CN101124996B - Secondary fermentation whole wheat chewing tablet and preparation method thereof - Google Patents
Secondary fermentation whole wheat chewing tablet and preparation method thereof Download PDFInfo
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- CN101124996B CN101124996B CN200710175481XA CN200710175481A CN101124996B CN 101124996 B CN101124996 B CN 101124996B CN 200710175481X A CN200710175481X A CN 200710175481XA CN 200710175481 A CN200710175481 A CN 200710175481A CN 101124996 B CN101124996 B CN 101124996B
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Abstract
The present invention aims at providing a secondary fermentation whole wheat chewable tablet, containing secondary fermentation whole wheat, composite vitamin, composite mineral matter, thinner, adhesive, lubricant and glidant; wherein, the content of the thinner in the preparation accounts for 10 to 30 percent, the content of the lubricant and the glidant adds up to 1 to 10 percent, preferring 1 to 5 percent accounted by the weight per cent; wherein, the thinner consists of the water-soluble thinner and the water-insoluble thinner, the weight ratio of the water-soluble thinner and the water-insoluble thinner in the thinner is from 1:1 to 5:1.
Description
Technical field
The present invention relates to a kind of as health oral chewable tablet and preparation method thereof, particularly a kind of secondary fermentation whole wheat chewing tablet and preparation method thereof.
Background technology
Overweight and obesity has become the unhealthful topmost problem of developed country, finally can cause a series of diseases, as angiocardiopathy and type ii diabetes.About 1.46 hundred million crowds in the whole world suffer from type ii diabetes, and just body can not be replied normal level insulin.The harm of diabetes is huge, in western countries, 1 example is just arranged by due to the diabetes in the blind case of per 2 examples.Need among the patient of regular dialysis at all, 65% is relevant with diabetes.Just there is 1 example to cause (2.8 ten thousand examples being arranged every year) in the per 2 routine amputation cases as Germany by diabetes.At present, people attempt to seek the dietary supplements that can control worker's type i diabetes blood sugar.
The secondary fermentation whole wheat that adopts yeast/lactobacillus-fermented is the full wheat products (the starch residual quantity is 2.9%) that a kind of content of starch significantly reduces, can strengthen the obese people insulin sensitivity, stimulate enteron aisle rule defecation, continue to reduce body weight, make insulin level and blood sugar level normal, avoid or reduce the use of diabetes medicament, be applicable to overweight, potential diabetes (hyperinsulinemia), be diagnosed as the borderline diabetes patient of hyperglycaemia by the doctor, do not take the diabetic of antidiabetic medicine and adhere to taking Remedies for diabetes patient's health diet.
Yet there is certain problem in secondary fermentation whole wheat when making tablet, is easy to generate situations such as unilateral coarse, pitted skin.And, if when further it being prepared into chewable tablets, because the not good problem of mouthfeel can appear in wherein full wheat content height for taking convenience.Therefore, need a kind of secondary fermentation whole wheat chewing tablet agent of attractive in appearance, comfortable taste easy to prepare, unilateral on the market.
Summary of the invention
Inventor of the present invention finds can obtain conforming in every respect to the secondary fermentation whole wheat chewing tablet agent of requirement, thereby finish the present invention under specific formulation constituent and certain proportioning through lot of experiments.
The purpose of this invention is to provide a kind of unilateral smooth, friability is qualified, the secondary fermentation whole wheat chewing tablet agent of good mouthfeel, contains secondary fermentation whole wheat, B B-complex, composite mineral matter and diluent, adhesive, lubricant and glidant.Wherein, the content of diluent in preparation is 10～30%, and the content of glidant and lubricant adds up to 1～10%, and is preferred 1～5%, by weight percentage.
B B-complex in the secondary fermentation whole wheat chewing tablet agent of the present invention comprises: vitamin A (1000IU/ sheet), vitamin D (800IU/ sheet), Cobastab (5mg/ sheet), vitamin C (20mg/ sheet), vitamin B1 (1.Omg/ sheet), vitamin B2 (1.0mg/ sheet), nicotinic acid (8mg/ sheet), pantothenic acid (1.7mg/ sheet), vitamin B6 (0.8mg/ sheet), folic acid (90.5ug/ sheet), cobalamin (2ug/ sheet), biotin (0.01mg/ sheet) and a spot of lactose; Composite mineral matter comprises: magnesium (180mg/ sheet), iron (15mg/ sheet), zinc (8mg/ sheet), phosphorus (306mg/ sheet), copper (0.55mg/ sheet), iodine (80ug/ sheet), manganese (1.1mg/ sheet), potassium (14.5mg/ sheet), calcium (465mg/ sheet), selenium (75ug/ sheet) and a spot of lactose.B B-complex of the present invention is encouraged into Industrial Co., Ltd. with composite mineral matter available from Shanghai
In the secondary fermentation whole wheat chewing tablet agent of the present invention, diluent is made up of water-soluble diluent and water-insoluble diluent, wherein, water-soluble diluent is selected from sweet mellow wine, sorbierite, xylitol, lactose, sucrose glucose or their mixture, preferred sweet mellow wine, sorbierite or their mixture, most preferably sweet mellow wine; The water-insoluble diluent is selected from microcrystalline cellulose, starch, dextrin, pregelatinized starch, calcium sulfate, calcium monohydrogen phosphate or their mixture, preferably microcrystalline cellulose.The weight ratio of water-soluble diluent and water-insoluble diluent is 1: 1 to 5: 1 in the diluent.
Among the preparation method of secondary fermentation whole wheat chewing tablet of the present invention, glidant is selected from superfine silica gel powder; Lubricant is selected from dolomol, stearic acid, calcium stearate, polyethylene glycol, talcum powder, zinc stearate etc., preferred dolomol.The weight ratio of glidant and lubricant is 1: 10 to 10: 1, preferred 1: 1 to 5: 1.
In the secondary fermentation whole wheat chewing tablet agent of the present invention, adhesive is selected from polyvinylpyrrolidone, hydroxypropyl methylcellulose, starch slurry etc., preferably polyethylene pyrrolidones.
Can also randomly add sweetener or aromatic in the chewable tablets of the present invention, wherein, sweetener can be selected from asccharin or its sodium salt, Stevioside, Aspartame, honey element, glycyrrhizin, preferably saccharin sodium, Stevioside, Aspartame.Aromatic in the chewable tablets can be selected from various natural and artificial essence and fragrant flavor enhancement, concrete as vanillic aldehyde, cinnamic acid, fragrant lance alcohol, cineol, petit grain oil, ennel oil, menthol, peppermint oil, lemon extract, cherry essence, strawberry essence, flavoring pineapple essence, red bayberry essence, grape essence, chocolate essence, coffee aroma, flavoring peach essence, milk flavour, orange flavor, preferably vanillic aldehyde, menthol, lemon extract, grape essence, milk flavour, orange flavor.Chewable tablets can not add colouring agent in addition, also can add colouring agent, concrete colouring agent that adds such as carrotene, sunset yellow, beet red, lemon yellow, chlorophyll, famille rose, amaranth, erythrosine etc.
Another object of the present invention, provide a kind of preparation method of secondary fermentation whole wheat chewing tablet agent, may further comprise the steps: full wheat was pulverized 80 orders, composite mineral matter, mixing diluents and was made particle, with adhesive 16 mesh sieve system particles, 55 degree forced air dryings behind the whole grain of 16 mesh sieves, add B B-complex powder, essence, glidant, lubricant, behind the mixing, compressing tablet.
Wherein, the content of diluent in preparation is 10～30%, and the content of glidant and lubricant adds up to 1～5%, by weight percentage.
In the secondary fermentation whole wheat chewing tablet agent of the present invention, diluent is made up of water-soluble diluent and water-insoluble diluent, wherein, water-soluble diluent is selected from sweet mellow wine, sorbierite, xylitol, lactose, sucrose glucose or their mixture, preferred sweet mellow wine, sorbierite or their mixture, most preferably sweet mellow wine; The water-insoluble diluent is selected from microcrystalline cellulose, starch, dextrin, pregelatinized starch or their mixture, preferably microcrystalline cellulose.The weight ratio of water-soluble diluent and water-insoluble diluent is 1: 1 to 5: 1 in the diluent.
Among the preparation method of secondary fermentation whole wheat chewing tablet of the present invention, glidant is selected from superfine silica gel powder; Lubricant is selected from dolomol, stearic acid, calcium stearate, polyethylene glycol, talcum powder, zinc stearate etc., preferred dolomol.The weight ratio of glidant and lubricant is 1: 10 to 10: 1.
In the secondary fermentation whole wheat chewing tablet agent of the present invention, adhesive is selected from polyvinylpyrrolidone, hydroxypropyl methylcellulose, starch slurry etc., preferably polyethylene pyrrolidones.
Can also randomly add sweetener or aromatic in the chewable tablets of the present invention, wherein, sweetener can be selected from asccharin or its sodium salt, Stevioside, Aspartame, honey element, glycyrrhizin, preferably saccharin sodium, Stevioside, Aspartame.Aromatic in the chewable tablets can be selected from various natural and artificial essence and fragrant flavor enhancement, concrete as vanillic aldehyde, cinnamic acid, fragrant lance alcohol, cineol, petit grain oil, ennel oil, menthol, peppermint oil, lemon extract, cherry essence, strawberry essence, flavoring pineapple essence, red bayberry essence, grape essence, chocolate essence, coffee aroma, flavoring peach essence, milk flavour, orange flavor, preferably vanillic aldehyde, menthol, lemon extract, grape essence, milk flavour, orange flavor.Chewable tablets can not add colouring agent in addition, also can add colouring agent, concrete colouring agent that adds such as carrotene, sunset yellow, beet red, lemon yellow, chlorophyll, famille rose, amaranth, erythrosine etc.
Secondary fermentation whole wheat chewing tablet of the present invention, the preparation method is simple, cost is low, active component stable in properties in the sheet, prepared tablet surface is smooth, friability is little, and be easy to transportation, store, good mouthfeel, the user takes like a shot.
Secondary fermentation whole wheat chewing tablet of the present invention is chewed and is taken, and has solved anhydrous problem of taking with dysphagia, chews in the process simultaneously and saliva is fully mixed, and helps absorbing of active ingredient, can be with the effect of good performance secondary fermentation whole wheat.The hardness of this chewable tablet is moderate, fragrant odour, good mouthfeel, is fit to all kinds of crowds' use.
The specific embodiment
Embodiment 1
Full wheat 66g
B B-complex 6.3g
Composite mineral matter 0.2g
Sweet mellow wine 13g
Microcrystalline cellulose 6.5g
Milk flavour 5g
Superfine silica gel powder 2g
Dolomol 1g
Method for making:
1, full wheat was pulverized 80 orders, composite mineral matter, sweet mellow wine, microcrystalline cellulose and was mixed and made into particle, with the 45% ethanolic solution system particle of 15%pvp, and 16 mesh sieve systems, 55 spend forced air dryings, about 2 hours.
2, behind the whole grain of 16 mesh sieves, add B B-complex powder, milk flavour, superfine silica gel powder, dolomol, behind the mixing, compressing tablet.The gained tablet is unilateral smooth, friability 0.5%.
Embodiment 2
Full wheat 66g
B B-complex 6.3g
Composite mineral matter 0.2g
Sorbierite 10.4g
Microcrystalline cellulose 2.1g
Milk flavour 5g
Superfine silica gel powder 2.5g
Dolomol 0.5g
Method for making:
1, full wheat was pulverized 80 orders, composite mineral matter, sorbierite, microcrystalline cellulose and was mixed and made into particle, with the 45% ethanolic solution system particle of 15%pvp, and 16 mesh sieve systems, 55 spend forced air dryings, about 2 hours.
2, behind the whole grain of 16 mesh sieves, add B B-complex powder, milk flavour, superfine silica gel powder, dolomol, behind the mixing, compressing tablet.Gained tablet friability 1.8%.
Embodiment 3
Full wheat 66g
B B-complex 6.3g
Composite mineral matter 0.2g
Sweet mellow wine 14.5g
Microcrystalline cellulose 15g
Milk flavour 5g
Superfine silica gel powder 1.5g
Dolomol 1.5g
Method for making:
1, full wheat was pulverized 80 orders, composite mineral matter, sorbierite, microcrystalline cellulose and was mixed and made into particle, with the 45% ethanolic solution system particle of 15%pvp, and 16 mesh sieve systems, 55 spend forced air dryings, about 2 hours.
2, behind the whole grain of 16 mesh sieves, add B B-complex powder, milk flavour, superfine silica gel powder, dolomol, behind the mixing, compressing tablet.Gained tablet friability 1.4%.
Embodiment 4
100 healthy volunteers give embodiment the secondary fermentation whole wheat chewing tablet of 1 preparation, and mouthfeel is divided into not good, general, good Three Estate, estimate.As a result, reflection good mouthfeel person accounts for 95%, and mouthfeel general person 5%, does not have reflection mouthfeel gastrointestinal disease patient.
Embodiment 5
50 body obesity volunteers give embodiment the secondary fermentation whole wheat chewing tablet of 1 preparation, took continuously three months, and changes of weight such as following table, wherein, body weight decline 5kg is above to be effective.
| Original body weight kg | Average weight decline kg | The experiment number | Efficient % |
| 100-120 | 9.2 | 40 | 80％ |
| 90-100 | 8.4 | 55 | 86.7 |
| 80-90 | 5.1 | 35 | 77.1 |
In the process of taking, volunteer's physique has good improvement, and the phenomenon of nonnutritive bad and microelement deficiencies, and the index of other healthy aspects is also all fine.
Claims (9)
1. secondary fermentation whole wheat chewing tablet agent, contain secondary fermentation whole wheat, B B-complex, composite mineral matter, diluent, adhesive, glidant and lubricant, wherein, the content of diluent in preparation is 10～30%, the content of glidant and lubricant adds up to 1～5%, by weight percentage, described diluent is made up of water-soluble diluent and water-insoluble diluent, and water-soluble diluent is selected from sweet mellow wine, sorbierite, xylitol, lactose, sucrose, glucose or their mixture; The water-insoluble diluent is selected from microcrystalline cellulose, starch, dextrin, pregelatinized starch, calcium sulfate, Lin acid hydrogen calcium or their mixture.
2. according to the chewable tablet of claim 1, wherein water-soluble diluent is selected from sweet mellow wine, sorbierite or their mixture, and the water-insoluble diluent is selected from microcrystalline cellulose.
3. according to the chewable tablet of claim 1 or 2, wherein, the weight ratio of water-soluble diluent and water-insoluble diluent is 1: 1 to 5: 1.
4. according to the chewable tablet of claim 1, wherein adhesive is selected from polyvinylpyrrolidone, hydroxypropyl methylcellulose, starch slurry.
5. according to the chewable tablet of claim 4, wherein adhesive is selected from polyvinylpyrrolidone.
6. according to the chewable tablet of claim 1, glidant is selected from superfine silica gel powder; Lubricant is selected from dolomol, stearic acid, calcium stearate, polyethylene glycol, zinc stearate.
7. according to the chewable tablet of claim 6, wherein lubricant is selected from dolomol.
8. according to the chewable tablet of claim .6 or 7, wherein the weight ratio of glidant and lubricant is 1: 10 to 10: 1
9. the preparation method of the chewable tablet of each claim among the claim 1-8, comprise full wheat pulverizing, composite mineral matter, mixing diluents are made particle, with adhesive system particle, dry, whole grain, add B B-complex powder, glidant, lubricant and other auxiliary material, the step of mixing compressing tablet.
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| CN200710175481XA CN101124996B (en) | 2007-09-29 | 2007-09-29 | Secondary fermentation whole wheat chewing tablet and preparation method thereof |
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| CN200710175481XA CN101124996B (en) | 2007-09-29 | 2007-09-29 | Secondary fermentation whole wheat chewing tablet and preparation method thereof |
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| CN101124996B true CN101124996B (en) | 2010-11-10 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101912110B (en) * | 2010-07-14 | 2012-10-31 | 北京世纪博康医药科技有限公司 | Composite with effects of losing weight and lowering blood sugar and blood lipid |
| CN102113606A (en) * | 2010-12-31 | 2011-07-06 | 张胜勇 | Slimming candy and preparation method thereof |
| CN105231442A (en) * | 2015-09-29 | 2016-01-13 | 福建农林大学 | Poria cocos wheat chewing tablet and preparation method thereof |
| CN106820133A (en) * | 2017-01-11 | 2017-06-13 | 江苏大学 | A kind of Lactobacillus plantarum fermentation Fructus Hordei Vulgaris extract tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1418574A (en) * | 2002-12-27 | 2003-05-21 | 周勇 | Chewing tablet made of food fiber, and its prepn. method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1418574A (en) * | 2002-12-27 | 2003-05-21 | 周勇 | Chewing tablet made of food fiber, and its prepn. method |
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Address after: 430056 Wuhan economic and Technological Development Zone, Hubei Maple Road No. three, No. 9 Patentee after: Ferguson (Wuhan) Biological Technology Co., Ltd. Address before: 430051 No. 8 building, hi tech Industrial Park, Wuhan economic and Technological Development Zone, Hubei Patentee before: Ferguson (Wuhan) Biological Technology Co., Ltd. |
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Address after: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee after: FERGUSON (WUHAN) BIOTECHNOLOGY CO., LTD. Address before: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei Patentee before: Ferguson (Wuhan) Biological Technology Co., Ltd. |