CN104014257B - A kind of precision transfusion automatic liquid-stopping nuclear pore filter film and preparation method thereof - Google Patents
A kind of precision transfusion automatic liquid-stopping nuclear pore filter film and preparation method thereof Download PDFInfo
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- CN104014257B CN104014257B CN201410239019.1A CN201410239019A CN104014257B CN 104014257 B CN104014257 B CN 104014257B CN 201410239019 A CN201410239019 A CN 201410239019A CN 104014257 B CN104014257 B CN 104014257B
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Abstract
The invention discloses a kind of precision transfusion automatic liquid-stopping nuclear pore filter film and preparation method thereof, the step of preparation method is: the particle irradiation gauge polyester thin film produced with accelerator, 55 80 DEG C, the sodium hydrate aqueous solution of 6.5 8.0mol/L etches 3 60 minutes；55 80 DEG C, 0.5 1mol/L sodium hydrate aqueous solution cleans；Clean the most in deionized water；In 60 DEG C of 80 DEG C of modification liquids, first ultrasonic immersion 3 10 minutes, stop ultrasonic immersion 15 40 minutes again, be further continued for ultrasonic immersion 3 10 minutes；Clean in deionized water；40 70 DEG C of drying, i.e. make precision transfusion automatic liquid-stopping nuclear pore filter film, and the method for the present invention is simple, and the film made is super hydrophilic, and water contact angle is less than 30 °, only liquid height 1.8 meters～3.0 meters.
Description
Technical field
The invention belongs to infusion solutions secondary filter technical field, particularly to the system of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film
Preparation Method.
Technical background
Fluid transport therapy originates from late nineteenth century, has a long history.Simple, convenient owing to having, evident in efficacy,
Feature efficiently, nineteen thirties become one of indispensable important means and method in modern clinical treatment the most,
There is in modern clinic extremely important status.
In clinical transfusion is put into practice, the most common filter infusion apparatus or precision liquid medicine excessively cross filter infusion apparatus, and all existing needs nurse
Paying special attention to avoid medicinal liquid to drip sky Mo Feishi dropper and phenomenon that medicinal liquid drips off occurs, medicinal liquid drips sky Mo Feishi dropper to be carried out needs
Secondary exhaust, if filter designs without transom window, then needs to change whole transfusion device, increases patient and pays and cause patient to be discontented with；Medicine
Drop is complete, then occur that blood backflow causes patient strains.
For alleviating nurse job intensity, occur in that band automatic liquid-stopping device i.e. uses tradition buoy to possess the transfusion of automatic liquid-stopping function
Device and the automatic liquid-stopping functional filters realized by filter membrane.Tradition buoy is used to possess the transfusion device [1-2] of automatic liquid-stopping function
Being to be affected blocking tube for transfusion by buoy by medicinal liquid buoyancy to reach automatic liquid-stopping effect, this function is by medicine liquid ingredient and pure
The impact of cleanliness is relatively big, slightly impurity, granule, and plastic buoy just cannot coincide with tube for transfusion, it is impossible to enough realizes automatic liquid-stopping.
What is more important, uses tradition buoy to possess its once automatic liquid-stopping of transfusion device of automatic liquid-stopping function, blocked below buoy
In transfusion device, the medicinal liquid of tens of milliliters cannot continue with human body, the loss of inevitable medicinal liquid.And use filter membrane to realize certainly
The filter of dynamic only liquid, its filter membrane is the perforated membrane that hydrophilic is extremely strong, and material is fibrous membrane.This only liquid filter is according to many
On pore membrane, the capillary theory of micropore realizes automatic liquid-stopping function, there is following drawback: 1) use fibrous membrane, in infusion solutions due to
Filter membrane is immersed in medicinal liquid for a long time, there is the risk of fibre shedding；2) perforated membrane pore-size distribution width, hole size heterogeneity,
Because only liquid height is strongly depend on aperture, thus there is the risk that only liquid is failed；3) filter membrane is perforated membrane, and thickness mostly is
Hundred microns, thus medicinal liquid absorption is big, causes certain loss of medicine.Beijing An Zhen hospital once to traditional infusion device for atropine,
The adsorptivity of 13 kinds of medicines such as nimodipine, nikethamide is studied, result show filter membrane to the adsorption rate of medicine is the highest can
Reach 50%.For clinical department, the high cardiology department of especially medication degree of accuracy, hematology, department of neurology, Anesthesia Department etc. face
For bed section office, owing to cannot accurately estimate that medicine used has that many I haven't seen you for ages runs off, accordingly, it is difficult to accomplish the essence according to the state of an illness actually
Really dosage medication.The adsorptivity of transfusion device, not only causes the waste of medicinal liquid, more importantly brings many to clinical position
Beyond thought difficulty.Accurate measurement medication and costly medicine infusion are clearly disadvantageous.
Nucleopore membranes be by heavy ion punch on megohmite insulant and chemical etching reaming form.When heavy ion is in megohmite insulant thin film
Etchable range more than film thickness time, the radiation damage produced on the heavy ion path of each vertical incidence, available chemistry
Method preferentially etches, and forms the straight channels (micropore) penetrating insulation film.There is the exhausted of one or more this penetrance micropore
Edge thin film is referred to as nucleopore membranes.
Nucleopore membranes have uniqueness physics, chemistry and biological property:
1) accurate, homogeneous aperture and hole density
Filter membrane separation efficiency is the most important Performance Characteristics of microporous filter membrane.This characteristic is controlled by aperture and the pore size distribution of film.Only
Reaching the high uniformity in aperture, the filtering accuracy of filter membrane can be only achieved pin-point accuracy.The micropore of accelerator-produced nucleopore membranes, hole
Footpath is homogeneous, hole shape rule, and energy 100% retains the microgranule more than aperture.
2) columned microcellular structure
Owing to nucleopore membranes has this microcellular structure, when filtering, all particles more than aperture are all trapped within the surface of film,
Using crossflow filtration technique can highly desirable control concentration polarization and filter cake is piled up, therefore long-time operation still can ensure higher
Flux.
3) rate of filtration is big
The porosity of nucleopore membranes is little, but its thickness is the least, compensate for the filtering velocity owing to low porosity causes and declines.
4) do not adsorb, without fibre shedding
Nucleopore membranes micropore specific area is little, only a thirtieth of cellulose membrane, thus absorbability is the lowest, to filtering some valencys
For medicinal liquid that lattice are high or a small amount of precious liquid, the loss caused owing to liquid is adsorbed by filter medium is by considerably less.Nucleopore membranes
Material be high molecular polymer, do not have any material that may migrate in filtrate, because of the side without portion's admixture in addition
Formula pollutes filtrate.
5) chemical stability is good
Can the erosion of acidproof and most organic solvent, particularly PET film, it almost can with resistance to hydrocarbon, alcohol, ether, acid,
The overwhelming majority organic solvent such as ester, halogenated hydrocarbons, is the good substitute of microporous teflon membran.
6) biologically inert is good
PC and PET nucleopore membranes is inert to microorganism, is neither corroded by microorganism, atomic due to solable matter, no again
The breeding that suppression is biological, thus on the one hand can work the most in wet condition, another aspect is quite safe to biology.
PC film is tested by UPS VI grade and biochemical etc. in the U.S., it was demonstrated that to biological nontoxic, uses safety, the most not in injection
Naturally stimulate or the generation of suppression cell.North China Pharmaceutical Factory of China had once carried out acute toxicity test in mice, rabbit to PET
Intradermoreaction test and hemolytic test, all show that biology is had no adverse reaction by PET.
7) Heat stability is good
PET film can stand 150 DEG C, and short-term can stand 175 DEG C, thus film dress can be repeated hot pressing sterilization in the filter
And do not rupture and deform.
Nucleopore membranes is with physics, chemistry and the biological property of its uniqueness, excellent particle cutoff performance, high throughput filtration speed and pole
Low medicinal liquid absorption so that it is become and meet infusion solutions ultimate filter, particularly accurate filter film requires ideal essence
Close filtering material.
The homogeneous characteristic in nucleopore membranes aperture makes it should be the preferable material utilizing aperture siphon principle to prepare automatic liquid-stopping secondary filter film
Material, because pore size is consistent, the most only liquid height and only liquid stable performance, if but the surface hydrophilicity of membrane material is bad, then
It is easily generated gas passage, causes only liquid performance failure.The precision transfusion filter kernel pore membrane filter material used clinically at present is polyester
Nucleopore membranes.The surface hydrophilicity of polyester material between hydrophilic and hydrophobic between.Therefore, if not carrying out the special handling of any surface
Conventional polyester nucleopore membranes cannot function as the liquid medicine filtering membrane of infusion solutions automatic liquid-stopping and uses.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of precision transfusion automatic liquid-stopping nuclear pore filter film.
Second object of the present invention is to provide the preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film.
Technical scheme is summarized as follows:
The preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film, comprises the steps: the 16MeV/u produced with accelerator
The Ar-40 particle irradiation thickness of Xe-132 particle, the Kr-84 particle of 15MeV/u or 10MeV/u be 8 μm-30 μm
Mylar, 55-80 DEG C, the sodium hydrate aqueous solution of 6.5-8.0mol/L etches 23-60 minute；55-80 DEG C,
0.5-1mol/L sodium hydrate aqueous solution cleans 6-10 minute；Clean the most in deionized water；In 60 DEG C of-80 DEG C of modification liquids,
First the most ultrasonic soak 3-10 minute, stop again ultrasonic soaking 15-40 minute, being further continued for ultrasonic immersion 3-10 minute；At deionization
Water cleans；40-70 DEG C of drying, i.e. makes precision transfusion automatic liquid-stopping nuclear pore filter film, and described modification liquid is in mass ratio by 15-20
Part potassium dichromate, 500-600 part concentrated sulphuric acid and 80-100 part deionized water composition.
The precision transfusion automatic liquid-stopping nuclear pore filter film prepared in aforementioned manners, the aperture of described film is 0.1-10 μm, water contact angle
9.6 °-30.0 °, thickness is 7.9-24 μm.
Advantages of the present invention
The method of the present invention is simple, and the precision transfusion automatic liquid-stopping nuclear pore filter film of the present invention is super hydrophilic, and water contact angle is less than 30 °,
Only liquid height is relevant to aperture and film surface hydrophilicity, only liquid height 1.8 meters～3.0 meters.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
The preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film, comprises the steps: the 16MeV/u produced with accelerator
The thickness of Xe-132 particle irradiation be 8 μm mylars, 55 DEG C, the sodium hydrate aqueous solution of 6.5mol/L etches
60 minutes；60 DEG C, 1mol/L sodium hydrate aqueous solution cleans 10 minutes；Clean the most in deionized water；Change at 80 DEG C
Property liquid in, first ultrasonic immersion 10 minutes, stop ultrasonic immersion 40 minutes again, be further continued for ultrasonic immersion 10 minutes；At deionization
Water cleans；50 DEG C of drying, i.e. make precision transfusion automatic liquid-stopping nuclear pore filter film, and this membrane aperture is 0.1 μm, water contact angle
Being 30.0 °, thickness 7.9 μm, when using as precision transfusion filter filter membrane, only liquid height reaches 3.0 meters.
Modification liquid is gone by 15 parts of potassium dichromates, 500 parts of concentrated sulphuric acids (mass concentration is the aqueous solution of 98%) and 80 parts in mass ratio
Ionized water forms.
Embodiment 2
The preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film, comprises the steps: the 15MeV/u produced with accelerator
The thickness of Kr-84 particle irradiation be 12 μm mylars, 65 DEG C, the sodium hydrate aqueous solution of 7.0mol/L etches
30 minutes；55 DEG C, 1mol/L sodium hydrate aqueous solution cleans 10 minutes；Clean the most in deionized water；Change at 70 DEG C
Property liquid in, first ultrasonic immersion 8 minutes, stop ultrasonic immersion 30 minutes again, be further continued for ultrasonic immersion 8 minutes；At deionized water
Middle cleaning；40 DEG C of drying, i.e. make precision transfusion automatic liquid-stopping nuclear pore filter film, and this membrane aperture is 2.0 μm, water contact angle
25.3 ° of thickness are 10 μm, and when using as precision transfusion filter filter membrane, only liquid height reaches 3.0 meters.
Modification liquid is gone by 20 parts of potassium dichromates, 550 parts of concentrated sulphuric acids (mass concentration is the aqueous solution of 98%) and 80 parts in mass ratio
Ionized water forms.
Embodiment 3
The preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film, is characterized in that comprising the steps:
It is 30 μm mylars with the thickness of the Kr-84 particle irradiation of the 15MeV/u of accelerator generation, at 75 DEG C, 7.0mol/L
Sodium hydrate aqueous solution in etch 30 minutes；75 DEG C, 0.5/L sodium hydrate aqueous solution cleans 10 minutes；Going again
Ionized water cleans；In 60 DEG C of modification liquids, first ultrasonic immersion 3 minutes, stop ultrasonic immersion 20 minutes again, be further continued for surpassing
Sound soaks 3 minutes；Clean in deionized water；60 DEG C of drying, i.e. make precision transfusion automatic liquid-stopping nuclear pore filter film, this film
Aperture is 5.0 μm, water contact angle 15.1 °, and thickness is 24 μm, when using as precision transfusion filter filter membrane, and only liquid
Highly reach 2.2 meters.
Modification liquid is in mass ratio by 20 parts of potassium dichromates, 600 parts of concentrated sulphuric acids (mass concentration is the aqueous solution of 98%) and 100 parts
Deionized water forms.
Embodiment 4
The preparation method of a kind of precision transfusion automatic liquid-stopping nuclear pore filter film, comprises the steps: to produce 10MeV/u with accelerator
The thickness of Ar-40 particle irradiation be 25 μm mylars, 80 DEG C, the sodium hydrate aqueous solution of 8.0mol/L etches
23 minutes；80 DEG C, 0.5/L sodium hydrate aqueous solution cleans 6 minutes；Clean the most in deionized water；80 DEG C of modifications
In liquid, first ultrasonic immersion 3 minutes, stop ultrasonic immersion 15 minutes again, be further continued for ultrasonic immersion 3 minutes；In deionized water
Clean；70 DEG C of drying, i.e. make precision transfusion automatic liquid-stopping nuclear pore filter film, and this membrane aperture is 10.0 μm, water contact angle 9.6 °
Thickness is 12 μm, and when using as precision transfusion filter filter membrane, only liquid height reaches 1.8 meters.
Modification liquid is gone by 20 parts of potassium dichromates, 600 parts of concentrated sulphuric acids (mass concentration is the aqueous solution of 98%) and 80 parts in mass ratio
Ionized water forms.
Claims (2)
1. a precision transfusion preparation method for automatic liquid-stopping nuclear pore filter film, is characterized in that comprising the steps: to produce with accelerator
The Ar-40 particle irradiation thickness of the raw Xe-132 particle of 16MeV/u, the Kr-84 particle of 15MeV/u or 10MeV/u is
8 μm-30 μm mylars, 55-80 DEG C, the sodium hydrate aqueous solution of 6.5-8.0mol/L etches 23-60 minute；
55-80 DEG C, 0.5-1mol/L sodium hydrate aqueous solution cleans 6-10 minute；Clean the most in deionized water；At 60 DEG C
In-80 DEG C of modification liquids, first the most ultrasonic soak 3-10 minute, stop again ultrasonic soaking 15-40 minute, being further continued for ultrasonic immersion 3-10
Minute；Clean in deionized water；40-70 DEG C of drying, i.e. makes precision transfusion automatic liquid-stopping nuclear pore filter film, described modification liquid
It is made up of 15-20 part potassium dichromate, 500-600 part concentrated sulphuric acid and 80-100 part deionized water in mass ratio.
2. the precision transfusion automatic liquid-stopping nuclear pore filter film that prepared by the method for claim 1, is characterized in that the aperture of described film is
0.1-10 μm, water contact angle 9.6 °-30.0 °, thickness is 7.9-24 μm.
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Families Citing this family (3)
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| CN104190269B (en) * | 2014-09-11 | 2016-09-21 | 浙江南洋慧通新材料有限公司 | A kind of raising hydrophilic method of heavy ion microporous membrane |
| CN104607054B (en) * | 2014-12-31 | 2017-11-10 | 浙江南洋慧通新材料有限公司 | Heavy ion microporous membrane preparation method with only liquid function and the transfusion device using film |
| CN109078503B (en) * | 2018-08-17 | 2021-01-12 | 东华大学 | Hydrophilic treatment process for PET precision transfusion filtering nuclear pore membrane |
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Effective date of registration: 20220921 Address after: Office Building, No. 18, Hanjiang Road, Lingang Economic Zone, Binhai New Area, Tianjin 300452 Patentee after: TIANJIN LIYUAN TECHNOLOGY CO.,LTD. Patentee after: TIANJIN SAIDE MEDICAL DEVICES CO.,LTD. Address before: No. 38, Gaoxin 5th Road, Binhai Science and Technology Park, Binhai New District, Tianjin 300384 Patentee before: TIANJIN LIYUAN TECHNOLOGY CO.,LTD. |