CN101133073B - 寡核苷酸的合成 - Google Patents

寡核苷酸的合成 Download PDF

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Publication number
CN101133073B
CN101133073B CN2006800066835A CN200680006683A CN101133073B CN 101133073 B CN101133073 B CN 101133073B CN 2006800066835 A CN2006800066835 A CN 2006800066835A CN 200680006683 A CN200680006683 A CN 200680006683A CN 101133073 B CN101133073 B CN 101133073B
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CN
China
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protected
group
hydroxyl
alkyl
activator
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Expired - Fee Related
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CN2006800066835A
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English (en)
Chinese (zh)
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CN101133073A (zh
Inventor
迈诺尔夫·朗格
安德烈亚斯·舍恩贝格尔
安德烈亚斯·霍尔菲尔德
奥拉夫·格罗塞尔
克里斯蒂·基希霍夫
弗里茨·林克
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Girindus AG
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Girindus AG
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Application filed by Girindus AG filed Critical Girindus AG
Publication of CN101133073A publication Critical patent/CN101133073A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN2006800066835A 2005-03-04 2006-03-06 寡核苷酸的合成 Expired - Fee Related CN101133073B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05101674.9 2005-03-04
EP05101674 2005-03-04
US66054905P 2005-03-11 2005-03-11
US60/660,549 2005-03-11
PCT/EP2006/060489 WO2006094963A1 (en) 2005-03-04 2006-03-06 Synthesis of oligonucleotides

Publications (2)

Publication Number Publication Date
CN101133073A CN101133073A (zh) 2008-02-27
CN101133073B true CN101133073B (zh) 2012-08-29

Family

ID=35229733

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800066835A Expired - Fee Related CN101133073B (zh) 2005-03-04 2006-03-06 寡核苷酸的合成

Country Status (11)

Country Link
EP (1) EP1858909B1 (https=)
JP (1) JP5435872B2 (https=)
KR (1) KR101437824B1 (https=)
CN (1) CN101133073B (https=)
AU (1) AU2006221999A1 (https=)
BR (1) BRPI0609351A2 (https=)
CA (1) CA2599259A1 (https=)
MX (1) MX2007010764A (https=)
RU (1) RU2465280C2 (https=)
UA (1) UA96411C2 (https=)
WO (1) WO2006094963A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL185439A0 (en) * 2005-03-04 2008-01-06 Girindus Ag Synthesis of oligonucleotides
KR20100022470A (ko) * 2007-05-22 2010-03-02 기린두스 아게 올리고뉴클레오타이드의 합성
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法
CN106589005B (zh) * 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
WO2018215049A1 (en) * 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates
CN111479818A (zh) * 2018-02-13 2020-07-31 深圳华大生命科学研究院 合成寡核苷酸的方法及系统
CN112898363B (zh) * 2021-01-25 2024-06-04 苏州金唯智生物科技有限公司 一种亚磷酰胺单体组合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2088588C1 (ru) * 1990-07-02 1997-08-27 Хехст АГ Олигонуклеотиды и способ их получения
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
DE69726276T2 (de) * 1996-05-03 2004-11-18 Avecia Biotechnology, Inc., Milford In situ herstellung von nukleosid-phosphoramiditen und ihre verwendung in der oligonukleotidsynthese
JPH1180185A (ja) * 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
JP5132025B2 (ja) * 2002-11-19 2013-01-30 第一三共株式会社 新規２’，５’−オリゴアデニル酸類縁体
JP2004168684A (ja) * 2002-11-19 2004-06-17 Rikogaku Shinkokai 核酸の短工程合成を可能にする新規ホスホロアミダイト化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAYAKAWA, YOSHIHIRO等.Acid/Azole Complexes as Highly Effective Promoters in the Synthesis of DNA and RNA Oligomers via the Phosphoramidite Method.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.2001,123(34),8165-8176，尤其是摘要和图1，BIT等. *
NURMINEN, ERKKI J.等.Nucleophilic and acid catalysis in phosphoramidite alcoholysis.JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2.2001,(11),2159-2165,尤其是表4和结论部分,甲基咪唑 三氟乙酸盐等. *

Also Published As

Publication number Publication date
EP1858909A1 (en) 2007-11-28
MX2007010764A (es) 2007-11-07
RU2465280C2 (ru) 2012-10-27
CA2599259A1 (en) 2006-09-14
AU2006221999A1 (en) 2006-09-14
CN101133073A (zh) 2008-02-27
KR101437824B1 (ko) 2014-10-02
KR20070110309A (ko) 2007-11-16
EP1858909B1 (en) 2014-09-10
RU2007136716A (ru) 2009-04-10
WO2006094963A1 (en) 2006-09-14
BRPI0609351A2 (pt) 2011-10-18
JP2008532946A (ja) 2008-08-21
UA96411C2 (en) 2011-11-10
JP5435872B2 (ja) 2014-03-05

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120829

Termination date: 20150306

EXPY Termination of patent right or utility model