CN101069679A - Composition for making womb relaxation and method for relieving dysmenorrhea - Google Patents
Composition for making womb relaxation and method for relieving dysmenorrhea Download PDFInfo
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- CN101069679A CN101069679A CN 200610081834 CN200610081834A CN101069679A CN 101069679 A CN101069679 A CN 101069679A CN 200610081834 CN200610081834 CN 200610081834 CN 200610081834 A CN200610081834 A CN 200610081834A CN 101069679 A CN101069679 A CN 101069679A
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- hysteranesis
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Abstract
The present invention relates to a method capable of relieving and curing woman dysmenorrheal by applying effective dose of essential oil. Said essential oil is extracted from origanum vulgare, rhododendron barbigera, perilla frutescens, molsa chinensis and zuoshaoxing and/or above-mentioned combination.
Description
Technical field
The invention relates to a kind of pharmaceutical composition, and especially in regard to a kind of method that is used to alleviate the pharmaceutical composition of dysmenorrhea and alleviates dysmenorrhea.
Background technology
Every month when woman month when coming, Nian Qing women particularly has the spasm of painful.Some women even in menstruation a few days ago has abdominal pain or congested sensation.To after the childbearing age, enlarged uterus inner membrance (liner in uterus) all can be come with blood and other liquid in the uterus in every month in the women.If women's pregnancy, then endometrium can provide nutrient to the embryo.But if not conceived ovulation (discharging ovum to the uterus) back women, then endometrium can be peeled off (being so-called menstrual cycle) after a few days.
Therefore, uterus muscle can shrink, and is lax again, with the extruding endometrium, makes its destruction and discharges the uterus.Liquid can be discharged via cervix uteri, and external through per vaginam discharging the women.General most uterine contraction can not felt, but strong and frequent contraction takes place sometimes and causes pain, promptly so-called dysmenorrhea.Dysmenorrhea may only occur in abdominal part, also may extend upwardly to around the back and extends downward shank.That some women then has is nauseating, vomiting or diarrheal symptom.
Medically, dysmenorrhea is called difficult menstruation again.Nearly all women (about 70% women) can have pain to a certain degree when menstrual cycle, for example, and the pain that has 1/10th women all can have feel very in every month in one to three approximately, and the normal life of influence.Dysmenorrhea all can take place in most (about 70% to 90%) young women.Young women is after the several years of passing through, and dysmenorrhea may slow down or stop, and many women also have the situation that alleviates dysmenorrhea after giving birth to child.
Medically, dysmenorrhea is divided into first type and second type, two big classes.The first type dysmenorrhea is only to have pain when difficult menstruation.The second type dysmenorrhea is by the situation on disease or the health caused (as cyst or endometriosis (the position growth of endometrium beyond in the uterus) are arranged in the ovary).If the situation of dysmenorrhea is serious or deterioration, helps the doctor with regard to demand and seek possible treatment.
In addition, also can take prescription drugs and treat, the amount of prostaglandin is controlled or reduced to wherein a kind of Therapeutic Method for taking oral contraceptive or NSAID (non-steroidal anti-inflammatory drug) (NSAIDs, non-steroidal anti-inflammatorydrugs).Shrink because of prostaglandin can cause uterus muscle, make endometrium discharge the uterus, and uterus muscle contraction (spasm) can cause pain.
Though prescription drugs can effectively slow down pain, medicine can have side effects to liver, kidney and digestive system and influence clinically use.Therefore, the present invention proposes to slow down dysmenorrhea with natural draft therapy.
Summary of the invention
The objective of the invention is to provides the quintessence oil that slows down periodicity pain to the women, after giving effective dose, can make hysteranesis effectively.
In one embodiment, the invention provides a kind of compositions that makes hysteranesis, the quintessence oil that comprises effective dose, extraction is from Adeps Bovis seu Bubali (Origanum vulgare (origanum)), Ran flower Cuculus polioephalus (Rhododendron anthopogan (anthopogan)), Folium Perillae (Perilla frutescens (perrila)), Mosla chinensis Maxim. (Mosla chinensis (herba moslae)), Canarium luzonicum Elemi (Canarium luzonicum (elemi)), (Plectranthus amboinicus (cuban oregano) or above-mentioned combination, its mode that can outside smear alleviates or relaxes women's dysmenorrhea and difficult menstruation to Plectlanthus amboinicus (Lour) Spreng.
In another embodiment, this impels the compositions of hysteranesis, the carvacrol (carvacrol), 1-nopinene (1-β-pinene) and/or the limonene (limonene) that comprise effective dose, and can also comprise quintessence oil, described quintessence oil extraction is from Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng or above-mentioned combination, to promote the lax of uterus.
For above and other objects of the present invention, feature and advantage can be become apparent, preferred embodiment cited below particularly, and cooperate appended diagram, be described in detail below.
Description of drawings
The 1st figure is presented at and gives oxytocin, prostaglandin F
2 α(PGF
2 α) and potassium chloride come under the stimulation in rats uterine contraction inhibition ability of Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng quintessence oil relatively respectively.
The 2nd figure is presented at and gives oxytocin, prostaglandin F
2 α(PGF
2 α) and the contraction of potassium chloride stimulation in rats uterus muscle down, compares the ability of carvacrol, 1-p-pinene, limonene, thymol (thymol), linalool (linalool) inhibition contraction respectively.
The specific embodiment
Quintessence oil, be called volatilization (volatile) oil or exquisite (ethereal) oil again, be aromatic oil liquid (aromatic oily liquid), can squeeze from plant material (as flower, bud, seed, leaf, twig, bark, herbaceous plant, timber, fruit, root), fermentation, enfleurage or extract (with reference to " Essential oils:their antibacterial properties andpotential applications in foods-a review " (Sara Burt, InternationalJournal of Food Microbiology 2004; 94:223-53)).Quintessence oil is made of minimum molecule usually, after externally local the use, and in being easy to penetrate to the skin, and effect in vivo.
The present invention finds six kinds of quintessence oils, and respectively from Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng, the uterus that can effectively relax helps to alleviate dysmenorrhea after being applied in the outside.
Embodiment
Table one quintessence oil raw material
| The quintessence oil sample | Popular name | Formal name used at school |
| A | Adeps Bovis seu Bubali | Origanum vulgare |
| B | Ran flower Cuculus polioephalus | Rhododendron anthopogan |
| C | Folium Perillae | Perilla frutescens |
| D | Mosla chinensis Maxim. | Mosla chinensis |
| E | Canarium luzonicum Elemi | Canarium luzonicum |
| F | Plectlanthus amboinicus (Lour) Spreng | Plectranthus amboinicus |
Quintessence oils such as above-mentioned Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi are bought from Hengyi Trade Co., Ltd (Taiwan), natural goods and materials industry (Natural ResourcesIndustries) (Nepal), Jishui County, the Jiangxi Province natural medicinal oil of colleague factory (China), magnificent imperial Flos Magnoliae exploitation limited company (China) and A.E. fragrance; (the A.E.Aromatic ﹠amp of quintessence oil company; Essential Oils) (India).Plectlanthus amboinicus (Lour) Spreng quintessence oil then with the clevenger-type device with way of distillation extraction leaf from Taiwan product kind of plant.
The activity of hysteranesis
With reference to Ostad SN, Soodi M, Shariffzadeh M, Khorshi di N, andMarzban H (The effect of fennel essential oil on uterine contractionas a model for dysmenorrhea, pharmacology and toxicology study.Journal of Ethnopharmacology 2001; Method 76:299-304) with the uterus muscle of oxytocin and potassium chloride stimulation in rats, is judged the activity of hysteranesis by muscle contraction.Obtain the SD rat from Yangming Univ.'s Experimental Animal Center, heavily about 200 to 300 grams.At the preceding estradiol (Estradiol) that gave 5mg/kg in 24 hours earlier of experiment (Sigma-Aldrich), again with CO
2Putting to death mouse takes out uterine cancer cell and cuts into strip.Then the uterus muscle cutlet is fixed in organizing in the bath of 10ml with 1 rest tension that restrains, above-mentioned organize to have in the bath contain hyperoxia (95% O
2And 5% CO
2) dejalon solution, and under 31 ℃, keep at least and made it balance in 1 hour.Prostaglandin F
2 α(PGF
2 α) uterus muscle of stimulation in rats shrinks the condition of ringer solution (Locge-Ringer solution) that experiment then uses improvement and 28 ℃ (with reference to Murata P, Hayakawa T, Satoh K, Kase Y, Ishige A, and Sasaki H. (Effects of Dai-Kenchu-to, a herbal medicine, on uterine and intestinal motility.PhytotherapyResearch 2001; 15:302-6).At last, utilize tonotransducer (Grass InstrumentsUSA) and MP 100 workstation softwares (Biopac Systems USA) to monitor the intensity of muscle contraction.Quintessence oil suppresses the ability of muscle shown in the 1st figure.
With reference to the 1st figure, giving oxytocin, prostaglandin F
2 α(PGF
2 α) and potassium chloride come under the stimulation in rats uterine contraction inhibition ability of Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng quintessence oil relatively respectively.Above-mentioned muscle is with oxytocin (10mU/ml), prostaglandin F
2 α(PGF
2 α) before (1 μ M) and potassium chloride (60mM) stimulates, do 10 minutes pretreatment with the quintessence oil of 80 μ g/ml earlier.And after stimulating, the maximal contractile response percentage ratio of muscle is with this response strength and does not do the pretreated matched group response strength of quintessence oil (being decided to be 100%) and relatively get, and calculates the mean+SD of 3 independent experiment data.The 1st figure shows, under shrinking with oxytocin stimulation in rats uterus muscle, the muscle contraction of handling through six kinds of quintessence oils is reflected between 8% to 16%, and expression is with respect to matched group (handling without quintessence oil), and quintessence oil can effectively suppress the contraction of uterus muscle 84% to 92%.And former row parathyrine F
2 α(PGF
2 α) the stimulation in rats uterus muscle shrinks down, Adeps Bovis seu Bubali and elemi quintessence oil have stronger ability (being respectively 82% and 66%) to suppressing muscle contraction, and Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim. and Plectlanthus amboinicus (Lour) Spreng quintessence oil then present the inhibition ability (31% to 43%) of moderate.Under potassium chloride stimulation in rats uterus muscle shrank, Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus and Plectlanthus amboinicus (Lour) Spreng quintessence oil had 78% to 91% inhibition ability.Folium Perillae and Mosla chinensis Maxim. quintessence oil then present the inhibition ability (being respectively 50% and 42%) of moderate.
Dysmenorrhea model in mice
Reference is from people such as Yang Minghua (Yang Minghua, Jin Zuhan, Guo Yuefang, Zhu Peiqing, Chen Wanji, the regulating menoxenia of capsules for regulating menstruation and activating blood, Chinese patent medicine, 2000; Dysmenorrhea model in mice 22:717-9) is through adjusting the activity that also is used to assess quintessence oil.Obtain 36 female ICR mices (heavily about 30 to 40 grams) from Taiwan Univ.'s medical college, be divided into 3 groups.The the 1st to 5 day and the 8th to 12 day, Jojoba oil, Adeps Bovis seu Bubali and Folium Rhododendri Mariaes quintessence oil (getting 30% respectively) that every day 1 time smears 1ml/kg respectively for the abdominal part of mice in Jojoba oil, then the 9th to 11 day every day 1 time to mouse peritoneal injection diethylstilbestrol (10mg/kg).At the 12nd day, to smear behind the quintessence oil 30 minutes, lumbar injection oxytocin (15 U/kg) also writes down and turns round the body number of times in the mice 30 minutes, and the result is as shown in Table 2.
Table two Adeps Bovis seu Bubali and Folium Rhododendri Mariaes quintessence oil are to the influence of dysmenorrhea mice
| Group | Turn round the mice number of body | Turn round the body number of times | Turn round body percentage ratio |
| Jojoba oil | 12 | 21.8±8.1 | 100 |
| Herba Origani Vulgaris quintessence oil | 12 | 5.1±5.3 | 23 |
| Folium Rhododendri Mariaes quintessence oil | 12 | 5.9±4.4 | 27 |
Mosla chinensis Maxim. and Fructus Perillae quintessence oil are similarly tested, and the result as shown in Table 3.
Table three Mosla chinensis Maxim. and Fructus Perillae quintessence oil are to the influence of dysmenorrhea mice
| Group | Turn round the mouse number of body | Turn round the body number of times | Turn round body percentage ratio |
| Jojoba oil | 12 | 14.5±6.2 | 100 |
| The Mosla chinensis Maxim. quintessence oil | 12 | 6.9±4.2 | 48 |
| Fructus Perillae quintessence oil | 12 | 3.8±3.5 | 26 |
With reference to table two, be subjected in the dysmenorrhea mice of oxytocin stimulation, with respect to smearing Jojoba oil, the mice of smearing Adeps Bovis seu Bubali and Folium Rhododendri Mariaes quintessence oil can reduce turns round body number of times (77% and 73%).With reference to shown in the table three, smear Mosla chinensis Maxim. and Fructus Perillae quintessence oil, that then can reduce the dysmenorrhea mice turns round body number of times (74% and 52%).
The chemical analysis of quintessence oil
The chemical constituent of further utilizing gas chromatography mass spectrometer to analyze above-mentioned six kinds of quintessence oils is formed.Wherein gas chromatograph is an Agilent 6890N type, and the capillary tube tubing string is HP-5MS type (30m * 0.25mm, film thickness are 0.25 μ m), and with the mass spectrograph of Agilent5973 type as monitor.The temperature of wherein injecting and monitoring (mass spectrograph transmission line) is set in 250 ℃ and 285 ℃ respectively.Utilize the helium vector gas of 1ml/min that the sample (1/10 in isopropyl alcohol) that dilutes is expelled to Autosampler (Agilent 7683Series).Wherein the temperature of heater is 40 ℃ (5min) in regular turn, 40 ℃ to 180 ℃ (3 ℃ of min
-1), 180 ℃ to 200 ℃ (6 ℃ of min
-1), 200 ℃ to 250 ℃ (8 ℃ of 3min
-1), and 250 ℃ (3min).The composition of quintessence oil can learn that the composition of six kinds of quintessence oils as shown in Table 4 by the data base (Wiley 275.L) of its retention index (retention indices) and mass spectrum comparison gas chromatography mass spectrometer computer.
Table four is with the content of each composition of gas chromatography spectrometer analysis quintessence oil
| Composition | Content % with each composition of gas chromatography spectrometer analysis quintessence oil | |||||
| Adeps Bovis seu Bubali | Ran flower Cuculus polioephalus | Folium Perillae | Herba Moslae | Canarium luzonicum Elemi | Plectlanthus amboinicus (Lour) Spreng | |
| Carvacrol | 35.66 | - | - | 6.39 | - | 57.98 |
| The 1-nopinene | - | 6.92 | - | - | - | - |
| Limonene | - | 8.77 | 20.32 | 31.36 | 29.28 | 1.24 |
| Thymol | 30 | - | - | 3.54 | - | - |
| Linalool | 6.05 | - | 1.38 | - | - | 0.20 |
Giving oxytocin, prostaglandin F
2 α(PGF
2 α) and the contraction of potassium chloride stimulation in rats uterus muscle down, compares the ability of carvacrol, 1-nopinene, limonene, thymol, linalool inhibition contraction respectively.With uterus muscle oxytocin (10 mU/ml), prostaglandin F
2 α(PGF
2 α) before (1 μ M) and potassium chloride (60mM) stimulates, handled 10 minutes with each above-mentioned composition of 20 μ g/ml earlier.After stimulation, the maximal contractile response of muscle compares with the matched group (100%) of not doing the quintessence oil processing.And calculating the mean+SD of 3 independent experiment data, the result is shown in the 2nd figure.
With reference to the 2nd figure, shrink down with oxytocin stimulation in rats uterus muscle, carvacrol, 1-nopinene, limonene, thymol, linalool all can slow down the contraction (24% to 78%) of muscle.Former row parathyrine F
2 α(PGF
2 α) the stimulation in rats uterus muscle shrinks down, carvacrol, 1-nopinene and limonene have 51% to 66% inhibition ability, but thymol, linalool then do not have significant inhibition ability.Under shrinking with potassium chloride stimulation in rats uterus muscle, carvacrol, thymol and linalool then have 27% to 46% inhibition ability.
By above-mentioned experimental result as can be known, extraction is shunk the effect of releiving that has in various degree from the quintessence oil of Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng for uterus muscle, therefore above-mentioned six kinds of quintessence oils can separately or merge use when handling dysmenorrhea or difficult menstruation, can be as the composition of lax uterus muscle.In addition, from the above-claimed cpd of the carvacrol of six kinds of quintessence oils, 1-nopinene, limonene, thymol, linalool when handling dysmenorrhea or difficult menstruation, the ability that also has lax uterus muscle, so above-claimed cpd also can be as the composition of lax uterus muscle.
Though the present invention with preferred embodiment openly as above; right its is not in order to qualification the present invention, any those skilled in the art, without departing from the spirit and scope of the present invention; when can doing a little change and retouching, so protection scope of the present invention is as the criterion when looking appended the claim person of defining.
Claims (18)
1. compositions that makes hysteranesis comprises the quintessence oil of effective dose, and extraction is from Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng and/or above-mentioned combination.
2. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil contains one or more and is selected from following composition: carvacrol, 1-nopinene, limonene, thymol or linalool.
3. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil comprises carvacrol.
4. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil comprises the 1-nopinene.
5. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil comprises limonene.
6. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil comprises thymol.
7. the compositions that makes hysteranesis as claimed in claim 1, wherein this quintessence oil comprises linalool.
8. the described compositions that makes hysteranesis of claim 1 is used for alleviating the purposes of the medicine of dysmenorrhea in preparation.
9. a compositions that makes hysteranesis comprises carvacrol, 1-nopinene, limonene and/or the above-mentioned combination of effective dose.
10. the compositions that makes hysteranesis as claimed in claim 9 is comprising Herba Origani Vulgaris quintessence oil.
11. the compositions that makes hysteranesis as claimed in claim 9 is comprising Folium Rhododendri Mariaes quintessence oil.
12. the compositions that makes hysteranesis as claimed in claim 9 is comprising Fructus Perillae quintessence oil.
13. the compositions that makes hysteranesis as claimed in claim 9 is comprising the Mosla chinensis Maxim. quintessence oil.
14. the compositions that makes hysteranesis as claimed in claim 9 is comprising elemi quintessence oil.
15. the compositions that makes hysteranesis as claimed in claim 9 is comprising Plectlanthus amboinicus (Lour) Spreng.
16. the compositions that makes hysteranesis as claimed in claim 9 is comprising the quintessence oil of Adeps Bovis seu Bubali, Ran flower Cuculus polioephalus, Folium Perillae, Mosla chinensis Maxim., Canarium luzonicum Elemi, Plectlanthus amboinicus (Lour) Spreng and/or combinations thereof.
17. the compositions that makes hysteranesis as claimed in claim 9, wherein said compositions are from following one or more quintessence oils: Herba Origani Vulgaris quintessence oil, Folium Rhododendri Mariaes quintessence oil, Fructus Perillae quintessence oil, Mosla chinensis Maxim. quintessence oil, elemi quintessence oil, Plectlanthus amboinicus (Lour) Spreng quintessence oil.
18. the compositions that claim 16 is described to make hysteranesis is used for alleviating the purposes of the medicine of dysmenorrhea in preparation.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101927031A (en) * | 2010-09-03 | 2010-12-29 | 云南清逸堂实业有限公司 | Sanitary towel heat sensitizer |
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2006
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101927031A (en) * | 2010-09-03 | 2010-12-29 | 云南清逸堂实业有限公司 | Sanitary towel heat sensitizer |
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