CN101133827B - Application of ackfruit extract in the aspect of relieving or neutralizing the effect of alcohol - Google Patents
Application of ackfruit extract in the aspect of relieving or neutralizing the effect of alcohol Download PDFInfo
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- CN101133827B CN101133827B CN2007101813061A CN200710181306A CN101133827B CN 101133827 B CN101133827 B CN 101133827B CN 2007101813061 A CN2007101813061 A CN 2007101813061A CN 200710181306 A CN200710181306 A CN 200710181306A CN 101133827 B CN101133827 B CN 101133827B
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- Prior art keywords
- extract
- jackfruit
- fruit
- alcohol
- adds
- Prior art date
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims description 19
- 230000000694 effects Effects 0.000 title description 6
- 230000003472 neutralizing effect Effects 0.000 title 1
- 244000025352 Artocarpus heterophyllus Species 0.000 claims abstract description 44
- 235000008725 Artocarpus heterophyllus Nutrition 0.000 claims abstract description 44
- 238000001556 precipitation Methods 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- 235000013399 edible fruits Nutrition 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000006188 syrup Substances 0.000 claims description 4
- 235000020357 syrup Nutrition 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 3
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 9
- 239000000843 powder Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000002775 capsule Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000028527 righting reflex Effects 0.000 description 3
- 206010003084 Areflexia Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000218232 Artocarpus Species 0.000 description 1
- 241000134253 Lanka Species 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000410468 Pterostyrax Species 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses an applicable of jack-fruit extract for relieving acute alcoholism. Said jack-fruit extract is obtained by adopting water extraction-alcohol precipitation process to extract jack-fruit. Said jack-fruit extract can be singly used or can be mixed with other Chinese medicinal material, and can be made into various oral dosage forms.
Description
Technical field
The present invention relates to a kind ofly be the extract of raw material with the jackfruit and have the food of antialcoholism action or the application in the medicine, belong to technical field of traditional Chinese medicines in preparation.
Background technology
Jackfruit (Artocarpus heterhyllus Lam.) claim artocarpus heterophyllus or jackfruit again, also writes jackfruit.The jackfruit Pterostyrax is aiphyllium in Moraceae, mainly grows or cultivates in the torrid zone and subtropical zone, and be typical tropical fruit tree, have the title of " the precious fruit in the torrid zone ".Jackfruit originates in India, and world's tropic countries such as Sri Lanka, Burma, Indonesia all have cultivation at present.China's cultivation jackfruit is the history in existing more than 1,000 year so far, and all there is cultivation in the tropical south subtropics area of existing Guangdong, Guangxi, Hainan, Yunnan, Fujian and South Sichuan, and with Hainan Province's plantation at most, the whole province's various places common cultivated is one of common tropical fruit tree.The jackfruit fruit is very large, and each is heavy 5～20 kilograms, when ripe fragrance strong, have a sweet taste.The nutritive value of jackfruit is very high, contains carbohydrate, sugar, protein, starch, vitamin, amino acid and the various mineral matters useful to human body.Though jackfruit is the fruit that a kind of people like, it is not well developed, and especially the jackfruit extract has the food of antialcoholism action or the application in the medicine in preparation, does not appear in the newspapers.
Summary of the invention
The purpose of this invention is to provide the jackfruit extract and have the food of antialcoholism action or the application in the medicine in preparation.
Jackfruit extract of the present invention can obtain by the following method:
After the jackfruit fruit is cut into several pieces or blends, the decocting that adds 6-12 times of volume boils 3-4 time, decocts 1-3 hour at every turn.Merge the water extract that each time obtains, after the filtration filtrate is condensed into the medicinal extract that proportion is 1.2-1.4, add 90-95% ethanol again and carry out alcohol precipitation, filter the back and reclaim solvent in the filtrate, the syrup that obtains is the jackfruit extract.
Jackfruit extract of the present invention, can use separately, or cooperate, through the preparation process of routine with other Chinese medicines or disintoxicating product, be prepared into the various peroral dosage forms in food processing and the pharmaceutical field, including, but not limited to powder, capsule, tablet, granule, oral liquid etc.
The antialcoholism action of jackfruit extract of the present invention is meant increases the tolerance of human body to alcohol.And through the jackfruit extract that the present invention obtains, owing to removed the impurity component that does not have effect in a large number, its antialcoholism action obviously improves than the control group of directly taking jackfruit.Its effect is shown by following experiment.
The drunk prevention experiment of mouse
Experiment material: the jackfruit extract that embodiment 1 is obtained is dissolved in water, and is mixed with debita spissitudo.In addition the jackfruit fruit with peeling blends, and pulverizes after the freeze drying, is processed into fine powder, and adding water, to be mixed with suitable suspension standby.It is standby that commercially available strong, colourless liquor distilled from sorghum is made into the aqueous solution of spirituosity 40%.
Method: get 100 of Kunming kind small white mouses, the male and female dual-purpose, body weight 18-20g is divided into 5 groups at random, 20 every group, difference setting model group, jackfruit control group 1,2 and the height of jackfruit extract, low dose group, each is organized and to wine 0.4mL/ only irritates stomach every day, model group gives wine preceding 30min every day, irritate stomach feedwater 0.4mL, each administration group gives wine preceding 30min every day, all gastric infusion 0.4mL, carried out continuously 30, and respectively the 2nd, 5,10,15, in the time of 20 days mouse is carried out righting reflex experiment, observe the number of elements of righting reflex loss occurring for behind the alcohol mouse in 1 hour, righting reflex loss can think that animal is drunk, 5 observed results of accumulative total calculate its drunk rate.
The result: experimental result shows that each administration group is compared with model group, and drunk rate obviously reduces, and demonstrate the drunk effect of good preventing, and the effect of jackfruit extract is obviously better than jackfruit.
The drunk prevention experiment of table 1 mouse
| Group | Dosage (g/kg) | Number of animals (individual) | Drunk (inferior) number | Drunk rate (%) |
| Jackfruit extract low dose group jackfruit extract high dose group jackfruit control group 1 jackfruit control group 2 model group | 0.10 0.50 0.50 2.50 0 | 20 20 20 20 20 | 24 5 26 6 80 | 24 5 26 6 80 |
In addition, the capsule product that the embodiment of the invention 2 obtains is through 50 experiments of multidigit alcohol user on dining table, and the drinking amount that general reaction is taken after this product can double and have no adverse reaction.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is elaborated.
The preparation of [embodiment 1] powder
The jackfruit fruit is cut into several pieces, and the decocting that adds 12 times of volumes for the first time boiled 3 hours, and the decocting that adds 10 times of volumes for the second time boiled 1.5 hours, and the decocting that adds 8 times of volumes for the third time boiled 1 hour, and the decocting of 6 times of volumes of the 4th adding boiled 1 hour.Merge four times decocting liquid, after the filtration filtrate is condensed into proportion and is 1.4 medicinal extract, add 90-95% ethanol then and carry out alcohol precipitation, filter the back and reclaim solvent in the filtrate, the syrup that obtains is the jackfruit extract.After the freeze drying, be processed into fine powder.
The preparation of [embodiment 2] capsule
The jackfruit fruit is blended, and the decocting that adds 12 times of volumes for the first time boiled 2 hours, and the decocting that adds 10 times of volumes for the second time boiled 1.5 hours, and the decocting that adds 8 times of volumes for the third time boiled 1 hour.Merge three times decocting liquid, after the filtration filtrate is condensed into proportion and is 1.2 medicinal extract, add 90-95% ethanol then and carry out alcohol precipitation, filter the back and reclaim solvent in the filtrate, the syrup that obtains is the jackfruit extract.After the spray-drying, be processed into fine powder, with stir back perfusion capsule of the medical starch of equivalent weight.
The preparation of [embodiment 3] tablet
The jackfruit extract fine powder that embodiment 1 is made adds auxiliary material and mixes, and suppresses in blocks.
The preparation of [embodiment 4] granule
The jackfruit extract fine powder adding ethanol that embodiment 1 makes is made binder, granulate.
The preparation of [embodiment 5] oral liquid
The syrupy shape extract that embodiment 1 is made, water-soluble the separating that adds 6 times of amounts filtered the back.
Claims (1)
1. jackfruit extract is characterized in that: obtain by the following method:
After the jackfruit fruit is cut into several pieces or blends, the decocting that adds 6-12 times of volume boils 3-4 time, the each decoction 1-3 hour, merge the water extract that each time obtains, after the filtration filtrate is condensed into the medicinal extract that proportion is 1.2-1.4, adds 90-95% ethanol again and carry out alcohol precipitation, filter the back and reclaim solvent in the filtrate, the syrup that obtains is the jackfruit extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101813061A CN101133827B (en) | 2007-10-19 | 2007-10-19 | Application of ackfruit extract in the aspect of relieving or neutralizing the effect of alcohol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101813061A CN101133827B (en) | 2007-10-19 | 2007-10-19 | Application of ackfruit extract in the aspect of relieving or neutralizing the effect of alcohol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101133827A CN101133827A (en) | 2008-03-05 |
| CN101133827B true CN101133827B (en) | 2010-12-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101813061A Expired - Fee Related CN101133827B (en) | 2007-10-19 | 2007-10-19 | Application of ackfruit extract in the aspect of relieving or neutralizing the effect of alcohol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101133827B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897399B (en) * | 2009-06-01 | 2012-09-05 | 张俊清 | Pineapple polysaccharide crude and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322495A (en) * | 2001-06-12 | 2001-11-21 | 陈传辉 | Sober-up beverage |
-
2007
- 2007-10-19 CN CN2007101813061A patent/CN101133827B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322495A (en) * | 2001-06-12 | 2001-11-21 | 陈传辉 | Sober-up beverage |
Non-Patent Citations (2)
| Title |
|---|
| 吴里平.解酒便方.家庭中医药.1980,(06),62. * |
| 王增.世界果王-菠萝蜜.果蔬解酒经.漓江出版社,1993,60-61. * |
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| Publication number | Publication date |
|---|---|
| CN101133827A (en) | 2008-03-05 |
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Granted publication date: 20101201 |