CN101234188A - Pharmaceutical composition for treating pain and preparation thereof - Google Patents
Pharmaceutical composition for treating pain and preparation thereof Download PDFInfo
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- CN101234188A CN101234188A CNA2007101177121A CN200710117712A CN101234188A CN 101234188 A CN101234188 A CN 101234188A CN A2007101177121 A CNA2007101177121 A CN A2007101177121A CN 200710117712 A CN200710117712 A CN 200710117712A CN 101234188 A CN101234188 A CN 101234188A
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Abstract
The invention discloses a medicine composition for treating pains, which substantially comprises clematis root, Notopterygium root, pubescent angelica, root of gentian, radix saposhnikoviae, lumbricus, Drynaria fortunei, dried ginger, etc., 35 raw medicinal medicines. The medicine composition of the invention has stronger penetrating power, good transdermal adsorption, which can increase the temperature of a lesion location, improve the blood circulation, eliminate an inflammation, unblocking a dampness blocking channel and clearing off the congestion, has remarkable effects on rheumatism pains, cancer pains, stomach cold ache and all pains resulted from cervical and lumbar hyperosteogeny, traumatic injury, fascial strain, sciatica, scapulohumeral periarthritis, etc.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of pain and preparation method thereof.
Background technology
Usually, pain is because the obstacle of tissue produces in this tissue part, and when disappearing in the tissue disorder that the pain part occurs, this pain also disappears.Pain takes place separately sometimes, but in cancer pain, in most of the cases, owing to give morphine, the compatibility of these medicines and morphine is poor, causes the side effect of morphine to increase sometimes.Therefore the medicine of treatment pain mostly exists effect not remarkable at present, and side effect is big.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of pain.
Another purpose of the present invention is to provide this preparation of drug combination method.
Another purpose of the present invention is to provide the purposes of this pharmaceutical composition.
The present invention seeks to be achieved through the following technical solutions
The crude drug of pharmaceutical composition of the present invention consists of:
A, Radix Clematidis 40-140 weight portion Rhizoma Et Radix Notopterygii 25-75 weight portion Radix Angelicae Pubescentis 25-75 weight portion
Radix Gentianae Macrophyllae 25-75 weight portion Radix Saposhnikoviae 25-75 weight portion Pheretima 25-75 weight portion
Rhizoma Drynariae 25-75 weight portion Rhizoma Zingiberis 40-140 weight portion rhizoma sparganic 25-75 weight portion
Rhizoma Curcumae 25-75 weight portion Caulis Sinomenii 25-75 weight portion Herba speranskiae tuberculatae 30-90 weight portion
Ramulus Cinnamomi 25-75 weight portion Caulis Spatholobi 25-75 weight portion Zaocys 25-75 weight portion
Caulis Piperis Kadsurae 25-75 weight portion Fructus Capsici 40-140 weight portion Rhizoma Corydalis 25-75 weight portion
Flos Daturae 25-75 weight portion Fructus Gleditsia 25-75 weight portion
B, Semen Strychni 30-90 weight portion Radix Aconiti Kusnezoffii 30-90 weight portion Eupolyphaga Seu Steleophaga 25-75 weight portion
Semen Sinapis Albae 15-45 weight portion Piper longum 15-45 weight portion Olibanum 15-45 weight portion
Myrrha 15-45 weight portion Sanguis Draxonis 15-45 weight portion Cortex Cinnamomi 25-75 weight portion
Herba Asari 15-45 weight portion Scorpio 15-45 weight portion Scolopendra 15-45 weight portion
Borneolum Syntheticum 20-60 weight portion Flos Caryophylli 15-45 weight portion Camphora 10-30 weight portion
The crude drug composition of pharmaceutical composition of the present invention is preferably:
A, Radix Clematidis 90 weight portion Rhizoma Et Radix Notopterygiis 50 weight portion Radix Angelicae Pubescentiss 50 weight portions
Radix Gentianae Macrophyllae 50 weight portion Radix Saposhnikoviaes 50 weight portion Pheretimas 50 weight portions
Rhizoma Drynariae 50 weight portion Rhizoma Zingiberiss 90 weight portion rhizoma sparganic 50 weight portions
Rhizoma Curcumae 50 weight portion Caulis Sinomeniis 50 weight portion Herba speranskiae tuberculataes 60 weight portions
Ramulus Cinnamomi 50 weight portion Caulis Spatholobis 50 weight portion Zaocyss 50 weight portions
Caulis Piperis Kadsurae 50 weight portion Fructus Capsicis 90 weight portion Rhizoma Corydalis 50 weight portions
Flos Daturae 50 weight portion Fructus Gleditsia 50 weight portions
B, Semen Strychni 60 weight portion Radix Aconiti Kusnezoffii 60 weight portion Eupolyphaga Seu Steleophagas 50 weight portions
Semen Sinapis Albae 30 weight portion Piper longums 30 weight portion Olibanums 30 weight portions
Myrrha 30 weight portion Sanguis Draxonis 30 weight portion Cortex Cinnamomis 50 weight portions
Herba Asari 30 weight portion Scorpio 30 weight portion Scolopendras 30 weight portions
Borneolum Syntheticum 40 weight portion Flos Caryophyllis 30 weight portion Camphoras 20 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
A, Radix Clematidis 60 weight portion Rhizoma Et Radix Notopterygiis 65 weight portion Radix Angelicae Pubescentiss 35 weight portions
Radix Gentianae Macrophyllae 65 weight portion Radix Saposhnikoviaes 35 weight portion Pheretimas 65 weight portions
Rhizoma Drynariae 35 weight portion Rhizoma Zingiberiss 120 weight portion rhizoma sparganic 35 weight portions
Rhizoma Curcumae 65 weight portion Caulis Sinomeniis 35 weight portion Herba speranskiae tuberculataes 80 weight portions
Ramulus Cinnamomi 35 weight portion Caulis Spatholobis 65 weight portion Zaocyss 35 weight portions
Caulis Piperis Kadsurae 65 weight portion Fructus Capsicis 60 weight portion Rhizoma Corydalis 65 weight portions
Flos Daturae 35 weight portion Fructus Gleditsia 65 weight portions
B, Semen Strychni 40 weight portion Radix Aconiti Kusnezoffii 80 weight portion Eupolyphaga Seu Steleophagas 35 weight portions
Semen Sinapis Albae 35 weight portion Piper longums 25 weight portion Olibanums 35 weight portions
Myrrha 25 weight portion Sanguis Draxonis 35 weight portion Cortex Cinnamomis 35 weight portions
Herba Asari 35 weight portion Scorpio 25 weight portion Scolopendras 35 weight portions
Borneolum Syntheticum 30 weight portion Flos Caryophyllis 35 weight portion Camphoras 25 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
A, Radix Clematidis 120 weight portion Rhizoma Et Radix Notopterygiis 35 weight portion Radix Angelicae Pubescentiss 65 weight portions
Radix Gentianae Macrophyllae 35 weight portion Radix Saposhnikoviaes 65 weight portion Pheretimas 35 weight portions
Rhizoma Drynariae 65 weight portion Rhizoma Zingiberiss 60 weight portion rhizoma sparganic 65 weight portions
Rhizoma Curcumae 35 weight portion Caulis Sinomeniis 65 weight portion Herba speranskiae tuberculataes 40 weight portions
Ramulus Cinnamomi 65 weight portion Caulis Spatholobis 35 weight portion Zaocyss 65 weight portions
Caulis Piperis Kadsurae 35 weight portion Fructus Capsicis 120 weight portion Rhizoma Corydalis 35 weight portions
Flos Daturae 65 weight portion Fructus Gleditsia 35 weight portions
B, Semen Strychni 80 weight portion Radix Aconiti Kusnezoffii 40 weight portion Eupolyphaga Seu Steleophagas 65 weight portions
Semen Sinapis Albae 25 weight portion Piper longums 35 weight portion Olibanums 25 weight portions
Myrrha 35 weight portion Sanguis Draxonis 25 weight portion Cortex Cinnamomis 65 weight portions
Herba Asari 25 weight portion Scorpio 35 weight portion Scolopendras 25 weight portions
Borneolum Syntheticum 50 weight portion Flos Caryophyllis 25 weight portion Camphoras 25 weight portions
Described Radix Aconiti Kusnezoffii is preferably Radix Aconiti Kusnezoffii.
Pharmaceutical composition of the present invention adds the exterior-applied formulation that conventional adjuvant is made clinical acceptance by practice of pharmacy, as emplastrum, ointment, spray, powder or liniment.
Preparation of drug combination method of the present invention is: after above-mentioned category-A crude drug is soaked 0.5-1.5 hour, heating decocts 1-3 time, boiled the follow-up 0.2-0.8 of frying in shallow oil hour at every turn, the leaching medicinal liquid, medicinal liquid was left standstill 12-36 hour, and the leaching supernatant concentration is standby to the extractum shape of relative density 1.1～1.20 (70-80 ℃);
Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 80-120 mesh sieve fine powder, and it is standby to put into hermetic container in the lump; Get 4000-8000 parts by weight resin glue, melt with slow fire, in the time of about 50-90 ℃ to be cooled, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 30-70 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
Preparation of drug combination method of the present invention is preferably: after above-mentioned category-A crude drug is soaked 1 hour, heating decocts 2 times, follow-up the frying in shallow oil 0.5 hour of at every turn boiling, the leaching medicinal liquid, medicinal liquid was left standstill 24 hours, and the leaching supernatant concentration is standby to the extractum shape of relative density 1.1～1.20 (70-80 ℃); Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 100 mesh sieve fine powders, and it is standby to put into hermetic container in the lump; Get 6000 weight portions Malaysia resin glue, melt with slow fire, to be cooled during to 70 ℃, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 50 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
Pharmaceutical composition of the present invention has stronger penetration power, and Transdermal absorption is good, and the lesions position temperature is raise, and improves blood circulation, diminishes inflammation, and it is unimpeded that the passages through which vital energy circulates of numbness resistance is able to, and blood stasis is dissipated.To treatment rheumatic Bi syndrome pain, cancerous protuberance pain, cold syndrome of the stomach pain, all pain effects that neck, lumbar vertebra hyperosteogeny, traumatic injury, fascia strain, sciatica, scapulohumeral periarthritis etc. cause are remarkable.
Following experimental example and embodiment are used to further specify the present invention but are not limited to the present invention.
Experimental example:
Pharmaceutical composition clinical observation pain patients 138 examples of the present invention, hyperosteogeny pain patients 36 examples wherein, scapulohumeral periarthritis pain patients 42 examples, lumbar muscle strain pain patients 60 examples obtain better curative effect, now are reported as follows:
One, physical data
36 routine hyperosteogeny patients, male's 20 examples wherein, women's 16 examples, the oldest 86 years old, minimum 30 years old, average 50 years old.The course of disease is the longest 15 years, and is the shortest 1 year.The course of treatment is the longest 6 months, and is the shortest 2 months.
42 routine scapulohumeral periarthritis patients, male's 20 examples wherein, women's 22 examples, the oldest 90 years old, minimum 38 years old, average 50 years old.The course of disease is the longest 10 years, and is the shortest 1 year.The course of treatment is the longest 4 months, and is the shortest 1 month.
60 routine lumbar muscle strain patients, male's 20 examples wherein, women's 22 examples, the oldest 50 years old, minimum 15 years old, average 28 years old.The course of disease is the longest 10 years, and is the shortest 1 year.The course of treatment is the longest 2 months, and is the shortest 15 days.
Two, diagnostic criteria
More than all cases all take the photograph inspections such as sheet B ultrasonic, CT and make a definite diagnosis through hospital above county level blood biochemical.
Three, Therapeutic Method
1, medicine is formed:
A, Radix Clematidis 90g, Rhizoma Et Radix Notopterygii 50g, Radix Angelicae Pubescentis 50g, Radix Gentianae Macrophyllae 50g, Radix Saposhnikoviae 50g, Pheretima 50g, Rhizoma Drynariae 50g, Rhizoma Zingiberis 90g, rhizoma sparganic 50g, Rhizoma Curcumae 50g, Caulis Sinomenii 50g, Herba speranskiae tuberculatae 60g, Ramulus Cinnamomi 50g, Caulis Spatholobi 50g, Zaocys 50g, Caulis Piperis Kadsurae 50g, Fructus Capsici 90g, Rhizoma Corydalis 50g, Flos Daturae 50g, Fructus Gleditsia 50g;
B, Semen Strychni 60g, Radix Aconiti Kusnezoffii 60g, Eupolyphaga Seu Steleophaga 50g, Semen Sinapis Albae 30g, Piper longum 30g, Olibanum 30g, Myrrha 30g, Sanguis Draxonis 30g, Cortex Cinnamomi 50g, Herba Asari 30g, Scorpio 30g, Scolopendra 30g, Borneolum Syntheticum 40g, Flos Caryophylli 30g, Camphora 20g.
2, preparation method
Preparation of drug combination method of the present invention is for after soaking 1 hour with above-mentioned category-A crude drug, heating decocts 2 times, boils follow-uply to fry in shallow oil the leaching medicinal liquid 0.5 hour at every turn, medicinal liquid was left standstill 24 hours, and the leaching supernatant concentration is standby to the extractum shape of relative density 1.1～1.20 (70-80 ℃); Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 100 mesh sieve fine powders, and it is standby to put into hermetic container in the lump; Get 6000g Malaysia resin glue (being called for short Malaysia glue), melt with slow fire, to be cooled during to 70 ℃, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 50 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
Four, therapeutic outcome (seeing the following form 1):
Table 1 pharmaceutical composition plaster of the present invention observation of curative effect
By table 1 result as can be known: pharmaceutical composition plaster treatment hyperosteogeny of the present invention, scapulohumeral periarthritis, lumbar muscle strain have good effect.
Five, model case:
Case 1 poplar, man, 50 years old, on October 10th, 2003 went to a doctor, tell left shoulder joint joint stuffiness pain 2 years surplus, through X-ray examination, be diagnosed as scapulohumeral periarthritis, Western medicine is injected invalid commentaries on classics, and I go to a doctor: through looking into, stretch the pain of being obstructed after left scapuloanterior (LScA) is put forward, give 12 * 24 large size the present invention, ten thousand clever patch and take on all caves, changed in per 5 days one, shoulder arthralgia is clearly better after forcing on 5 days, continues to paste the medicine first quarter moon and heal (healing through X-ray examination).
Case 2 Huangs, the man, 62 years old, on October 1st, 2004 went to a doctor, and told through the X-ray film making and showed cervical vertebra 4,5,6 vertebra matter hypertrophy, the slight backward bulging of neck 5,6 vertebras.Existing disease nape aching limitation of activity has numbness when both hands refer to, through methods such as massage, doctor trained in Western medicine injection hormones, symptom fails to alleviate, and introduces to come to stick through the friend, gives large size 8 * 10cm the present invention ten thousand clever patch and applies, one puted up five days, told after five days and ached, and both hands refer to not numb.Give three again and puted up 15 days after the X-ray examination hyperosteogeny obviously reduces, all doing well,improvings are advised and are adhered to pasting medicine reinforcement exercise, follow up a case by regular visits to and do not have recurrence in 2 years so far.
Surplus the case 3 certain, the man 48 years old, went to a doctor on October 1st, 2005.Tell have an intense pain unable to move around two days of waist.Taking the photograph sheet through county hospital injury of the bone section shows: not seeing has the unusual indication of sclerotin.Examine and be acute lumbar muscle sprain, lumbar muscle strain.Treat the commentaries on classics of not getting better with medicines such as Radix Salviae Miltiorrhizae, hormones, by the agency of is treated with plaster of the present invention.Often tired back outbreak before the inquiry.Palpation patient two SHENYU acupoint and place, two pang kuang shu caves tenderness are obvious.The disease of this fascia strain.Give three of the present invention ten thousand clever cream large size 15 * 20cm, every plaster sticked five days, pasted pain relief improvement after a day, and pain disappeared in three days.Advise and strengthen the psoas muscle enure at ordinary times, after 15 days, recovery from illness is followed up a case by regular visits to and is not had recurrence so far.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1:
A, Radix Clematidis 90g Rhizoma Et Radix Notopterygii 50g Radix Angelicae Pubescentis 50g Radix Gentianae Macrophyllae 50g Radix Saposhnikoviae 50g
Pheretima 50g Rhizoma Drynariae 50g Rhizoma Zingiberis 90g rhizoma sparganic 50g Rhizoma Curcumae 50g
Caulis Sinomenii 50g Herba speranskiae tuberculatae 60g Ramulus Cinnamomi 50g Caulis Spatholobi 50g Zaocys 50g
Caulis Piperis Kadsurae 50g Fructus Capsici 90g Rhizoma Corydalis 50g Flos Daturae 50g Fructus Gleditsia 50g
B, Semen Strychni 60g Radix Aconiti Kusnezoffii 60g Eupolyphaga Seu Steleophaga 50g Semen Sinapis Albae 30g Piper longum 30g
Olibanum 30g Myrrha 30g Sanguis Draxonis 30g Cortex Cinnamomi 50g Herba Asari 30g
Scorpio 30g Scolopendra 30g Borneolum Syntheticum 40g Flos Caryophylli 30g Camphora 20g
After above-mentioned category-A crude drug soaked 1 hour, heating decocted 2 times, follow-up the frying in shallow oil 0.5 hour of at every turn boiling, and the leaching medicinal liquid leaves standstill medicinal liquid 24 hours, and the leaching supernatant concentration is standby to the extractum shape of relative density 1.1～1.20 (70-80 ℃); Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 100 mesh sieve fine powders, and it is standby to put into hermetic container in the lump; Get 6000g Malaysia resin glue, melt with slow fire, to be cooled during to 70 ℃, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 50 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.Whenever puted up five days.
Embodiment 2:
A, Radix Clematidis 60kg Rhizoma Et Radix Notopterygii 65kg Radix Angelicae Pubescentis 35kg Radix Gentianae Macrophyllae 65kg Radix Saposhnikoviae 35kg
Pheretima 65kg Rhizoma Drynariae 35kg Rhizoma Zingiberis 120kg rhizoma sparganic 35kg Rhizoma Curcumae 65kg
Caulis Sinomenii 35kg Herba speranskiae tuberculatae 80kg Ramulus Cinnamomi 35kg Caulis Spatholobi 65kg Zaocys 35kg
Caulis Piperis Kadsurae 65kg Fructus Capsici 60kg Rhizoma Corydalis 65kg Flos Daturae 35kg Fructus Gleditsia 65kg
B, Semen Strychni 40kg Radix Aconiti Kusnezoffii 80kg Eupolyphaga Seu Steleophaga 35kg Semen Sinapis Albae 35kg Piper longum 25kg
Olibanum 35kg Myrrha 25kg Sanguis Draxonis 35kg Cortex Cinnamomi 35kg Herba Asari 35kg
Scorpio 25kg Scolopendra 35kg Borneolum Syntheticum 30kg Flos Caryophylli 35kg Camphora 25kg
Said medicine technology routinely adds conventional adjuvant and makes spray.
Embodiment 3:
A, Radix Clematidis 120kg Rhizoma Et Radix Notopterygii 35kg Radix Angelicae Pubescentis 65kg Radix Gentianae Macrophyllae 35kg Radix Saposhnikoviae 65kg
Pheretima 35kg Rhizoma Drynariae 65kg Rhizoma Zingiberis 60kg rhizoma sparganic 65kg Rhizoma Curcumae 35kg
Caulis Sinomenii 65kg Herba speranskiae tuberculatae 40kg Ramulus Cinnamomi 65kg Caulis Spatholobi 35kg Zaocys 65kg
Caulis Piperis Kadsurae 35kg Fructus Capsici 120kg Rhizoma Corydalis 35kg Flos Daturae 65kg Fructus Gleditsia 35kg
B, Semen Strychni 80kg Radix Aconiti Kusnezoffii 40kg Eupolyphaga Seu Steleophaga 65kg Semen Sinapis Albae 25kg Piper longum 35kg
Olibanum 25kg Myrrha 35kg Sanguis Draxonis 25kg Cortex Cinnamomi 65kg Herba Asari 25kg
Scorpio 35kg Scolopendra 25kg Borneolum Syntheticum 50kg Flos Caryophylli 25kg Camphora 25kg
Said medicine technology routinely adds conventional adjuvant and makes liniment.
Claims (10)
1. pharmaceutical composition for the treatment of pain is characterized in that the crude drug of said composition consists of:
A, Radix Clematidis 40-140 weight portion Rhizoma Et Radix Notopterygii 25-75 weight portion Radix Angelicae Pubescentis 25-75 weight portion
Radix Gentianae Macrophyllae 25-75 weight portion Radix Saposhnikoviae 25-75 weight portion Pheretima 25-75 weight portion
Rhizoma Drynariae 25-75 weight portion Rhizoma Zingiberis 40-140 weight portion rhizoma sparganic 25-75 weight portion
Rhizoma Curcumae 25-75 weight portion Caulis Sinomenii 25-75 weight portion Herba speranskiae tuberculatae 30-90 weight portion
Ramulus Cinnamomi 25-75 weight portion Caulis Spatholobi 25-75 weight portion Zaocys 25-75 weight portion
Caulis Piperis Kadsurae 25-75 weight portion Fructus Capsici 40-140 weight portion Rhizoma Corydalis 25-75 weight portion
Flos Daturae 25-75 weight portion Fructus Gleditsia 25-75 weight portion;
B, Semen Strychni 30-90 weight portion Radix Aconiti Kusnezoffii 30-90 weight portion Eupolyphaga Seu Steleophaga 25-75 weight portion
Semen Sinapis Albae 15-45 weight portion Piper longum 15-45 weight portion Olibanum 15-45 weight portion
Myrrha 15-45 weight portion Sanguis Draxonis 15-45 weight portion Cortex Cinnamomi 25-75 weight portion
Herba Asari 15-45 weight portion Scorpio 15-45 weight portion Scolopendra 15-45 weight portion
Borneolum Syntheticum 20-60 weight portion Flos Caryophylli 15-45 weight portion Camphora 10-30 weight portion.
2. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
A, Radix Clematidis 90 weight portion Rhizoma Et Radix Notopterygiis 50 weight portion Radix Angelicae Pubescentiss 50 weight portions
Radix Gentianae Macrophyllae 50 weight portion Radix Saposhnikoviaes 50 weight portion Pheretimas 50 weight portions
Rhizoma Drynariae 50 weight portion Rhizoma Zingiberiss 90 weight portion rhizoma sparganic 50 weight portions
Rhizoma Curcumae 50 weight portion Caulis Sinomeniis 50 weight portion Herba speranskiae tuberculataes 60 weight portions
Ramulus Cinnamomi 50 weight portion Caulis Spatholobis 50 weight portion Zaocyss 50 weight portions
Caulis Piperis Kadsurae 50 weight portion Fructus Capsicis 90 weight portion Rhizoma Corydalis 50 weight portions
Flos Daturae 50 weight portion Fructus Gleditsia 50 weight portions;
B, Semen Strychni 60 weight portion Radix Aconiti Kusnezoffii 60 weight portion Eupolyphaga Seu Steleophagas 50 weight portions
Semen Sinapis Albae 30 weight portion Piper longums 30 weight portion Olibanums 30 weight portions
Myrrha 30 weight portion Sanguis Draxonis 30 weight portion Cortex Cinnamomis 50 weight portions
Herba Asari 30 weight portion Scorpio 30 weight portion Scolopendras 30 weight portions
Borneolum Syntheticum 40 weight portion Flos Caryophyllis 30 weight portion Camphoras 20 weight portions.
3. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
A, Radix Clematidis 60 weight portion Rhizoma Et Radix Notopterygiis 65 weight portion Radix Angelicae Pubescentiss 35 weight portions
Radix Gentianae Macrophyllae 65 weight portion Radix Saposhnikoviaes 35 weight portion Pheretimas 65 weight portions
Rhizoma Drynariae 35 weight portion Rhizoma Zingiberiss 120 weight portion rhizoma sparganic 35 weight portions
Rhizoma Curcumae 65 weight portion Caulis Sinomeniis 35 weight portion Herba speranskiae tuberculataes 80 weight portions
Ramulus Cinnamomi 35 weight portion Caulis Spatholobis 65 weight portion Zaocyss 35 weight portions
Caulis Piperis Kadsurae 65 weight portion Fructus Capsicis 60 weight portion Rhizoma Corydalis 65 weight portions
Flos Daturae 35 weight portion Fructus Gleditsia 65 weight portions;
B, Semen Strychni 40 weight portion Radix Aconiti Kusnezoffii 80 weight portion Eupolyphaga Seu Steleophagas 35 weight portions
Semen Sinapis Albae 35 weight portion Piper longums 25 weight portion Olibanums 35 weight portions
Myrrha 25 weight portion Sanguis Draxonis 35 weight portion Cortex Cinnamomis 35 weight portions
Herba Asari 35 weight portion Scorpio 25 weight portion Scolopendras 35 weight portions
Borneolum Syntheticum 30 weight portion Flos Caryophyllis 35 weight portion Camphoras 25 weight portions.
4. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
A, Radix Clematidis 120 weight portion Rhizoma Et Radix Notopterygiis 35 weight portion Radix Angelicae Pubescentiss 65 weight portions
Radix Gentianae Macrophyllae 35 weight portion Radix Saposhnikoviaes 65 weight portion Pheretimas 35 weight portions
Rhizoma Drynariae 65 weight portion Rhizoma Zingiberiss 60 weight portion rhizoma sparganic 65 weight portions
Rhizoma Curcumae 35 weight portion Caulis Sinomeniis 65 weight portion Herba speranskiae tuberculataes 40 weight portions
Ramulus Cinnamomi 65 weight portion Caulis Spatholobis 35 weight portion Zaocyss 65 weight portions
Caulis Piperis Kadsurae 35 weight portion Fructus Capsicis 120 weight portions;
B, Semen Strychni 80 weight portion Radix Aconiti Kusnezoffii 40 weight portion Eupolyphaga Seu Steleophagas 65 weight portions
Semen Sinapis Albae 25 weight portion Piper longums 35 weight portion Olibanums 25 weight portions
Myrrha 35 weight portion Sanguis Draxonis 25 weight portion Cortex Cinnamomis 65 weight portions
Herba Asari 25 weight portion Scorpio 35 weight portion Scolopendras 25 weight portions
Borneolum Syntheticum 50 weight portion Flos Caryophyllis 25 weight portion Camphoras 25 weight portions.
5. according to the described pharmaceutical composition of one of claim 1-4, it is characterized in that described Radix Aconiti Kusnezoffii is a Radix Aconiti Kusnezoffii.
6. according to the described pharmaceutical composition of one of claim 1-4, it is characterized in that said composition adds conventional adjuvant by practice of pharmacy and makes the emplastrum of clinical acceptance, ointment, spray, powder or liniment exterior-applied formulation.
7. pharmaceutical composition according to claim 5 is characterized in that said composition adds the exterior-applied formulation that conventional adjuvant is made clinical acceptance by practice of pharmacy, as emplastrum, ointment, spray, powder or liniment.
8. according to the described preparation of drug combination method of one of claim 1-4, it is characterized in that this method is: after above-mentioned category-A crude drug is soaked 0.5-1.5 hour, heating decocts 1-3 time, boiled the follow-up 0.2-0.8 of frying in shallow oil hour at every turn, the leaching medicinal liquid, medicinal liquid was left standstill 12-36 hour, the leaching supernatant concentration during to 70-80 ℃ relative density be that 1.1～1.20 extractum shape is standby; Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 80-120 mesh sieve fine powder, and it is standby to put into hermetic container in the lump; Get 4000-8000 parts by weight resin glue, melt with slow fire, in the time of about 50-90 ℃ to be cooled, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 30-70 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
9. preparation of drug combination method according to claim 5, it is characterized in that this method is: after above-mentioned category-A crude drug is soaked 0.5-1.5 hour, heating decocts 1-3 time, boiled the follow-up 0.2-0.8 of frying in shallow oil hour at every turn, the leaching medicinal liquid, medicinal liquid was left standstill 12-36 hour, the leaching supernatant concentration during to 70-80 ℃ relative density be that 1.1～1.20 extractum shape is standby; Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 80-120 mesh sieve fine powder, and it is standby to put into hermetic container in the lump; Get 4000-8000 parts by weight resin glue, melt with slow fire, in the time of about 50-90 ℃ to be cooled, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 30-70 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
10. preparation of drug combination method according to claim 8, it is characterized in that this method is for after soaking 1 hour with above-mentioned category-A crude drug, heating decocts 2 times, follow-up the frying in shallow oil 0.5 hour of at every turn boiling, the leaching medicinal liquid, medicinal liquid was left standstill 24 hours, the leaching supernatant concentration during to 70-80 ℃ relative density be that 1.1～1.20 extractum shape is standby; Borneolum Syntheticum, the Camphora of category-B crude drug are pulverized separately, all the other mix pulverizing again, cross 100 mesh sieve fine powders, and it is standby to put into hermetic container in the lump; Get 6000 weight portions Malaysia resin glue, melt with slow fire, to be cooled during to 70 ℃, under constantly stirring, slowly add the category-A drug extract, after stirring, continuation to remove steam, is cooled to adding category-B fine powder about 50 ℃ from fire with the slow fire heating again, can spread out after stirring and paint plaster.
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| CN108310331A (en) * | 2018-05-08 | 2018-07-24 | 葛新军 | A kind of the external application medical ointment formula and preparation method and application of analgesic |
| CN108671200A (en) * | 2018-07-16 | 2018-10-19 | 张振启 | A kind of paste of set a broken bone |
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