CN101156586B - Process for the preparation of NMDA antagonists - Google Patents
Process for the preparation of NMDA antagonists Download PDFInfo
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- CN101156586B CN101156586B CN2006100691310A CN200610069131A CN101156586B CN 101156586 B CN101156586 B CN 101156586B CN 2006100691310 A CN2006100691310 A CN 2006100691310A CN 200610069131 A CN200610069131 A CN 200610069131A CN 101156586 B CN101156586 B CN 101156586B
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- guanidine
- crustacean
- containing antimicrobial
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- crust
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Abstract
The invention provides a preparation method for crustacean guanidine containing antimicrobial. The crustacean guanidine containing antimicrobial is compounded after the reaction of crustacean guanidine, chitosan, and surfactant. The preparation method has the procedure that the chitosan is dissolved in the acid containing water, when the temperature rises to 20-60 DEG C under stirring for 0.5-5 hour reaction, then the crustacean guanidine is added for 0.1-2 hours full reaction, and finally the surfactant evenly added and stired; and then the crustacean guanidine containing antimicrobial is made. The crustacean guanidine containing antimicrobial in the textile has the application that the padding process is used to ensure that the textile possesses antibiotic, moisturizing, and skin protecting functions. The application in the agriculture is realized by diluting the crustacean guanidine containing antimicrobial proportionately into operating liquid of definite consistence, then applying the operating liquid to the crops or fruit trees in the means of spray or irrigation. The crustacean guanidine containing antimicrobial can inhibit the microorganisms, can destroy virus, can preserve moisture, and can increase the yield.
Description
Technical field:
The present invention relates to a kind of is the antibacterial agent that feedstock production becomes with natural products guanidine and chitin, particularly a kind of preparation method who contains natural polymer chitosan base guanidinesalt (hereinafter to be referred as the crust guanidine) antibacterial agent.
Technical background:
Guanidine is present in natural productss such as albumen, nucleic acid, streptomycin and the various plants such as beet, rice husk, mushroom and beans, the guanidine that also contains trace in the humans and animals body, but free guanidine is very unstable, easily absorb carbon dioxide in air, generate guanidine carbonate, so guanidine is usually with the form stable existence of guanidinesalt.Guanidinesalt is an important component part in the guanidine compound, and can derive is miscellaneous guanidine derivative, and these derivatives have the excellent antibiotic performance.
Chitin is the general designation of chitin and shitosan, and shitosan has antibacterial activity under certain condition because of containing amino, and obtains many application because of having biocompatibility and natural sex.
Though shitosan or guanidinesalt can be as antibacterial agents, shitosan is subjected to the influence of molecular weight and environment for use bigger as antibacterial agent, only under molecular weight that is fit to and sour environment tangible antibacterial activity is arranged, thereby has limited its purposes.In existing technology, Chinese patent 2003101055431 discloses a kind of " chitin and biomembrane finishing agent and preparation and the technique for applying that are used for textile ", uses chitosan quaternary ammonium salt instead as antibacterial agent for the defective that overcomes the chitosan anti-bacteria difference.Though the guanidinesalt antibacterial activity is stronger, be subjected to the influence of environmental condition also less, but molecular weight is very little usually, soluble in water, when being used for textile etc. and needing the antibiotic purposes of certain durability and inapplicable, the prescription of a kind of " guanidine like polymer disinfectant detergent agent for clothes hydrochloric acid polyoxyethylene hydroxyl guanidine " is disclosed as Chinese patent 01127470, though product having enhanced antibacterial action, it but is the disposable sterilization inorganic agent that is used for clothing, do not have durability, and be not suitable for doing the textile post-treatment agent, in addition, the less stable of harmonic component guanidinesalt is easy to decompose that to lose antibacterial activity easily also be defective.
Summary of the invention:
The objective of the invention is to overcome existing shitosan and low molecule guanidinesalt separately as the existing above-mentioned defective of antibacterial agent, seeking a kind of is the preparation method of main antibacterial agent with the crust guanidine.
To achieve these goals, the present invention adopts crust guanidine and shitosan, surfactant, through reacting the synthetic antibacterial agent that contains the crust guanidine.Shitosan is dissolved in the water that contains acid, under agitation is warming up to 20 ℃～60 ℃ reaction 0.5～5h, add the crust guanidine and fully react 0.1～2h, add surfactant at last again and stir and promptly make the antibacterial agent that contains the crust guanidine.The organic acid that used acid can be acetic acid, formic acid in preparation, citric acid is the same also can be inorganic acids such as hydrochloric acid and sulfuric acid; Surfactant is cation or nonionic, cationic surfactant adopts dodecyl benzyl dimethyl ammonium chloride (trade name 1227, geramine), softex kw (trade name 1631, bromogeramine) etc., non-ionic surface active agent adopts fatty alcohol-polyoxyethylene ether (trade name JFC, OP, peregal), alkylphenol polyoxyethylene (trade name TX-10, TX-n) etc.The crust guanidine is 100%～0.001% to 0%～99.999% with auxiliary element shitosan and surface-active ratio; Shitosan is 100%～80% to 0%～20% with the ratio of surfactant.
The application method of antibacterial agent on textile that contains the crust guanidine is to adopt to pad technology, will contain NMDA antagonists earlier and be diluted to certain density working solution in proportion, pads the back oven dry by padder and gets final product.
The application method of antibacterial agent on agricultural that contains the crust guanidine is to be diluted to certain density working solution in proportion, adopts the method for the method of spraying or irrigation to grant crops or fruit tree, flowers again.
The present invention had compared following advantage with former technology:
1, adopts natural polymer chitosan base guanidinesalt, be the crust guanidine as main antibacterial agent, overcome independent use shitosan or guanidinesalt and with composite simply, durability poor of shitosan and guanidinesalt and all bad problem of stability as the antibiotic property that antibacterial agent brought.It is continue with its new purposes of developing after as humectant that the crust guanidine is used for textile and agricultural antibacterial agent.
2, chitin and crust guanidine all are derived from natural biologic material, compare with the heavy metal antibacterial agent with traditional synthetic organic antibacterial agent, and be biodegradable, environmentally friendly.Be used for textile and have anti-bacteria wet keeping skin care multi-functional concurrently, be used for crops have concurrently antibiotic, disease-resistant, preserve moisture, increase production multi-functional, all meet the characteristics of potion multiple-effect.
Embodiment:
Enforcement of the present invention can be carried out according to following example:
Embodiment 1:
Prepare 1% acetum 1000mL, stir down wherein, be warming up to 50 ℃ of reaction 1h, again crust guanidine 70g is slowly dissolved wherein, continue the antibacterial agent that reaction 30min promptly obtains containing crust guanidine 7% shitosan 30g dissolving.
Contain the application of NMDA antagonists:
With 10 times of above-mentioned NMDA antagonists dilute with waters, textile is cotton towel, blend fabric or nonwoven napkin, select for use and pad technology two and soak two and roll 30 ℃～70 ℃, 150 ℃～190 ℃ → antimicrobial product of 85 ℃～105 ℃ of pick-ups 60%～200% → oven dry → bake.
With 300～500 times of above-mentioned NMDA antagonists dilute with waters, adopt spray-on process to be used for the antibiotic diseases prevention of crops, fruits and vegetables.
Embodiment 2:
Prepare 1.5% acetum 100L, stir down wherein, be warming up to 45 ℃ of reaction 2h, again crust guanidine 5.5Kg is slowly dissolved wherein shitosan 2Kg dissolving, adding 5% dodecyl benzyl dimethyl ammonium chloride 10Kg stirs evenly after continuing reaction 1h, promptly obtains containing the NMDA antagonists of crust guanidine 5%.
With 10 times of above-mentioned NMDA antagonists dilute with waters, textile is cotton towel, blend fabric or nonwoven napkin, select for use and pad technology, two soak two rolls 30 ℃～70 ℃, 150 ℃～190 ℃ → antimicrobial product of 85 ℃～105 ℃ of pick-ups 60%～200% → oven dry → bake.
With 300～500 times of above-mentioned NMDA antagonists dilute with waters, adopt spray-on process to be used for the antibiotic diseases prevention of crops, fruits and vegetables.
Claims (2)
1. preparation method who contains NMDA antagonists is to be that raw material forms through reaction with crust guanidine and auxiliary element, it is characterized in that shitosan is dissolved in the water that contains acid, stirs and is warming up to 20 ℃～60 ℃ reaction 0.5～5h; Add the crust guanidine and fully react 0.1～2h; The last surfactant that adds again stirs and promptly makes the antibacterial agent that contains the crust guanidine.
2. a kind of preparation method who contains NMDA antagonists according to claim 1 is characterized in that the crust guanidine and the ratio of auxiliary element shitosan and surfactant are 100%～0.001% to 0%～99.999%; Shitosan is 100%～80% to 0%～20% with the ratio of surfactant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100691310A CN101156586B (en) | 2006-10-03 | 2006-10-03 | Process for the preparation of NMDA antagonists |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100691310A CN101156586B (en) | 2006-10-03 | 2006-10-03 | Process for the preparation of NMDA antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101156586A CN101156586A (en) | 2008-04-09 |
| CN101156586B true CN101156586B (en) | 2010-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100691310A Expired - Fee Related CN101156586B (en) | 2006-10-03 | 2006-10-03 | Process for the preparation of NMDA antagonists |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103554301B (en) * | 2013-10-18 | 2015-09-30 | 青岛大学 | A kind of preparation method of antiseptic-germicide |
| CN112724469A (en) * | 2020-12-30 | 2021-04-30 | 潘红蓉 | Preparation method and application of antibacterial chitosan-cellulose biomass composite film |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637681A (en) * | 1992-08-19 | 1997-06-10 | Stockel; Richard F. | Aminosaccharide biguanides |
| CN1583854A (en) * | 2004-06-02 | 2005-02-23 | 武汉大学 | Chitin-alkylpolyglycoside complex and its preparation and use |
| CN1583990A (en) * | 2004-06-01 | 2005-02-23 | 武汉大学 | Chitin betaine surfactant composition and its preparation and agent |
-
2006
- 2006-10-03 CN CN2006100691310A patent/CN101156586B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637681A (en) * | 1992-08-19 | 1997-06-10 | Stockel; Richard F. | Aminosaccharide biguanides |
| CN1583990A (en) * | 2004-06-01 | 2005-02-23 | 武汉大学 | Chitin betaine surfactant composition and its preparation and agent |
| CN1583854A (en) * | 2004-06-02 | 2005-02-23 | 武汉大学 | Chitin-alkylpolyglycoside complex and its preparation and use |
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| CN101156586A (en) | 2008-04-09 |
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Granted publication date: 20100922 Termination date: 20111003 |