter point between self and group: select chronic gastritis 60 examples of making a definite diagnosis through fibergastroscope for use; be divided into test-meal group (Chinese medicine preparation of the embodiment of the invention 2 treatment gastropathy) and matched group (stomach is auspicious peaceful) at random; viewing duration; stopping using, other is used for the medicine or the health product of chronic gastritis; after one month; its result shows that the Chinese medicine preparation of the embodiment of the invention 2 treatment gastropathy can make chronic gastritis examination trencherman symptom integral value significantly descend; improve tenderness sign under symptom and the sword preferably; produce effects 4 examples; effective 20 examples; total effective rate 80%; matched group produce effects 3 examples; effective 20 examples; total effective rate 76.67%; each organizes 10 example check gastroscope persons; the inflammatory cell that its gastric mucosa and pathological biopsy are seen is shown with the effect of protection gastric mucosa; hemoglobin before and after the test-meal; leukocyte; total serum protein; albumin; glutamic oxaloacetic transaminase, GOT; glutamate pyruvate transaminase; blood urea nitrogen; inosine; Clinical detection indexs such as blood fat are all in normal range; but do not find untoward reaction, illustrate that the Chinese medicine preparation of the embodiment of the invention 2 broad-spectrum curing gastropathies is harmless to health.
This survey report only is responsible for submitted sample
" Chinese medicine preparation of embodiment 2 broad-spectrum curing gastropathies " human experiment visual report
1, materials and methods
1.1 sample: the Chinese medicine preparation of the embodiment of the invention 2 broad-spectrum curing gastropathies that provided by Chen Zhijun is as test-meal group, stomach auspicious peaceful (Sino-German Aoma pharmacy Co., Ltd., Hainan Prov produces) group in contrast, and both are electuary.
1.2 study subject: choosing is diagnosed as chronic superficial gastritis person 60 examples through gastroscopy, and the age is at 18～65 years old, complication persons such as no severe cardiac, liver, kidney, be divided into test-meal group and matched group at random, each organizes 30 examples, adopts the own control design, is control design between group between two groups.
1.3 trial method: adopt counter point, the test-meal group gives embodiment the Chinese medicine preparation of 2 broad-spectrum curing gastropathies, and matched group gives stomach auspicious peaceful, is secondary every day, each bag.Stopping using, other treats the health food of stomach medicine or protection gastric mucosa, continuous 30 days.
2.1 effect observation
2.1.1 observation of symptoms
Inquiry portion medical history is understood examination trencherman medical history, the course of disease, clinical symptoms in detail; Symptoms such as stomachache, pantothenic acid, heartburn, abdominal distention, xerostomia hardship, dry stool knot.By the symptom weight, (serious symptom 3 minutes, moderate 2 minutes, light disease 1 minute) adds up integrated value before and after test-meal, and improves (2 fens produce effects 1 of each doing well,improving are divided into effectively) observation doing well,improving rate with regard to its cardinal symptom.
2.1.2 sign is observed: tenderness degree under the xiphoid-process.
2.1.3 gastroscope check: in matched group and test-meal group, respectively get 10 examples at random, do the check of gastroscope and pathology.
2.2 safety is observed
2.2.1 the blood routine inspection, red blood cell count(RBC), hemoglobin, numeration of leukocyte.
2.2.2 biochemical indicator is measured: serum albumin A L B, total protein T B, darling renal function (glutamic oxaloacetic transaminase, GOT A S T, glutamate pyruvate transaminase A C T, blood urea nitrogen B U N, inosine (C r e).
2.2.3 Abdominal B type ultrasonography, electrocardiogram, X line fluoroscopy of chest routine.
3. effect criterion: reference≤new Chinese medicine clinical research guideline 〉=formulation.
3.1 produce effects: symptom and sign all improves more than 2 grades, gastroscope and biopsy, and acute inflammation disappears substantially, chronic inflammatory disease degree improvement 1 degree.
3.2 effectively: symptom and sign all improves more than 1 grade, gastroscope and the biopsy mucosa infection 1/2 above active chronic inflammation degree of dwindling alleviates 1 degree.
3.3 it is invalid: as not reach effective standard or deterioration person on the contrary.
4. result
4.1 physical data
Observe 60 routine test-meal groups altogether, male's 18 examples, women's 12 examples, minimum 30 years old of age, the oldest 65 years old, average 53.7 years old, average course of disease 4.76, matched group male 16 examples, women's 14 examples, minimum 29 years old of age, the oldest 65 years old, average 52.82 years old, average course of disease 4.87 was chronic superficial gastritis.
4.2 data relatively as two groups of observations were last
Situation relatively as table 1 observation was last
Every index no significant difference before two groups of test-meals has comparability
4.3 effect statistics
Table 2 effect statistics
Two groups of effect no significant difference p＞0.5
4.4 cardinal symptom is improved
Table 3 cardinal symptom is improved situation
() matched group
4.5 clinical symptoms integration
Table 4 clinical symptoms integration statistics
p＜0.05 p＜0.001
The clinical symptoms effect that all has clear improvement of test-meal group and matched group
4.6 sign relatively before and after the test-meal
Remarkable to stomach tenderness test-meal group and the equal effect of matched group
4.7 gastroscope check after the test-meal
Gastric mucosa changes after table 6 test-meal
Two groups of gastric mucosas all have improvement
4.8 the mucosa pathological biopsy relatively
Table 7 cell infiltration
Two groups of pathological biopsies are shown with improvement
4.9 the biochemical safety index of blood and blood is observed
Before and after two groups of test-meals, the every index of blood testing is all in normal range
5. sum up
" 5.1 stomach auspicious peaceful " cures mainly chronic gastritis, exact efficacy, and the Chinese medicine preparation of the broad-spectrum curing gastropathy of itself and the embodiment of the invention 2 is all bagged soluble granules, so select its articles for use as positive controls.
5.2 the Chinese medicine preparation of the broad-spectrum curing gastropathy of embodiment 2 can make the symptom integral value significantly descend; improve symptoms such as gastric abscess, feeling of fullness, pantothenic acid, inappetence preferably; alleviate tenderness sign under the sword, total effective rate reaches 80%, illustrates that it has protective effect to gastric mucosa.
5.3 among two groups of experimenters; respectively ask 10 examples to do the gastroscope check at random; its presentation of results sees thoroughly that to gastric mucosa color and blood vessel the improvement effect is arranged; pathological biopsy also has the improvement effect to inflammatory cell infiltration; though this big or small inconvenience takes statistics to learn and handles, the Chinese medicine preparation of the broad-spectrum curing gastropathy of embodiment 2 is protected the trend of gastric mucosa as can be seen.
5.4 hemoglobin, erythrocyte, leukocyte, total serum protein, albumin, glutamate pyruvate transaminase, inosine before and after the Chinese medicine preparation of the broad-spectrum curing gastropathy of test-meal embodiment 2, (T-CHOL, triglyceride, HDL-C etc. are all in normal range for blood urea nitrogen, B ultrasonic, electrocardiogram, perspective are normal substantially, illustrate that this product has no adverse effects to health).
5.5 the Chinese medicine preparation of the embodiment of the invention 2 broad-spectrum curing gastropathies in the test-meal process, is not observed allergy and other untoward reaction.
Claims (4)
1.. the Chinese medicine preparation of a broad-spectrum curing gastropathy is prepared from by the crude drug of following parts by weight;
Crude drug A 25-40 crude drug B 60-80
Wherein said raw material A is prepared from by the crude drug of following parts by weight;
Fructus Amomi 15-25 Semen Raphani 20-30
Fructus Crataegi 20-30 Flos Caryophylli 3-8
Fructus Gardeniae 10-20 Pericarpium Citri Reticulatae 7-15
Wherein said raw material B is prepared from by the crude drug of following parts by weight;
Rhizoma Euonymus 30-50 Rhizoma Dioscoreae 30-50
Endothelium Corneum Gigeriae Galli 7-15 Bulbus Allii Macrostemonis 3-7
Radix Angelicae Dahuricae 3-8
2. the Chinese medicine preparation of a kind of broad-spectrum curing gastropathy according to claim 1, its crude drug by following parts by weight is prepared from
Crude drug A 30 crude drug B 70
Wherein said raw material A is prepared from by the crude drug of following parts by weight;
Fructus Amomi 20 Semen Raphanis 25
Fructus Crataegi 25 Flos Caryophyllis 5
Fructus Gardeniae 15 Pericarpium Citri Reticulataes 10
Wherein said raw material B is prepared from by the crude drug of following parts by weight;
Rhizoma Euonymus 40 Rhizoma Dioscoreaes 40
Endothelium Corneum Gigeriae Galli 10 Bulbus Allii Macrostemonis 5
The Radix Angelicae Dahuricae 5
3. the Chinese medicine preparation of a kind of broad-spectrum curing gastropathy according to claim 1, when taking under the situation that is not subjected to the water temperature restriction, after water is washed open, i.e. agglutination fluid.
4. the preparation method of the Chinese medicine preparation of a kind of broad-spectrum curing gastropathy according to claim 1, it may further comprise the steps;
(1) preparation of crude drug A: take by weighing each raw material by formula ratio, decoct with water after the mixing 3 times, add water weight for the 1st time and be 10 times of raw material A gross weight, decocted 120 minutes, and added water weight for the 2nd time and be 8 times of raw material A gross weight, decocted 90 minutes, add water weight for the 3rd time and be 6 times of raw material A gross weight, decocted 60 minutes, and merged the filtrate that decocts for 3 times, be concentrated into that relative density is 1.17 in the time of 70 ℃, concentrated solution 200 orders filter, collect filtrate, the filtrate spray drying, standby;
(2) preparation of crude drug B: take by weighing each raw material by formula ratio, rinsing, oven dry mixes, and the vacuum air blast is crushed to the 80-100 order, inserts the blowing-type constant temperature roaster, and temperature control is at 82 ℃-86 ℃, 4200 minutes-4800 minutes time, be little yellow to material, take out standby;
(3) with crude drug A and crude drug B, press the abundant mix homogeneously of formula proportion after, and obtain the Chinese medicine preparation that the present invention treats gastropathy.
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| CN102106536A (en) * | 2011-01-19 | 2011-06-29 | 四川回春堂生物科技有限公司 | Compound dahurian angelica granules for nourishing stomach and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824182A (en) * | 2005-12-28 | 2006-08-30 | 巴悦霞 | Chinese medicinal formula for treating chronic gastritis |
| CN100544614C (en) * | 2006-04-05 | 2009-09-30 | 魏书敏 | Health care seasoning |
| CN101028500A (en) * | 2007-03-21 | 2007-09-05 | 孙喜灵 | Two-purpose food with appetising and sobering-up functions and its production |
-
2008
- 2008-03-21 CN CN2008100851319A patent/CN101249242B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106536A (en) * | 2011-01-19 | 2011-06-29 | 四川回春堂生物科技有限公司 | Compound dahurian angelica granules for nourishing stomach and preparation method thereof |
| CN102106536B (en) * | 2011-01-19 | 2012-08-22 | 四川回春堂生物科技有限公司 | Compound dahurian angelica granules for nourishing stomach and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101249242B (en) | 2010-07-28 |
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