CN101247801B - Composition for prevention of increase in blood alcohol level - Google Patents
Composition for prevention of increase in blood alcohol level Download PDFInfo
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- CN101247801B CN101247801B CN2006800308919A CN200680030891A CN101247801B CN 101247801 B CN101247801 B CN 101247801B CN 2006800308919 A CN2006800308919 A CN 2006800308919A CN 200680030891 A CN200680030891 A CN 200680030891A CN 101247801 B CN101247801 B CN 101247801B
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- acid
- alcohol
- salt
- blood
- amino acid
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Pharmaceutical compositions, functional foods and the like are demanded which can prevent the increase in blood alcohol level after drinking to reduce the drunken degree and provide a comfortable drunken state so as to enjoy a moderate drunkenness. Thus, provided is a composition capable of preventing the increase in blood alcohol level. The composition comprises a basic amino acid (e.g., ornithine, arginine, lysine, histidine, citrulline) or a salt thereof as an active ingredient.
Description
Technical field
The present invention relates to contain basic amino acid or its salt rises as the blood-alcohol concentration of effective ingredient and suppresses to use compositions.
Background technology
In the dead drunk state that excessive drinking causes, follow the social activity failure of drinking, accident that disturbance of consciousness causes, incident increase etc. to bring a lot of negative factors to society.
In the past; As alcohol concentration in the bleeding from anus of drinking being descended or suppress the material or the compositions of its rising, known have persimmon vinegar (with reference to patent documentation 1), a mixture of squeezing the juice of Caulis et Folium Brassicae capitatae, purple Soviet Union, Radix Ginseng and parsley (with reference to patent documentation 2); The alcohol-insoluble substance of the aqueous solvent extraction thing of Korean Ginseng (with reference to patent documentation 3); Glycerol (with reference to patent documentation 4) contains the compositions (with reference to patent documentation 5) of tea extract and porphyrin class pigment, Fructus Cucumidis sativi extract (with reference to patent documentation 6) etc.
On the other hand; In the acute alcoholism model; Knownly rise, but give separately with survival rate do not rise (with reference to patent documentation 7) through organic acids such as aminoacid such as arginine, lysine, ornithine, KG, malic acid, oxaloacetic acid, acetone acid through amino acid whose giving with survival rate separately such as alanine, threonine, leucine, isoleucine.
Patent documentation 1: japanese kokai publication sho 63-141562 communique
Patent documentation 2: japanese kokai publication hei 2-138128 communique
Patent documentation 3: japanese kokai publication hei 5-170659 communique
Patent documentation 4: japanese kokai publication hei 6-14751 communique
Patent documentation 5: japanese kokai publication hei 6-256201 communique
Patent documentation 6: TOHKEMY 2001-58592 communique
Patent documentation 7: japanese kokai publication sho 61-50917 communique
Summary of the invention
Expectation can be risen through alcohol concentration in the bleeding from anus that suppresses to drink and prevented dead drunk state, produces the pharmaceuticals of enjoying the drunk happy state of drinking of appropriateness, functional food etc.
That is, the purpose of this invention is to provide the blood-alcohol concentration rising and suppress to use compositions.
The present invention relates to following (1)～(14).
(1) a kind of blood-alcohol concentration rises and suppresses to use compositions, and it contains basic amino acid or its salt as effective ingredient.
(2) compositions of above-mentioned (1), wherein, basic amino acid is ornithine, arginine, lysine, histidine or citrulline.
(3) compositions of above-mentioned (1) or (2), it contains organic acid.
(4) compositions of above-mentioned (3), wherein, organic acid is acetic acid, lactic acid, malic acid, fumaric acid, tartaric acid or citric acid.
(5) each compositions of above-mentioned (1)～(4), wherein, compositions is medicine or food additive.
(6) a kind of diet article, it contains the food additive of above-mentioned (5).
(7) a kind of blood-alcohol concentration rising inhibition method comprises to the object of needs and gives basic amino acid or its salt of using or make its picked-up effective dose.
(8) method of above-mentioned (7), wherein, basic amino acid is ornithine, arginine, lysine, histidine or citrulline.
(9) method of above-mentioned (7) or (8) comprises further giving and uses or the picked-up organic acid.
(10) method of above-mentioned (9), wherein, organic acid is acetic acid, lactic acid, malic acid, fumaric acid, tartaric acid or citric acid.
(11) basic amino acid or its salt are used to make the blood-alcohol concentration rising and suppress the application with compositions.
(12) application of above-mentioned (11), wherein, basic amino acid is ornithine, arginine, lysine, histidine or citrulline.
(13) application of above-mentioned (11) or (12) comprises further use organic acid.
(14) application of above-mentioned (13), wherein, organic acid is acetic acid, lactic acid, malic acid, fumaric acid, tartaric acid or citric acid.
The invention effect
Through the present invention, can provide and contain basic amino acid or its salt and rise as the blood-alcohol concentration safely and effectively of effective ingredient and suppress to use compositions.
Description of drawings
Fig. 1 is the figure that the expression ornithine suppresses the effect that concentration of alcohol rises in the alcohol panning bleeding from anus.■ among the figure representes matched group, zero expression test group 1 (picked-up dlornithine hydrochloride), and △ representes test group 2 (picked-up dlornithine hydrochloride and citric acid).In addition, the longitudinal axis is represented concentration of alcohol in the blood (g/L), transverse axis represent behind the alcohol panning elapsed time (hour).
*With
*Be illustrated in the student t check risk separately less than 5% and less than 1%, and expression there were significant differences for matched group.
Fig. 2 is the figure that the expression histidine suppresses the effect that concentration of alcohol rises in the alcohol panning bleeding from anus.■ among the figure representes matched group, zero expression test group 1 (picked-up histidine), and △ representes test group 2 (picked-up histidine hydrochloride).In addition, the longitudinal axis is represented concentration of alcohol in the blood (g/L), transverse axis represent behind the alcohol panning elapsed time (hour).
*Be illustrated in the student t check risk less than 5%, and expression there were significant differences for matched group.
Fig. 3 is the figure that expression lysine or citrulline suppress the effect that concentration of alcohol rises in the alcohol panning bleeding from anus.■ among the figure representes matched group, and △ representes test group 1 (picked-up lysine citrate), zero expression test group 2 (picked-up citrulline).In addition, the longitudinal axis is represented concentration of alcohol in the blood (g/L), transverse axis represent behind the alcohol panning elapsed time (hour).
*Be illustrated in the student t check risk less than 5%, and expression there were significant differences for matched group.
Fig. 4 is the figure that expression lysine suppresses the effect that concentration of alcohol rises in the alcohol panning bleeding from anus.■ among the figure representes matched group, zero expression test group 1 (picked-up lysine hydrochloride).In addition, the longitudinal axis is represented concentration of alcohol in the blood (g/L), transverse axis represent behind the alcohol panning elapsed time (hour).
*Be illustrated in the student t check risk less than 5%, and expression there were significant differences for matched group.
Fig. 5 is the figure that the expression arginine suppresses the effect that concentration of alcohol rises in the alcohol panning bleeding from anus.■ among the figure representes matched group, zero expression test group 1 (picked-up arginine).In addition, the longitudinal axis is represented concentration of alcohol in the blood (g/L), transverse axis represent behind the alcohol panning elapsed time (hour).
*Be illustrated in the student t check risk less than 5%, and expression there were significant differences for matched group.
The specific embodiment
The basic amino acid that uses among the present invention can be enumerated: ornithine, arginine, lysine, histidine or citrulline etc., preferred ornithine.In addition, above-mentioned basic amino acid can use separately separately, also can use the mixture more than 2 kinds.In addition, above-mentioned basic amino acid can use any one in L-isomer, D-isomer and L-isomer and the D-mixture of isomers separately, preferably uses the L-isomer.
As the salt of basic amino acid, can enumerate acid-addition salts, slaine, ammonium salt, organic amine addition salts, amino acid addition salt etc.
As acid-addition salts; Can enumerate inorganic acid salts such as hydrochlorate, sulfate, nitrate, phosphate, acylates such as acetate, maleate, fumarate, citrate, malate, lactate, alpha-ketoglutarate, gluconate, caprylate.
As slaine, can enumerate alkali metal salts such as sodium salt, potassium salt, alkali salts such as magnesium salt, calcium salt, ammonium salt, zinc salt etc.
As ammonium salt, can enumerate the salt of ammonium, tetramethyl-ammonium etc.
As the organic amine addition salts, can enumerate the salt of morpholine, piperidines etc.
As amino acid addition salt, can enumerate the salt of glycine, phenylalanine, lysine, aspartic acid, glutamic acid etc.
As the organic acid that uses among the present invention, can enumerate acetic acid, lactic acid, malic acid, fumaric acid, tartaric acid, citric acid etc., preferred acetic acid or citric acid, more preferably citric acid.In addition, above-mentioned organic acid can use separately separately, also can use the mixture more than 2 kinds.
Compositions of the present invention except containing above-mentioned basic amino acid or its salt as the effective ingredient, also can further contain above-mentioned organic acid.Contain in the compositions of the present invention under the organic acid situation, basic amino acid or its salt and organic acid mixing ratio (weight ratio) are preferably 1/0.01～100, and more preferably 1/0.1～10, preferred especially 1/1～1.5.
Compositions of the present invention can be used as pharmaceuticals or food additive (below, be also referred to as medicine of the present invention or food additive) and uses.
Under the situation of compositions of the present invention as the medicine use, can directly give, but the preferred usually form with various preparations provides with basic amino acid or its salt.
Preparation contains basic amino acid or its salt as effective ingredient, but can further contain other effective ingredient that is used to treat arbitrarily.In addition, these pharmaceutical preparations can be through being mixed together one or more the carrier of allowing on effective ingredient and the pharmacology, and utilize the known any means manufacturing of galenic pharmacy technical field.
The administering mode of preparation preferably uses the best mode of when treatment effect, can enumerate oral administration or non-oral administrations such as intravenous, intraperitoneal or subcutaneous administration for example, the preferred oral administration.
Dosage form as administration; Can be oral agents such as tablet, powder, granule, pill, suspending agent, Emulsion, preserved material/decoct, capsule, syrup, liquid preparation, elixir, extractum, tincture, fluid extract for example; In the non-oral agents such as injection, drop, cream, suppository any one preferably uses oral agents.
Be suitable for the such liquid modulator of for example syrup of oral administration; Can process preparation through adding following material: saccharides such as water, sucrose, sorbitol, fructose, glycolss such as Polyethylene Glycol, propylene glycol, Oleum sesami, olive oil, Semen sojae atricolor wet goods oils; Antiseptic such as parabens; P-hydroxybenzoic acid derivants such as methyl parahydroxybenzoate, preservative agents such as sodium benzoate, strawberry flavor, Herba Menthae wet goods perfumery etc.
In addition; Be suitable for for example tablet, powder and the granule etc. of oral administration; Can process preparation through adding following material: saccharides such as lactose, white sugar, glucose, sucrose, mannitol, sorbitol; Rhizoma Solani tuber osi, Semen Tritici aestivi, corn and other starches, excipient such as plant powder such as inorganic matters such as calcium carbonate, calcium sulfate, calcium bicarbonate, sodium chloride, crystalline cellulose, Radix Glycyrrhizae powder, Radix Gentianae powder; Disintegrating agents such as starch, agar, gelatin powder, crystalline cellulose, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, calcium carbonate, sodium bicarbonate, sodium alginate; Lubricants such as magnesium stearate, Talcum, hydrogenated vegetable oil, Polyethylene Glycol, silicone oil; Binding agents such as polyvinyl alcohol, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, carboxymethyl cellulose, gelatin, farinaceous size; Surfactants such as fatty acid ester; Plasticizers such as glycerol etc.
Be suitable for the for example injection of non-oral administration, preferably constitute by the sterilization aqueous formulation that comprises with the isoosmotic basic amino acid of receiver's blood or its salt.For example, under the situation of injection, use the solution of the preparing carriers injection that the mixture by saline solution, glucose solution or saline solution and glucose solution constitutes.
In addition, in these non-oral agents, also can be added on one or more auxiliary elements of selecting in illustrative antiseptic, preservative agent, perfumery, excipient, disintegrating agent, lubricant, binding agent, surfactant, the plasticizer etc. in the oral agents.
The basic amino acid in the medicine of the present invention or the concentration of its salt can be according to the kinds of preparation, suitably select through giving the effect expected with said preparation etc.; As basic amino acid or its salt; Be generally 0.1～100 weight %, preferred 0.5～80 weight %, preferred especially 1～70 weight %.
The dosage of the present invention medicine and administration number of times be according to the character of administering mode, patient's age, body weight, the symptom that will treat or the order of severity and difference, the every day of being grown up usually in basic amino acid or its salt usually with the amount of 50mg～30g, preferred 100mg～10g, preferred especially 200mg～3g once a day to the several administration.
The not special restriction of administration cycle is generally 1 day～1 year, preferred 1 week～3 month.
Use under the situation of compositions of the present invention as food additive, basic amino acid or its salt can directly use, still, and also can be through containing basic amino acid or its salt food additive as effective ingredient with the preparation of the same method of above-mentioned preparation.
Food additive of the present invention can be mixed or dissolve other food additive as required and processed, is fabricated to the for example form of powder, granule, pill, tablet, various liquid preparations.
Contain the diet article (below be also referred to as diet article of the present invention) of food additive of the present invention, except adding to food additive of the present invention in the diet article, can process, make through using general diet article manufacturing approach.
In addition; Diet article of the present invention can use for example prilling process such as fluidized bed prilling, stirring-granulating, extruding pelletization, rotating granulation, air-flow pelletize, compression molding pelletize, broken pelletize, mist projection granulating, air prilling; Coating methods such as pan coating, fluidized bed coating, dry-method coating; Expansion methods such as explosion puffing drying, excessive water steaming process, foam-drying method, microwave heating method, extrusion methods such as extruding granulator or extruder wait to be made.
As diet article of the present invention; For example can be following any one form: milk product such as fruit juice class, refreshment drink water, teas, lactobacillus beverage, fermentation milk, ices, butter, cheese, yogurt, modified milk, skimmed milk; Poultry meat products such as Petaso, sausage, hamburger; The flesh of fish such as breaded fish stick, fish sausage, fried fish tartar souce meat ball is mediated goods; Egg products such as meat soup fried egg, steaming egg bean curd, snack categories such as cookie, fruit jelly, chewing gum, confection, snack, Bread and Pastries, Noodles, pickled thing class, smoked product, dry, salty seafood, salted article, soup class, the flavouring agent class etc. of cooking.
In addition, diet article of the present invention can be forms such as powdered food product, sheet-like food, bottled food, canned food, cooking food, capsule-shaped food, drug sheet food, fluid food, potus for example.
Diet article of the present invention can be used as diet article uses such as the health food that is used to suppress blood-alcohol concentration and rises, functional food, dietary supplement, specific food for health care.
In food additive of the present invention or the diet article; Can add the general additive that in the diet article, uses; For example food additives representes that the sweet taste material described in the handbook (japanese food additive association puts down into distribution on January 6th, 9), colouring matter, preservation material, thickening stabilizing agent, antioxidant, colour former, bleach, antifungus agent, gum base, bitterness material, enzyme, polishing material, acid flavoring, flavouring agent, emulsifying agent, hardening agent, manufacturing are with agent, spice, hot flavorings extract etc.
The addition of the food additive of the present invention in the diet article of the present invention can be according to the kind of diet article, suitably select through absorbing effect that these diet article expect etc., adds with the content of 0.1～90 weight %, preferred 0.5～80 weight %, preferred especially 1～70 weight % usually in basic amino acid or its salt.
The intake of diet article of the present invention is grown up one day in basic amino acid or the common once extremely several administration of amount with 50mg～30g, preferred 100mg～10g, preferred especially 200mg～3g of its salt usually with absorbing form, taking the photograph taker age, body weight etc. and difference.
The not special restriction of picked-up cycle is generally 1 day～1 year, preferred 1 week～3 month.
Through drink preceding, drink in or the back of drinking give with or absorb medicine of the present invention or diet article, can suppress the blood-alcohol concentration rising.
Below, list the Test Example that the effect of basic amino acid inhibition blood-alcohol concentration rising is studied.
Test Example 1
In the test, use DBA/2Cr mice (male, 7 weeks are big, buy) from Japanese SLC company.The raising condition is that 22 ± 2 ℃ of room temperatures, humidity 35 ± 15%, feedstuff and water freely absorb.
Each test group constitutes by 5 mices; At first ethanol is given with the amount per os of every 1kg body weight 4g and used; After 30 minutes; To using distilled water, make every 1kg body weight absorb the dlornithine hydrochloride of 2g (the Kyowa Hakko's system of coordinating) for aqueous solution to the mice in control group per os, make every 1kg body weight absorb the dlornithine hydrochloride of 0.935g and the citric acid (with the pure medicine corporate system of light) of 1.065g for aqueous solution with preparation to its mouse oral of test group 2 with preparation to its mouse oral of test group 1.
From begin to ethanol after 1 hour after 4.5 hours, use F-kit ethanol (ロ シ ユ ダ イ ア グ ノ ス テ イ Star Network ス society system) to measure the concentration of alcohol in each mouse blood, calculate meansigma methods of each group.In addition, upcheck T check of significant difference is carried out.
The result is as shown in Figure 1.As can beappreciated from fig. 1, all receive remarkable inhibition to rising in test group 1, the test group 2 with concentration of alcohol in the blood behind the ethanol.In addition, in the test group 2, particularly give with in 90 minutes behind the ethanol, said effect is remarkable.
Can find out that from above result ornithine has the effect that the obvious suppression blood-alcohol concentration rises.
Test Example 2
In Test Example 1; Except making every 1kg body weight absorb the histidine of 2g (consonance Kyowa Hakko system), make every 1kg body weight absorb the histidine hydrochloride of 2g (consonance Kyowa Hakko system) for aqueous solution for aqueous solution, likewise make an experiment with Test Example 1 with preparation to its mouse oral of test group 1 with preparation to its mouse oral of test group 2.
The result is as shown in Figure 2.As can beappreciated from fig. 2, all receive remarkable inhibition to rising in test group 1, the test group 2 with concentration of alcohol in the blood behind the ethanol.
Can find out that from above result histidine has the effect that the obvious suppression blood-alcohol concentration rises.
Test Example 3
In Test Example 1; Except making every 1kg body weight absorb the lysine citrate of 2g (consonance Kyowa Hakko system), make every 1kg body weight absorb the citrulline of 2g (consonance Kyowa Hakko system) for aqueous solution for aqueous solution, likewise make an experiment with Test Example 1 with preparation to its mouse oral of test group 1 with preparation to its mouse oral of test group 2.
The result is as shown in Figure 3.As can beappreciated from fig. 3, particularly give in test group 1, the test group 2 with rising with concentration of alcohol in the interior blood in 90 minutes behind the ethanol and all receive remarkable inhibition.
Can find out that from above result lysine, citrulline have the effect that the obvious suppression blood-alcohol concentration rises.
Test Example 4
In Test Example 1,, make the lysine hydrochloride (consonance Kyowa Hakko system) of every 1kg body weight picked-up 2g in addition, likewise make an experiment for aqueous solution with preparation with Test Example 1 to its mouse oral of test group 1 except constituting matched group and 1 liang of group of test group.
The result is as shown in Figure 4.As can beappreciated from fig. 4, receive remarkable inhibition to rising in the test group 1 with concentration of alcohol in the blood behind the ethanol.
Can find out that from above result lysine has the effect that the obvious suppression blood-alcohol concentration rises.
Test Example 5
In Test Example 1,, make the arginine (consonance Kyowa Hakko system) of every 1kg body weight picked-up 1g in addition, likewise make an experiment for aqueous solution with preparation with Test Example 1 to its mouse oral of test group 1 except constituting matched group and 1 liang of group of test group.
The result is as shown in Figure 5.As can beappreciated from fig. 5, particularly give in the test group 1 with rising with concentration of alcohol in the interior blood in 90 minutes behind the ethanol and receive remarkable inhibition.
Can find out that from above result arginine has the effect that the obvious suppression blood-alcohol concentration rises.
Below list embodiments of the invention.
Contain the manufacturing of the tablet of ornithine
Use taper blender (Japanese drying machine Co., Ltd. system; CB-1200 type blender) with dlornithine hydrochloride 136.2kg (consonance Kyowa Hakko system; The L-dlornithine hydrochloride), microcrystalline Cellulose 36.0kg (chemical company of Asahi Chemical Industry system; Avicel FD101), sucrose fatty acid ester 6.6kg (the first industrial drugmaker system; DK Ester F-20W), calcium phosphate 1.2kg (peaceful chemical industry corporate system, tricalcium phosphate) and beta-schardinger dextrin-20.0kg (japanese food chemical company system, Celldex B-100) mix.Use rotary compressing forming machine (chrysanthemum water makes society of institute system, VIRGO524SS1AY) with compression molding pressure 10kN with the mixture compression molding that obtains, prepared the tablet of diameter 8mm, 250mg.
Contain the manufacturing of the tablet of ornithine and citric acid
To make citric acid (consonance Ha イ Off one ズ society system) 1000g, ornithine hydrochloride 1000g and reduction malt syrup (the former business of the woods society system of M-2 type (sieve 0.5mm) pulverizing of manufacturing of nara machinery; Powder マ PVC Star ト 50M) mixture of 2747.5g makes water (Off ロ イ Application ト industry society system FLO-5) is carried out granulation with the fluidized bed prilling drying machine.In the pelletize thing 4557.6g that obtains, sneak into sucralose (three Rong Yuan FFI corporate systems) 2.4g and sucrose fatty acid ester (long rapids industry corporate system, DK Ester F-20W) 240g.Use rotary compressing forming machine with compression molding pressure 10kN with the mixture compression molding that obtains, prepared the tablet of diameter 9mm, 300mg.
Contain the manufacturing of the beverage of ornithine and citric acid
With dlornithine hydrochloride 1.28kg, erithritol 3kg (day is ground chemical company's system), citric acid 0.05kg, artificial sweetener 3g, spice 0.06kg stirring and dissolving in the water 50L of 70 ℃ of liquid temperature; After with citric acid pH being transferred to 3.3; After using board-like (プ レ one ト) antibacterial to sterilize and bottle; Carry out the sterilization of crust formula, prepared the beverage that contains ornithine and citric acid.
Industrial applicability
According to the present invention, can provide and contain basic amino acid or its salt and rise as the blood-alcohol concentration safely and effectively of effective ingredient and suppress to use compositions.
Claims (3)
1. ornithine, arginine, histidine or citrulline or their salt are used to make the blood-alcohol concentration rising and suppress the application with compositions.
2. the described application of claim 2 comprises further use organic acid.
3. the described application of claim 3, wherein, organic acid is acetic acid, lactic acid, malic acid, fumaric acid, tartaric acid or citric acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| JP243641/2005 | 2005-08-25 | ||
| JP2005243641 | 2005-08-25 | ||
| PCT/JP2006/316678 WO2007023931A1 (en) | 2005-08-25 | 2006-08-25 | Composition for prevention of increase in blood alcohol level |
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| CN101247801A CN101247801A (en) | 2008-08-20 |
| CN101247801B true CN101247801B (en) | 2012-08-22 |
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| JP (1) | JP5188181B2 (en) |
| CN (1) | CN101247801B (en) |
| WO (1) | WO2007023931A1 (en) |
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| JP5534806B2 (en) * | 2007-02-23 | 2014-07-02 | 協和発酵バイオ株式会社 | Citrulline-containing beverage |
| WO2008105384A1 (en) * | 2007-02-26 | 2008-09-04 | Kyowa Hakko Bio Co., Ltd. | Citrulline-containing tablet |
| FR2913885B1 (en) * | 2007-03-22 | 2012-07-20 | Univ Paris Descartes | USE OF CITRULLINE FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH INCREASED CARBONYLATION OF PROTEINS |
| WO2009064004A1 (en) | 2007-11-16 | 2009-05-22 | Kyowa Hakko Bio Co., Ltd. | Citrulline-containing drink |
| JP4964793B2 (en) * | 2008-01-22 | 2012-07-04 | アサヒ飲料株式会社 | Citrulline-containing food and drink and method for producing the same |
| TW201431552A (en) | 2008-07-28 | 2014-08-16 | Takeda Pharmaceutical | Pharmaceutical composition |
| JP2010115124A (en) * | 2008-11-11 | 2010-05-27 | Iwata Kagaku Kogyo Kk | Brown-sugar fermented product for decreasing ethanol concentration in blood |
| JP5687423B2 (en) * | 2009-10-22 | 2015-03-18 | 協和発酵バイオ株式会社 | Alcohol fatigue improver |
| WO2011051742A1 (en) * | 2009-10-28 | 2011-05-05 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| JP5227978B2 (en) * | 2010-01-08 | 2013-07-03 | キリンホールディングス株式会社 | Alcohol-free malt beverage with high flavor ornithine |
| JP2013124243A (en) | 2011-12-15 | 2013-06-24 | Matsutani Chem Ind Ltd | Agent for suppressing elevation of blood alcohol concentration |
| ITBO20120226A1 (en) * | 2012-04-24 | 2013-10-25 | Alfa Wassermann Spa | COMPOSITIONS INCLUDING ALPINE-KETOGLUTARATE ORNITINE, PROCESSES FOR THEIR ACHIEVEMENT AND THEIR USE. |
| JP6573756B2 (en) * | 2014-08-22 | 2019-09-11 | アサヒグループホールディングス株式会社 | Tomato-containing food and drink |
| JP2019043861A (en) * | 2017-08-30 | 2019-03-22 | アサヒグループホールディングス株式会社 | Composition for improving lactic acid/pyruvic acid ratio |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279068A (en) * | 1999-06-26 | 2001-01-10 | B·布劳恩梅尔松根股份公司 | Aqueous solution for parenteral absorption |
| CN1451426A (en) * | 2003-05-18 | 2003-10-29 | 漆又毛 | Medicinal composition and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS62143678A (en) * | 1985-12-17 | 1987-06-26 | Nakano Vinegar Co Ltd | Production of alcoholic drink to prevent deep drunkenness |
| JPS63141562A (en) * | 1986-12-04 | 1988-06-14 | Nakano Vinegar Co Ltd | Food having lowering action on concentration of alcohol in blood |
| JP3479986B2 (en) * | 1992-10-07 | 2003-12-15 | 大正製薬株式会社 | Composition for preventing alcoholic liver injury |
| GB9725061D0 (en) * | 1997-11-27 | 1998-01-28 | Tagg Npd Limited | Revitalisation formulation |
| JP3843298B2 (en) * | 2001-02-05 | 2006-11-08 | 国立大学法人 奈良先端科学技術大学院大学 | Active oxygen scavenger containing citrulline |
| TWI309162B (en) * | 2001-03-15 | 2009-05-01 | Rikagaku Kenkyusho | Amino acid composition for improving functional disorder of liver |
| JP4042397B2 (en) * | 2001-11-07 | 2008-02-06 | ひかり製菓株式会社 | Taste improving agent |
-
2006
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279068A (en) * | 1999-06-26 | 2001-01-10 | B·布劳恩梅尔松根股份公司 | Aqueous solution for parenteral absorption |
| CN1451426A (en) * | 2003-05-18 | 2003-10-29 | 漆又毛 | Medicinal composition and use thereof |
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| CN101247801A (en) | 2008-08-20 |
| JP5188181B2 (en) | 2013-04-24 |
| WO2007023931A1 (en) | 2007-03-01 |
| JPWO2007023931A1 (en) | 2009-02-26 |
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