CN101167750B - Forest frog soft capsule and its preparing process - Google Patents
Forest frog soft capsule and its preparing process Download PDFInfo
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- CN101167750B CN101167750B CN2007101576988A CN200710157698A CN101167750B CN 101167750 B CN101167750 B CN 101167750B CN 2007101576988 A CN2007101576988 A CN 2007101576988A CN 200710157698 A CN200710157698 A CN 200710157698A CN 101167750 B CN101167750 B CN 101167750B
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Abstract
The invention discloses a wood frog soft capsule and process for preparation, comprising wood frog powder, wood frog oil, hydrolytic pearl powder, black current oil, vitamin E, span 80, beta-carotene, salad oil and beeswax. The soft capsule is manufactured by technological process such as comminuting, drying, homogenized emulsification, and pelleting, etc. The invention adopts advanced process technology under low-temperature, thereby protecting various components of raw material effectively. The form of the soft capsule intensifies the taking comfort, thereby taking conveniently, absorbing quickly and completely and exerting the action of invigorating the kidney and the sperm, nourishing lung and yin, keeping humectant, anti-spotting, improving the elasticity of skin and withstanding, and senescence of the skin, etc.
Description
(1) technical field
The present invention relates to a kind of with the wood frog be major ingredient make have wood frog soft capsule of looks improving and the skin nourishing effect and preparation method thereof.
(2) background technology
Wood frog is completely spoken and is called " Chinese forest frog ", is a kind of extremely precious tonic.The effect that the kidney invigorating and essence nourishing, nourishing YIN and moistening the lung, enhancing immunity, microcirculation improvement are arranged is used for physical weakness, imbalance after being ill, spiritlessness and weakness, deficiency of the kidney spirit deficiency, palpitation and insomnia, night sweat is more than, the consumptive disease diseases such as hemoptysis of coughing.According to the characteristics of wood frog, it is the nutritional supplement of major ingredient with the wood frog that people have developed many kinds.
It is the precious batrachia of one that the full township wood frog that is grown in the new guest of LiaoNing, China, a clear former band collects food, medicine, benefit three usefulness especially, and its whole body all is a treasured.Past people is confined to Oviductus Ranae to the utilization of wood frog more, and remaining dried wood frog had all been discarded after wood frog had been got oil, and this is the significant wastage to the wood frog resource.Rana sylvatica Le conte skin all has tangible effect to the preserving moisture of human skin, speckle dispelling, enhancing skin elasticity, anti aging effect etc.Studies show that Rana sylvatica Le conte skin also has following function:
1. full township's Rana sylvatica Le conte skin treatment acne function.Studies show that, active ingredient-macropore the polypeptide factor of the frog skin through extracting has the broad-spectrum sterilization effect, can effectively kill the antibacterial that skin surface causes that pox mouth, acne produce, add its Moisture factor effect, temperature rising, the blood circulation of horny layer of epidermis softness, skin surface are improved, can reach the purpose of skin wet speckle dispelling, treatment acne.
2. full township Rana sylvatica Le conte skin moisture-keeping functions.Collagen content can reach 48% in the middle of the full township Rana sylvatica Le conte skin, and polypeptide class content can reach more than 10%, and more rare is also to contain typical case's representative---the hyaluronic acid HA of nature moisturizing factor in the middle of the full township Rana sylvatica Le conte skin.Hyaluronic acid HA is the present universally acknowledged optimal material of preserving moisture of human body skin, can play Moisture factor content in the added body, pinning the effect of whole body moisture, is the essential moisture-keeping nutrient composition in the present cosmetics of super quality, cosmetic health product and the ophthalmic remedy in the world.
3. full township Rana sylvatica Le conte skin spot-removing function.In the antioxidation test; hyaluronic acid HA can show the identical effects of non-enzyme free radical scavenger such as taking off sweet peptide with paddy in the full township Rana sylvatica Le conte skin; therefore; it has ideal cytoprotection; can delay owing to free radical is encroached on skin aging and the Pigmented appearance that occurs; and can improve skin metabolism, accelerate melanin decomposition in the skin, and can improve the skin resistance against diseases.
4. full township Rana sylvatica Le conte skin wrinkle removal function.Studies show that collagen content can reach 48% in the middle of the full township Rana sylvatica Le conte skin, polypeptide class content can reach more than 10%.Collagen protein in the full township Rana sylvatica Le conte skin, oral administration absorbs, and can effectively replenish the collagen protein that lacks in the human senility skin, improves skin elasticity, and can reduce the wrinkle generation.In addition, the Moisture factor hyaluronic acid HA in the middle of the full township Rana sylvatica Le conte skin can effectively strengthen Moisture factor content in the skin, improves skin moisturizing, and can reduce because the infringement that the radical pair skin that ultraviolet radiation produces causes can improve the skin resistance against diseases.The comprehensive function result can be so that the skin aging sx, and recovers original elasticity gradually.
In sum, being used for the health product of looks improving and the skin nourishing with wood frog (especially Rana sylvatica Le conte skin) production and processing, is fully feasible, also is of practical significance very much.
Extremely thin and very soft after the Rana sylvatica Le conte skin drying, the various pulverizers of our usefulness all can't be crushed to this material below 120 orders now, jet mill also can not be pulverized it fully, and some producers are heated to 90 ℃～110 ℃ to it usually and dry in order to pulverize wood frog.When material is done near carbonization, pulverize, and at this moment in the material contained active ingredient all destroyed.
Collagen content can reach 48% in the wood frog powder, and polypeptide class content can reach more than 10%, also contains typical case's representative---the hyaluronic acid HA of nature moisturizing factor simultaneously; Its cutaneous gland contains various active factorses, comprising 14 peptide species class factors such as Moisture factor, polypeptide growth factor, the biological antibiotic factor, vasotonia prime factor, the bombesin class factor, bradykinin sample polypeptide, thyrotropin peptide class, the morphine factors.The temperature of guaranteeing the quality of this class material is general many below 80 ℃.Protein degeneration when temperature reaches more than 90 ℃, Moisture factor HA is with destroyed, and present grinding and processing technology all is that material is heated to more than 90 ℃ even 100 ℃.The degeneration of this temperature protein, other various active ingredients all lose totally.
(3) summary of the invention
The purpose of this invention is to provide and a kind ofly can improve immunity, defying age; The health product of speckle dispelling, looks improving and the skin nourishing---wood frog soft capsule and preparation method thereof.
The technical solution used in the present invention is: the core material of wood frog soft capsule is a major ingredient with the wood frog powder, and adding Oviductus Ranae, hydrolyzed pearl powder, blackcurrant oil, vitamin E, sorbester p17, beta-carotene and salad wet goods adjuvant are made, the mass fraction of used material is: wood frog powder: 1, Oviductus Ranae: 0.290～0.334, hydrolyzed pearl powder: 0.200～0.226, blackcurrant oil: 0.290～0.334, vitamin E: 0.033～0.065, sorbester p17: 0.033～0.052, beta-carotene: 0.003～0.006, salad oil 1.201～1.280, Cera Flava: 0.096～0.117.
Wood frog preparation of soft capsule method is: a, the dried wood frog that will remove frog oil and internal organs earlier are crushed to 50～70 orders, add water and granulate with granulator, and be dry under 60～75 ℃ temperature, makes it water content and reach about 2%; Dried material is crushed to 120～200 orders with super micron mill.
B, Oviductus Ranae is put into 40 times purified water, steep raising 12 hours, till the transparent no lump of frog oil white color that distributes, stand-by;
C, wood frog powder, hydrolyzed pearl powder, blackcurrant oil, VE, beta-carotene are thrown in the material-compound tank; Salad oil is pressed formula ratio take out 1/5 heating, be placed in the oil of heating after then Cera Flava being thinly sliced, after treating all to melt, drop in the material-compound tank.
D, sorbester p17 thrown into to send out add remaining salad oil in the good frog oil and grind with colloid mill, treat homodisperse after, drop in the material-compound tank.
E, with material-compound tank whole materials are carried out homogenizing, temperature is controlled by the water of interlayer, and general temperature is lower than 80 ℃.After stirring in material-compound tank, get in the charging basket with spray pump, last high-speed emulsifying machine carries out further emulsifying.The material that emulsifying is good is built the back and was placed 10 hours, treats that air entrapment can pelleting after overflowing naturally.
F, again processization glue, pelleting, typing drying, wash ball, making that dry in the air ball and processes such as inspection pill package etc. have promptly been finished the wood frog soft capsule.
It is raw material that the present invention selects full township wood frog, frog oil and hydrolyzed pearl powder etc. for use, and advanced processing technique is adopted in material processing at low temperatures all the time in the process of producing, and the various compositions of raw material are effectively protected.And the form of making soft capsule has greatly increased its suitable clothes, makes its taking convenience, absorbs rapidly fully, gives full play to its kidney invigorating and essence nourishing, nourishing lung-YIN, preserves moisture, effects such as speckle dispelling, enhancing skin elasticity, anti aging effect.
(4) specific embodiment
| Sequence number | Supplementary material | Prescription one (mg) | Prescription two (mg) | Prescription three (mg) |
| 1 | The wood frog powder | 150 | 155 | 152.5 |
| 2 | Oviductus Ranae | 50 | 45 | 47.5 |
| 3 | Hydrolyzed pearl powder | 30 | 35 | 32.5 |
| 4 | Blackcurrant oil | 50 | 45 | 47.5 |
| 5 | Vitamin E | 5 | 10 | 7.5 |
| 6 | Span 80 | 5 | 8 | 6.5 |
| 7 | Beta-carotene (natural) | 0.5 | 0.8 | 0.65 |
| 8 | Salad oil | 192 | 186.2 | 189.1 |
| 9 | Cera Flava | 17.5 | 15 | 16.25 |
| Add up to | 500 | 500 | 500 |
Manufacture method is:
One, the production of raw material:
1. wood frog natural drying (string together and hang to dry) takes out frog oil, removes internal organs.
2. pulverize (need change the 70 purposes sieve end into) powder with coarse powder machine or super micron mill and become the 50-70 order.
3. add an amount of purified water (adding about 1/10 approximately), stir.
4. with granulator the material that has stirred is granulated.
5. dehydrator on the granule is dry under 60～75 ℃ temperature, makes it water content and reaches about 2%.
6. pulverize with super micron mill, the sieve end, be less than 120 orders.
Two, blending process:
1. get the purified water (not using hot water) that a certain amount of frog oil is put into 40 times, steep raising 12 hours, till the transparent no lump of frog oil white color that distributes, stand-by.
2. wood frog powder, hydrolyzed pearl powder, blackcurrant oil, VE oil, beta-carotene are thrown in the material-compound tank by formula ratio.
3. salad oil is pressed formula ratio and take out 1/5 heating, be placed in the oil of heating after then Cera Flava being thinly sliced, after treating all to melt, drop in the material-compound tank.
4. sorbester p17 is thrown into to send out and adds remaining salad oil in the good frog oil and grind with colloid mill, treat homodisperse after, drop in the material-compound tank.
5. with material-compound tank whole materials are carried out homogenizing, temperature is controlled by the water of interlayer, and general temperature is lower than 80 ℃ just.
6. after stirring in material-compound tank, get in the charging basket with spray pump, last high-speed emulsifying machine carries out further emulsifying.
7. the good material of emulsifying is built the back and was placed 10 hours, treats that air entrapment can pelleting after overflowing naturally.
Three, change the glue process:
1. pharmagel and purified water, glycerol ratio in 1: 1: 0.4; Pigment is an amount of on demand, in the putting into glue jar.
2. the water of changing in the glue jar interlayer is heated, be heated to 60～75 ℃ always, change the glue time at 1.5 hours to 2 hours.
3. reaching 75 ℃ when glue, stop heating, beginning evacuation, pressure be controlled at-0.08～-0.05MPa (medicinal liquid extractionization glue jar is not advisable).
4. after exhausting bubble, glue is put into storage glue jar, temperature left standstill 10 hours at 45 ℃.
Four, pelleting:
Pelleting is the core work that soft capsule is produced, and finishes the rubber preparation by RJN---2 type main frame, and the medicinal liquid weight feed is finally finished envelope molding soft capsule.
Common processes parameter: 37～50 ℃ of sprinkler body temperature; Content temperature ≯ 40 ℃; 55～65 ℃ of glue temperatures
Five, typing is dry:
Capsule is put into dry rotating cage to carry out dynamically air-dry.Usually be 6～8 hours drying time.
Six, wash the ball and the ball that dries in the air:
1. put into rotating cage with fiberless silk cloth, the oil on ball surface is wiped clean.
2. after ball being taken out, put into stainless steel disc from rotating cage, standing and drying, general 12～16 hours, make soft capsule moisture reach 10%, feel better can be sent to the inspection ball.
Seven, inspection pill package:
The inspection ball is with external form, the underproof soft capsule of joint close, chooses, and certified products is sent to done physics and chemistry and microbiological Test, if qualified then can the packing dispatched from the factory.
Claims (2)
1. wood frog soft capsule, it is characterized in that: the material by following mass fraction is made: wood frog powder: 1, Oviductus Ranae: 0.290～0.334, hydrolyzed pearl powder: 0.200～0.226, blackcurrant oil: 0.290～0.334, vitamin E: 0.033～0.065, sorbester p17: 0.033～0.052, beta-carotene: 0.003～0.006, salad oil 1.201～1.280, Cera Flava: 0.096～0.117; Described wood frog powder is to make by the following method: the dried wood frog that will remove frog oil and internal organs is crushed to 50～70 orders; adding water granulates with granulator; dry under 60～75 ℃ temperature, make it water content and reach about 2%, dried material is crushed to 120～200 orders with super micron mill.
2. wood frog preparation of soft capsule method as claimed in claim 1, it is characterized in that: a, the dried wood frog that will remove frog oil and internal organs are crushed to 50～70 orders, adding water granulates with granulator, dry under 60～75 ℃ temperature, make it water content and reach about 2%, dried material is crushed to 120～200 orders with super micron mill; B, Oviductus Ranae is put into 40 times purified water, steep raising 12 hours; C, wood frog powder, hydrolyzed pearl powder, blackcurrant oil, VE, beta-carotene are thrown in the material-compound tank; Salad oil is pressed formula ratio take out 1/5 heating, be placed in the oil of heating after then Cera Flava being thinly sliced, after treating all to melt, drop in the material-compound tank; D, sorbester p17 thrown into to send out add remaining salad oil in the good frog oil and grind with colloid mill, treat homodisperse after, drop in the material-compound tank; E, with material-compound tank whole materials are carried out homogenizing, temperature is lower than 80 ℃, and the reuse high-speed emulsifying machine carries out further emulsifying, places 10 hours; F, change glue, pelleting, typing drying, wash ball, ball and inspection pill package dry in the air.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101576988A CN101167750B (en) | 2007-10-26 | 2007-10-26 | Forest frog soft capsule and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101576988A CN101167750B (en) | 2007-10-26 | 2007-10-26 | Forest frog soft capsule and its preparing process |
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| Publication Number | Publication Date |
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| CN101167750A CN101167750A (en) | 2008-04-30 |
| CN101167750B true CN101167750B (en) | 2010-07-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101576988A Active CN101167750B (en) | 2007-10-26 | 2007-10-26 | Forest frog soft capsule and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114568642A (en) * | 2022-03-03 | 2022-06-03 | 福建省健丰生物科技有限公司 | Preparation method of quasipaa spinosa soft capsules |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277845A (en) * | 2000-03-30 | 2000-12-27 | 白山市北亚药业有限责任公司 | Method for preparing soft capsule of forest frog oil |
| CN1449769A (en) * | 2002-04-11 | 2003-10-22 | 樊牧 | Soft capsule of Chinese Forest Frog's Oviduct Fat and preparation method thereof |
| CN1593465A (en) * | 2004-07-13 | 2005-03-16 | 于永利 | Soft capsule of forest frog oil and its preparation method |
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2007
- 2007-10-26 CN CN2007101576988A patent/CN101167750B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277845A (en) * | 2000-03-30 | 2000-12-27 | 白山市北亚药业有限责任公司 | Method for preparing soft capsule of forest frog oil |
| CN1449769A (en) * | 2002-04-11 | 2003-10-22 | 樊牧 | Soft capsule of Chinese Forest Frog's Oviduct Fat and preparation method thereof |
| CN1593465A (en) * | 2004-07-13 | 2005-03-16 | 于永利 | Soft capsule of forest frog oil and its preparation method |
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| CN101167750A (en) | 2008-04-30 |
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