CN101219201A - Traditional Chinese medicine liquid capsule and its preparing method - Google Patents
Traditional Chinese medicine liquid capsule and its preparing method Download PDFInfo
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- CN101219201A CN101219201A CNA2007100000548A CN200710000054A CN101219201A CN 101219201 A CN101219201 A CN 101219201A CN A2007100000548 A CNA2007100000548 A CN A2007100000548A CN 200710000054 A CN200710000054 A CN 200710000054A CN 101219201 A CN101219201 A CN 101219201A
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- Prior art keywords
- capsule
- radix
- chinese medicine
- mentholum
- bulbus fritillariae
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- 239000002775 capsule Substances 0.000 title claims abstract description 99
- 239000007788 liquid Substances 0.000 title claims abstract description 96
- 239000003814 drug Substances 0.000 title claims abstract description 94
- 238000000034 method Methods 0.000 title claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000000203 mixture Substances 0.000 claims abstract description 47
- 239000000284 extract Substances 0.000 claims abstract description 46
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 40
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine liquid capsule and a preparation method thereof and comprises traditional Chinese medicine active constituents and medicinal auxiliary materials of medically acceptable dose. Tendrilleaf fritillary bulb is crushed into coarse powder; percolate is collected according to the percolation (Appendix IO of Volume I of Chinese Pharmacopoeia, 2005 Edition ) below the items of fluidextract and extracts, and ethanol is recycled, thus acquiring tendrilleaf fritillary bulb extract; Pummelo peel, ginger and liquorice are respectively dipped in an ethanol solution and filtered, and ethanol is reclaimed from filtrate by filtration and concentrated into thick paste A; Folium eriobotryae, root of straight ladybell, tuckahoe, balloonflower root, prepared pinellia tuber, semen trichosanthis and armeniaca amara are decocted with water, then decoction is gathered together, stood and filtered; the filtrate, the tendrilleaf fritillary bulb extract and the thick paste A are evenly mixed, menthol ethanol solution, aqua armeniacae and the medicinal auxiliary materials are added to the mixture, and the liquid capsule is prepared. The traditional Chinese medicine liquid capsule of the invention has the advantages of remarkable effectiveness in treatment, high bioavailability, quick potency, insignificant toxicity and side-effects, convenienct use and favorability to sufferers, which is used for curing cough due to yin deficiency, dry pharynx and sore pharynx, small but sticky sputum, red tongue and thinly coated tongue.
Description
Technical field
The present invention relates to a kind of herb liquid body capsule that is used for nourishing YIN and moistening the lung, lowering the adverse-rising QI to resolve phlegm, be specifically related to a kind ofly be used for the treatment of that cough, expectoration or expectoration are not well, the herb liquid body capsule of dry mouth and throat, the present invention also relates to the preparation method of this herb liquid body capsule.
Background technology
Cough is a kind of commonly encountered diseases, and pathogenic factor is a lot.Traditional medicine is thought: lung the master give vent to anger, kidney governing inspiration, and the prolonged illness cough with asthma, not only the lung kidney is all empty, and middle burnt temper is stranded, the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm, because abundant expectoration is seen in cough more, the full vexed disease of waiting of chest and diaphragm.Multiple cough suppressing medicine is arranged in the market, pharmacy of western medicine thinks that cough is the respiratory tract irriate, as microorganisms such as antibacterial, virus, mycoplasma and mycetes, weather cataclysm, cold, drying, meteorological factor such as overheated, after the stimulation of sensitizing agents such as pollen, hair, foreign protein, send impulsion and import a kind of Pathophysiology reflection that the oblongata coughing centre causes into.Such cough of western medicine is mainly used antibiotic and is used the medicine with antitussive effect, cost an arm and a leg, and toxic and side effects is also higher.
Domestic Chinese medicine has " baihe gujin decoction ", " Herba Menthae Forsythiae Decoction ", " nourishing the lung to arrest cough mixture ", " Periostracum Cicadae loose wind soup ", " husky wheat Radix Platycodonis decoction " etc., wherein " baihe gujin decoction " is based on nourishing YIN and moistening the lung, relieving cough and resolving phlegm, main treatment deficiency of YIN of both the lung and kidney, the disease of hyperactivity of deficient fire, but this side is to nourish the lung kidney YIN nourishing of internal injury." Herba Menthae Forsythiae Decoction " cures mainly lung and defends scorching disease, but Fang Zhongwu supports the agent of lung yin." nourishing the lung to arrest cough mixture " main to contain Radix Stemonae, the Radix Rehmanniae, Radix Ophiopogonis, orange, the Radix Astragali, Semen Armeniacae Amarum etc., based on the nourishing YIN and moistening the lung cough-relieving, cures mainly the lung cough of suffering from a deficiency of the kidney." Periostracum Cicadae loose wind soup " is main to contain Periostracum Cicadae, Herba Schizonepetae, Radix Saposhnikoviae, Bombyx Batryticatus, Folium Mori, Flos Lonicerae, Radix Platycodonis, Herba Ephedrae, Radix Glycyrrhizae etc., cure mainly itching throat, cough, choke cough, few expectorant." Radix Adenophorae (Radix Glehniae) Radix Platycodonis decoction " supported the lung stomach clearly, promoted the production of body fluid and moisturize, and controls dry impairing the lung stomach, the body fluid loss, but the convergence antitussive action is not good enough.The composition of the curative effect composition of above-mentioned decoction medicine is unfixing, and drug dose varies with each individual, and influenced by decocting time, decocting method etc., so the factor that affects the treatment is more.
Summary of the invention
The purpose of this invention is to provide a kind of evident in efficacy, bioavailability is high, rapid-action, toxic and side effects is little, taking convenience, be easy to that cough, expectoration or expectoration are not well, the herb liquid body capsule of dry mouth and throat by patient being used for the treatment of of accepting.
Another object of the present invention provides a kind of method for preparing above-mentioned herb liquid body capsule.
For achieving the above object, the inventor designs through a large amount of experiment and performing creative labour on the basis of existing technology and a kind ofly is used for the treatment of that cough, expectoration or expectoration are not well, the herb liquid body capsule of the Chinese medicinal soft capsule of dry mouth and throat, comprise softgel shell and capsule liquid, described capsule liquid comprises following components by part by weight:
Chinese medicine extract 6-15 dispersant 12-16 suspending agent 0.4~0.7;
Described Chinese medicine extract is formed by the following components in part by weight processing and preparing:
Bulbus Fritillariae Cirrhosae 50-120 Folium Eriobotryae 55-145 Radix Adenophorae (Radix Glehniae) 10-40 Poria 10-35
Exocarpium Citri Grandis 10-30 Radix Platycodonis 35-100 Rhizoma Pinelliae Preparatum 10-40 GUALOUZI 20-60
Semen Armeniacae Amarum 15-70 Rhizoma Zingiberis Recens 5-30 Radix Glycyrrhizae 5-35 Mentholum 0.5-5
Aqua armeniacae 3-20.
Preferably, described Chinese medicine extract is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Bulbus Fritillariae Cirrhosae 65-100 Folium Eriobotryae 80-120 Radix Adenophorae (Radix Glehniae) 10-25 Poria 15-30
Exocarpium Citri Grandis 15-25 Radix Platycodonis 55-100 Rhizoma Pinelliae Preparatum 10-25 GUALOUZI 25-50
Semen Armeniacae Amarum 30-55 Rhizoma Zingiberis Recens 10-25 Radix Glycyrrhizae 15-30 Mentholum 1-2.5
Aqua armeniacae 3-10.
Preferably, described Chinese medicine extract is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Bulbus Fritillariae Cirrhosae 75-85 Folium Eriobotryae 90-100 Radix Adenophorae (Radix Glehniae) 15-20 Poria 15-25
Exocarpium Citri Grandis 15-20 Radix Platycodonis 75-85 Rhizoma Pinelliae Preparatum 15-25 GUALOUZI 30-45
Semen Armeniacae Amarum 35-45 Rhizoma Zingiberis Recens 15-20 Radix Glycyrrhizae 15-20 Mentholum 1.5-2.5
Aqua armeniacae 5-8.
Described dispersant is polyethylene glycols or vegetable oil; Described suspending agent is one or more the mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
Described vegetable oil is a kind of or wherein several mixture of Oleum Arachidis hypogaeae semen, soybean oil, Oleum sesami, Oleum Brassicae campestris or other consumption vegetable oil.
The antiseptic and/or the surfactant that contain convention amount in the described capsule liquid.
Described antiseptic is parabens or glycerol monostearate; Described surface activity reaches and is tween or span.
A kind of method for preparing described herb liquid body capsule comprises the steps:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, makees solvent for the 50-90% alcoholic solution, flood percolation after 15-90 hour, filter out fully, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution to the solubility composition with percent by volume;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae were flooded 10-25 days for the 50-95% alcoholic solution with percent by volume respectively, filtered, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2-3 time, each 1-3 hour, collecting decoction, leave standstill, filter, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously, add dispersant and suspending agent, colloid mill is ground to mix homogeneously, gets capsule liquid, filling is prepared into liquid capsule in the capsule softgel shell.
Also add antiseptic and/or surfactant in the described capsule liquid.。
To be the inventor preferably come out from crude drug through a large amount of tests the Chinese medicine extract of herb liquid body capsule of the present invention, has the effect of nourishing YIN and moistening the lung, relieving cough and resolving phlegm, is used for the treatment of diseases such as cough due to yin deficiency, dry pharynx pharyngalgia, expectorant are few and sticking, the few tongue of red tongue.For covering the bad smell of medicine, make the patient be easy to accept, the inventor has carried out a large amount of research to the dosage form of preparation and the selection of used adjuvant, and the moulding process to preparation has carried out performing creative labour simultaneously, finally determines to select for use liquid capsule preparation.
The technological difficulties of liquid capsule mainly are the preparation of capsule liquid, and for guaranteeing the uniform and stable of capsule liquid, general capsule liquid is made up of medicine, dispersant and suspending agent.How to select suitable dispersant and suspending agent, need do creationary research.
One, the selection of dispersant: the selection of medicine dispersant is one of key of development liquid capsule, and it should be able to guarantee the accuracy and the stability of formulation of content, thereby guarantees the safety and effectiveness of medicine.At present common dispersants has consumption vegetable oil and Polyethylene Glycol-400 (PEG-400), and the inventor screens above the two consumption by experiment.
Get three parts of Chinese medicine extract, add soybean oil, Oleum Arachidis hypogaeae semen and the Polyethylene Glycol-400 of capacity respectively, fully mix after colloid mill ground 30 minutes, put in 2000 rev/mins the centrifuge centrifugal 20 minutes, the precipitation situation of observing two mixed liquors the results are shown in Table 1.
The different dispersant sedimentation of table 1 situation result of the test
Dispersant | The sedimentation situation |
Soybean oil Oleum Arachidis hypogaeae semen Polyethylene Glycol-400 | Do not find precipitation, vegetable oil and medicated powder not layering are not found precipitation, and precipitation does not appear in vegetable oil and medicated powder not layering, Polyethylene Glycol-400 and not layering of medicated powder |
As seen from the experiment, two kinds of consumption vegetable oil and Polyethylene Glycol-400 all can be used as the dispersant of this prescription.But discover that Polyethylene Glycol-400 pair softgel shell has induration, need to add propylene glycol and regulated; In addition, dry run must appropriately be grasped drying time than very fast when being dispersant with Polyethylene Glycol-400, and overlong time can make softgel shell break, and the time is too short, since liquid aqueous in the liquid capsule, liquid capsule seepage in storage period then caused; Then there is not above-mentioned shortcoming with vegetable oil as dispersant.So vegetable oil is an optimal choice, have good stable for guaranteeing liquid capsule preparation, this prescription preparation selects for use the consumption vegetable oil as dispersant.Through experiment confirm, used vegetable oil can also be Oleum sesami, Oleum Brassicae campestris and other edible vegetable oil, all can obtain essentially identical effect.
Two, the selection of dispersive agent ratio: the consumption of dispersant directly has influence on the yield rate and the loading amount of liquid capsule.Dispersive agent ratio is low excessively, good stability, but mobile poor, be difficult for pelleting, yield rate is low; Dispersive agent ratio is excessive, and the thixotroping value is low, good fluidity, but loading amount is big and be easy to seepage.Therefore screen the dispersant of different proportion, thereby determine optimal proportion.Get the medicated powder of three parts of equivalent, add not commensurability vegetable oil respectively, fully mix, observe its state, the results are shown in Table 2 after colloid mill ground 30 minutes.
The selection result of the test of table 2 dispersive agent ratio
Dispersant: medicated powder | The medicinal liquid situation |
1∶1 1.5∶1 2∶1 | The medicinal liquid thickness, mobile bad medicinal liquid is even, and mobile better medicinal liquid is rarer, good fluidity |
By result in the table as can be known, when the ratio of dispersant and medicated powder was 1.5: 1, the flowability of medicinal liquid can satisfy the requirement of liquid capsule pressing.In that further the test back is definite, be 1.2: 1~1.6: 1 o'clock in ratio, better effects is all arranged, best with 1.4: 1 o'clock.
Three, the selection of suspending agent: in the process of preparation sample, find, when simple medication powder and vegetable oil suspendible, effect is not desirable especially, so it is very necessary needing to select suitable suspending agent, adding its Chinese medicine of liquid capsule of making behind the suspending agent is to be scattered in the oil with molecularity, oil phase enters blood through lymph in vivo, is not subjected to the influence of first pass effect, thereby produces high bioavailability.The kind of suspending agent is a lot of as Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, and suspending agent can be the mixture of above-mentioned one or more.Because the Cera Flava cost is minimum and be easy to get, so the inventor preferentially selects Cera Flava to test as suspending agent, as suspending agent, carries out the screening of suspending agent consumption with different Cera Flava ratios, the results are shown in Table 3.
The selection result of the test of table 3 suspending agent ratio
Suspending agent accounts for medicated powder | The medicinal liquid situation |
2% 5% 10% | Medicinal liquid is inhomogeneous, and it is even the lamination medicinal liquid to occur, no lamination, and easily moulding capsule medicinal liquid is even, no lamination, when treating the moulding capsule, medicinal liquid solidifies |
As can be seen from the above table, the consumption of suspending agent is 5% o'clock of medicated powder, is fit to for this prescription, and medicinal liquid is even, and is easy to the neutralizing liquid capsule.After further testing, find that the Cera Flava consumption is the effect that all can play stably in 4%~7% scope of medicated powder amount, optimised quantity is 6% again.The inventor still studies other several suspending agents respectively, finds that the suspending agent consumption is at 4%~7% o'clock that medicated powder is, can play the effect of stablizing suspending.It is best suspending agent that final inventor still selects Cera Flava.
In order to guarantee the steady quality of final products, also can in capsule liquid, add a certain amount of antiseptic, according to circumstances different as parabens, glyceryl monostearate etc., addition is also different, and is general in about 0.3% of amount of liquid medicine, as long as reach fungistatic effect.Can also add an amount of surfactant, as the Tweens span, addition depends on the circumstances, and generally is no more than 1%, with can make capsule liquid mix homogeneously, stabilize to good.
The liquid capsule of the present invention preparation can be covered the taste of drug substance contents, the problem that change is made us or made groups of people be difficult to take, and make that it is clean and tidy, attractive in appearance, swallow easily; Dosage is accurate relatively, and degree of accuracy is higher, can reach the metering of milligram/grain; The bioavailability of medicament height, comparatively speaking, capsule and tablet, pill are different, do not need to add binding agent and pressure during preparation, belong to dissolving or trickle powder again substantially and be scattered in the content, in case disintegrate just together discharges, imitate rapidly so be, it is good obviously also to absorb soon than pill, tablet; The reason that bioavailability of medicament is high reaches the needed haemoconcentration of identical drug effect, and the unit administration amount of liquid capsule reaches the curative effect of tablet with identical purpose etc. with regard to reducing relatively.Test shows that liquid capsule of the present invention and tablet be once oral 100mg respectively, and 6 example clothes liquid capsule persons are on average peaked at the 1.5h blood level, are 6g/ml; 6 example clothes tablet persons are on average just peaked at the 2.5h blood level, and are had only 3.5 μ g/ml in addition.Improve medicine stability,, meet damp and hot unsettled medicine as photosensitive medicine, the medicine of easy oxidation etc., because its relative closure encystation, so can be prepared into the liquid capsule that adds opacifier, protection medicine is subjected to the effect of oxygen, light in wet and the air, thereby improves its stability; Contain a large amount of creosotes in the Chinese medicine extract of the present invention, be difficult for making ball, tablet, and the liquid capsule preparation of making has digestive tract good absorbing effect, curative effect height, good stability, dosage advantage accurately, carry light and handy, easy to use.
Pharmacodynamic experiment studies show that, the experimentation by pharmacodynamics shows that medicine of the present invention can suppress the mice capillary permeability by highly significant, has certain antiinflammatory action; Highly significant prolongs the mouse cough latent time and reduces the cough number of times, and having must antitussive effect; Highly significant increases the phenol red secretory volume of mice tunica mucosa tracheae, and certain phlegm-dispelling functions is promptly arranged; Thereby be the treatment cough, expectoration or expectoration are not well, and diseases such as dry mouth and throat provide the pharmacodynamics foundation.
Pharmacodynamics test research
Medicine of the present invention has nourishing YIN and moistening the lung, and the function of lowering the adverse-rising QI to resolve phlegm is applicable to cough, and expectoration or expectoration are not well, diseases such as dry mouth and throat.
This research employing white mice carries out antiinflammatory, antitussive, the pharmacodynamic experiment of three aspects of eliminating the phlegm, with the drug action of checking medicine of the present invention.
1 experiment material
Animal: white mice, the Kunming kind, one-level is qualified, male and female half and half, body weight 18-21g is provided by The Fourth Military Medical University's Experimental Animal Center.
Medicine and reagent: the used preparation of test group is liquid capsule (Bulbus Fritillariae Cirrhosae 80g, Folium Eriobotryae 100g, the Poria 20g according to the embodiment of the invention 11 preparations, Exocarpium Citri Grandis 20g, Rhizoma Pinelliae Preparatum 20g, Semen Trichosanthis 40g, Rhizoma Zingiberis Recens 20g, Radix Adenophorae (Radix Glehniae) 20g, Radix Platycodonis 80g, Semen Armeniacae Amarum 40g, Radix Glycyrrhizae 20g, Mentholum 2g, aqua armeniacae 7ml), be the lab scale medicine, provide, lot number 060513 by Jiangxi Yaodu Renhe Pharmaceutical Co., Ltd.Control drug: nourishing YIN and clearing away lung-heat cream, the accurate word Z11020376 of traditional Chinese medicines, lot number 20060217, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory; Phenol red, lot number 20060129 is produced by Military Medical Science Institute.
Instrument: Tianjin, island UV-260 spectrophotometer.
2 experimental techniques and result
2.1 antiinflammatory test
Choose 50 of Kunming mouses, be divided into 5 groups at random by body weight, the positive drug matched group is irritated stomach and is given the obtain solution 0.4mL/20g of nourishing YIN and clearing away lung-heat cream institute, be 1g/kg, the high, medium and low dosage group of liquid capsule is irritated stomach respectively and is joined solution 0.4mL/20g for the lab scale medicine of variable concentrations, i.e. 0.8g/kg, 0.4g/kg, 0.2g/kg; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Every day 1 time, successive administration 3 days, in the last administration after 1 hour, the blue 0.2ml/20g mice of the ivens of intravenous injection 0.5%, lumbar injection 0.6% acetum 0.2ml/ is only immediately, put to death after 20 minutes, lumbar injection 6ml normal saline/only, cleaning mixture is collected in the washing abdominal cavity, get supernatant after leaving standstill with Tianjin, island UV-260 spectrophotometer, survey the trap value at wavelength 590nm place.Experimental result sees Table 1.
The antiinflammatory action of table 1 pair mice (x ± SD)
Annotate: compare with the blank group
*P<0.05.
Table 1 is the result show, the middle and high dosage group of liquid capsule all can suppress the mice capillary permeability by highly significant, has certain antiinflammatory action, and effect is identical with nourishing YIN and clearing away lung-heat cream, compares (P<0.05) with positive controls, has statistical significance.
2.2 antitussive test
Choose 50 of Kunming mouses, be divided into 5 groups at random by body weight, the positive drug matched group is irritated stomach and is given the obtain solution 0.4mL/20g of nourishing YIN and clearing away lung-heat cream institute, be 1g/kg, the high, medium and low dosage group of liquid capsule is irritated stomach respectively and is joined solution 0.4mL/20g for the lab scale medicine of variable concentrations, i.e. 0.8g/kg, 0.4g/kg, 0.2g/kg; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Every day 1 time, successive administration 3 days, after 1 hour, the strong aqua ammonia of quantitatively spraying is observed the cough reaction of mice, record cough latent period and the cough number of times in 1 minute in the last administration.Experimental result sees Table 2.
The antitussive action of table 2 pair mice (x ± SD)
Annotate: compare with the blank group
*P<0.05.
Table 3 is the result show, liquid capsule low, in and high dose group all can prolong the mouse cough latent time and reduce the cough number of times by highly significant, have certain antitussive action; Effect is identical with nourishing YIN and clearing away lung-heat cream, compares (P<0.05) with the blank group, has statistical significance.
2.3 expectorant test
Choose 50 of Kunming mouses, be divided into 5 groups at random by body weight, the positive drug matched group is irritated stomach and is given the obtain solution 0.4mL/20g of nourishing YIN and clearing away lung-heat cream institute, be 1g/kg, the high, medium and low dosage group of liquid capsule is irritated stomach respectively and is joined solution 0.4mL/20g for the lab scale medicine of variable concentrations, i.e. 0.8g/kg, 0.4g/kg, 0.2g/kg; Blank group group is irritated the normal saline 0.4mL/20g of stomach equal volume.Every day 1 time, successive administration 3 days, after 30 minutes, lumbar injection 0.2ml/20g phenol red solution was put to death animal after 30 minutes in the last administration, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation, put into the test tube that fills the 2ml normal saline, add the 1mol/L sodium hydroxide of 0.2ml again from thyroid cartilage, with Tianjin, island UV-260 spectrophotometer, survey the trap value at wavelength 546nm place.Experimental result sees Table 3.
The phlegm-dispelling functions of table 3 pair mice (x ± SD)
Annotate: compare with the blank group
*P<0.05.
Table 3 result as seen, liquid capsule low, in and high dose group all can increase the phenol red secretory volume of mice tunica mucosa tracheae by highly significant, certain phlegm-dispelling functions is promptly arranged, effect is identical with nourishing YIN and clearing away lung-heat cream, compare (P<0.01) with the blank group, have statistical significance.
3 discuss
Experimentation by pharmacodynamics shows that medicine of the present invention can suppress the mice capillary permeability by highly significant, has certain antiinflammatory action; Highly significant prolongs the mouse cough latent time and reduces the cough number of times, and having must antitussive effect; Highly significant increases the phenol red secretory volume of mice tunica mucosa tracheae, and certain phlegm-dispelling functions is promptly arranged; Thereby be the treatment cough, expectoration or expectoration are not well, and diseases such as dry mouth and throat provide the pharmacodynamics foundation.
The specific embodiment:
Embodiment one
Capsule liquid: Chinese medicine extract 10kg, soybean oil 12kg, Cera Flava 0.4kg;
Described Chinese medicine extract is formed by Bulbus Fritillariae Cirrhosae 50kg, Folium Eriobotryae 140kg, Radix Adenophorae (Radix Glehniae) 12kg, Poria 35kg, Exocarpium Citri Grandis 18kg, Radix Platycodonis 70kg, Rhizoma Pinelliae Preparatum 34kg, GUALOUZI 30kg, Semen Armeniacae Amarum 60kg, Rhizoma Zingiberis Recens 5kg, Radix Glycyrrhizae 28kg, Mentholum 5kg, aqua armeniacae 18L processing and preparing;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item (IO of Chinese Pharmacopoeia version in 2005), with percent by volume is that 90% alcoholic solution is made solvent, flood percolation after 15 hours, filter out fully to the solubility composition, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution; The speed of percolation is 3ml/min;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are 70% alcoholic solution dipping 20 days with percent by volume respectively, filter, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2 times, 2 hours for the first time, 3 hours for the second time, collecting decoction leaves standstill, and filters, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously, add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously gets Chinese medicine extract;
Get Chinese medicine composition 10kg and add dispersant soybean oil and suspending agent Cera Flava, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment two
Capsule liquid: Chinese medicine extract 12kg, Oleum Arachidis hypogaeae semen 16kg, lecithin 0.7kg, tween 80 0.1kg;
Softgel shell: gelatin 100kg, glycerol 30kg, water 120kg, oxybenzene second fat 8kg, iron oxide black 3.0kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 65kg, Folium Eriobotryae 55kg, Radix Adenophorae (Radix Glehniae) 40kg, Poria 26kg, Exocarpium Citri Grandis 12kg, Radix Platycodonis 95kg, Rhizoma Pinelliae Preparatum 15kg, GUALOUZI 60kg, Semen Armeniacae Amarum 20kg, Rhizoma Zingiberis Recens 28kg, Radix Glycyrrhizae 15kg, Mentholum 1.2kg, aqua armeniacae 12L;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item (IO of Chinese Pharmacopoeia version in 2005), with percent by volume is that 50% alcoholic solution is made solvent, flood percolation after 90 hours, filter out fully to the solubility composition, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution; The speed of percolation is 1ml/min;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are 95% alcoholic solution dipping 10 days with percent by volume respectively, filter, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 3 times, 1 hour for the first time, 2 hours for the second time, 3 hours for the third time, collecting decoction, leave standstill, filter, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously gets Chinese medicine extract;
Get Chinese medicine composition 12kg and add dispersant Oleum Arachidis hypogaeae semen, suspending agent lecithin and surfactant tween 80, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment three
Capsule liquid: Chinese medicine extract 14kg, Polyethylene Glycol-200 13kg, aluminum monostearate 0.2kg, propylene glycol 0.4kg, ethyl hydroxybenzoate 0.1kg, tween 20 0.1kg;
Softgel shell: gelatin 105kg, glycerol 45kg, water 85kg, oxybenzene second fat 12kg, iron oxide red 2.5kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 120kg, Folium Eriobotryae 80kg, Radix Adenophorae (Radix Glehniae) 34kg, Poria 12kg, Exocarpium Citri Grandis 10kg, Radix Platycodonis 55kg, Rhizoma Pinelliae Preparatum 25kg, GUALOUZI 36kg, Semen Armeniacae Amarum 70kg, Rhizoma Zingiberis Recens 15kg, Radix Glycyrrhizae 5kg, Mentholum 2.5kg, aqua armeniacae 4L;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item (IO of Chinese Pharmacopoeia version in 2005), with percent by volume is that 60% alcoholic solution is made solvent, flood percolation after 20 hours, filter out fully to the solubility composition, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution; The speed of percolation is 2ml/min;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are 50% alcoholic solution dipping 25 days with percent by volume respectively, filter, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2 times, 2 hours for the first time, 3 hours for the second time, collecting decoction leaves standstill, and filters, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously, add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously gets Chinese medicine extract;
Get Chinese medicine composition 14kg and add dispersant Polyethylene Glycol-200, suspending agent aluminum monostearate and ethyl cellulose, antiseptic ethyl hydroxybenzoate, surfactant tween 20, colloid mill is ground to mix homogeneously, filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment four
Capsule liquid: Chinese medicine extract 6kg, Oleum Brassicae campestris 15kg, aluminum monostearate 0.5kg, glycerol monostearate 0.1kg, Tween-60 0.1kg;
Softgel shell: gelatin 120kg, glycerol 40kg, water 80kg, oxybenzene second fat 10kg, iron oxide black 5.0kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 105kg, Folium Eriobotryae 115kg, Radix Adenophorae (Radix Glehniae) 24kg, Poria 30kg, Exocarpium Citri Grandis 30kg, Radix Platycodonis 40kg, Rhizoma Pinelliae Preparatum 10kg, GUALOUZI 25kg, Semen Armeniacae Amarum 50kg, Rhizoma Zingiberis Recens 10kg, Radix Glycyrrhizae 22kg, Mentholum 0.5kg, aqua armeniacae 20L;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item (IO of Chinese Pharmacopoeia version in 2005), with percent by volume is that 80% alcoholic solution is made solvent, flood percolation after 45 hours, filter out fully to the solubility composition, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution; The speed of percolation is 1.5ml/min;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are 60% alcoholic solution dipping 15 days with percent by volume respectively, filter, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2 times, 2 hours for the first time, 3 hours for the second time, collecting decoction leaves standstill, and filters, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously, add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously gets Chinese medicine extract;
Get Chinese medicine composition 6kg and add dispersant Oleum Brassicae campestris, suspending agent aluminum monostearate, antiseptic glycerol monostearate, surfactant Tween-60, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment five
Capsule liquid: Chinese medicine extract 8kg, Polyethylene Glycol-40013kg, Cera Flava 0.3kg, lecithin 0.2kg, ethyl hydroxybenzoate 0.1kg, tween 20 0.1kg;
Softgel shell: gelatin 90kg, glycerol 35kg, water 90kg, oxybenzene second fat 13kg, iron oxide red 1.0kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 90kg, Folium Eriobotryae 145kg, Radix Adenophorae (Radix Glehniae) 10kg, Poria 15kg, Exocarpium Citri Grandis 26kg, Radix Platycodonis 100kg, Rhizoma Pinelliae Preparatum 30kg, GUALOUZI 20kg, Semen Armeniacae Amarum 35kg, Rhizoma Zingiberis Recens 22kg, Radix Glycyrrhizae 10kg, Mentholum 4kg, aqua armeniacae 16L;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item (IO of Chinese Pharmacopoeia version in 2005), with percent by volume is that 85% alcoholic solution is made solvent, flood percolation after 70 hours, filter out fully to the solubility composition, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution; The speed of percolation is 2.5ml/min;
Step 2., 3. 4. with embodiment four;
Get Chinese medicine composition 8kg and add dispersant Polyethylene Glycol-400, suspending agent Cera Flava and lecithin, antiseptic ethyl hydroxybenzoate, surfactant tween 20, colloid mill is ground to mix homogeneously, adopts filling in No. 1 capsule softgel shell, is prepared into liquid capsule.
Embodiment six
Capsule liquid: Chinese medicine extract 15kg, Oleum sesami 14kg, ethyl cellulose 0.6kg, glycerol monostearate 0.1kg, Arlacel-60 0.1kg;
Softgel shell: gelatin 80kg, glycerol 60kg, water 110kg, oxybenzene second fat 16kg, iron oxide red 0.5kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 115kg, Folium Eriobotryae 110kg, Radix Adenophorae (Radix Glehniae) 38kg, Poria 10kg, Exocarpium Citri Grandis 15kg, Radix Platycodonis 35kg, Rhizoma Pinelliae Preparatum 40kg, GUALOUZI 48kg, Semen Armeniacae Amarum 55kg, Rhizoma Zingiberis Recens 8kg, Radix Glycyrrhizae 18kg, Mentholum 1.8kg, aqua armeniacae 6L;
Preparation method:
Wherein step is 1. with embodiment four;
Step 2., 3., 4. with embodiment three;
Get Chinese medicine composition 15kg and add dispersant Oleum sesami, suspending agent ethyl cellulose, antiseptic glycerol monostearate, surfactant Arlacel-60, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment seven
Capsule liquid: Chinese medicine extract 9kg, Oleum Brassicae campestris 14.5kg, aluminum monostearate 0.5kg, ethyl cellulose 0.1kg, glycerol monostearate 0.1kg, Tween-40 0.15kg;
Softgel shell: gelatin 85kg, glycerol 43kg, water 92kg, oxybenzene second fat 13.5kg, iron oxide black 2.5kg;
Described Chinese medicine extract is prepared from by Bulbus Fritillariae Cirrhosae 100kg, Folium Eriobotryae 120kg, Radix Adenophorae (Radix Glehniae) 16kg, Poria 34kg, Exocarpium Citri Grandis 24kg, Radix Platycodonis 50kg, Rhizoma Pinelliae Preparatum 22kg, GUALOUZI 42kg, Semen Armeniacae Amarum 15kg, Rhizoma Zingiberis Recens 30kg, Radix Glycyrrhizae 12kg, Mentholum 0.8kg, aqua armeniacae 3L;
Preparation method:
Wherein step is 1. with embodiment two;
Step 2., 3., 4. with embodiment three;
Get Chinese medicine composition 9kg and add dispersant Oleum Brassicae campestris, suspending agent aluminum monostearate and ethyl cellulose, antiseptic glycerol monostearate, surfactant Arlacel-40, colloid mill is ground to mix homogeneously, adopts filling in No. 1 capsule softgel shell, is prepared into liquid capsule.
Embodiment eight
Capsule liquid: Chinese medicine extract 12.5kg, Polyethylene Glycol-600 13kg, propylene glycol 0.55kg, ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Softgel shell: gelatin 85kg, glycerol 57kg, water 95kg, oxybenzene second fat 10kg, iron oxide black 3.2kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 60kg, Folium Eriobotryae 130kg, Radix Adenophorae (Radix Glehniae) 26kg, Poria 24kg, Exocarpium Citri Grandis 17kg, Radix Platycodonis 85kg, Rhizoma Pinelliae Preparatum 36kg, GUALOUZI 38kg, Semen Armeniacae Amarum 30kg, Rhizoma Zingiberis Recens 12kg, Radix Glycyrrhizae 25kg, Mentholum 1kg, aqua armeniacae 14L;
Preparation method:
Wherein step is 1. with embodiment two;
Step 2., 3., 4. with embodiment three;
Get Chinese medicine composition 12.5kg and add dispersant Polyethylene Glycol-600, suspending agent propylene glycol, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment nine
Capsule liquid: Chinese medicine extract 7.5kg, soybean oil 15.5kg, Cera Flava 0.45kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Softgel shell: gelatin 115kg, glycerol 35kg, water 105kg, oxybenzene second fat 10kg, iron oxide red 3.2kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 75kg, Folium Eriobotryae 70kg, Radix Adenophorae (Radix Glehniae) 30kg, Poria 22kg, Exocarpium Citri Grandis 28kg, Radix Platycodonis 45kg, Rhizoma Pinelliae Preparatum 12kg, GUALOUZI 34kg, Semen Armeniacae Amarum 25kg, Rhizoma Zingiberis Recens 18kg, Radix Glycyrrhizae 30kg, Mentholum 1.5kg, aqua armeniacae 10L;
Preparation method:
1. Bulbus Fritillariae Cirrhosae powder being broken into coarse powder, is that 75% alcoholic solution is made solvent with percent by volume, floods percolation after 80 hours, filters out fully to the solubility composition, collects percolate, reclaims ethanol, gets the Bulbus Fritillariae Cirrhosae extracting solution;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are 80% alcoholic solution dipping 18 days with percent by volume respectively, filter, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2 times, 2 hours for the first time, 3 hours for the second time, collecting decoction, leave standstill, filter filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously, add Mentholum alcoholic solution and aqua armeniacae, get Chinese medicine extract;
Get Chinese medicine composition 7.5kg and add dispersant soybean oil, suspending agent Cera Flava, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, adopt dropping preparation method to be packed into softgel shell, filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment ten
Capsule liquid: Chinese medicine extract 10.5kg, Oleum sesami 12.5kg, ethyl cellulose 0.65kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Softgel shell: gelatin 119kg, glycerol 33kg, water 118kg, oxybenzene second fat 11kg, iron oxide black 1.5kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 75kg, Folium Eriobotryae 70kg, Radix Adenophorae (Radix Glehniae) 30kg, Poria 22kg, Exocarpium Citri Grandis 28kg, Radix Platycodonis 45kg, Rhizoma Pinelliae Preparatum 12kg, GUALOUZI 34kg, Semen Armeniacae Amarum 25kg, Rhizoma Zingiberis Recens 18kg, Radix Glycyrrhizae 30kg, Mentholum 1.5kg, aqua armeniacae 10L;
Preparation method:
Wherein step 1., 2., 3., 4. with embodiment two;
Get Chinese medicine composition 10.5kg and add dispersant Oleum sesami, suspending agent ethyl cellulose, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Embodiment 11
Capsule liquid: Chinese medicine extract 14.5kg, Oleum Arachidis hypogaeae semen 14.3kg, lecithin 0.48kg, single ethyl hydroxybenzoate 0.1kg, Tween-40 0.12kg
Softgel shell: gelatin 112kg, glycerol 52kg, water 101kg, oxybenzene second fat 13.5kg, iron oxide red 1.5kg;
Described Chinese medicine extract is to be prepared from by Bulbus Fritillariae Cirrhosae 80g, Folium Eriobotryae 100g, Radix Adenophorae (Radix Glehniae) 20g, Poria 20g, Exocarpium Citri Grandis 80g, Radix Platycodonis 20g, Rhizoma Pinelliae Preparatum 40g, GUALOUZI 40g, Semen Armeniacae Amarum 40g, Rhizoma Zingiberis Recens 20g, Radix Glycyrrhizae 20g, Mentholum 2g, aqua armeniacae 7ml;
Preparation method:
Wherein step 1., 2., 3., 4. with embodiment three;
Get Chinese medicine composition 14.5kg and add dispersant Oleum Arachidis hypogaeae semen, suspending agent lecithin, antiseptic list ethyl hydroxybenzoate, surfactant Tween-40, colloid mill is ground to mix homogeneously, and filling is prepared into liquid capsule in No. 1 capsule softgel shell.
Claims (9)
1. one kind is used for the treatment of that cough, expectoration or expectoration are not well, the herb liquid body capsule of dry mouth and throat, comprises softgel shell and capsule liquid, it is characterized in that described capsule liquid comprises following components by part by weight:
Chinese medicine extract 6-15 dispersant 12-16 suspending agent 0.4~0.7;
Described Chinese medicine extract is formed by the following components in part by weight processing and preparing:
Bulbus Fritillariae Cirrhosae 50-120 Folium Eriobotryae 55-145 Radix Adenophorae (Radix Glehniae) 10-40 Poria 10-35
Exocarpium Citri Grandis 10-30 Radix Platycodonis 35-100 Rhizoma Pinelliae Preparatum 10-40 GUALOUZI 20-60
Semen Armeniacae Amarum 15-70 Rhizoma Zingiberis Recens 5-30 Radix Glycyrrhizae 5-35 Mentholum 0.5-5
Aqua armeniacae 3-20.
2. according to the described herb liquid body capsule of claim 1, it is characterized in that described Chinese medicine extract is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Bulbus Fritillariae Cirrhosae 65-100 Folium Eriobotryae 80-120 Radix Adenophorae (Radix Glehniae) 10-25 Poria 15-30
Exocarpium Citri Grandis 15-25 Radix Platycodonis 55-100 Rhizoma Pinelliae Preparatum 10-25 GUALOUZI 25-50
Semen Armeniacae Amarum 30-55 Rhizoma Zingiberis Recens 10-25 Radix Glycyrrhizae 15-30 Mentholum 1-2.5
Aqua armeniacae 3-10.
3. according to the described herb liquid body capsule of claim 2, it is characterized in that described Chinese medicine extract is formed through processing and preparing by following parts by weight of Chinese traditional medicine raw material:
Bulbus Fritillariae Cirrhosae 75-85 Folium Eriobotryae 90-100 Radix Adenophorae (Radix Glehniae) 15-20 Poria 15-25
Exocarpium Citri Grandis 15-20 Radix Platycodonis 75-85 Rhizoma Pinelliae Preparatum 15-25 GUALOUZI 30-45
Semen Armeniacae Amarum 35-45 Rhizoma Zingiberis Recens 15-20 Radix Glycyrrhizae 15-20 Mentholum 1.5-2.5
Aqua armeniacae 5-8.
4. according to claim 1,2 or 3 described herb liquid body capsules, it is characterized in that described dispersant is polyethylene glycols or vegetable oil; Described suspending agent is one or more the mixture in Cera Flava, lecithin, aluminum monostearate, ethyl cellulose, the propylene glycol.
5. according to the described herb liquid body capsule of claim 5, it is characterized in that described vegetable oil is a kind of or wherein several mixture of Oleum Arachidis hypogaeae semen, soybean oil, Oleum sesami, Oleum Brassicae campestris or other consumption vegetable oil.
6. according to claim 1,2 or 3 described herb liquid body capsules, it is characterized in that containing in the described capsule liquid antiseptic and/or the surfactant of convention amount.
7. according to the described herb liquid body capsule of claim 6, it is characterized in that described antiseptic is parabens or glycerol monostearate; Described surface activity reaches and is tween or span.
8. a method for preparing claim 1,2 or 3 described herb liquid body capsules comprises the steps:
1. Bulbus Fritillariae Cirrhosae powder is broken into coarse powder, makees solvent for the 50-90% alcoholic solution, flood percolation after 15-90 hour, filter out fully, collect percolate, reclaim ethanol, get the Bulbus Fritillariae Cirrhosae extracting solution to the solubility composition with percent by volume;
2. Exocarpium Citri Grandis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae were flooded 10-25 days for the 50-95% alcoholic solution with percent by volume respectively, filtered, and filtrate recycling ethanol is condensed into thick paste A;
3. Mentholum is dissolved in ethanol, gets the Mentholum alcoholic solution;
4. Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria, Radix Platycodonis, Rhizoma Pinelliae Preparatum, GUALOUZI, Semen Armeniacae Amarum are decocted with water 2-3 time, each 1-3 hour, collecting decoction, leave standstill, filter, filtrate and Bulbus Fritillariae Cirrhosae extracting solution, thick paste A mix homogeneously add Mentholum alcoholic solution and aqua armeniacae, mix homogeneously, add dispersant and suspending agent, colloid mill is ground to mix homogeneously, gets capsule liquid, filling is prepared into liquid capsule in the capsule softgel shell.
9. in accordance with the method for claim 8, it is characterized in that also adding antiseptic and/or surfactant in the described capsule liquid.
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