CN101125107A - Device and method for measuring animal motion ability - Google Patents
Device and method for measuring animal motion ability Download PDFInfo
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- CN101125107A CN101125107A CNA2006101094251A CN200610109425A CN101125107A CN 101125107 A CN101125107 A CN 101125107A CN A2006101094251 A CNA2006101094251 A CN A2006101094251A CN 200610109425 A CN200610109425 A CN 200610109425A CN 101125107 A CN101125107 A CN 101125107A
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- cage
- upset
- animal
- upset cage
- control system
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- 241001465754 Metazoa Species 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims description 18
- 230000007306 turnover Effects 0.000 claims abstract 2
- 238000010171 animal model Methods 0.000 claims description 11
- 238000012360 testing method Methods 0.000 claims description 9
- 238000005183 dynamical system Methods 0.000 claims description 8
- 238000011017 operating method Methods 0.000 claims description 2
- 238000011160 research Methods 0.000 abstract description 3
- 231100000027 toxicology Toxicity 0.000 abstract description 2
- 230000006399 behavior Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000037 inhalation toxicity test Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000002341 toxic gas Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- Housing For Livestock And Birds (AREA)
Abstract
The invention provides a device for measuring the movement capacity of an animal by utilizing an overturning cage. The device consists of a turnover cage, a bracket, a control system and a power system; when the turning cage is used, animals are placed in the turning cage, and the cage body can be turned for 180 degrees at any given time, so that the animals in the cage are turned to be ventral-side-up. The animal's ability to correct posture by itself is used to measure its ability to move. The device can continuously measure the movement ability of the animal without manual intervention, and compared with the traditional rotating cage, the device has clear judgment standard, less influence of environmental factors on animal behaviors and obvious advantages. The invention can be used for teaching and scientific research of pharmacology and toxicology.
Description
Technical field
The present invention is applicable to the toxicology field, can measure change and action time that various factors (medicine, poisonous gas etc.) causes the laboratory animal motor capacity.
Background technology
The method of measuring animal sports ability has multiple.The rotating cage method is the present method comparatively widely of using, and animal is placed rotating cage, and animal promptly begins to run and drives the rotation of upset cage, can rotate to determine the motor capacity of animal by the measurement rotating cage.The defective of this method is that animal is run continuously and can cause the fatigue of animal itself in the test of long period, also can make the hypomotility of animal, may obscure mutually with the hypomotility that experimental factor is caused.On the other hand, the terminal point of these class methods relatively is difficult for interpretation, when being subjected to the external disturbance factor affecting, occurs after the stop motion a period of time phenomenon of setting in motion again sometimes, has also influenced the result who measures.Other method such as rotating rods method, hill climbing etc., can not be under the situation of no manual intervention METHOD FOR CONTINUOUS DETERMINATION automatically, inapplicable for the inhalation test of carrying out in the exposure chamber.
Summary of the invention
For overcoming the existing deficiency of measuring animal sports ability rotating cage method, the present invention has designed the device of upset cage mensuration animal sports ability.The present invention comprises: a) utilize the upset cage to measure the device of animal sports ability; B) utilize the upset cage to measure the method for testing of animal sports ability.
The invention describes a kind of device of measuring animal sports ability, its general structural features in mind is: it is made of upset cage 8, support 3, control system 7, dynamical system; Upset cage 8 is installed on the support 3, profile, the size of support 3 and upset cage 8, and the quantity of upset cage 8 is different because of the animal species that it holds on the support 3.Dynamical system drives 8 rotations of upset cage by rotating shaft 11, and control system 7 is connected with control signal interface 1 by holding wire 2, the start and stop of control motor 6.
The present invention describes a kind of method of using said apparatus to measure animal sports ability, and its operating procedure is as follows: the moment of upset cage 8 upsets at first is set on controller 7, and laboratory animal is put into upset cage 8.After medicine, toxic gas etc. made the factor of animal sports ability change act on animal, the upset cage began by predefined moment upset, and user judges by the behavior of animal in the cage whether its motor capacity changes.If after the upset cage turned over turnback, animal capable independently recovered the regular appearance, thinks that its motor capacity does not have obvious change as yet; If after the upset of upset cage, animal transfers the outside of belly to and makes progress or the body appearance of lying on one's side, and can not independently recover regular appearance person, thinks that then it has lost motor capacity thereupon.The method can be used for measuring the laboratory animal motor capacity change that various factors causes.
Measuring the control system 7 of animal sports ability device is made up of programmable single chip computer, relay, contact switch 14, realize following function by programming: can set in advance the interval between motor operation number of times, the each running, and at specified time signaling, make motor begin rotation, control upset cage 8 turns over turnback in setting-up time.Specific implementation is: have metallic rod 13 in the upset cage rotating shaft 11, be provided with two contact switches 14 around the rotating shaft, its position is with respect to rotating shaft 11 symmetries.Controller 7 sends rotating signal, and motor 6 is started working, and drives rotating shaft 11 rotations by belt 16 and ratio wheel 17, drives all travelling gears 10 via driving chain 12, and upset cage 8 just begins synchronous rotation, and metallic rod 13 is rotation thereupon also.During to certain angle, metallic rod 13 is touched contact switch 14, and signal is passed controller 7 back, sends "signal for " stop " to motor 6 again.At this moment, upset cage 8 stops the rotation.To next specified rotation constantly, controller 7 sends rotating signal again, and upset cage 8 metallic rod 13 behind the Rotate 180 degree is met another contact switch 14, stops the rotation again.Circulation has and so forth realized every purpose of specifying the cage of order upset constantly Rotate 180 degree.
Measuring the dynamical system of animal sports ability device is made up of motor 6, ratio wheel 17, belt 16, travelling gear 10, chain 12, rotating shaft 11.Motor 6 rotations drive chain 12 after slowing down by ratio wheel 17, and chain 12 drives upset cage 8 and rotates synchronously.The rotational time of motor 6, angle are by control system 7 controls.
This device can carry out the motor capacity test automatically, continuously under the situation of no manual intervention.Do not expend a large amount of muscle power because laboratory animal is reversed the process of back recovery regular appearance, therefore can avoid the fatigue of animal in the long period test.Can to recover the regular appearance as the standard of judging whether motor capacity changes, terminal point be clear and definite clear, is not vulnerable to the influence of external disturbance factor, is easy to interpretation.Lose the factor of motor capacity applicable to the different animals that causes.
Description of drawings
The present invention is further described below in conjunction with drawings and Examples.
Fig. 1 is that the upset cage is measured animal sports ability apparatus structure sketch map.
Fig. 2 is dynamical system and control system principle schematic.
Among the figure: 1-control signal interface, 2-holding wire, 3-support, 4-bearing, 5-laboratory animal, 6-motor, the 7-control system, the 8-cage that overturns, 9-handle, 10-travelling gear, 11-rotating shaft, 12-chain, the 13-metal bar, 14-contact switch, 15-internal wiring, 16-belt, 17-ratio wheel.
The specific embodiment
Be example now, sketch the specific embodiment of this device and method with animal experiment in the research of fire smoke toxic hazard.
At first six rats are put into upset cage 8 respectively, and install on the support 3, support and upset cage are put into the fire gases exposure chamber, and holding wire 2 passes the exposure locular wall and is connected to the controller 7 that is positioned at outside the exposure chamber.It is appropriate to treat that holding wire 2 connects, and sets total upset number of times respectively and upset blanking time is 60 times and 30 seconds on controller, can begin to test.When the poisonous gas at simulated fire scene was sent into exposure chamber, opening controller order upset cage assembly began to overturn by preset program.Examine the behavior of upset cage when upset laboratory animal,, think that its motor capacity do not have obvious change if after the upset cage turned over turnback, animal capable independently recovered the regular appearance; If after the upset of upset cage, animal transfers the outside of belly to and makes progress or the body appearance of lying on one's side, and can not independently recover regular appearance person, thinks that then it has lost motor capacity thereupon.If find that animal has lost motor capacity when the N time upset, the moment that so really loses motor capacity should be between the N-1 time upset and the N time upset, for the ease of calculating, sets the moment T that this is positioned at the N-1 time upset constantly
N-1Moment T with N upset
NThe middle.Also promptly:
Lose motor capacity time=(T
N-1+ T
N)/2.
After the off-test, the motor capacity time that loses that we observe six rats was respectively 8.25,7.75,8.25,7.75,8.75,8.75 minutes, gas concentration then is in the exposure chamber that measures: oxygen 22.23%, carbon monoxide 4615ppm, carbon dioxide 2.79%.
Through repeatedly similarly test, gas concentration in the exposure chamber and animal LOM time are checked one against another, can study the rule that variable concentrations, various composition fire smokes influence the rat motor ability, as shown in table 1.
Table 1 fire smoke toxicity research test data
| Gas concentration | The rat LOM time (min) | |||||||
| CO(ppm) | CO 2(％) | O 2(％) | |
|
|
|
|
|
| 4614.99 4701.04 0.54 3831.65 3152.65 3959.16 2319.68 2215.91 2001.92 0.28 4533.11 1960.03 3294.60 3173.08 3641.62 0.07 | 2.79 6.31 7.69 0.35 0.47 6.76 0.38 7.12 9.05 9.38 8.60 4.17 2.68 0.34 9.07 3.86 | 22.23 23.62 22.40 22.27 22.05 21.85 21.27 21.14 21.13 21.11 20.99 20.81 20.67 20.36 20.22 19.28 | 8.25 8.75 5.75 8.25 18.75 11.75 13.75 13.75 10.25 28.75 | 7.75 7.25 5.25 8.25 18.25 18.25 6.75 14.25 11.75 25.75 | 8.25 9.75 6.25 7.75 20.25 5.75 14.25 9.75 16.75 | 7.75 10.25 5.75 9.25 9.25 25.75 14.75 11.75 7.75 | 8.75 10.75 5.75 7.75 16.25 7.75 11.75 9.25 13.75 | 8.75 8.25 6.25 8.75 17.25 24.25 13.75 11.75 8.25 20.25 |
Claims (5)
1. a device of measuring animal sports ability is characterized by: be made of upset cage (8), support (3), control system (7), dynamical system; Upset cage (8) is installed on the support (3), and dynamical system drives upset cage (8) rotation by rotating shaft (11), and control system (7) is connected with control signal interface (1) by holding wire (2), the start and stop of control motor (6).
2. method of measuring animal sports ability, it is characterized by: this method operating procedure is as follows: at first be provided with the upset cage (8) always overturn number of times and the upset blanking time, and with laboratory animal put into the upset cage, upset cage (8) begins turning, periodically the body appearance of breaking test animal is recovered the ability of regular appearance voluntarily and is weighed the laboratory animal motor capacity according to laboratory animal.
3. mensuration animal sports ability device according to claim 1 is characterized in that: control system (7) is made up of programmable single chip computer, relay, contact switch (14), and control upset cage (8) turns over turnback in setting-up time; When control system (7) is sent rotating signal, motor (6) drives rotating shaft (11) rotation by belt (16) and ratio wheel (17), makes six upset cages (8) beginning rotation synchronously, during to certain angle, metallic rod (13) is touched contact switch (14), and upset cage (8) stops the rotation; To next specified rotation constantly, control system (7) is sent rotating signal again, and circulation and so forth reaches the purpose of specifying the cage (8) of order upset constantly Rotate 180 degree.
4. mensuration animal sports ability device according to claim 1 is characterized in that: dynamical system is made up of motor (6), ratio wheel (17), belt (16), travelling gear (10), chain (12), rotating shaft (11); Under control system (7) control, drive upset cage (8) rotation.
5. mensuration animal sports ability device according to claim 1, it is characterized by: can hold different laboratory animals in the upset cage (8), the upset cage is installed on the support (3), upset cage (8) two ends are rotating shaft (11), rotating shaft (11) can be dismantled from the bearing of support (3), and handle (9) is equipped with in support (3) upper end; By the dynamical system driving, under control system control, upset cage (8) can turn over turnback at setting-up time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610109425A CN101125107B (en) | 2006-08-15 | 2006-08-15 | Device for measuring animal sports ability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610109425A CN101125107B (en) | 2006-08-15 | 2006-08-15 | Device for measuring animal sports ability |
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| Publication Number | Publication Date |
|---|---|
| CN101125107A true CN101125107A (en) | 2008-02-20 |
| CN101125107B CN101125107B (en) | 2010-05-12 |
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ID=39093303
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200610109425A Expired - Fee Related CN101125107B (en) | 2006-08-15 | 2006-08-15 | Device for measuring animal sports ability |
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| Country | Link |
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| CN (1) | CN101125107B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810516A (en) * | 2010-04-07 | 2010-08-25 | 中国航天员科研训练中心 | Rat swing experiment table |
| CN102608276A (en) * | 2012-04-10 | 2012-07-25 | 英贝儿(天津)测控设备有限责任公司 | Rotating cage device for measuring smoke toxicity of building material and automatic speed measurement method for rotating cage device |
| CN106896222A (en) * | 2017-01-22 | 2017-06-27 | 浙江中医药大学 | A kind of mouse horizontally rotates persistence test device |
| CN108438738A (en) * | 2018-04-02 | 2018-08-24 | 安徽古井贡酒股份有限公司 | Automate knee-piece turnover device |
| CN111972302A (en) * | 2020-06-22 | 2020-11-24 | 道赛尔生物科技（武汉）有限公司 | Depression animal model construction system and experimental method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2673086Y (en) * | 2003-12-29 | 2005-01-26 | 陈闻天 | Experimental mouse exercise wheel frame |
| JP4160003B2 (en) * | 2004-02-26 | 2008-10-01 | 株式会社冨永樹脂工業所 | Small animal breeding equipment |
-
2006
- 2006-08-15 CN CN200610109425A patent/CN101125107B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810516A (en) * | 2010-04-07 | 2010-08-25 | 中国航天员科研训练中心 | Rat swing experiment table |
| CN101810516B (en) * | 2010-04-07 | 2011-06-22 | 中国航天员科研训练中心 | Rat swing experiment table |
| CN102608276A (en) * | 2012-04-10 | 2012-07-25 | 英贝儿(天津)测控设备有限责任公司 | Rotating cage device for measuring smoke toxicity of building material and automatic speed measurement method for rotating cage device |
| CN106896222A (en) * | 2017-01-22 | 2017-06-27 | 浙江中医药大学 | A kind of mouse horizontally rotates persistence test device |
| CN108438738A (en) * | 2018-04-02 | 2018-08-24 | 安徽古井贡酒股份有限公司 | Automate knee-piece turnover device |
| CN111972302A (en) * | 2020-06-22 | 2020-11-24 | 道赛尔生物科技（武汉）有限公司 | Depression animal model construction system and experimental method thereof |
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| Publication number | Publication date |
|---|---|
| CN101125107B (en) | 2010-05-12 |
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