CN101112584A - Chinese traditional medicine compound preparations and method for preparing the same and use thereof - Google Patents
Chinese traditional medicine compound preparations and method for preparing the same and use thereof Download PDFInfo
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Abstract
The present invention provides a traditional Chinese medicine compound prescription for treating gynecological inflammation, the compound prescription is composed of 10 traditional Chinese medicines of white paeony root, Chinese angelica, Szechuan lovage rhizome, baical skullcap root, golden thread, radix rehmanniae preparata, largehead atractylodes rhizome, oriental waterplantain rhizome, common burreed rhizome, zedoary and so on; the present invention further provides the preparation method of the traditional Chinese medicine compound prescription, which mainly includes the preparation of the volatile oil, the preparation of the immersed ointment, mixing and other steps; the active medicine powder which is prepared by the extraction via the solvent can be added with appropriate pharmaceutical excipients to prepare any preparation form which is acceptable on pharmacy, and the preparation is mainly a variety of oral preparations. The compound prescription and the preparation provided by the present invention can be used in the application of preparing the drugs for the treatment of various acute and chronic pelvic inflammatory diseases, cervicitis, and other gynecological inflammatory diseases, which include the pelvic peritonitis, endometritis, salpingitis and so on.
Description
Technical field:
The invention belongs to Chinese medicine development field, relate to a kind of compound Chinese medicinal preparation and its production and use, relate generally to a kind of Chinese medicine compound for the treatment of gynecological inflammation and preparation method thereof, also related to the pharmaceutical preparation of this Chinese medicine compound simultaneously.
Background technology:
Gynecological inflammation is a kind of commonly encountered diseases and frequently-occurring disease of gynecological, mainly is meant the inflammation of female sex organ, comprises female vulva inflammation that a variety of causes causes, vaginitis, cervicitis, pelvic inflammatory disease etc.With leucorrhea amount increase, menoxenia, vaginal hemorrhage, lumbago, few abdomen pain etc. are main clinic symptoms.Acute inflammation stage is seen heating more, and profuse leukorrhea or metrorrhagia are more than, and poly-not the loosing of damp and hot knot can become enclosed mass, diseases such as the retardance vessels of the uterus is consequently infertile, amenorrhea, lumbago, lower abdominal pain.It is touching that female chronic inflammation has patient's condition, and the characteristics that the course of disease is long are heavy during feelings during the state of an illness, whenever in through the back, puerperal or gynecologic surgery outbreak, lose control, with the passing of time wrong treatment then delay and do not heal year surplus the course of disease is 10 sometimes.This type of disease belongs to sick category such as " lump in the abdomen " in the traditional medicine, " dysmenorrhea ", " leukorrhagia ", " infertile ", and the patient is deficient towards appointing, and spleen kidney two loses, deficient qi and blood, disease are seen giddy, weak, soreness of the loins and weakness of the limbs, it is sagging to suffer from abdominal pain, profuse leukorrhea, the dripping more than disease such as grade of vaginal hemorrhage.Particularly chronic cervicitis, chronic pelvic inflammatory disease (comprising endometritis, salpingitis, tubo-ovarian abscess, pelvioperitonitis etc.) have characteristics such as long, the easy recurrence of the course of disease, not only bring great health harm to the women, but also usually cause infertile, ectopic pregnancy, pelvic pain etc., have a strong impact on WomanHealth, and increase family and social economy's burden.Simple antibiotic therapy medicine is difficult to reach the focus part, and can not alleviate adhesion in the pelvic cavity, expands so lower abdomen weighs down, and pain and waist and sacrum pain symptom are difficult for eliminating.Chinese patent medicine can blood circulation promoting and blood stasis dispelling, promotes the pelvic cavity local blood circulation, has overcome simple antibiotic and has used the characteristics such as relief of symptoms, drug resistance and dysbacteriosis generation that are difficult for.For the pelvic inflammatory disease patient who shows effect repeatedly, use the cure rate that Chinese medicine can improve the gynecopathy such as pelvic inflammatory inflammation greatly clinically; The Chinese patent medicine side effect is little, is suitable for long-term prescription, has adapted to the gynecological inflammation characteristics of recurrence easily.
Summary of the invention:
Technical problem to be solved by this invention provides a kind of compound Chinese medicinal preparation and preparation method thereof, and the application in the medicine for preparing urgent chronic pelvic inflammatory diseases such as treatment acute and chronic cervicitis and endometritis, salpingitis, tubo-ovarian cyst, pelvic cavity intimitis of this Chinese medicine compound and all preparations thereof also is provided simultaneously.
The present invention is that the technical scheme by the following stated realizes: the present invention selects ten flavor Chinese crude drugs such as the Radix Paeoniae Alba, Rhizoma Coptidis, Radix Scutellariae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae Preparata for use, through cleaning, pulverize, dry, technological processes such as solvent extracts, merge, concentrate, drying make effective spice.The application that the Chinese crude drug of this compound recipe and the effective spice that makes thereof can be used for preparing the medicine for the treatment of gynecological inflammation.
Chinese medicine compound provided by the invention is to be made by the Chinese crude drug of following weight range: 10～50 parts of the Radix Paeoniae Albas, 5～25 parts of Rhizoma Coptidis, 5～30 parts of Radix Scutellariaes, 10～40 parts of Radix Angelicae Sinensis, 5～30 parts of Rhizoma Chuanxiongs, 5～20 parts of Rhizoma Alismatis, 5～20 parts of the Rhizoma Atractylodis Macrocephalaes, 5～20 parts of rhizoma sparganic, 5～15 parts of Rhizoma Curcumae, 10～40 parts in Radix Rehmanniae Preparata; Used Chinese crude drug preferable amount is 40 parts of the Radix Paeoniae Albas, 15 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 30 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Alismatis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of rhizoma sparganic, 10 parts of Rhizoma Curcumae, 25 parts in Radix Rehmanniae Preparata.
The preparation method of effective spice of Chinese medicine compound of the present invention mainly is made up of following steps:
(1) preparation of volatile oil: the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae two flavor Chinese crude drugs extract volatile oil in the above-mentioned ten flavor medical materials, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby;
(2) preparation of extractum: eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 2～3 times, and each decocting time is 0.5～2 hour, merges decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 60%～80%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.10～1.40 (50 ℃～80 ℃), drying is pulverized;
(3) mix: get above-mentioned powder, add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil, mixing is granulated.
Chinese medicine compound provided by the present invention and effective spice thereof can be according to patient's different demands, select different pharmaceutic adjuvants to be prepared into different dosage forms, the form that comprises oral, non-intestinal, rectum, intranasal administration also can be made the form of administrations such as aerosol, inhalant.The dosage form preferred oral preparation of this medicine: oral administration solid comprises tablet such as ordinary tablet, slow releasing tablet, controlled release tablet, dispersible tablet, oral cavity disintegration tablet etc., and hard capsule, soft capsule, pill, granule, drop pill etc.; Oral liquid can be mixture (oral liquid), syrup, Emulsion, suspensoid, elixir or suspension, can also be that water or other suitable carriers reconstitute the dry products of taking before it uses.In the preparation process of preparation, except being prepared into sugared dosage form, can also be prepared into the demand that the sugar-free preparation satisfies patients such as diabetes.
Non-intestinal drug delivery agent can be prepared into injection, preferred intravenous, subcutaneous, intramuscular injection.Can be with the ampoule form, also can add antiseptic and be prepared into the transfusion form.Said preparation can be solution, suspension or the emulsion form in aqueous or the oiliness carrier, can also add the reagent of suitable suspending agent, stabilizing agent, dispersant or adjusting osmotic pressure etc.In addition, active component can be made the solid sterile powder, dissolves with suitable carrier preparation before using.
The present invention can also be prepared into rectally preparation suppository etc.The substrate of suppository can be selected WitepsolH, S and E, and Polyethylene Glycol, glycerin gelatine, tween 61, poloxamer etc.Also can be prepared into preparations such as suitable aerosol, spray, drop.
Chinese medicine compound provided by the present invention and preparation thereof have following advantage and characteristics:
The first, from the composition of prescription: reuse the Radix Paeoniae Alba the side, get that its picric acid is slightly cold, easing the affected liver reason spleen, nourish blood and seek; Radix Scutellariae, Rhizoma Coptidis two medicine heat clearing and damp drying, eliminating fire and detoxication; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata blood circulation promoting and blood stasis dispelling, easing the affected liver and blood, nourishing YIN and benefiting blood more with Rhizoma Alismatis, Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening, promoting diuresis to eliminate damp pathogen, add rhizoma sparganic, the circulation of qi promoting of Rhizoma Curcumae removing blood stasis, eliminate indigestion pain relieving, dispersing swelling and dissipating binds again.Full side's compatibility has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain, integrated application Chinese medicine to Therapeutic Principle such as treatment clearing away heat-damp and promoting diuresis that gynaecological inflammation disease adopted, eliminating stasis and resolving masses, blood circulation promoting and blood stasis dispelling, thereby reach the purpose of comprehensive treatment disease.
The second, from the result of modern pharmacology research: heat and toxic materials clearing away medicine has stronger broad spectrum antibiotic the side, has stronger antiinflammatory action, the pathological reaction that can diminish inflammation; The Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis have the turbid effect of damp eliminatingization in the side, have given play to tangible clearing away heat and eliminating dampness behind the compatibility, drive away the merit of interior-heat damp; The Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong, rhizoma sparganic, the powerful blood circulation promoting and blood stasis dispelling of all medicine performances of Rhizoma Curcumae in the side, reduce capillary permeability, minimizing is oozed out, effectively improve inflammation, promote and improve local blood circulation, thereby overcome simple antibiotic and used the characteristics such as relief of symptoms, drug resistance and dysbacteriosis generation that are difficult for.
The 3rd, from dosage form, the Chinese medicine compound that this invention provided can be prepared into various modern formulations according to different needs, and is easy to carry, with different needs and the selection of satisfying the patient.
The 4th, Chinese medicine compound provided by the invention and preparation thereof do not have toxic and side effects, and suitable patient takes for a long time, have adapted to gynaecological inflammation disease course of disease characteristics long, that easily recur.
In sum, Chinese medicine compound provided by the invention and preparation thereof have multiple efficacies such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain, can be used for leucorrhoea grow in quantity, lower abdomen weigh down expand, gynecological inflammations such as lumbus sacrum pain, pruritus vulvae, menoxenia, dizzy disease such as weak and various acute and chronic cervicitis, pelvic inflammatory disease, adnexitis, endometritis, vaginitis are seen above-mentioned sign person, are a kind of natural drugs that can effectively treat multiple gynaecological inflammation disease.
The invention will be further described by the following examples, but be not limited in this.
The specific embodiment:
Embodiment 1 granule
Radix Paeoniae Alba 300g Rhizoma Coptidis 100g
Radix Scutellariae 100g Radix Angelicae Sinensis 200g
Rhizoma Chuanxiong 100g Rhizoma Alismatis 50g
Rhizoma Atractylodis Macrocephalae 100g rhizoma sparganic 100g
Rhizoma Curcumae 50g Radix Rehmanniae Preparata 200g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 3 times, and decocting time was respectively 2 hours, 1 hour, 0.5 hour, merged three times decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 70%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.30～1.40 (50 ℃), drying is pulverized; Add adjuvants such as an amount of sucrose, dextrin, spray into above-mentioned volatile oil, mixing is granulated, and dry back granulate is distributed into bag.
Embodiment 2 sugar-free tablets
Radix Paeoniae Alba 250g Rhizoma Coptidis 125g
Radix Scutellariae 150g Radix Angelicae Sinensis 200g
Rhizoma Chuanxiong 150g Rhizoma Alismatis 100g
Rhizoma Atractylodis Macrocephalae 100g rhizoma sparganic 100g
Rhizoma Curcumae 75g Radix Rehmanniae Preparata 200g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 2 times, and it is 2 hours that decocting time is, and merges decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 60%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.20～1.25 (80 ℃), drying is pulverized; Add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil, mixing is made the sugar-free granule, tabletting.
Embodiment 3 contains the sugar-tablet agent
Radix Paeoniae Alba 120g Rhizoma Coptidis 40g
Radix Scutellariae 40g Radix Angelicae Sinensis 80g
Rhizoma Chuanxiong 40g Rhizoma Alismatis 20g
Rhizoma Atractylodis Macrocephalae 40g rhizoma sparganic 40g
Rhizoma Curcumae 20g Radix Rehmanniae Preparata 80g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 2 times, and it is 2 hours that decocting time is, and merges decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 65%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.15～1.20 (75 ℃), drying is pulverized; Add appropriate amount of auxiliary materials such as sucrose, spray into above-mentioned volatile oil, mixing is granulated tabletting.
Embodiment 4 hard capsules
Radix Paeoniae Alba 450g Rhizoma Coptidis 180g
Radix Scutellariae 200g Radix Angelicae Sinensis 250g
Rhizoma Chuanxiong 250g Rhizoma Alismatis 150g
Rhizoma Atractylodis Macrocephalae 120g rhizoma sparganic 120g
Rhizoma Curcumae 80g Radix Rehmanniae Preparata 300g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 3 times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour, merged decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 80%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.20～1.25 (70 ℃), drying is pulverized; Add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil, mixing is granulated, dry back granulate, fill capsule.
Embodiment 5 soft capsules
Radix Paeoniae Alba 200g Rhizoma Coptidis 75g
Radix Scutellariae 100g Radix Angelicae Sinensis 150g
Rhizoma Chuanxiong 100g Rhizoma Alismatis 50g
Rhizoma Atractylodis Macrocephalae 75g rhizoma sparganic 75g
Rhizoma Curcumae 50g Radix Rehmanniae Preparata 125g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 3 times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour, merged decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 75%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.10～1.15 (70 ℃), drying is pulverized; Add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil and get effective spice.
Effective spice 0.05～0.40 gram/grain of Chinese medicine compound
300～450 milligrams/of diluent
5～7.5 milligrams/of suspending agents
5～7.5 milligrams/of emulsifying agents
60～90 milligrams/in water
The component and the content of every softgel shell are as follows:
100～150 milligrams in gelatin
30～50 milligrams of glycerol
100～150 milligrams in water
Antiseptic is an amount of
Gelatin is placed the glue jar, add the purified water of solubilized gelatin amount, glue jar temperature is suitable, after dissolving, adds glycerol, antiseptic, stirs, and insulation is left standstill after the vacuumize degassing; In proportion with effective spice and diluent, emulsifying agent, suspending agent mix homogeneously, content and the gelatin for preparing are put rotation press the capsule machine, be pressed into soft capsule, typing, dry getting final product.Can change the soft capsule that content is prepared into different size according to different needs.
Embodiment 6 drop pills
Radix Paeoniae Alba 50g Rhizoma Coptidis 25g
Radix Scutellariae 25g Radix Angelicae Sinensis 50g
Rhizoma Chuanxiong 25g Rhizoma Alismatis 25g
Rhizoma Atractylodis Macrocephalae 25g rhizoma sparganic 25g
Rhizoma Curcumae 25g Radix Rehmanniae Preparata 50g
The Rhizoma Atractylodis Macrocephalae, the Rhizoma Curcumae two flavor Chinese crude drugs of getting above-mentioned amount extract volatile oil, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby; Eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 3 times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour, merged decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 75%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.10～1.15 (70 ℃), drying is pulverized; Add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil and get effective spice.
Get the effective spice of above-mentioned Chinese medicine, add water and make even pasty state, add molten matrix liquid again, heating and melting becomes supernatant liquid, pour in the drop pill device of preheating, control is dripped the system temperature and is dripped speed, splashes in the condensed fluid, blot condensed fluid after becoming ball, collect drop pill, put and promptly get drop pill in the exsiccator.
Embodiment 7 rectal suppositories
Get the effective spice of Chinese medicine of embodiment 3 gained, it is melted in the suspension among the Witepsol H15, make the suppository of rectally through proper device in will its 1 gram suppository mold of packing into.
Embodiment 8 oral liquids
Hydroxypropyl emthylcellulose is dispersed in the hot water, cooling, the effective spice and the adjuvants such as an amount of correctives, sweeting agent that add the Chinese medicine compound of an amount of embodiment 1 gained then mix, and add the purified water modulation and need volume and mix homogeneously, sterilization back packing.
Further specify the present invention with pharmacological evaluation below.
One, the experimentation of antiinflammatory action
1.1 the influence of this product xylol induced mice auricle edema
1.1.1 experimental technique faces with preceding, and that this product is mixed with the 100mg/ml suspension with 0.5%CMC-Na is standby, healthy kunming mice, and body weight is 18～22g.Mice is divided into 4 groups (matched group 0.9% sodium chloride injections) at random, every group 10, irritate the long-pending 20ml/kg of body of stomach, continuous irrigation stomach 10 days, administration every day 1 time, with microsyringe dimethylbenzene 0.05ml is applied to every mouse right ear behind the last administration 30min, put to death mice behind the 15min, cut two ears along the auricle baseline, dash with the 8mm diameter steel and to lay round auricle in left and right sides auricle same area respectively, claim two ear weight in wet bases, with two auricle weight differences as the swelling level index, calculate and respectively organize swelling degree average and standard deviation, carry out the t check.Inhibitory rate of intumesce %=(the average swelling degree of the matched group-average swelling degree of administration the group)/average swelling degree of matched group * 100%
1.1.2 experimental result shows two dosage groups of this product and matched group relatively, auricle swelling degree obviously alleviates, and property that there were significant differences illustrates that this product has good antiinflammatory action.Experimental result sees Table 1:
| Group | Dosage/gkg -1 | The animal number of elements | Average swelling degree/mg | Suppression ratio (%) |
| Matched group | 20ml·kg -1 | 10 | 25.35±4.80 | - |
| FUKE QIANJIN PIAN | 2.0 | 10 | 17.86±5.46 ** | 29.55 |
| This product small dose group | 1.0 | 10 | 17.79±5.38 ** | 29.86 |
| The heavy dose of group of this product | 2.0 | 10 | 14.27±4.91 * | 43.71 |
Annotate: compare with matched group,
*P＜0.01,
*P＜0.05.
1.2 this product is to the influence of rat uterus inflammation
1.2.1 the experimental technique animal is selected the SD female rat for use, body weight is at 180～220g.Animal is divided into 4 groups, 10 every group.Each treated animal under etherization, cut off the hypogastric region hair, the sterilization back is in abdomen medisection 2cm, expose the uterus, make a kerf in the place, a plastic cup (sterilization) is positioned over intrauterine along 1cm on the left hand corner of uterus, with the uterine incision sutured, postoperative beginning in two hours administration, once a day, the administration volume is 10mlkg
-1, administration 10 days, put to death animal half an hour after the last administration, takes out the uterus, both sides, remove fat, weigh, left side, every Mus uterus is inflammation swelling degree with the difference on right side, calculate and respectively organize swelling degree value and standard deviation, obtain the swelling rate and the suppression ratio of administration group, carry out the t check.Swelling rate %=(cause scorching uterus average weight-do not cause scorching uterus average weight)/do not cause scorching uterus average weight * 100%.Suppression ratio %=(the average swelling rate in the matched group uterus-average swelling rate in administration group the uterus)/average swelling rate in matched group uterus * 100%.
1.2.2 experimental result
Matched group both sides swelling rate obvious difference, the administration group is not obvious, and this product is better than FUKE QIANJIN PIAN to the suppression ratio of inflammation of uterus, illustrates that this product has the effect of good anti-inflammation of uterus.Experimental data the results are shown in Table 2
| Group | Dosage/gkg -1 | The animal number of elements | Swelling rate (%) | Suppression ratio (%) |
| Matched group | 20ml·kg -1 | 10 | 211.25 | |
| FUKE QIANJIN PIAN | 1.0 | 10 | 23.50 ** | 88.87 |
| This product small dose group | 0.5 | 10 | 15.69 ** | 92.57 |
| The heavy dose of group of this product | 1.0 | 10 | 10.43 * | 95.06 |
Annotate: compare with matched group,
*P＜0.01,
*P＜0.05.
1.3 this product is to the outgrowth influence of mice filter paper granuloma
1.3.1 the experimental technique animal is Kunming mouse, and is female, body weight 18～22g is divided into 4 groups at random, 10 every group.Mouse web portion is made a little otch that is about to 0.3cm at the abdominal part median line through routine disinfection, implants the 4mg filter paper of sterilizing subcutaneous, sews up the incision routine disinfection.Postoperative began gastric infusion the same day, and once a day, successive administration 10 days was put to death mice on the 11st day, and hara kiri skin is peeled off filter paper and granuloma.Placed 80 ℃ of baking ovens dry 1 hour, taking-up is weighed, and the weight that deducts round filter paper is granulomatous weight, calculates granulomatous average weight and standard deviation, carries out the t check.
1.3.2 experimental result shows that two kinds of dosage groups of this product compare with matched group, there were significant differences; Relatively there were significant differences for FUKE QIANJIN PIAN group and matched group, shows that each group of administration all has to suppress the outgrowth effect of granuloma due to the filter paper preferably, illustrates that each medicine has antiinflammatory action to chronic inflammatory disease, compares with FUKE QIANJIN PIAN, and this product is better than FUKE QIANJIN PIAN.Experimental data sees Table 3:
| Group | Dosage/gkg -1 | The animal number of elements | Granuloma weight/mgkg -1 | Suppression ratio (%) |
| Matched group | 20ml·kg -1 | 10 | 18.09±2.89 | - |
| FUKE QIANJIN PIAN | 2.0 | 10 | 14.46±2.49 ** | 20.07 |
| This product small dose group | 1.0 | 10 | 12.45±2.20 **# | 31.12 |
| The heavy dose of group of this product | 2.0 | 10 | 10.89±2.10 *# | 39.30 |
Annotate: compare with matched group,
*P＜0.01,
*P＜0.05; Compare with the FUKE QIANJIN PIAN group
#P＜0.05.
2, this product is to the influence of rabbit external uterine
2.1 this product is to the influence of normal rabbits external uterine smooth muscle contraction
2.1.1 experimental technique is got female white rabbit, body weight 2.5～3.5kg is divided into 3 groups at random, 10 every group.Test and gave rabbit intramuscular injection diethylstilbestrol 1.0mgkg in preceding 48 hours
-1During experiment, put to death rabbit, cut off the abdominal cavity, peel off fat around the uterus, the taking-up uterus is put into and is filled the culture dish that DeJalon solution is housed, and removes connective tissue and fat, get the long uterus muscle of one section 2cm, two ends are pricked with No. 0 toe-in, and an end is fixed on the L type ventilation hook, and the other end and muscular strength transducer join, place Maxwell bath of liquid groove, bath temperature is 37 ℃, constantly ventilates in groove, behind one section normal contraction curve of same uterus record, wash repeatedly with DeJalon solution, observe the uterotonic frequency in administration front and back, amplitude and energy (being the long-pending of frequency and amplitude) are carried out before and after the administration and the contrast between group, add up with the t check.
2.1.1 experimental result shows rabbit external uterine smooth muscle under external constant condition, can keep more stable frequency and amplitude of regular hour, begins behind the 50min to descend.Contrast before two dosage groups of this product and FUKE QIANJIN PIAN groups and the administration, all there were significant differences for its frequency, amplitude and energy, illustrates that this product has in various degree inhibitory action to normal uterine smooth muscle.Experimental result sees Table 4:
| Group | Dosage/mgml -1 | Frequency/time (10min) -1 | Amplitude/mm | Energy/mm (10min) -1 |
| Before the administration | - | 6.8±2.9 | 8.2±1.5 | 54.9±9.0 |
| The heavy dose of group of this product small dose group this product FUKE QIANJIN PIAN group after the administration | 1.0 0.5 1.0 | 4.4±1.8 ** 4.0±2.1 ** 4.3±1.9 ** | 7.4±1.5 ** 6.4±1.9 * 6.7±1.7 ** | 33.0±3.6 28.4±4.1 **# 36.3±4.6 ** |
Annotate: compare with matched group,
*P＜0.01,
*P＜0.05; Compare with the FUKE QIANJIN PIAN group
#P＜0.05.
2.2 this product is to the influence of rabbit external uterine smooth muscle contraction due to the oxytocin
2.2.1 experimental technique is got female white rabbit, body weight 2.5～3.5kg is divided into 5 groups at random, 10 every group.After the uterine smooth muscle of normal contraction adds oxytocin, contraction frequency, amplitude and energy all are significantly increased, about 10min peaks, be stabilized in this level afterwards, disappear gradually behind about 40min, add the test suspension at the about 20min of oxytocin effect, relatively the difference of the plain effect of this product and uterine contraction is added up with the t check.
2.2.2 experimental result shows that oxytocin adds two groups of this product its shrinkage factor, amplitude and energy and oxytocin comparing difference when effect 10min significance is arranged, oxytocin adds the FUKE QIANJIN PIAN group and its contraction frequency is compared in oxytocin, the amplitude difference significant difference is not obvious, energy difference type is remarkable, description of test this product has uterine smooth muscle spasm effect due to the obvious antagonism oxytocin, and its effect is stronger than FUKE QIANJIN PIAN.Experimental data sees Table 5:
| Group | Dosage/mgml -1 | Frequency/time (10min) -1 | Amplitude/mm | Energy/mm (10min) 1 |
| The normal control group | - | 6.7±2.9 | 8.1±1.8 | 54.5±8.7 |
| The oxytocin group | 10.00mU | 10.5±2.9 ** | 10.8±2.7 ** | 110.3±9.7 * |
| Oxytocin+this product small dose group | 1.0 | 6.6±2.8 # | 7.9±2.8 # | 60.1±9.5 ## |
| The heavy dose of group of oxytocin+this product | 0.5 | 5.3±2.7 ## | 7.3±2.6 # | 40.3±8.6 ## |
| Oxytocin+FUKE QIANJIN PIAN group | 1.0 | 7.5±2.8 | 8.6±2.2 | 65.9±8.6 ## |
Annotate: compare with the normal control group,
*P＜0.01,
*P＜0.05; Compare with the oxytocin group,
*P＜0.05,
*P＜0.01; Compare with oxytocin+FUKE QIANJIN PIAN group,
△P＜0.01.
3, the analgesic activity of this product
3.1 this product is to the influence of mice hot plate method pain threshold
3.1.1 experimental technique is got kunming mice body weight 18～22g.Preceding mice is put of medication measured mice metapedes contact hot plate to licking the sufficient time as basic threshold value on the hot plate dolorimeter, select the reaction agility of 10～30s, stable, not dancing mice, is divided into 4 groups at random, 10 every group.Matched group 0.9% sodium chloride injection, all the other are each medicinal liquid continuous irrigation stomach 10 days, administration every day 1 time, 30min and 90min measure each Mus pain threshold respectively after the last administration, do the t check.
3.1.2 experiment shows that this product has significant analgesia role, effect is because FUKE QIANJIN PIAN.Experimental data sees Table 6:
| Group | Dosage/gkg -1 | The animal number of elements | Pain threshold after the medication | |
| 30min | 90min | |||
| The heavy dose of group of matched group FUKE QIANJIN PIAN group this product small dose group this product | 20ml·kg -1 2.0 1.0 2.0 | 10 10 10 10 | 23.0±7.8 33.6±5.9 * 34.8±10.4 ** 48.0±9.1 *# | 27.4±8.3 38.3±10.3 * 49.7±6.9 *# 55.2±6.1 *# |
Annotate: compare with matched group:
*P＜0.01,
*P＜0.05; Compare with FUKE QIANJIN PIAN
#P＜0.05.
3.2 this product is to the inhibitory action of mouse writhing reaction
3.2.1 experimental technique is divided into 4 groups at random with mice, continuous irrigation stomach 10 days, after the last administration behind the 90min mouse peritoneal inject 0.7% glacial acetic acid 0.1ml (10g)
-1, observe in the counting mice 15min and turn round the body number of times, carry out the t check.
3.2.2 experimental result shows that this product has the reagentia of obvious suppression mouse writhing, illustrates that it has good analgesic activity, action effect is because FUKE QIANJIN PIAN.Experimental data sees Table 7:
| Group | Dosage/gkg -1 | The animal number of elements | Turn round the body number of times/time | Suppression ratio (%) |
| The heavy dose of group of matched group FUKE QIANJIN PIAN group this product small dose group this product | 20ml·kg 1 2.0 1.0 2.0 | 10 10 10 10 | 33.6±9.0 23.3±5.7 * 19.8±5.4 *** 15.4±5.1 *# | - 30.65 41.07 54.17 |
Annotate: compare with matched group:
*P＜0.01; Compare with FUKE QIANJIN PIAN:
*P＜0.05,
#P＜0.01.
Claims (7)
1. compound Chinese medicinal preparation is characterized in that this Chinese medicine compound is to be made by the crude drug of following amount ranges:
5～25 parts of 10～50 portions of Rhizoma Coptidis of the Radix Paeoniae Alba
10～40 parts of 5～30 parts of Radix Angelicae Sinensis of Radix Scutellariae
5～20 parts of 5～30 portions of Rhizoma Alismatis of Rhizoma Chuanxiong
5～20 parts of 5～20 parts of rhizoma sparganic of the Rhizoma Atractylodis Macrocephalae
10～40 parts in 5～15 parts of Radix Rehmanniaes Preparata of Rhizoma Curcumae.
2. compound Chinese medicinal preparation according to claim 1 is characterized in that the crude drug of the preferred following consumption of this Chinese medicine compound is made:
15 parts of 40 portions of Rhizoma Coptidis of the Radix Paeoniae Alba
30 parts of 20 parts of Radix Angelicae Sinensis of Radix Scutellariae
10 parts of 20 portions of Rhizoma Alismatis of Rhizoma Chuanxiong
15 parts of 15 parts of rhizoma sparganic of the Rhizoma Atractylodis Macrocephalae
25 parts in 10 parts of Radix Rehmanniaes Preparata of Rhizoma Curcumae
3. preparation method that contains the described Chinese medicine compound of claim 1 is characterized in that mainly comprising following processing step:
(1) preparation of volatile oil: the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae two flavor Chinese crude drugs extract volatile oil in the above-mentioned ten flavor medical materials, and the aqueous solution after distillation device is in addition deposited, and medicinal residues are standby;
(2) preparation of extractum: eight flavor Chinese crude drugs such as the medicinal residues of gained and other Radix Paeoniae Albas, Rhizoma Coptidis, Radix Scutellariae decoct with water 2～3 times, and each decocting time is 0.5～2 hour, merges decoction liquor, filter, leave standstill, get supernatant, be concentrated in right amount, put and be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 60%～80%, fully stir, standing over night filters, get supernatant, add above-mentioned aqueous solution, being condensed into relative density is the extractum of 1.10～1.40 (50 ℃～80 ℃), drying is pulverized;
(3) mix: get above-mentioned powder, add appropriate amount of auxiliary materials, spray into above-mentioned volatile oil, mixing is granulated.
4. purposes that contains the described Chinese medicine compound of claim 1, it is characterized in that this compound recipe and effectively spice can be used for preparing the application of the medicine of gynecological inflammation diseases such as various urgent chronic pelvic inflammatory diseases that treatment comprises pelvioperitonitis, endometritis, salpingitis etc., cervicitis.
5. the purposes of Chinese medicine compound according to claim 4 is characterized in that being used to being prepared into the medicine of oral, rectum, intramuscular, intravenous, nasal cavity, all form of medication such as subcutaneous.
6. the dosage form of Chinese medicine compound according to claim 1 is characterized in that described preparation comprises pharmaceutically acceptable preparations such as conventional tablet, buccal tablet, slow releasing tablet, controlled release tablet, dispersible tablet, oral cavity disintegration tablet, hard capsule, soft capsule, granule, drop pill, pill, injection, Emulsion, inhalant, aerosol or suppository.
7. the dosage form of Chinese medicine compound according to claim 6 is characterized in that oral formulations such as described preparation preferred tablet, hard capsule, soft capsule, granule, drop pill, dispersible tablet, oral cavity disintegration tablet.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614432A (en) * | 2012-03-22 | 2012-08-01 | 陈蕊 | Traditional Chinese medicine composition for treating cervicitis |
| CN105521158A (en) * | 2016-01-04 | 2016-04-27 | 段希福 | Pharmaceutical preparation for treatment of scanty menstruation caused by chronic endometritis |
| CN110507793A (en) * | 2019-07-23 | 2019-11-29 | 广州伍氏神健康产业有限公司 | It is a kind of for treating the composition of medicine and its preparation method of uterine cancer, oophoroma and myomata |
| CN112168937A (en) * | 2019-07-02 | 2021-01-05 | 易松群 | Oral medicine for treating hysteromyoma, cervical cyst and mammary gland agglomeration and preparation method thereof |
-
2006
- 2006-07-26 CN CNA200610040811XA patent/CN101112584A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614432A (en) * | 2012-03-22 | 2012-08-01 | 陈蕊 | Traditional Chinese medicine composition for treating cervicitis |
| CN102614432B (en) * | 2012-03-22 | 2013-11-27 | 陈蕊 | Traditional Chinese medicine composition for treating cervicitis |
| CN105521158A (en) * | 2016-01-04 | 2016-04-27 | 段希福 | Pharmaceutical preparation for treatment of scanty menstruation caused by chronic endometritis |
| CN112168937A (en) * | 2019-07-02 | 2021-01-05 | 易松群 | Oral medicine for treating hysteromyoma, cervical cyst and mammary gland agglomeration and preparation method thereof |
| CN110507793A (en) * | 2019-07-23 | 2019-11-29 | 广州伍氏神健康产业有限公司 | It is a kind of for treating the composition of medicine and its preparation method of uterine cancer, oophoroma and myomata |
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