CN101116673A - Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes for their preparation - Google Patents
Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes for their preparation Download PDFInfo
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- CN101116673A CN101116673A CNA2006100696460A CN200610069646A CN101116673A CN 101116673 A CN101116673 A CN 101116673A CN A2006100696460 A CNA2006100696460 A CN A2006100696460A CN 200610069646 A CN200610069646 A CN 200610069646A CN 101116673 A CN101116673 A CN 101116673A
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Abstract
A diarrhea-relieving with astringents colon-positioning enteric-coated pharmaceutical preparation and the preparation method thereof belong to a colon-positioning enteric-coated pharmaceutical preparation technical field. Active ingredients of the preparation are montmorillonite and Rhizome Rhodesia; adopting coating treatment with colon coating materials, the medicine does not disintegrate and release on an upper digestive tract; the preparation arrives at a colon part and disintegrates rapidly and releases the medicine in order that the medicine can be contacted with an intestinal focus part directly to improve curative effect.
Description
Technical field
The present invention relates to the pharmaceutical preparation of a kind of conlon targeting enteric, be specifically related to middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes and preparation method thereof.
Background technology
The Montmorillonitum medicine, have lamellar structure and heterogeneity CHARGE DISTRIBUTION, toxin to digestive tract virus, pathogenic bacteria and generation thereof has fixed inhibitory action, the digestion mucous membrane there is very strong covering power, and by mutually combining with mucous glycoprotein, from quality and quantity two aspect reparations, improve the defense function of mucosal barrier to attack factor.Montmorillonitum does not enter blood circulation, and together with the wriggling of fixed attack factor by digestive tract self excrete, Montmorillonitum does not influence X-ray examination, does not change the color of stool, does not change normal enterokinesia.
Rhizoma Rodgersiae is the Miao Ethnomedicine conventional crude drugs, and nature and flavor hardship, puckery is flat.Function cure mainly for analgesic, dispel the wind, the convergence.Be used for enteritis, dysentery, traumatic hemorrhage.Montmorillonitum and Rhizoma Rodgersiae associating prescription help the recovery of function of intestinal canal.
At present, the pharmaceutical dosage form that uses relieving diarrhea with astringents to loose on the market is powder, keeps the relieving diarrhea with astringents coloclysis administration of loosing in order to improve treatment colitis effect, also to adopt clinically, be beneficial to the colonic pathological change position directly, the long period contact.So clinical therapeutic efficacy is preferable.But coloclysis administration patient is very painful, and medical personnel's workload is big, and uses inconvenience, thereby patient's poor compliance.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of good drug efficacy, middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes that patient's compliance is strong and preparation method thereof are provided.
Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes effective ingredient of the present invention is Montmorillonitum and Rhizoma Rodgersiae.Said preparation is tablet or capsule.
Said preparation also comprises pharmaceutic adjuvant, mainly contains binding agent, lubricant etc.Binding agent is selected from starch, carboxymethyl starch sodium or microcrystalline Cellulose.Lubricant is magnesium stearate or Pulvis Talci.
Said preparation has the outer coatings film, and coating solution components is polyacrylic resin III, dibutyl phthalate, Pulvis Talci, titanium dioxide and ethanol.Preferred 80% ethanol of ethanol wherein.
Preferably, described tablet ingredients is as follows, is weight portion:
(1) label prescription:
500～1000 parts of Montmorillonitums
833～1667 parts of Rhizoma Rodgersiae
10～50 parts of binding agents
0.5～5 part of lubricant
(2) coating fluid prescription:
30～200 parts of polyacrylic resin III
2.5～20 parts of dibutyl phthalates
8～50 parts of titanium dioxides
8～50 parts of Pulvis Talci
500～1000 parts of ethanol.
Preferably, described capsule component is as follows, is weight portion:
(1) capsule 's content prescription:
500～750 parts of Montmorillonitums
833～1250 parts of Rhizoma Rodgersiae
10～50 parts of binding agents
0.5～5 part of lubricant
By above prescription, the conventional capsule of packing into, and carry out coating with following coating solution; Or in the colon colloidal sol capsule of using following coating solution coating of packing into;
(2) coating fluid prescription:
30～200 parts of polyacrylic resin III
2.5～20 parts of dibutyl phthalates
8～50 parts of Pulvis Talci
500～1000 parts of ethanol.
The preparation method of a kind of relieving diarrhea with astringents conlon targeting pharmaceutical preparation, step is as follows:
(a) pretreatment of Rhizoma Rodgersiae medical material;
Take by weighing the Rhizoma Rodgersiae pulverizing medicinal materials and become coarse powder, with 80% soak with ethanol three times, for the first time, soaked 48 hours, soaking with the ethanol consumption is 5～10 times of medical material weight, the second time with soaked for the third time 24 hours, the ethanol consumption is 3～5 times of Rhizoma Rodgersiae weight, merge three times soak, decompression recycling ethanol also is concentrated into the extractum of 1.10～1.20/50～60 ℃ of relative densities.Add hydrochloric acid and regulate pH value to 2, standing over night filters, and filtrate decompression is concentrated into the thick paste of 1.20～1.40/50～60 ℃ of relative densities, add 5 times of amount 80% ethanol and make dissolving, add activated carbon decolorizing, filter, filtrate is concentrated into 1/2 of former thick paste volume, leave standstill, filter, get crystalline deposit, be ground into fine powder dry below 80 ℃;
(b) preparation of tablet:
With the Rhizoma Rodgersiae after handling and Montmorillonitum and binding agent mix by above-mentioned tablet formulation close even after, with 80% ethanol system soft material, granulation, drying, granulate, add the mix lubricant tabletting; By above-mentioned coating fluid prescription preparation coating solution, tabletting is carried out coating, promptly get the relieving diarrhea with astringents colon-positioning enteric tablet;
(c) preparation of capsule:
Take by weighing Montmorillonitum, Rhizoma Rodgersiae and other compositions by the capsule 's content mixed pelletization of writing out a prescription, the conventional capsule of packing into; By above-mentioned coating fluid prescription preparation coating solution, capsule is carried out coating, promptly get relieving diarrhea with astringents conlon targeting enteric coated capsule.
Preferably, described coating parameter is: coating flow velocity 2.6ml/min, and 40 ℃ of inlet temperatures, 1.3kgf/cm is pressed in spray
2
Relieving diarrhea with astringents colon-positioning enteric tablet dissolution in vitro of the present invention: 2hrs in 37 ℃ of simulated gastric fluids, coating membrane is intact, not disintegrate of slice, thin piece; 3hrs in the pH6.8 simulated intestinal fluid, coating membrane is intact, not disintegrate of slice, thin piece; In the artificial colonic fluid of pH7.8, the 1hr stripping is more than 85%.
Relieving diarrhea with astringents conlon targeting enteric coated capsule dissolution in vitro of the present invention: 2hrs in 37 ℃ of simulated gastric fluids, softgel shell is intact, not disintegrate of capsule; 3hrs in the pH6.8 simulated intestinal fluid, softgel shell is intact, not disintegrate of capsule; In the artificial colonic fluid of pH7.8, the 1hr stripping is more than 85%.
Relieving diarrhea with astringents colon-positioning enteric tablet of the present invention and relieving diarrhea with astringents conlon targeting enteric coated capsule, all adopt packing barium sulfate spike preparation to carry out tracking test in the human body, X-ray checks that film making record result shows: the barium sulfate spike preparation that human body is obeyed is all in the disintegrate of ileocecum position.
The present invention uses elite adjuvant, different according to each position pH value of human stomach, small intestinal and colon.Make it disintegrate under colon pH environment, discharge medicine.Be prepared into the relieving diarrhea with astringents colon location preparation, reach the purpose of conlon targeting.This kind preparation arrives distal small intestine in not disintegrate of upper digestive tract, do not discharge, disintegrate and discharge medicine when the colon position, and medicine is concentrated relatively and is distributed in the colon position, directly contacts the raising curative effect with the intestinal lesions position.This EXPERIMENTAL DESIGN barium sulfate-containing spike preparation carries out human body X-ray and follows the tracks of, to determine said preparation disintegrate position in human body.Result of the test shows that this colon location preparation returns at human body, the directed disintegrate in caecum position discharges.
The specific embodiment
Embodiment 1. relieving diarrhea with astringents colon-positioning enteric tablets
Label prescription: (1000)
Montmorillonitum 500.0g
Rhizoma Rodgersiae 833.3g
Starch 10.0g
Magnesium stearate 2.5g
Coating fluid prescription:
Polyacrylic resin III 35.0g
Dibutyl phthalate 3.5g
Titanium dioxide 8.0g
Pulvis Talci 8.0g
80% ethanol 680g
Preparation method, step is as follows:
(a) pretreatment of Rhizoma Rodgersiae medical material;
Take by weighing the Rhizoma Rodgersiae pulverizing medicinal materials and become coarse powder, with 80% soak with ethanol three times, for the first time, soaked 48 hours, soaking with the ethanol consumption is 8 times of medical material amounts, the second time with soaked for the third time 24 hours, the ethanol consumption is 4 times of Rhizoma Rodgersiae weight, merge three times soak, decompression recycling ethanol also is concentrated into the extractum of 1.10～1.20/50～60 ℃ of relative densities.Add hydrochloric acid and regulate pH value to 2, standing over night filters, and filtrate decompression is concentrated into the thick paste of 1.20～1.40/50～60 ℃ of relative densities, add 5 times of amount 80% ethanol and make dissolving, add activated carbon decolorizing, filter, filtrate is concentrated into 1/2 of former thick paste volume, leave standstill, filter, get crystalline deposit, be ground into fine powder dry below 80 ℃;
(b) preparation of tablet:
Rhizoma Rodgersiae after handling and Montmorillonitum and binding agent are pressed label write out a prescription behind the mix homogeneously,, add the mix lubricant tabletting with 80% ethanol system soft material, granulation, drying, granulate; By coating fluid prescription preparation coating solution, tabletting is carried out coating, promptly get the relieving diarrhea with astringents colon-positioning enteric tablet; The coating parameter: the flow velocity 2.6ml/min of coating solution, 40 ℃ of inlet temperatures, 1.3kgf/cm is pressed in spray
2, coating weightening finish 6～10%.
Embodiment 2. relieving diarrhea with astringents colon-positioning enteric tablets
Label prescription: (1000)
Montmorillonitum 500g
Rhizoma Rodgersiae 833.3g
Carboxymethyl starch sodium 30g
Magnesium stearate 2.5g
Coating fluid prescription:
Polyacrylic resin III50g
Dibutyl phthalate 16g
Titanium dioxide 40g
Pulvis Talci 40g
80% ethanol 850g
Preparation method is with embodiment 1, and coating increases weight 6～10%.
Embodiment 3. relieving diarrhea with astringents colon-positioning enteric tablets
Label prescription: (1000)
Montmorillonitum 500g
Rhizoma Rodgersiae 833.3g
Starch 30g
Magnesium stearate 3g
Coating fluid prescription:
Polyacrylic resin III 100g
Dibutyl phthalate 10g
Titanium dioxide 50g
Pulvis Talci 50g
80% ethanol 850g
The coating parameter:
The flow velocity 2.6ml/min of coating solution
40 ℃ of inlet temperatures
1.3kgf/cm is pressed in spray
2
Preparation method is with embodiment 1, and coating increases weight 6～10%.
Embodiment 4. relieving diarrhea with astringents colon-positioning enteric tablets
Label prescription: (1000)
Montmorillonitum 1000g
Rhizoma Rodgersiae 1667g
Microcrystalline Cellulose 10g
Pulvis Talci 5g
Coating fluid prescription:
Polyacrylic resin III 50g
Dibutyl phthalate 2.4g
Titanium dioxide 30g
Pulvis Talci 30g
80% ethanol 850g
Preparation method is with embodiment 1, and coating increases weight 3～6%.
Embodiment 5. relieving diarrhea with astringents colon-positioning enteric tablets
The label prescription:
Montmorillonitum 500g
Rhizoma Rodgersiae 833.3g
Microcrystalline Cellulose 10g
Magnesium stearate 2.5g
Coating fluid prescription:
Polyacrylic resin III 50g
Dibutyl phthalate 2.4g
Titanium dioxide 35g
Pulvis Talci 35g
80% ethanol 850g
Preparation method is with embodiment 1, and coating increases weight 3～6%.
Embodiment 6. relieving diarrhea with astringents colon-positioning enteric tablets
Label prescription: (1000)
Montmorillonitum 750g
Rhizoma Rodgersiae 1200g
Microcrystalline Cellulose 30g
Magnesium stearate 3g
Coating fluid prescription:
Polyacrylic resin III 50g
Dibutyl phthalate 3.5g
Titanium dioxide 8g
Pulvis Talci 8g
80% ethanol 680g
Preparation method is with embodiment 1, and coating increases weight 6～10%.
Embodiment 7. relieving diarrhea with astringents conlon targeting enteric coated capsulees
Capsule 's content prescription: (1000)
Montmorillonitum 750g
Rhizoma Rodgersiae 1200g
Starch 30g
Magnesium stearate 4g
By above prescription, the conventional capsule of packing into, and carry out coating with following coating solution; The flow velocity 2.6ml/min of coating solution, 40 ℃ of inlet temperatures, 1.3kgf/cm is pressed in spray
2, coating weightening finish 6～10%.
Coating fluid prescription:
Polyacrylic resin III 100g
Dibutyl phthalate 2.4g
Pulvis Talci 45g
80% ethanol 680g.
The pretreatment of Rhizoma Rodgersiae medical material is with embodiment 1.
Embodiment 8. relieving diarrhea with astringents conlon targeting enteric coated capsulees
The capsule 's content prescription:
Montmorillonitum 500g
Rhizoma Rodgersiae 833g
Starch 10g
Magnesium stearate 1g
By above prescription, the conventional capsule of packing into, and carry out coating with following coating solution; The flow velocity 2.6ml/min of coating solution, 40 ℃ of inlet temperatures, 1.3kgf/cm is pressed in spray
2, coating weightening finish 6～10%.
Coating fluid prescription:
Polyacrylic resin III 60g
Dibutyl phthalate 3.4g
Pulvis Talci 10g
80% ethanol 700g.
The pretreatment of Rhizoma Rodgersiae medical material is with embodiment 1.
It below is the clinical trial case of middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes of the present invention.
Case 1: Lee so-and-so, man, 57 years old, medical history: irritable bowel syndrome.The clinical manifestation of taking the preceding patient of this preparation is: stomachache, diarrhea, stool variable interval, stool is the water sample shape, surplus times of defecation reaches 6 average every day time, abdominal part has distending pain, adopts this preparation for treating after 15 days, and patient's stomachache alleviates, the distending pain sense slows down, stool is shaped, and times of defecation obviously reduces every day about 2 times.
Case 2: Zhao, woman, 47 years old, medical history: colitis.The clinical manifestation of taking the preceding patient of this preparation is: abdominal part distending pain, diarrhea, and the stool variable interval, stool is rare shape, times of defecation average every day about 5-6 time, take this preparation for treating after 15 days, patient's abdominal part distending pain transference cure, stool is shaped, and times of defecation obviously reduces, average every day 1-2 time.
Case 3: Zhang, man, 52 years old, medical history: colitis.The clinical manifestation of taking the preceding patient of this preparation is: stomachache, abdominal distention, stool are irregular, abdominal pain with tenesmus, stool are sticking pus shape, and times of defecation reaches 5-7 surplus time, patient is very painful, take this preparation for treating after 15 days, patient's stomachache is obviously alleviated, and the abdominal pain with tenesmus sense disappears, stool is shaped, BOR, average every day about 1-2 time, clinical manifestation disappears.
Case 4: the king so-and-so, man, 39 years old, medical history: colitis.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain, it is irregular to defecate, and frequent diarrhoea, times of defecation dare not arrive the other places and go on business more than 3-5 time, bring very big inconvenience to work, take this preparation after 15 days, patient's abdominal part distending pain sense disappears, and the regularity of stool increases, the stool forming, the number of times of stool also obviously reduces.Other clinical manifestations take a turn for the better.
Case 5, the field so-and-so, woman, 32 years old, medical history: irritable bowel syndrome.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain, lower abdomen has bearing down, it is irregular to defecate, shapeless, be the water sample shape, take this preparation for treating after 15 days, patient's abdominal part distending pain, bearing down obviously alleviate, stool is shaped, and times of defecation also has reduce to every day about 2 times 7-8 time original every day, and patients clinical shows and is clearly better.
Case 6: appoint certain, man, 42 years old, medical history: irritable bowel syndrome.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain is strong, the irregular water sample that is of defecating, frequent diarrhoea, times of defecation 4-5 time.Brought very big inconvenience to work, taken this preparation for treating after 15 days, patient's abdominal part distending pain sense disappears, and the regularity of stool increases, the stool forming, and the number of times of stool is normal.Other clinical improvements.
Case 7: Wu so-and-so, man, 31 years old, medical history: colitis.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain, bearing down is arranged, and it is irregular to defecate, not molding, times of defecation is taken this preparation after 15 days more than 3 times, and patient's abdominal part distending pain sense disappears, and the regularity of stool increases, forming.Other clinical manifestations take a turn for the better.
Case 8: field, man, 29 years old, medical history: colitis.Taking the preceding clinical manifestation of this preparation is: abdominal distention stomachache, and it is irregular to defecate, and uses antibiotic therapy but often recurrence, times of defecation 3-4 time was taken this preparation after 15 days, and patient's abdominal part distending pain sense disappears, the regularity of stool increases, the stool forming, and other clinical manifestations take a favorable turn.
Case 9: high so-and-so, woman, 47 years old, medical history: colitis.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain, it is irregular to defecate, and frequent diarrhoea, times of defecation dare not arrive the other places and go on business more than 3-5 time, bring very big inconvenience to work, take this preparation after 15 days, patient's abdominal part distending pain sense disappears, and the regularity of stool increases, the stool forming, the number of times of stool also obviously reduces.Other clinical improvements.
Case 10: Yan, man, 52 years old, medical history: colitis.The clinical manifestation of taking before this preparation is: stomachache, diarrhea, stool variable interval, and stool is the water sample shape, and times of defecation is taken this preparation after 15 days more than 3 times, and patient's abdominal part distending pain, diarrhoea disappear, stool normal, the stool forming, clinical manifestation takes a turn for the better.
Case 11: Jiang, man, 46 years old, medical history: colitis.Taking the preceding clinical manifestation of this preparation is: the abdominal part distending pain, bearing down is arranged, and the not molding of defecating of suffering from diarrhoea, times of defecation 3-4 time was taken this preparation after 15 days, and patient's abdominal part distending pain sense, bearing down disappear, the stool forming, the number of times of stool also obviously reduces.Other clinical improvements.
Claims (8)
1. middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes, the effective ingredient that it is characterized in that said preparation is Montmorillonitum and Rhizoma Rodgersiae.
2. middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes as claimed in claim 1 is characterized in that said preparation is tablet or capsule.
3. middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes as claimed in claim 2 is characterized in that described tablet ingredients is as follows:
(1) label prescription:
500～1000 parts of Montmorillonitums
833～1667 parts of Rhizoma Rodgersiae
10～50 parts of binding agents
0.5～5 part of lubricant
(2) coating fluid prescription:
30～200 parts of polyacrylic resin III
2.5～20 parts of dibutyl phthalates
8～50 parts of titanium dioxides
8～50 parts of Pulvis Talci
500～1000 parts of ethanol.
4. middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes as claimed in claim 2 is characterized in that described capsule component is as follows:
(1) capsule 's content prescription:
500～750 parts of Montmorillonitums
833～1250 parts of Rhizoma Rodgersiae
10～50 parts of binding agents
0.5～5 part of lubricant
By above prescription, the conventional capsule of packing into, and carry out coating with following coating solution; Or in the colon colloidal sol capsule of using following coating solution coating of packing into;
(2) coating fluid prescription:
30～200 parts of polyacrylic resin III
2.5～20 parts of dibutyl phthalates
8～50 parts of Pulvis Talci
500～1000 parts of ethanol.
5. as claim 3 or 4 described middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes, it is characterized in that described binding agent is selected from starch, carboxymethyl starch sodium or microcrystalline Cellulose.
6. as claim 3 or 4 described middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes, it is characterized in that described lubricant is magnesium stearate or Pulvis Talci.
7. preparation method as any one middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes in claim 3 or 4 is characterized in that step is as follows:
(a) pretreatment of Rhizoma Rodgersiae medical material;
Take by weighing the Rhizoma Rodgersiae pulverizing medicinal materials and become coarse powder, with 80% soak with ethanol three times, for the first time, soaked 48 hours, soaking with the ethanol consumption is 5～10 times of medical material amounts, the second time with soaked for the third time 24 hours, the ethanol consumption is 3～5 times of Rhizoma Rodgersiae weight, merge three times soak, decompression recycling ethanol also is concentrated into the extractum of 1.10～1.20/50～60 ℃ of relative densities.Add hydrochloric acid and regulate pH value to 2, standing over night filters, and filtrate decompression is concentrated into the thick paste of 1.20～1.40/50～60 ℃ of relative densities, add 5 times of amount 80% ethanol and make dissolving, add activated carbon decolorizing, filter, filtrate is concentrated into 1/2 of former thick paste volume, leave standstill, filter, get crystalline deposit, be ground into fine powder dry below 80 ℃;
(b) preparation of tablet:
Behind Rhizoma Rodgersiae and Montmorillonitum and binding agent mix homogeneously after handling,, add the mix lubricant tabletting with 80% ethanol system soft material, granulation, drying, granulate; The preparation coating solution carries out coating to tabletting, promptly gets the relieving diarrhea with astringents colon-positioning enteric tablet;
(c) preparation of capsule:
Take by weighing the granulation that is mixed of Montmorillonitum, Rhizoma Rodgersiae and other compositions, the conventional capsule of packing into; The preparation coating solution carries out coating to capsule, promptly gets relieving diarrhea with astringents conlon targeting enteric coated capsule.
8. according to the preparation method of the middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes described in the claim 7, it is characterized in that described coating parameter is: coating flow velocity 2.6ml/min, 40 ℃ of inlet temperatures, 1.3kgf/cm is pressed in spray
2
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| CNB2006100696460A CN100566724C (en) | 2006-08-03 | 2006-08-03 | Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100696460A CN100566724C (en) | 2006-08-03 | 2006-08-03 | Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes and preparation method thereof |
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| CN101116673A true CN101116673A (en) | 2008-02-06 |
| CN100566724C CN100566724C (en) | 2009-12-09 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934079A (en) * | 2010-08-20 | 2011-01-05 | 温州小伦包衣技术有限公司 | Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof |
| CN102836185A (en) * | 2012-09-14 | 2012-12-26 | 云南施普瑞生物工程有限公司 | Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application |
| CN102866213A (en) * | 2012-09-14 | 2013-01-09 | 云南施普瑞生物工程有限公司 | Quality control method of intestine astringe antidiarrheic preparation |
-
2006
- 2006-08-03 CN CNB2006100696460A patent/CN100566724C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934079A (en) * | 2010-08-20 | 2011-01-05 | 温州小伦包衣技术有限公司 | Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof |
| CN101934079B (en) * | 2010-08-20 | 2013-03-13 | 温州小伦包衣技术有限公司 | Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof |
| CN102836185A (en) * | 2012-09-14 | 2012-12-26 | 云南施普瑞生物工程有限公司 | Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application |
| CN102866213A (en) * | 2012-09-14 | 2013-01-09 | 云南施普瑞生物工程有限公司 | Quality control method of intestine astringe antidiarrheic preparation |
| CN102836185B (en) * | 2012-09-14 | 2015-02-04 | 云南施普瑞生物工程有限公司 | Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application |
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| Publication number | Publication date |
|---|---|
| CN100566724C (en) | 2009-12-09 |
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