CN101028484B - Chinese medicinal paste for treating tumor and its production - Google Patents

Chinese medicinal paste for treating tumor and its production Download PDF

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CN101028484B
CN101028484B CN2007100133766A CN200710013376A CN101028484B CN 101028484 B CN101028484 B CN 101028484B CN 2007100133766 A CN2007100133766 A CN 2007100133766A CN 200710013376 A CN200710013376 A CN 200710013376A CN 101028484 B CN101028484 B CN 101028484B
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parts
rhizoma
powder
radix
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CN101028484A (en
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张崇亮
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Abstract

The invention discloses a Chinese herbal plaster for treating tumor and a manufacture process thereof, which solves the problems such as big side effect and severe harm to human body in the prior drug for treating tumor, and is convenient for patient self-administration, has advantages of small side effect, good treatment effect, convenient patient self-treatment and the like. Each component of the formula of the Chinese herbal plaster according to weight parts comprises: 1-2 parts of cyperus rotundus, 1-2 parts of magnolia officinalis, 1-2 parts of rhizoma spargani, 1-2 parts of rhizoma curcumae, 1-2 parts of angelica sinensis, 1-2 parts of raw radix aconiti, 1-2 parts of raw monkshood root, 1-2 parts of garlic, 1-2 parts of fructus quisqualis, 1-2 parts of dung beetle, 1-2 parts of rhizoma corydalis, 1-2 parts of radix angelicae dahuricae, 1-2 parts of squama maniti, 1-2 parts of seed of cochinchia momordica, 1-2 parts of rhubarb, 1-2 parts of rhizoma picrorrhizae, 1-2 parts of castor seed, 0.1-0.3 parts of olibanum, 0.1-0.3 parts of myrrh, 0.1-0.3 parts of aloe, 0.1-0.3 parts of dragon's blood, 1-1.5 parts of realgar, 1-1.5 parts of cinnamomum cassia, 1-1.5 parts of camphor, 1-2 parts of asafetida, 1-2 parts of mirabilite, 1-1.5 parts of nux vomica, 1-2 parts of toad venom, 0.4 parts of nano far infrared ceramic powder. Furthermore 0.5 parts of peppermint oil, 1.05 parts of L-menthol, 1.05 parts of laurocapram, 0.5 parts of borneol and appropriate substance are added into the Chinese herbal plaster.

Description

The Chinese medicine patch and the processing technology thereof that are used for oncotherapy
Technical field
The present invention relates to a kind of tumor treatment medicine, relate in particular to a kind of Chinese medicine patch and processing technology thereof that is used for oncotherapy.
Background technology
The medicine that is used for oncotherapy at present, mostly be oral medication or drug administration by injection, concerning tumor patient particularly part gastrointestinal and the Infusion in Patients with Digestive oral medicine swallow difficulty, have bigger side reaction as phenomenons such as nausea and vomiting occurring, and medicine in vivo digest and assimilate the comparison difficulty, often in therapeutic process, be difficult to get a desired effect; And drug administration by injection often needs full-time medical worker, is not easy to patient's automedication.
Summary of the invention
The present invention is overcome the existing drug side effect that is used for the treatment of tumor big, heavy to human body harm, and be convenient to problems such as patient's automedication, provide that a kind of to have toxic and side effects little, therapeutic effect is good, and the patient can carry out the Chinese medicine patch that is used for oncotherapy and the processing technology thereof of advantages such as Heal Thyself easily.
For achieving the above object, this utility model adopts following technical scheme:
A kind of Chinese medicine patch that is used for oncotherapy, it is grouped into by following one-tenth by weight, 1~2 part of 1~1.5 part of Venenum Bufonis of 1~2 part of Semen Strychni of 1~2 part of Natrii Sulfas of 1~1.5 part of Resina Ferulae of 1~1.5 part of Camphora of 1~1.5 portion of Cortex Cinnamomi of 0.1~0.3 portion of Realgar of 0.1~0.3 part of Sanguis Draxonis of 0.1~0.3 portion of Aloe of 0.1~0.3 part of Myrrha of 1~2 part of Olibanum of 1~2 part of Semen Ricini of 1~2 part of Rhizoma Picrorhizae of 1~2 part of Radix Et Rhizoma Rhei of 1~2 part of Semen Momordicae of 1~2 part of Squama Manis of 1~2 part of Radix Angelicae Dahuricae of 1~2 part of Rhizoma Corydalis of 1~2 portion of Catharsii molossi of 1~2 part of Fructus Quisqualis of 1~2 portion of Bulbus Allii of 1~2 part of Radix Aconiti of 1~2 part of Radix Aconiti Kusnezoffii of 1~2 part of Radix Angelicae Sinensis of 1~2 part of Rhizoma Curcumae of 1~2 part of rhizoma sparganic of 1~2 part of Cortex Magnoliae Officinalis of Rhizoma Cyperi, 0.4 part of nano far infrared ceramic powder also should add 0.5 part of 1.05 parts of Borneolum Syntheticum of 1.05 parts of azones of 0.5 part of L-menthol of Oleum menthae and an amount of substrate simultaneously.
Described each composition by weight, 2 parts of 2 parts of Semen Momordicaes of 2 parts of Radix Aconiti of 2 parts of Radix Aconiti Kusnezoffii of 2 parts of Radix Angelicae Sinensis of 2 parts of Rhizoma Curcumae of 2 parts of rhizoma sparganic of 2 parts of Cortex Magnoliae Officinalis of Rhizoma Cyperi, 2 parts of Squama Maniss of 2 parts of Radixs Angelicae Dahuricae of 2 parts of Rhizoma Corydalis of 2 portions of Catharsii molossis of 2 portions of Bulbus Alliis, 2 Fructus Quisqualis, 1.5 parts of 1.5 parts of Camphoras of 1.5 portions of Cortex Cinnamomis of 300 portions of Realgars of 0.3 part of Sanguis Draxonis of 0.3 portion of Aloe of 0.3 part of Myrrha of 2 parts of Olibanums of 2 parts of Semen Ricini of 2 parts of Rhizoma Picrorhizae of Radix Et Rhizoma Rhei, 2 parts of 1.5 parts of Venenum Bufoniss of 2 parts of Semen Strychni Pulveratums of 2 parts of Natrii Sulfas of Resina Ferulae, 0.4 part of nano far infrared ceramic powder, 0.5 part of 1.05 parts of Borneolum Syntheticum of 1.0 parts of azones of 0.5 part of L-menthol of Oleum menthae, substrate: an amount of.
A kind of processing technology that is used for the Chinese medicine patch of oncotherapy, its method be,
(1) concocts raw material
With the Rhizoma Corydalis processed with vinegar, be ground into 200 order impalpable powders behind the Semen Strychni stir-baking in sand; Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe powder become fine powder, cross 200 mesh sieves, and standby, the Venenum Bufonis powder dissolves with a small amount of 75% ethanol after becoming fine powder; Radix Aconiti, Radix Aconiti Kusnezoffii is given birth to usefulness, and all the other medical materials are made only, feed intake with clean medical material;
(2) extract, concentrate
A. alcohol extraction: get the above-mentioned Rhizoma Cyperi that cooks, Cortex Magnoliae Officinalis, rhizoma sparganic, Rhizoma Curcumae, Squama Manis, Semen Momordicae, Catharsii molossi, Cortex Cinnamomi, Rhizoma Corydalis (processed with vinegar), Radix Angelicae Sinensis, Bulbus Allii, Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Rhizoma Picrorhizae, Semen Ricini, add 10 times of amount 75% ethanol, reflux, extract, 3 hours is collected extracting solution for the first time; Add 8 times of amount 75% alcohol reflux again 3 hours, and collected extracting solution for the second time; (how is the ratio between them with twice extracting solution? be 1: 1) be no more than under 60 ℃ in temperature, be evaporated to relative density and be 1.2 clear paste, medicinal residues are standby;
B. acid percolation: with Radix Aconiti Kusnezoffii, Radix Aconiti, powder becomes 10 purpose coarse powder, uses earlier an amount of acidic ethanol, its purity is 95%, and PH=3 soaks into after 6 hours, total adds 12 times of amount acidic ethanol, and its purity is 95%, PH=3, pack in the percolator, flood after 48 hours, with the infiltration rate of 2~3ml/min, the beginning percolation is collected percolate, is no more than under 60 ℃ in temperature, it is 1.2 clear paste to relative density that percolate is reclaimed ethanol, and medicinal residues are standby;
C. water is carried: get above-mentioned two kinds of medicinal residues, decoct with water at least 2 times, add for the first time 10 times of water gagings and decocted 5 hours, add 8 times of water gagings for the second time and decocted 3 hours, merge medicinal liquid, the desuperheat degree is no more than 60 ℃ of pressures, and to be concentrated into relative density be 1.2 clear paste;
D. mix: the Venenum Bufonis powder is dissolved the clear paste mix homogeneously that back and above-mentioned alcohol extraction and water are carried with a small amount of 75% ethanol, slowly stir and add Resina Ferulae, Camphora, Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe, Semen Strychni fine drug powder down, adding Oleum menthae, L-menthol, azone, Borneolum Syntheticum, far infrared ceramic powder at last fully stirs, weigh, in medicine: the ratio of substrate=1: 3.6 adds in the substrate.
(3) molding: above-mentioned mastic is coated on the non-woven fabrics, and polyethylene film is covered on the surface, drying, promptly.
One, clinical physical data:
Male 27 people, women 23 people; 37 people more than 50 years old; Cadre 19 people, workman 21 people.Case mostly is the crowd of the symptoms such as local lump, pain and edema that tumor causes.
Two, the setting of matched group:
Adopt random method to select the crowd of the symptoms such as local lump, pain and edema that 50 examples cause because of tumor to be matched group.
Three, clinical examination project:
Inspection item: 1, lump size 2, pain relief degree 3, edema extinction situation
Four, clinical effectiveness classification standard:
Three grades of criteria for classifying are: effective, improvement, invalid.
Effectively: the alleviation of clinical symptoms and sign.
Take a turn for the better: the alleviating of clinical symptoms and sign.
Invalid: clinical symptoms and sign no change.
Five, record is implemented in clinical verification:
Observation group: will go Wei long-pending eliminating mass and relieving fullness to be affixed on affected part, painful area and back relevant Yu cave, change once in per three days, 18 days is a course of treatment.All case is all finished use.
Matched group: only use corresponding medicine, observed continuously 30 days.
Six, untoward reaction:
The crowd does not find untoward reaction between the operating period.
Seven, clinical effectiveness statistics:
Figure G07113376620070329D000031
Annotate: require computer card side's statistical value and P value.
As calculated, Z=3.461 P=0.001<0.05
Eight, checking result statistics:
In observation group's 50 examples, 41 people effectively, 4 people of improvement, 5 invalid people; In matched group 50 examples, 23 people effectively, 17 people of improvement, 10 invalid people.
Nine, checking conclusion:
50 people of observation group use this product to observe 18 days, effective 41 people of crowd of the symptoms such as local lump, pain and edema that tumor is caused, and 4 people of improvement, 5 invalid people do not find any side effect between the operating period, total effective rate 90%.Compare with matched group, significant difference (Z=3.461, P=0.001<0.05) is arranged.
The invention has the beneficial effects as follows:
1, avoids the first-pass effect of liver, also avoided medicine that gastrointestinal is stimulated;
2, tumor patient generally all can produce the pathological changes of locality, and the present invention directly sticks the local patholoic change position, absorbs by epidermis to enter local blood capillary, reaches the purpose of quick acting, helps to alleviate patient's misery;
3, the percutaneous administration prescription just, medication at any time or drug withdrawal, the treatment that can make tumor patient obtain continuing;
4, use novel penetrating agent,, the transmitance of drug molecule is improved, make the drug effect performance more complete by penetrating agent and the cuticular effect of skin surface.
5, macromolecular material in the substrate and skin-friendliness are good, no skin irritation reaction.
6, the prescription among the present invention derives from the folk tradition prescription, the clinical qi stagnation hemagglutination that tumor causes, lump in the abdomen mass in the abdomen, epigastric pain, the treatment of diseases such as fullness and distention in the chest and hypochondrium, the determined curative effect of always being used for for many years.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Paste in output 10000,
Get rhizoma cyperi 2kg bark of official magnolia 2kg triangular 2kg curcuma zedoary 2kg Radix Angelicae Sinensis 2kg Radix Aconiti Kusnezoffii 2kg Radix Aconiti 2kg garlic 2kg fruit of Rangoon creeper's 2kg dung beetle 2kg corydalis tuber (vinegar is processed) 2kg root of Dahurain angelica 2kg pangolin 2kg semen momordicae 2kg rheum officinale 2kg Radix picrorrhizae 2kg castor bean 2kg frankincense 300g myrrh 300g aloe 300g dragon's blood 300g realgar 1.5kg Chinese cassia tree 1.5kg camphor 1.5kg asafoetide 2kg saltcake 2kg prepared nux vomica (sand scalds) 1.5kg dried venom of toads 2kg nano far infrared ceramic powder 400g Peppermint Oil 50 0g MENTHOL 1.05kg azone 1.05kg borneol 500g matrix: an amount of. The specification of making is 10 * 14cm2/ paste.
Its method is:
1. get above-mentioned medical material, the Rhizoma Corydalis processed with vinegar is ground into impalpable powder (200 order) behind the Semen Strychni stir-baking in sand, Radix Aconiti, and Radix Aconiti Kusnezoffii gives birth to usefulness, and all the other a few flavor medical materials are made only by 2005 editions official methods, feed intake with clean medical material.Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe powder become fine powder in the above-mentioned medical material, cross 200 mesh sieves, and standby, the Venenum Bufonis powder dissolves with a small amount of 75% ethanol after becoming fine powder.
2. extract, concentrate
A. alcohol extraction: get the above-mentioned Rhizoma Cyperi that cooks, Cortex Magnoliae Officinalis, rhizoma sparganic, Rhizoma Curcumae, Squama Manis, Semen Momordicae, Catharsii molossi, Cortex Cinnamomi, Rhizoma Corydalis (processed with vinegar), Radix Angelicae Sinensis, Bulbus Allii, Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Rhizoma Picrorhizae, Semen Ricini, add 10 times of amount 75% ethanol, reflux, extract, 3 hours, after collecting extracting solution 1, add 8 times of amount 75% alcohol reflux again 3 hours, and collected extracting solution 2; It is 1.2 clear paste (temperature is no more than 60 ℃) that extracting solution 1 and 2 is evaporated to relative density, medicinal residues standby (medicinal residues 1).
B. acid percolation: with Radix Aconiti Kusnezoffii, Radix Aconiti, powder becomes 10 purpose coarse powder, earlier with an amount of acidic ethanol (95%, PH=3), soak into after 6 hours, total adds 12 times of amount acidic ethanol (95%, PH=3), pack in the percolator, flood after 48 hours, with the infiltration rate of 2~3ml/min, the beginning percolation, collect percolate, it is 1.2 clear paste (temperature is no more than 60 ℃) that percolate reclaims ethanol to relative density, medicinal residues standby (medicinal residues 2).
C. water is carried: get above-mentioned medicinal residues 1 and medicinal residues 2, decoct with water 2 times, add 10 times of water gagings for the first time and decocted 5 hours, add 8 times of water gagings for the second time and decocted 3 hours, merge medicinal liquid, be evaporated to relative density and be 1.2 clear paste (temperature is no more than 60 ℃).
D. mix: the Venenum Bufonis powder is dissolved the clear paste mix homogeneously that back and above-mentioned alcohol extraction and water are carried with a small amount of 75% ethanol, slowly stir and add fine drug powders such as Resina Ferulae, Camphora, Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe, Semen Strychni down, adding Oleum menthae, L-menthol, azone, Borneolum Syntheticum, far infrared ceramic powder at last fully stirs, weigh, press medicine: substrate (1: 7) adds in the substrate.
3. molding: above-mentioned mastic is coated on the non-woven fabrics, and polyethylene film is covered on the surface, drying, promptly.

Claims (2)

1. Chinese medicine patch that is used for oncotherapy, it is characterized in that: its raw material and weight portion thereof are, 1~2 part of 1~1.5 part of Venenum Bufonis of 1~2 part of Semen Strychni of 1~2 part of Natrii Sulfas of 1~1.5 part of Resina Ferulae of 1~1.5 part of Camphora of 1~1.5 portion of Cortex Cinnamomi of 0.1~0.3 portion of Realgar of 0.1~0.3 part of Sanguis Draxonis of 0.1~0.3 portion of Aloe of 0.1~0.3 part of Myrrha of 1~2 part of Olibanum of 1~2 part of Semen Ricini of 1~2 part of Rhizoma Picrorhizae of 1~2 part of Radix Et Rhizoma Rhei of 1~2 part of Semen Momordicae of 1~2 part of Squama Manis of 1~2 part of Radix Angelicae Dahuricae of 1~2 part of Rhizoma Corydalis of 1~2 portion of Catharsii molossi of 1~2 part of Fructus Quisqualis of 1~2 portion of Bulbus Allii of 1~2 part of Radix Aconiti of 1~2 part of Radix Aconiti Kusnezoffii of 1~2 part of Radix Angelicae Sinensis of 1~2 part of Rhizoma Curcumae of 1~2 part of rhizoma sparganic of 1~2 part of Cortex Magnoliae Officinalis of Rhizoma Cyperi, 0.4 part of nano far infrared ceramic powder also should add 0.5 part of 1.05 parts of Borneolum Syntheticum of 1.05 parts of azones of 0.5 part of L-menthol of Oleum menthae and an amount of substrate simultaneously.
2. described processing technology that is used for the Chinese medicine patch of oncotherapy of claim 1 is characterized in that: its method is,
(1) concocts raw material
With the Rhizoma Corydalis processed with vinegar, be ground into 200 order impalpable powders behind the Semen Strychni stir-baking in sand; Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe powder become fine powder, cross 200 mesh sieves, and standby, the Venenum Bufonis powder dissolves with a small amount of 75% ethanol after becoming fine powder; Radix Aconiti, Radix Aconiti Kusnezoffii is given birth to usefulness, and all the other medical materials are made only, feed intake with clean medical material;
(2) extract, concentrate
A. alcohol extraction: get the above-mentioned Rhizoma Cyperi that cooks, Cortex Magnoliae Officinalis, rhizoma sparganic, Rhizoma Curcumae, Squama Manis, Semen Momordicae, Catharsii molossi, Cortex Cinnamomi, Rhizoma Corydalis (processed with vinegar), Radix Angelicae Sinensis, Bulbus Allii, Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, Rhizoma Picrorhizae, Semen Ricini, add 10 times of amount 75% ethanol, reflux, extract, 3 hours is collected extracting solution for the first time; Add 8 times of amount 75% alcohol reflux again 3 hours, and collected extracting solution for the second time; With the ratio of twice extracting solution according to 5: 4, be no more than under 60 ℃ in temperature, be evaporated to relative density and be 1.2 clear paste, medicinal residues are standby;
B. acid percolation: with Radix Aconiti Kusnezoffii, Radix Aconiti, powder becomes 10 purpose coarse powder, uses earlier an amount of acidic ethanol, its purity is 95%, and PH=3 soaks into after 6 hours, total adds 12 times of amount acidic ethanol, and its purity is 95%, PH=3, pack in the percolator, flood after 48 hours, with the infiltration rate of 2~3ml/min, the beginning percolation is collected percolate, is no more than under 60 ℃ in temperature, it is 1.2 clear paste to relative density that percolate is reclaimed ethanol, and medicinal residues are standby;
C. water is carried: get above-mentioned two kinds of medicinal residues, decoct with water at least 2 times, add for the first time 10 times of water gagings and decocted 5 hours, add 8 times of water gagings for the second time and decocted 3 hours, merge medicinal liquid, temperature is no more than and is evaporated to relative density under 60 ℃ is 1.2 clear paste;
D. mix: the Venenum Bufonis powder is dissolved the clear paste mix homogeneously that back and above-mentioned alcohol extraction and water are carried with a small amount of 75% ethanol, slowly stir and add Resina Ferulae, Camphora, Olibanum, Myrrha, Sanguis Draxonis, Natrii Sulfas, Realgar, Aloe, Semen Strychni fine drug powder down, adding Oleum menthae, L-menthol, azone, Borneolum Syntheticum, far infrared ceramic powder at last fully stirs, weigh, in medicine: the ratio of substrate=1: 3.6 adds in the substrate;
(3) molding: above-mentioned mastic is coated on the non-woven fabrics, and polyethylene film is covered on the surface, drying, promptly.
CN2007100133766A 2007-03-13 2007-03-13 Chinese medicinal paste for treating tumor and its production Expired - Fee Related CN101028484B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101181573B (en) * 2007-12-13 2010-09-22 晁平显 Medicine for curing tumor and preparation method thereof
CN102872217B (en) * 2012-10-29 2014-08-20 韦成旺 Chinese medicinal ointment for treating tumors, hyperthyroidism and lymph nodes and preparation method thereof
CN103055272A (en) * 2013-01-29 2013-04-24 上海浦东高星生物技术研究所 Aweisanpi plaster
CN105030979B (en) * 2015-08-04 2018-02-16 河南科技大学 A kind of anti-osteoma compound ointment preparation and preparation method thereof
CN107713080A (en) * 2017-10-09 2018-02-23 陈建军 A kind of health care sleeveless jacket

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