CN101224324B - Charged particles ray treatment device - Google Patents
Charged particles ray treatment device Download PDFInfo
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- CN101224324B CN101224324B CN2008100035414A CN200810003541A CN101224324B CN 101224324 B CN101224324 B CN 101224324B CN 2008100035414 A CN2008100035414 A CN 2008100035414A CN 200810003541 A CN200810003541 A CN 200810003541A CN 101224324 B CN101224324 B CN 101224324B
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F1/00—Originals for photomechanical production of textured or patterned surfaces, e.g., masks, photo-masks, reticles; Mask blanks or pellicles therefor; Containers specially adapted therefor; Preparation thereof
- G03F1/20—Masks or mask blanks for imaging by charged particle beam [CPB] radiation, e.g. by electron beam; Preparation thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
- A61N5/1079—Sharing a beam by multiple treatment stations
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F5/00—Screening processes; Screens therefor
- G03F5/02—Screening processes; Screens therefor by projection methods
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/70—Microphotolithographic exposure; Apparatus therefor
- G03F7/70058—Mask illumination systems
- G03F7/70208—Multiple illumination paths, e.g. radiation distribution devices, microlens illumination systems, multiplexers or demultiplexers for single or multiple projection systems
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/70—Microphotolithographic exposure; Apparatus therefor
- G03F7/70216—Mask projection systems
- G03F7/70275—Multiple projection paths, e.g. array of projection systems, microlens projection systems or tandem projection systems
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/70—Microphotolithographic exposure; Apparatus therefor
- G03F7/708—Construction of apparatus, e.g. environment aspects, hygiene aspects or materials
- G03F7/7085—Detection arrangement, e.g. detectors of apparatus alignment possibly mounted on wafers, exposure dose, photo-cleaning flux, stray light, thermal load
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/26—Electron or ion microscopes; Electron or ion diffraction tubes
- H01J37/28—Electron or ion microscopes; Electron or ion diffraction tubes with scanning beams
Abstract
The invention provides a charged particle ray irradiation unit for confirming the irradiation position of desired site. An irradiation room (103) comprises a charged particle ray irradiation part (1) rotating around the irradiated object (51), a detection part (30) for detecting the silent gamma ray generated by the irradiated object (51) which can move along the extending direction of the pivot point X of the charged particle ray irradiation part (1). Thus, the detection part moves along the direction of the X axle to prevent the detection part (30) interfering the rotation of the charged particle ray irradiation part (1). Moreover, when the irradiated object moves into and out the irradiation room (103), the detection part (30) is out of the way. And, the position confirmation of the desired site can be performed. The detection part (30) moves upwards along the direction of axle X and cooperates with the size of the irradiation object, thus the detection range of the detection part (30) can be enlarged.
Description
Technical field
The present invention relates to a kind of charged particle beam therapeutic apparatus that possesses the exposure cell, this exposure cell has the charged particle line irradiating part that can rotate around the irradiated body of illuminated charged particle line.
Background technology
In the past, as the charged particle beam therapeutic apparatus of irradiation charged particle line, for example known irradiation proton line and treat the proton beam therapeutic apparatus of tumor.In this oncotherapy, need design irradiation plans such as absolute dosages, dose distribution and irradiation position according to the shape and the position of tumor, and plan the irradiation of carrying out the charged particle line accurately according to this irradiation.Under the situation to patient exposure proton line, in order to avoid the irradiation to important organ, brain stem, optic nerve and spinal cord etc., the precision of irradiation position is even more important.And; The proton beam therapeutic apparatus that in this oncotherapy, uses has exposure cell's (rotary frame); This exposure cell has the proton line irradiating part that rotates freely around the patient, improves the degree of freedom (for example, with reference to patent documentation 1) that moves of proton line irradiating part thus.
Patent documentation 1: japanese kokai publication hei 11-47287 communique
In recent years, in the charged particle beam therapeutic apparatus of irradiation charged particle line, seek the charged particle line that is shone is irradiated onto on which position of irradiated body and detect.Therefore developed following technology: use the PET photographing unit; Annihilation gamma ray to from the positron radioactive nucleus that produces through charged particle line and the illuminated intravital nuclear nuclear reaction that is irradiated onto on the irradiated body detects, and detects the irradiation position of charged particle line.But in this technology,, therefore seek to carry out the location confirmation of desired site because the PET photographing unit is fixed, can only carries out the location confirmation of specific part.
Summary of the invention
The present invention carries out for solving above-mentioned problem, and its objective is provides a kind of charged particle beam therapeutic apparatus that can carry out in the affirmation of the irradiation position of desired site.
Charged particle beam therapeutic apparatus of the present invention; Possesses the exposure cell; This exposure cell has the charged particle line irradiating part that can rotate around the irradiated body of illuminated charged particle line, and this charged particle beam therapeutic apparatus is characterised in that to have a pair of test section; Across irradiated body be configured in both sides, detect because the irradiation of above-mentioned charged particle line and the annihilation gamma ray that generates at irradiated body; With the bearing of trend of the rotary middle spindle of above-mentioned charged particle line irradiating part as X-direction; Test section can move on X-direction with respect to above-mentioned exposure cell.
Charged particle beam therapeutic apparatus according to formation like this; Possess that have can be around the exposure cell of the charged particle line irradiating part of irradiated body rotation, the test section that the annihilation gamma ray that generates at irradiated body is detected can move on the X-direction as the bearing of trend of the rotary middle spindle of charged particle line irradiating part.Thus, on X-direction, move, can prevent that test section from hindering the rotation of charged particle line irradiating part through making test section.And, become obstacle to the Shi Buhui that moves into, takes out of of exposure cell at irradiated body.And, can carry out the location confirmation of desired site.And,, therefore can enlarge the detection range of test section because test section is moved on X-direction.
At this, preferred detection portion can be around the rotation of X axle.Thus, because test section can be around irradiated body rotation, the degree of freedom that moves of test section improves, and therefore can use the test section (for example PET photographing unit) of miniaturization and 3 dimensions of carrying out irradiation position are measured.
And preferred detection portion follows being rotated rotatably of charged particle line irradiating part.Thus, on one side can keep from the position relation of the charged particle line and the test section of charged particle line irradiating part irradiation, Yi Bian carry out the instrumentation of irradiation position.
And preferred detection portion and charged particle line irradiating part are for be rotated integratedly.Thus, be used to make the rotary driving part of charged particle line irradiating part rotation to make the test section rotation, therefore, do not need to be provided with in addition rotary driving part in order to make the test section rotation owing to can use.
And preferred detection portion can move on approaching each other direction.Thus, through make across irradiated body be configured in both sides test section on approaching each other direction, move, can make test section carry out the mensuration of irradiation position, and can improve the mensuration precision near irradiated body ground.
And, preferably will with the orthogonal direction of X-direction as Y direction, test section can be around Y axle rotation.Thus, because the degree of freedom that moves of test section further improves, and can carry out the mensuration of irradiation position from all directions, therefore can make and measure precision and further improve.And; Owing to the position of axle rotation change test section of the regulation that test section is centered around extend on the Y direction, therefore, for example when test section is elongate shape; Length direction through with test section disposes along X-direction, can easily carry out the moving to X-direction of test section.
According to this charged particle beam therapeutic apparatus of the present invention,, can prevent that therefore test section from hindering the rotation of charged particle line irradiating part because test section is moved along X-direction.And to the moving into of exposure cell, when taking out of, test section does not become obstacle at irradiated body.And,, therefore can carry out the affirmation of the irradiation position of desired site owing to can test section moved along X-direction.
Description of drawings
Fig. 1 is the axonometric chart of the proton beam therapeutic apparatus of expression the 1st embodiment of the present invention.
Fig. 2 is the cutaway view of proton beam therapeutic apparatus shown in Figure 1.
Fig. 3 is the figure of each key element of the proton line irradiating part in the expression pie graph 1.
Fig. 4 is PET photographing unit and the plane graph of PET photographing unit support in the presentation graphs 1.
Fig. 5 is that the V-V of Fig. 4 is to view.
Fig. 6 is the flow chart of operation of the proton line illuminating method of expression embodiment of the present invention.
Fig. 7 is PET photographing unit and the plane graph of PET photographing unit support of the proton beam therapeutic apparatus of expression the 2nd embodiment of the present invention.
Fig. 8 is that the VIII-VIII of Fig. 7 is to view.
The specific embodiment
Below, preferred the 1st embodiment of charged particle beam therapeutic apparatus of the present invention is described with reference to Fig. 1～Fig. 5.In addition, in the explanation of accompanying drawing, give identical symbol, and omit repeat specification identical or suitable key element.In this embodiment, to the situation of charged particle beam therapeutic apparatus as the proton beam therapeutic apparatus described.
Like Fig. 1～shown in Figure 3, proton beam therapeutic apparatus 100 is the devices to intravital tumor of the patient's (irradiated body) 51 (irradiation object) P irradiation proton line (charged particle line).
This proton beam therapeutic apparatus 100 has the proton line irradiating part (charged particle line irradiating part) 1 that is installed on the rotary frame 103 (exposure cell), can centers on treatment table (mounting table) 105 rotations.
As shown in Figure 3, this proton line irradiating part 1 has: scattering object 5, arrange in order along the direction of illumination A of proton line, make the proton wire harness in order through and shaping ridged wave filter (リ Star ヅ Off イ Le タ) portion 7 is carried out in halved tie; Detection radar (Off ア イ Application デ イ グ レ one ダ) 9; Block collimator (Block ロ Star Network コ リ メ one タ) 11; Tissue filler (ボ one ラ ス: bolus) 13; Multi-diaphragm collimator (マ Le チ リ one Off コ リ メ one タ) 15; Irradiation control part 17 is controlled the driving of installing each one.
Proton line by producing as the acting cyclotron 3 of proton line generation portion is admitted to this proton line irradiating part 1 through conveyer device.And, the scattering object (bundle expansion section) 5 of the thinner proton line of sending into through making through for example forming by the lead of several mm of thickness, make thus its with the orthogonal direction of direction of illumination A on enlarge, and be expanded into the bigger bundle of width.
Proton wire harness from above-mentioned scattering object 5 is incided ridged filter section (peak value adjustment filter section) 7, and this ridged filter section 7 is used for distribute the accordingly energy degree of depth of proton line of thickness (length of direction of illumination A) with patient 51 intravital tumor P.This ridged filter section 7 has and a plurality of thickness is arranged in the curtain shape by the metal bar of stepped variation and the wave filter 7a that forms, and these wave filter 7a forms expansion Prague peak value (below be called " SOBP ") of different each other proton lines through the difference of the shape of metal bar.And ridged filter section 7 has following mechanism: driven through the control of irradiation control part 17, the wave filter that will from above-mentioned a plurality of wave filter 7a, suitably select inserts the position of passing through of proton line.Constitute through this, ridged filter section 7 can change the wave filter 7a that the proton line passes through selectively, and can adjust the width of peak value of the SOBP of proton line.
The proton line that has passed through this ridged filter section 7 is incided detection radar (beam energy adjustment part) 9, and this detection radar 9 is used for according to the energy of adjusting bundle as the degree of depth of the patient 51 intravital tumor P of treatment target, and the maximum degree of depth that arrives of adjustment.This detection radar 9 for example by 2 become propylene piece 9a wedge shape, relative, 9b constitutes, and the control coincidence system of regulating above-mentioned 9a, 9b through irradiation control part 17 can make the thickness of the part that the proton line passes through change continuously thus.Because the thickness of proton line and the material that passes through is degradedness correspondingly; The degree of depth that in patient's 51 bodies, arrives changes; Therefore through the adjusting of this detection radar 9, matched in the position of the SOBP of proton line with the position of the depth direction (direction of illumination A) of patient 51 intravital tumor P.
The proton wire harness that has passed through this detection radar 9 is incided block collimator 11, and this block collimator 11 is used for the flat shape of shaping proton line roughly (shape of seeing from direction of illumination A).Except that after the multi-diaphragm collimator 15 stated, at this, the shaping of carrying out block collimator 11 is in order near the patient, not produce the secondary radiation line of block collimator 11.
Passed through the proton line of this block collimator 11, for example be imported into, carried out and the cross sectional shape of the depth capacity of tumor P and the relevant correction of inhomogeneities of tissue as the tissue filler (compensating filter) 13 of resinous irregularly shaped wave filter.The shape of this tissue filler 13 is to calculate according to the electron density of the contour line of tumor and perienchyma, and the electron density of this perienchyma is tried to achieve according to the for example data of X line CT.Through using this tissue filler 13 and since the form fit of the three-dimensional shape of the distal part (the maximum part that arrives the degree of depth) of proton wire harness and the depth capacity part of tumor P by shaping, can further improve dosage centrality thus for tumor P.
The proton wire harness that has passed through this tissue filler 13 is incided multi-diaphragm collimator (shape variable collimator) 15.Multi-diaphragm collimator 15 constitutes as follows: 2 15a of shade line portion, 15b with brazen, that width is several mm a plurality of broach are arranged as, and the front end of above-mentioned broach docks at the center.And through the control of irradiation control part 17, the 15a of shade line portion, 15b be through making a plurality of above-mentioned broach advance and retreat in the longitudinal direction respectively, and multi-diaphragm collimator 15 can make position and the change of shape of the opening 15c that the proton wire harness passes through thus.
The proton wire harness that has passed through multi-diaphragm collimator 15 is cut into the profile corresponding with the shape of above-mentioned opening 15c, so multi-diaphragm collimator 15 can cut out the plan-position and the flat shape of the expectation of incident proton wire harness through making the change of shape of opening 15c.So, on the desired plane position, the proton wire harness that is cut into the flat shape of expectation is irradiated to patient 51 as treatment with the proton line.And; The plan-position of opening 15c through making multi-diaphragm collimator 15 and flat shape change; And the sequence of positions ground of irradiation area is moved and irradiation repeatedly on (with the orthogonal direction of direction of illumination A) in the horizontal direction, thus to tumor P WBR proton wire harness.
And this proton line irradiating part 1 has dose monitoring device 23, is irradiated to the unit of the exposure dose of irradiation area as supervision.Dose monitoring device 23 is arranged between detection radar 9 and the block collimator 11, detects the dosage of the proton line that passes through.Dose monitoring device 23 sends to irradiation control part 17 with the dosage that detects as supervisory signal s1, and irradiation control part 17 can be discerned the exposure dose that is irradiated to irradiation area according to supervisory signal s1.
And, in proton beam therapeutic apparatus 100, be provided with the X line photographic attachment (X line fluoroscopy images is obtained the unit) of the X line fluoroscopy images of obtaining patient 51.This X line photographic attachment has x-ray generator and detects the X thread detector of the X line that has seen through patient 51.These x-ray generators and X thread detector are fixed on the rotary frame 103, can be around patient's 51 rotations.In this embodiment, have 2 x-ray generators, these x-ray devices are configured on the position that differs 90 degree.And, on the position relative, dispose the X thread detector with x-ray generator.X line photographic attachment can be made patient 51 X line fluoroscopy images according to the data that detected by the X thread detector, and detects bone, metal marker and measure patient 51 position.
At this, proton beam therapeutic apparatus 100 has PET device 31, and this PET device 31 has a pair of PET photographing unit (detector) 30 that is installed on the rotary frame 103, can centers on treatment table 105 rotations.That is, PET photographing unit 30 can rotate around the X axle with the proton line irradiating part 1 that is installed on the rotary frame 103 with becoming one.PET device 31 also has not shown image processing part, record portion and display part etc. except that PET photographing unit 30.Image processing part carries out Flame Image Process according to the image information that is obtained by PET photographing unit 30, and generates the PET image.The PET image that record portion record is generated etc.The PET image that is generated is shown by display part.
This PET photographing unit 30 is configured in the patient's 51 on the treatment table 105 both sides, is used to detect annihilation gamma ray.Specifically, patient 51 (for example, is dropped into radiopharmaceutical agent that (injection) gather tumor P
11The C methionine), PET photographing unit 30 detects the annihilation gamma ray that produces from tumor P (in-position of radiopharmaceutical agent).PET device 31 works as the irradiation target position detection unit that the testing result according to the annihilation gamma ray of PET photographing unit 30 detects the position of tumor P.
And PET photographing unit 30 can detect the annihilation gamma ray from the positron radioactive nucleus, and this positron radioactive nucleus is to generate through the incident proton nuclei of the proton line that shines patient 51 and the nuclear reaction between the atomic nucleus in the tumor P.And; PET device 31 works as proton line (charged particle line) in-position detecting unit; This proton line in-position detecting unit detects actual irradiated proton line in patient 51 intravital in-positions according to the testing result of the annihilation gamma ray of PET photographing unit 30.Promptly; 31 pairs of annihilation gamma rays from positron radiation nuclear species of PET device carry out instrumentation and measure the intensity distributions that each generates nuclear species; This positron radiation nuclear species is to generate in vivo through the incident proton nuclei of the proton line that in treatment, uses and patient's 51 intravital nuclear mutual nuclear reaction, can detect proton line in-position actual in patient's 51 bodies thus.
As shown in Figure 4, PET photographing unit 30 can move on the rotary middle spindle X of rotary frame 103 (below, be called " X axle ") direction, and can with the orthogonal Y direction of X axle on move.The PET photographing unit support 32 that supports a pair of PET photographing unit 30 respectively has: the support unit 33 that on X-direction, extends; The X-direction moving-member 34 that on X-direction, moves along this support unit 33; Be arranged on the leading section 34a of this X-direction moving-member 34 and the Y direction extension component 35 that on Y direction, extends; With the Y direction moving-member 36 that on Y direction, moves along this Y direction extension component 35.And PET photographing unit 30 is fixed on Y direction moving-member 36, and its detection faces 30a is configured to each other relatively.
On support unit 33, form the extension 33a that stretches out to the outside of Y direction, this extension 33a is fixed on the framework 103a (with reference to Fig. 2) of rotary frame 103.And support unit 33 is configured in the rear side (diagram right side) of the backplate 103b of rotary frame 103.The rail plate 38 that the direction that formation is moved X-direction moving-member 34 on support unit 33 and X-direction moving-member 34 leads, X-direction moving-member 34 is supported to and can on X-direction, moves via rail plate 38.And X-direction moving-member 34 is driven by the cylinder 37 that is fixed on the support unit 33, can on X-direction, move back and forth.
As shown in Figure 5; On Y direction extension component 35 and Y direction moving-member 36; The rail plate 39 that direction that Y direction moving-member 36 is moved leads is set, and Y direction moving-member 36 is supported to and can on Y direction, moves via rail plate 39.And Y direction moving-member 36 is driven by the motor 40 that is fixed on the Y direction extension component 35, can on Y direction, move back and forth.
And, on Y direction moving-member 36, on Y direction, be formed with tooth bar 48 with gear 45 engagements.And through rotary driving motor 40, by gear 45 and tooth bar 48 transmission of drive force, Y direction moving-member 36 moves back and forth on Y direction.Thus, can make PET photographing unit 30 near patient 51.Through near patient ground configuration PET photographing unit 30, can improve the accuracy of detection of annihilation gamma ray.
This PET photographing unit 30 can be incorporated in the rear side of the backplate 103b of rotary frame 103, and when instrumentation, is driven by cylinder 37 and be configured in patient 51 both sides.
And proton beam therapeutic apparatus 100 has the treatment table position control section (mounting table control part) of the position adjustment of carrying out treatment table 105.And; This treatment table position control section does; According to PET image of obtaining by PET device 31 and the X line fluoroscopy images obtained by X line photographic attachment; Position to treatment table 105 is controlled, and the position of adjustment treatment table 105, so that the patient on the treatment table 105 51 tumor P is shone the proton line.
And the bundle adjustment of proton line is carried out in irradiation control part 17 in-positions according to the proton line that is detected by PET device.That is, irradiation control part 17 is controlled the bundle of the action ground adjustment proton line of ridged filter section 7, detection radar 9 and multi-diaphragm collimator 15, so that the actual in-position of patient's 51 intravital proton lines and the position consistency of tumor P.
Below, the proton line illuminating method (charged particle line illuminating method) of the proton beam therapeutic apparatus 100 that uses formation like this is described.
When not using proton beam therapeutic apparatus 100, PET photographing unit 30 becomes the state of the rear side that is incorporated in backplate 103b.At this,, the proton line treatment for patient with brain tumors is described as an example.At first, patient 51 is lain on the treatment table 105 in the rotary frame 103.Patient 51 height direction is disposed along X-direction.Secondly, patient 51 is dropped into
11C methionine (S1), and wait for
11The C methionine accumulates in the cerebral tumor (S2).Then, measure from accumulating in the cerebral tumor through PET photographing unit 30
11(the 1st detects operation to the annihilation gamma ray that the C methionine is emitted, S3).At this moment, drive cylinder 37 and PET photographing unit 30 is moved on X-direction and be configured in patient 51 both sides, and drive motor 40 and PET photographing unit 30 is moved on Y direction, and regulate the interval between the PET photographing unit 30.When carrying out 3 d image mensuration, make rotary frame 103 rotations, and carry out the instrumentation of annihilation gamma ray.
Then, according to the mensuration result of PET photographing unit 30, make the PET image and detect the position of the cerebral tumor (operation is detected in the irradiation target location, S4).Then, have an X-rayed photography and make patient 51 X line image (X line fluoroscopy images is obtained operation) by X line photographic attachment, and confirm the position of bone and metal marker.In addition, also can exchange the order of PET photography and the photography of X line, also can alternatively repeatedly photograph.And, as required, can make rotary frame 103 rotations, and change the position of x-ray generator, X thread detector.
Then, design irradiation plan (S6) according to PET image and X line image.At this,, for example determine absolute dosages, dose distribution and patient's 51 position etc. as the irradiation plan.Then, according to the irradiation plan that is determined, carry out treatment table 105 position adjustment (mounting table position adjustment operation, S7), and in position with patient's 51 configurations.
Then, restraint adjustment, and make rotary frame 103 rotations as required according to the irradiation plan that is determined, and the position of change proton line irradiating part 1, and towards tumor irradiation 1 proton line (S8).And, detect with 30 pairs of annihilation gamma rays of PET photographing unit that (the 2nd detects operation, and S9), this positron radioactive nucleus is that proton line and the patient's 51 intravital nuclear nuclear reactions passing through to be shone generate from the positron radioactive nucleus.At this moment, PET photographing unit 30 is closely moved on Y direction each other, and will make PET photographing unit 30, and carry out the detection of annihilation gamma ray near patient 51.And, PET photographing unit 30 is measured rotatably.Then, according to the mensuration result of PET photographing unit 30, make the PET image and detect patient 51 intravital proton line in-positions, and the irradiation area of reality is confirmed that (operation is detected in charged particle line in-position, S10).
Then; The proton line that reality is shone compares in the irradiation target location (position of tumor) of patient 51 intravital in-positions and irradiation plan; And under the situation of location skew; The allowed band of irradiation target location is interior (restraints the adjustment operation, S11) so that the proton line is irradiated onto in the adjustment of restrainting.After the bundle adjustment finishes, irradiation proton line (S12).In addition, also can implement S8～S11 once more.
According to this kind of proton beam therapeutic apparatus 100; Because rotary frame 103 is provided with PET photographing unit 30; Through this PET photographing unit 30; Can carry out instrumentation to the annihilation gamma ray from the positron radioactive nucleus, this positron radioactive nucleus is that the incident proton nuclei of the proton line that passes through to be shone and the nuclear nuclear reaction in the tumor generate, and can confirm the in-position of the actual proton line that is shone thus.That is, while can in treatment, shine the in-position that the proton line detects the proton line.And, owing on rotary frame 103, be fixed with PET photographing unit 30, therefore can make PET photographing unit 30 ordinatedly, and can after having shone the proton line, carry out the mensuration of annihilation gamma ray immediately with the rotation of rotary frame 103 around patient's 51 rotations.And, can improve the degree of freedom that moves of PET photographing unit 30, and can use the PET photographing unit 30 that is miniaturized to carry out 3 dimensions and measure, the other rotary driving part of PET photographing unit 30 usefulness need be set.And,, concern on one side therefore can keep the position of the direction of rotation of PET photographing unit 30 and proton line irradiating part 1, Yi Bian carry out the detection of annihilation gamma ray because PET photographing unit 30 synchronously rotates with proton line irradiating part 1.
And PET photographing unit 30 can move on X-direction, and can be incorporated in the rear side of the backplate 103b of rotary frame 103.So, on X-direction, move, can enlarge the detection range of PET photographing unit 30 through making PET photographing unit 30.And, suitably moving through making PET photographing unit 30, PET photographing unit 30 can not hinder the rotation of proton line irradiating part 1.And patient 51 moving in rotary frame 103, when taking out of, PET photographing unit 30 can not become obstacle.And,, confirm the irradiation position of desired site thus easily owing to also can PET photographing unit 30 moved.
And; PET photographing unit 30 can be gone up in the direction (Y direction) across patient 51 and move; And can at random change the distance between the PET photographing unit 30, therefore through make PET photographing unit 30 on Y direction near patient 51, can improve the accuracy of detection of annihilation gamma ray.
And, in the past, for example in the radiation cure of the cerebral tumor,, used the head of setting tool immobilized patients for location with the done with high accuracy patient, therefore concerning the patient, become very big burden.In proton beam irradiating apparatus of the present invention and proton line illuminating method; Can be in the exposure cell; Lie in the position of using PET photographing unit 30 to confirm tumor under the state on the treatment table 105 patient 51; And can revise the knub position and the offset of the in-position of the actual proton line that is shone, with patient 51 location in position.Thus, can carry out patient's location accurately, therefore can realize the fixed simplification of patient and alleviate patient's burden.
Below, with reference to Fig. 7 and Fig. 8 the proton beam therapeutic apparatus of the 2nd embodiment of the present invention is described.The proton beam therapeutic apparatus of the 2nd embodiment is that the PET photographing unit 60 of the 2nd embodiment can also rotate around the Y axle, and the shape of the detection faces 60a of PET photographing unit 60 is different with the proton beam therapeutic apparatus of the 1st embodiment 100 different points.
The PET photographing unit support 61 of supporting PET photographing unit 60 has PET photographing unit 60 is fixed on the photographing unit fixed part 62 on the end 36a of inboard of Y direction moving-member 36.The motor 63 that rotation drives PET photographing unit 60 is installed on this photographing unit fixed part 62.This motor 63 is configured to, and its output shaft 64 is along Y direction.And PET photographing unit 60 is connected with the output shaft 64 of motor 63, and can be around the rotation of Y axle.
The detection faces 60a of PET photographing unit 60 bends to circular-arc, and a pair of detection faces 60a is configuration relatively each other.PET photographing unit 60 is configured to, and when taking in and when X-direction moves, its length direction is along X-direction (state shown in Figure 7).And when gamma-ray instrumentation, it is parallel with X-direction that PET photographing unit 60 is configured to the central shaft of circular arc.In addition, can the rotation of PET photographing unit 60 be stopped becoming uneven position, and measure from all angles with X-direction.
Even so constitute; Also can access the effect identical with the proton beam therapeutic apparatus of the 1st embodiment 100; In addition, because PET photographing unit 60 can center on the rotation of Y axle, so the degree of freedom that moves of PET photographing unit 60 further improves; Can carry out the mensuration of irradiation position from all directions, and realize measuring the raising of precision.
The invention is not restricted to above-mentioned the 1st embodiment and the 2nd embodiment (below, be called " above-mentioned embodiment ").In the above-described embodiment, constituting the PET photographing unit can rotate around the X axle, but also can be the formation of not rotating around the X axle, but can center on the formation of other direction rotation.And constituting the PET photographing unit can move on approaching each other direction, but also can be the formation that the PET photographing unit does not move on approaching each other direction.And, use cylinder, motor to make the PET camera movement, also can use other driving device such as hydraulic cylinder, linear motor to make the PET camera movement.And, the moving of the X-direction of PET photographing unit, Y direction move also can not be linearity move, and can be curve-like, circular-arc moving.
And in the above-described embodiment, the PET photographing unit is installed on the rotary frame, and can rotate around the X axle with proton line irradiating part with becoming one, but the PET photographing unit can not rotate with rotary frame and proton line irradiating part with becoming one yet.For example; Also can be provided for rotating the driving device that drives the PET photographing unit in addition; And make the PET photographing unit follow the rotation rotatably of rotary frame and proton line irradiating part, also can make the irrelevant to rotation ground rotation of PET photographing unit and rotary frame and proton line irradiating part.
And, in the above-described embodiment, have Roentgen apparatus and implement the photography of X line, but also can omit the photography of X line.And, in the above-described embodiment, methionine as radiopharmaceutical agent, but also can be used other radiopharmaceutical agent according to the irradiation object.And, in the above-described embodiment, in the exposure cell, implement to have used the PET inspection of radiopharmaceutical agent, but also can use the data of implementing in other places, carry out the location of irradiated body.And, in the above-described embodiment, the cerebral tumor is illustrated, but also goes for other tumor.
And, in the above-described embodiment, the present invention is applicable to the proton beam irradiating apparatus of irradiation proton line, but the present invention also goes for other charged particle beam therapeutic apparatus such as carbon beam exposure apparatus.
Claims (6)
1. a charged particle beam therapeutic apparatus possesses the exposure cell, and this exposure cell has the charged particle line irradiating part of the irradiated body rotation that can be shone around the charged particle line, and this charged particle beam therapeutic apparatus is characterised in that,
Have a pair of test section, be configured in both sides, detect the annihilation gamma ray that generates at above-mentioned irradiated body owing to the irradiation of above-mentioned charged particle line across above-mentioned irradiated body;
With the bearing of trend of the rotary middle spindle of above-mentioned charged particle line irradiating part as X-direction;
Above-mentioned test section can move on above-mentioned X-direction with respect to above-mentioned exposure cell.
2. charged particle beam therapeutic apparatus as claimed in claim 1 is characterized in that,
Above-mentioned test section can be around above-mentioned X axle rotation.
3. charged particle beam therapeutic apparatus as claimed in claim 2 is characterized in that,
Above-mentioned test section is followed being rotated rotatably of above-mentioned charged particle line irradiating part.
4. charged particle beam therapeutic apparatus as claimed in claim 3 is characterized in that,
Above-mentioned test section and above-mentioned charged particle line irradiating part are rotated with becoming one.
5. like each described charged particle beam therapeutic apparatus of claim 1～4, it is characterized in that,
Above-mentioned test section can move on approaching each other direction.
6. like each described charged particle beam therapeutic apparatus of claim 1～4, it is characterized in that,
Will with the orthogonal direction of above-mentioned X-direction as Y direction;
Above-mentioned test section can be around above-mentioned Y axle rotation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| JP009524/2007 | 2007-01-18 | ||
| JP2007009524A JP4797140B2 (en) | 2007-01-18 | 2007-01-18 | Charged particle beam irradiation equipment |
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| CN101224324A CN101224324A (en) | 2008-07-23 |
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| JP (1) | JP4797140B2 (en) |
| KR (1) | KR100960823B1 (en) |
| CN (1) | CN101224324B (en) |
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| WO2010013345A1 (en) * | 2008-08-01 | 2010-02-04 | 独立行政法人放射線医学総合研究所 | Detector-shift radiation therapy/pet combined apparatus |
| US8461539B2 (en) | 2008-08-01 | 2013-06-11 | National Institute Of Radiological Sciences | Combined radiation therapy/pet apparatus |
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| WO2010046983A1 (en) * | 2008-10-23 | 2010-04-29 | 株式会社島津製作所 | Particle beam treatment apparatus |
| JP5339592B2 (en) * | 2009-01-28 | 2013-11-13 | 独立行政法人国立がん研究センター | Simulation method for activity distribution of positron emitting nuclides in proton therapy |
| KR101127680B1 (en) * | 2009-09-08 | 2012-03-23 | 중앙대학교 산학협력단 | Apparatus for charged particle beam computed tomography using toroidal coils and method of the same |
| EP2490765B1 (en) * | 2009-10-23 | 2016-09-21 | Ion Beam Applications | Gantry comprising beam analyser for use in particle therapy |
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| KR100960823B1 (en) | 2010-06-07 |
| TW200836792A (en) | 2008-09-16 |
| CN101224324A (en) | 2008-07-23 |
| KR20080068594A (en) | 2008-07-23 |
| JP4797140B2 (en) | 2011-10-19 |
| TWI352605B (en) | 2011-11-21 |
| JP2008173297A (en) | 2008-07-31 |
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