CN101104136A - Nuclear pore filter membrane for precision medicine liquid filter and preparation method thereof - Google Patents
Nuclear pore filter membrane for precision medicine liquid filter and preparation method thereof Download PDFInfo
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- CN101104136A CN101104136A CNA200710068918XA CN200710068918A CN101104136A CN 101104136 A CN101104136 A CN 101104136A CN A200710068918X A CNA200710068918X A CN A200710068918XA CN 200710068918 A CN200710068918 A CN 200710068918A CN 101104136 A CN101104136 A CN 101104136A
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Abstract
The invention relates to the medical clinic transfusion field, more particularly, relating to the nuclear track microporous membrane used on a precision medical solution filter and the preparation method. The substrate membrane of the nuclear track microporous membrane used on the precision medical solution filter selects the polycarbonate as the material, and the nuclear track microporous membrane is obtained by high energy charged particle radiation and then sensitized and etching treatment to the substrate membrane, the apertures of the nuclear track microporous membrane are between zero point two micron and ten microns, the density of the nucleopores is that the membrane has five multiply one hundred and five to seven multiply one hundred and five pores per square centimeter. The preparation method of the nuclear track microporous membrane of the invention includes steps of radiation, sensitized treatment, etching and rinsing. The arrangement and application of the precision filter made by the nuclear track microporous membrane of the invention on the terminal of the infusion set of the disposable precision filtering infusion set can effectively filter the insoluble particles in the medical solution, and the filtration rate is more than or equal to ninety five percent, and hold the last pass of the medical solution form entering the human body, thus truly blocking the invasion of the insoluble particles to patients.
Description
Technical field
The present invention relates to medical clinical transfusion field, relate in particular to nuclear pore filter film that precision liquid medicine filter uses and preparation method thereof.
Background technology
Fluid transport therapy is applied to clinical from the 19th-century end, have simple, convenient, evident in efficacy, characteristics efficiently, continuous development along with clinical pharmacy and medical skill, fluid transport therapy has become one of indispensable important means and method in the modern clinical treatment, has extremely important status in the modern times in clinical.In China, clinical transfusion is to the utmost to be general, and the annual use amount of disposable infusion set has reached 3,000,000,000.But fluid transport therapy also has its very disadvantageous one side when having extremely superiority, mainly show: the particulate matter in the soup is to the harm of human body.A large amount of particulate intravasations during transfusion, some can allergic reactions such as erythema, itch, swelling occur when transfusion or after the transfusion, and myocyte's necrosis takes place in the obstruction microcirculation that has; The allergic symptom that has just occurred after several days, also often was considered to other disease.Hide in addition insoluble little in the blood vessel and in the little blood vessel that brain, lung, kidney, liver, eye etc. are located, cause obstruction, cause necrosis and damage in various degree, be called infraction; Because the phlebothrombosis that particulate forms affects people's microcirculation, the incidence of disease of cardiovascular and cerebrovascular diseases is constantly raise and rejuvenation.Make the people after several years or decades, diseases such as apoplexy, embolism just occur.
Domestic general infusion set only is aimed at that the particulate more than 20 microns carries out filtering in the soup, rejection rate 〉=80%.The not effect of holding back almost for diameter 6-10 microparticles, and the capillary that adult's capillary is generally 6-8 micron, baby only is 3 microns, the bad reaction of therefore infusing unavoidable with the transfusion remote effect (such as red swelling of the skin, produce phlebitis, cerebral arteriovenous malformation etc.).
Nylon membrane that the general employing of the filter membrane of existing precision liquid medicine filter is common or tunica fibrosa form by the stack that repeats of fiber, hole shape is irregular, and accurate classification, skewness can't be carried out in the aperture, in use be easy to generate fibre shedding, thereby cause automatic pollution; Big to the absorption in the soup, thus may have influence on the normal curative effect of medicine; Because pore-size distribution is inhomogeneous, the film material of identical effective filtration area, its fluid flow has only 1/2 of nuclear pore filter film, even littler.
Summary of the invention
In order to solve the technical problem that existing precision liquid medicine filter filter membrane exists, the purpose of this invention is to provide that a kind of good stability, filter opening are evenly distributed, aperture homogeneous, no automatic pollution, flow the nuclear pore filter film that measured precision liquid medicine filter is used.
A further object of the invention provides the preparation method of above-mentioned nuclear pore filter film.
In order to realize first purpose, the present invention has adopted following technical scheme:
Nuclear pore filter membrane for precision medicine liquid filter, the base material film of nuclear pore filter film is selected polycarbonate for use, and through high energy charged particles irradiation, sensitization and etch processes obtain nuclear pore filter film then by base material film, the aperture of nuclear pore filter film is 0.2～10 micron, and the density of nucleopore is every square centimeter 5 * 10
5～7 * 10
5Individual.It is that density is less than 5 * 10 that the present invention adopts the density main cause of above-mentioned nucleopore
5The time, influencing fluid flow, density is greater than 7 * 10
5The time, influence the intensity of filter membrane, when doing large aperture, big flow, cause rejection rate defective easily.
As preferably, the aperture of nuclear pore filter film is 2～5 microns.
In order to realize second purpose, the preparation method of nuclear pore filter membrane for precision medicine liquid filter of the present invention comprises the steps:
(1) irradiation: the polycarbonate base material film by the heavy ion tandem electrostatic accelerator, is stayed micropore on base material film, through hole density is every square centimeter 5 * 10
5～7 * 10
5Individual;
(2) sensitization is handled: place a period of time at normal temperatures, make the edge sharpening of micropore;
(3) etching: by lye tank (vat), the concentration of alkali lye is 3～15mol/L concentration with the base material film after the sensitization, and soaking temperature is 35 ℃～50 ℃, and soak time is 1～20 minute;
(4) rinsing:, make pH value reach neutral with the base material film rinsing of step (3) gained.
As preferably, the etched alkali lye of above-mentioned steps (3) is NaOH solution, and soaking temperature is 45 ± 2 ℃, and to keep constant temperature, the time of soaking in solution be 7～8 minutes as far as possible.
As preferably, the time that above-mentioned steps (2) sensitization is handled is 30～45 days.
As preferably, the ultrasonic film machine fine purifiation of washing of above-mentioned process after above-mentioned steps (4) rinsing, the fine purifiation step comprises that deionized water soaks, ultrasonic wave cleans and the water for injection spray.
Nuclear pore filter film beneficial effect of the present invention is as follows:
A. nuclear pore filter film employing polycarbonate film (PC) is a base material, has extraordinary chemistry and biological stability.
B. nuclear pore filter film has how much shape hole shapes of rule, is evenly distributed.
C. nuclear pore filter film aperture homogeneous can accurately be measured, and therefore can accurately separate particulate.
D. nuclear pore filter film in use itself can not produce foreign matter and comes off, and also free from admixture is moved in the filtrate, thereby can not produce soup and pollute.
The water imbibition of e, nuclear pore filter film is minimum, and in use, the aperture can not change, and is very low to the tiny Molecular Adsorption in the soup, can not influence the effective ingredient of soup.
Disposable use precision filter infusion set installs the accurate filter that application nuclear pore filter film of the present invention is made additional in the terminal of transfusion device, can carry out effective filtering to the particulate matter in the soup, rejection rate 〉=95%, held soup and entered closing together at last of human body, really stoped the infringement of particulate matter the patient.
Description of drawings
Fig. 1 is a process chart of the present invention.
Fig. 2 is the process chart of fine purifiation.
The specific embodiment
Be 5 microns with the processing aperture below, the nuclear pore filter film that base material thickness is 25 microns is that example is described further the specific embodiment of the present invention, as shown in Figure 1.
1, irradiation: with the polycarbonate is base material film, and base material film in anion accelerator, utilizes high energy charged particles by the large-scale heavy ion tandem electrostatic accelerator of Chinese atomic energy research institute HI-13 when passing base material film, produces ionization radiation injury.Stay micropore on base material film, through hole density is 5 * 5E for every square centimeter.
2, sensitization is handled: can make edge sharpening through base material film, the especially micropore of irradiation, and not yielding, be the preparatory process of etch process, need place at normal temperatures 30～45 days for general.
3, etching: with the NaOH solution of 6 mol concentration, 45 ± 2 ℃ of temperature, and keep constant temperature as far as possible, can make the aperture even as much as possible, guarantee the every bit that the film material passes through in the aqueous slkali, in solution, soaked 7～8 minutes.
4, rinsing:, make pH value reach neutral with the base material film rinsing of step 3 gained.
5, fine purifiation: adopt the ultrasonic film machine fine purifiation of washing, the fine purifiation step comprises deionized water immersion 1, ultrasonic wave cleaning 2 and water for injection spray 3, dries 4 then.As shown in Figure 2, ultrasonic speed of washing the film machine: 1-10m/h, bake out temperature: 40-60 ℃.
6, cutting: according to the cutting of accurate filter cavity shape.
Above-mentioned nuclear pore filter film can in the soup 〉=particulate matter of 5 μ m carries out effective filtering, rejection rate 〉=95% has been held soup and has been entered the last of human body and close together, has really stoped the infringement of particulate matter to the patient.The present invention is used for the flow rate of liquid of precision filter infusion set: under the 1m static pressure, the average discharge of the NaCl solution that 10min flows out exists: 250～375ml/cm
2
Claims (6)
1. nuclear pore filter membrane for precision medicine liquid filter, the base material film that it is characterized in that nuclear pore filter film is selected polycarbonate for use, nuclear pore filter film is by base material film process high energy charged particles irradiation, sensitization and etch processes obtain then, the aperture of nuclear pore filter film is 0.2～10 micron, and the density of nucleopore is every square centimeter 5 * 10
5～7 * 10
5Individual.
2. nuclear pore filter membrane for precision medicine liquid filter according to claim 1 is characterized in that the aperture of nuclear pore filter film is 2～5 microns.
3. the preparation method of nuclear pore filter membrane for precision medicine liquid filter according to claim 1 and 2 is characterized in that comprising the steps:
(1) irradiation: the polycarbonate base material film by the heavy ion tandem electrostatic accelerator, is stayed micropore on base material film, through hole density is every square centimeter 5 * 10
5～7 * 10
5Individual;
(2) sensitization is handled: place a period of time at normal temperatures, make the edge sharpening of micropore;
(3) etching: by lye tank (vat), the concentration of alkali lye is 3～15mol/L concentration with the base material film after the sensitization, and soaking temperature is 35 ℃～50 ℃, and soak time is 1～20 minute;
(4) rinsing:, make pH value reach neutral with the base material film rinsing of step (3) gained.
4. the preparation method of nuclear pore filter membrane for precision medicine liquid filter according to claim 3 is characterized in that etched alkali lye is NaOH solution, and soaking temperature is 45 ± 2 ℃, and to keep constant temperature, the time of soaking in solution be 7～8 minutes as far as possible.
5. the preparation method of nuclear pore filter membrane for precision medicine liquid filter according to claim 3 is characterized in that the time that sensitization is handled is 30～45 days.
6. the preparation method of nuclear pore filter membrane for precision medicine liquid filter according to claim 3 is characterized in that after the rinsing that through the ultrasonic film machine fine purifiation of washing, the fine purifiation step comprises that deionized water soaks, ultrasonic wave cleans and the water for injection spray.
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| CNB200710068918XA CN100556516C (en) | 2007-05-25 | 2007-05-25 | Nuclear pore filter membrane for precision medicine liquid filter and preparation method thereof |
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|---|---|---|---|
| CNB200710068918XA CN100556516C (en) | 2007-05-25 | 2007-05-25 | Nuclear pore filter membrane for precision medicine liquid filter and preparation method thereof |
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| CN101104136A true CN101104136A (en) | 2008-01-16 |
| CN100556516C CN100556516C (en) | 2009-11-04 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102059058A (en) * | 2010-12-09 | 2011-05-18 | 中山国安火炬科技发展有限公司 | Safeguard structure used in nuclepore membrane production process and production method of nuclepore membrane |
| CN101766959B (en) * | 2009-12-22 | 2012-01-11 | 武汉智迅创源科技发展股份有限公司 | Small-bore nuclear pore filter membrane and production method thereof |
| CN103134746A (en) * | 2011-11-23 | 2013-06-05 | 苏州宏瑞净化科技有限公司 | Double-flow particle counter |
| CN103830804A (en) * | 2012-11-26 | 2014-06-04 | 嘉兴珀尔滤材有限公司 | Nuclear pore filter membrane and manufacturing method thereof |
| CN104014257A (en) * | 2014-05-30 | 2014-09-03 | 天津理源科技有限公司 | Automatic liquid stopping nucleopore filter membrane used for precision transfusion and preparing method thereof |
| CN104607054A (en) * | 2014-12-31 | 2015-05-13 | 浙江南洋慧通新材料有限公司 | Heavy-ion microporous membrane infusion apparatus capable of stopping liquid and membrane preparation method thereof |
| CN104689419A (en) * | 2015-02-12 | 2015-06-10 | 武汉博硕聚才科技有限公司 | Method for preparing closed soft bag for floating body of infusion apparatus and anti-blood return infusion apparatus |
| CN106076124A (en) * | 2016-08-17 | 2016-11-09 | 中山双安微医疗科技有限公司 | The processing method of heavy ion microporous aseptic filtration film and the needle-based sterilizing filter of this film preparation |
| CN107774141A (en) * | 2016-08-30 | 2018-03-09 | 邻得膜科技（北京）有限公司 | The preparation method of Nano Silver nucleus micropore filtering film, filter and filter membrane |
Families Citing this family (1)
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| TWI395610B (en) * | 2010-12-24 | 2013-05-11 | Univ Nat Cheng Kung | Liquid filtering device and filtering method using the same |
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2007
- 2007-05-25 CN CNB200710068918XA patent/CN100556516C/en active Active
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766959B (en) * | 2009-12-22 | 2012-01-11 | 武汉智迅创源科技发展股份有限公司 | Small-bore nuclear pore filter membrane and production method thereof |
| CN102059058A (en) * | 2010-12-09 | 2011-05-18 | 中山国安火炬科技发展有限公司 | Safeguard structure used in nuclepore membrane production process and production method of nuclepore membrane |
| CN102059058B (en) * | 2010-12-09 | 2013-01-30 | 中山国安火炬科技发展有限公司 | Safeguard structure used in nuclepore membrane production process and production method of nuclepore membrane |
| CN103134746A (en) * | 2011-11-23 | 2013-06-05 | 苏州宏瑞净化科技有限公司 | Double-flow particle counter |
| CN103830804A (en) * | 2012-11-26 | 2014-06-04 | 嘉兴珀尔滤材有限公司 | Nuclear pore filter membrane and manufacturing method thereof |
| CN104014257A (en) * | 2014-05-30 | 2014-09-03 | 天津理源科技有限公司 | Automatic liquid stopping nucleopore filter membrane used for precision transfusion and preparing method thereof |
| CN104014257B (en) * | 2014-05-30 | 2016-08-17 | 天津理源科技有限公司 | A kind of precision transfusion automatic liquid-stopping nuclear pore filter film and preparation method thereof |
| CN104607054A (en) * | 2014-12-31 | 2015-05-13 | 浙江南洋慧通新材料有限公司 | Heavy-ion microporous membrane infusion apparatus capable of stopping liquid and membrane preparation method thereof |
| CN104689419A (en) * | 2015-02-12 | 2015-06-10 | 武汉博硕聚才科技有限公司 | Method for preparing closed soft bag for floating body of infusion apparatus and anti-blood return infusion apparatus |
| CN106076124A (en) * | 2016-08-17 | 2016-11-09 | 中山双安微医疗科技有限公司 | The processing method of heavy ion microporous aseptic filtration film and the needle-based sterilizing filter of this film preparation |
| CN107774141A (en) * | 2016-08-30 | 2018-03-09 | 邻得膜科技（北京）有限公司 | The preparation method of Nano Silver nucleus micropore filtering film, filter and filter membrane |
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| CN100556516C (en) | 2009-11-04 |
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Address after: Jiaxing City, Zhejiang province 314500 Tongxiang Wutong Street No. 3618 Ring Road Patentee after: ZHEJIANG FUERTE MEDICAL INSTRUMENT CO., LTD. Address before: 314500 Xinmin South Road, Tongxiang Economic Development Zone, Zhejiang, 35 Patentee before: Zhejiang Fert Medical Instrument Co., Ltd. |
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Denomination of invention: Nuclear pore filter membrane for precision medicine liquid filter and preparation method thereof Effective date of registration: 20190401 Granted publication date: 20091104 Pledgee: Bank of Hangzhou Limited by Share Ltd Tongxiang branch Pledgor: ZHEJIANG FUERTE MEDICAL INSTRUMENT CO., LTD. Registration number: 2019330000089 |
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Date of cancellation: 20200927 Granted publication date: 20091104 Pledgee: Bank of Hangzhou Limited by Share Ltd. Tongxiang branch Pledgor: ZHEJIANG FERT MEDICAL DEVICE Co.,Ltd. Registration number: 2019330000089 |