CN101027410A - 用于癌症诊断的寡核苷酸 - Google Patents
用于癌症诊断的寡核苷酸 Download PDFInfo
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- CN101027410A CN101027410A CN200580026265.8A CN200580026265A CN101027410A CN 101027410 A CN101027410 A CN 101027410A CN 200580026265 A CN200580026265 A CN 200580026265A CN 101027410 A CN101027410 A CN 101027410A
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006128082A2 (en) * | 2005-05-26 | 2006-11-30 | The Johns Hopkins University | Biomarkers for breast cancer |
JP2007275027A (ja) * | 2006-04-12 | 2007-10-25 | Fujifilm Corp | 癌関連欠失遺伝子マーカーを用いた癌の診断方法 |
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GB201000688D0 (en) * | 2010-01-15 | 2010-03-03 | Diagenic Asa | Product and method |
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Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981783A (en) * | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5871928A (en) * | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
JP2802125B2 (ja) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | 核酸の検出方法 |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
ATE143700T1 (de) | 1991-09-23 | 1996-10-15 | Pfizer | Verfahren für die detektion von spezifische mrns und dns in zellen |
GB2260811B (en) | 1991-10-23 | 1995-07-05 | Yorkshire Cancer Research Camp | Detection of malignant tumours |
WO1993018143A1 (en) | 1992-03-04 | 1993-09-16 | Synaptic Pharmaceutical Corporation | Dna encoding taurine and gaba transporters and uses thereof |
US6114114A (en) | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
US5633137A (en) * | 1992-12-01 | 1997-05-27 | The University Of South Florida | Method for measuring specific gene expression: transcriptional activity per gene dose |
US5677125A (en) * | 1994-01-14 | 1997-10-14 | Vanderbilt University | Method of detection and diagnosis of pre-invasive cancer |
US5830645A (en) * | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
JP2000504575A (ja) | 1996-02-08 | 2000-04-18 | アフィメトリックス,インコーポレイテッド | 微生物のチップベースの種分化および表現型特徴付け |
AU4327697A (en) | 1996-08-20 | 1998-03-06 | Motorola, Inc. | Method and apparatus for detecting predetermined molecular structures in a sample |
US6235474B1 (en) | 1996-12-30 | 2001-05-22 | The Johns Hopkins University | Methods and kits for diagnosing and determination of the predisposition for diseases |
US6190857B1 (en) * | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
NO972006D0 (no) * | 1997-04-30 | 1997-04-30 | Forskningsparken I Aas As | Ny metode for diagnose av sykdommer |
US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
AU9071098A (en) | 1997-07-29 | 1999-02-22 | Lambert C. J. Dorssers | Breast cancer resistance genes, methods for their detection and uses thereof |
US6607879B1 (en) * | 1998-02-09 | 2003-08-19 | Incyte Corporation | Compositions for the detection of blood cell and immunological response gene expression |
US6174680B1 (en) * | 1998-12-30 | 2001-01-16 | Dana-Farber Cancer Institute, Inc. | Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof |
ATE347102T1 (de) | 1998-02-25 | 2006-12-15 | Us Health | Zellulare anordnungen für schnelle molekulare profilidentifizierung |
US6004755A (en) * | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
US6696246B1 (en) | 1998-08-21 | 2004-02-24 | Naxcor, Inc. | Assays using crosslinkable immobilized nucleic acids |
US20080261292A1 (en) * | 1998-09-22 | 2008-10-23 | Oncomedx, Inc. | Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions |
US6593084B2 (en) | 1998-10-13 | 2003-07-15 | Robert E. Bird | Carcinogen assay |
EP1121471A1 (en) | 1998-10-13 | 2001-08-08 | Clontech Laboratories, Inc. | Nucleic acid arrays |
EP1131470A4 (en) | 1998-10-28 | 2004-11-10 | Vysis Inc | CELLULAR NETWORKS AND METHODS FOR DETECTION AND USE OF GENETIC DISORDER MARKERS |
WO2000026412A1 (en) | 1998-11-02 | 2000-05-11 | Kenneth Loren Beattie | Nucleic acid analysis using sequence-targeted tandem hybridization |
AU1853600A (en) | 1999-01-06 | 2000-07-24 | Choong-Chin Liew | Method for the detection of gene transcripts in blood and uses thereof |
US20040241728A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of lung disease related gene transcripts in blood |
US7473528B2 (en) * | 1999-01-06 | 2009-01-06 | Genenews Inc. | Method for the detection of Chagas disease related gene transcripts in blood |
US20050123938A1 (en) | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
US20050003394A1 (en) * | 1999-01-06 | 2005-01-06 | Chondrogene Limited | Method for the detection of rheumatoid arthritis related gene transcripts in blood |
US20040248169A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of obesity related gene transcripts in blood |
US20040265868A1 (en) * | 1999-01-06 | 2004-12-30 | Chondrogene Limited | Method for the detection of depression related gene transcripts in blood |
US20040265869A1 (en) * | 1999-01-06 | 2004-12-30 | Chondrogene Limited | Method for the detection of type II diabetes related gene transcripts in blood |
US20040241727A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of schizophrenia related gene transcripts in blood |
US20050042630A1 (en) * | 1999-01-06 | 2005-02-24 | Chondrogene Limited | Method for the detection of asthma related gene transcripts in blood |
US20040241726A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of allergies related gene transcripts in blood |
US20040248170A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of hyperlipidemia related gene transcripts in blood |
DE19937187A1 (de) * | 1999-08-06 | 2001-03-01 | Qiagen Gmbh | Automatisierte Proteinreinigung im Multiwellformat durch Vakuumfiltration |
WO2002008765A2 (en) * | 2000-07-26 | 2002-01-31 | Stanford University | Basal cell markers in breast cancer and uses thereof |
US7108969B1 (en) * | 2000-09-08 | 2006-09-19 | Affymetrix, Inc. | Methods for detecting and diagnosing oral cancer |
US6955876B2 (en) * | 2000-11-01 | 2005-10-18 | Kane Michael D | Compositions and systems for identifying and comparing expressed genes (mRNAs) in eukaryotic organisms |
WO2002059367A2 (en) | 2000-11-30 | 2002-08-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis |
JP4368110B2 (ja) * | 2001-01-12 | 2009-11-18 | エール ユニヴァーシティ | 癌患者の生物学的流体中のサバイビンの検出 |
US20020132274A1 (en) * | 2001-01-17 | 2002-09-19 | Nevalainen Marja T. | Diagnostic and monitorings methods for cancer |
AU2002253878A1 (en) * | 2001-01-25 | 2002-08-06 | Gene Logic, Inc. | Gene expression profiles in breast tissue |
WO2002070737A2 (en) | 2001-02-28 | 2002-09-12 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
EP1384079A2 (en) * | 2001-05-02 | 2004-01-28 | Oxford GlycoSciences (UK) Limited | Proteins, genes and their use for diagnosis and treatment of breast cancer |
US20020169560A1 (en) * | 2001-05-12 | 2002-11-14 | X-Mine | Analysis mechanism for genetic data |
US7335467B2 (en) * | 2001-05-15 | 2008-02-26 | Ludwig Institute For Cancer Research | Breast cancer antigens |
US20030036077A1 (en) * | 2001-05-31 | 2003-02-20 | Chronix Biomedical | Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers |
US7297480B2 (en) * | 2001-06-28 | 2007-11-20 | Dermtech International | Method for detection of melanoma |
WO2003008963A1 (en) * | 2001-07-18 | 2003-01-30 | University Of Louisville Research Foundation, Inc. | E-genechip online web service for data mining bioinformatics |
US7229774B2 (en) * | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
US7622260B2 (en) * | 2001-09-05 | 2009-11-24 | The Brigham And Women's Hospital, Inc. | Diagnostic and prognostic tests |
CA2466483A1 (en) * | 2001-11-07 | 2003-07-03 | John D. Shaughnessy | Diagnosis prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling |
US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
US20030232350A1 (en) * | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
WO2003041562A2 (en) * | 2001-11-14 | 2003-05-22 | Whitehead Institute For Biomedical Research | Molecular cancer diagnosis using tumor gene expression signature |
AU2002361908A1 (en) * | 2001-12-31 | 2003-07-24 | Quark Biotech, Inc. | Methods for identifying marker genes for cancer |
US20030195431A1 (en) * | 2002-04-10 | 2003-10-16 | Sukhatme Vikas P. | Observation of effects of body fluids on indicator cells for disease diagnosis |
WO2003100000A2 (en) * | 2002-05-24 | 2003-12-04 | Tularik Inc. | Amplification and overexpression of oncogenes |
US20060281081A1 (en) * | 2002-08-30 | 2006-12-14 | Yusuke Nakamura | Method of diagnosing colon and gastric cancers |
EP1581652A4 (en) | 2002-09-12 | 2008-02-13 | Genenews Corp | IDENTIFICATION OF SEQUENCES PARTICULAR USEFUL IN THE DIAGNOSIS AND IDENTIFICATION OF THERAPEUTIC TARGETS FOR OSTEO ARTHRITIS |
US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
GB0227238D0 (en) * | 2002-11-21 | 2002-12-31 | Diagenic As | Product and method |
US7910550B2 (en) * | 2004-04-16 | 2011-03-22 | Stc.Unm | Human kunitz-type inhibitor with enhanced antifibrinolytic activity |
EP1809765A2 (en) * | 2004-11-04 | 2007-07-25 | Roche Diagnostics GmbH | Classification of acute myeloid leukemia |
US20070178503A1 (en) * | 2005-12-19 | 2007-08-02 | Feng Jiang | In-situ genomic DNA chip for detection of cancer |
-
2004
- 2004-06-02 GB GBGB0412301.4A patent/GB0412301D0/en not_active Ceased
-
2005
- 2005-06-02 EP EP05747218A patent/EP1766056B1/en not_active Expired - Lifetime
- 2005-06-02 DK DK05747218.5T patent/DK1766056T3/da active
- 2005-06-02 AT AT05747218T patent/ATE493511T1/de not_active IP Right Cessation
- 2005-06-02 CN CN200580026265.8A patent/CN101027410A/zh active Pending
- 2005-06-02 JP JP2007514130A patent/JP5060945B2/ja not_active Expired - Fee Related
- 2005-06-02 SI SI200531251T patent/SI1766056T1/sl unknown
- 2005-06-02 CA CA002568889A patent/CA2568889A1/en not_active Abandoned
- 2005-06-02 WO PCT/GB2005/002180 patent/WO2005118851A1/en active Application Filing
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- 2005-06-02 AU AU2005250219A patent/AU2005250219B2/en not_active Ceased
- 2005-06-02 US US11/628,300 patent/US8105773B2/en not_active Expired - Fee Related
- 2005-06-02 AP AP2006003862A patent/AP2006003862A0/xx unknown
-
2006
- 2006-12-20 NO NO20065939A patent/NO20065939L/no not_active Application Discontinuation
-
2012
- 2012-01-05 US US13/344,088 patent/US20120295800A1/en not_active Abandoned
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CN104822844B (zh) * | 2012-10-01 | 2019-05-07 | 米伦纽姆医药公司 | 预测对抑制剂的反应的生物标记物和方法以及其用途 |
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CN111910002A (zh) * | 2014-06-18 | 2020-11-10 | 东丽株式会社 | 食道癌的检测试剂盒或装置以及检测方法 |
CN109529018B (zh) * | 2019-01-10 | 2021-11-30 | 南方医科大学南方医院 | Atxn2l用于制备逆转胃癌奥沙利铂耐药的药物的用途 |
CN109529018A (zh) * | 2019-01-10 | 2019-03-29 | 南方医科大学南方医院 | Atxn2l用于制备逆转胃癌奥沙利铂耐药的药物的用途 |
CN113913436B (zh) * | 2021-11-18 | 2023-09-29 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 逆转录转座基因l1-atp8b1及其作为肺鳞癌标志物的用途和治疗肺鳞癌的药物 |
CN113913436A (zh) * | 2021-11-18 | 2022-01-11 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 逆转录转座基因l1-atp8b1及其作为肺鳞癌标志物的用途和治疗肺鳞癌的药物 |
CN115976212A (zh) * | 2022-12-21 | 2023-04-18 | 四川大学华西医院 | 一种用于检测骨肿瘤诊断相关基因的探针库及试剂盒 |
CN115976212B (zh) * | 2022-12-21 | 2024-06-11 | 四川大学华西医院 | 一种用于检测骨肿瘤诊断相关基因的探针库及试剂盒 |
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ATE493511T1 (de) | 2011-01-15 |
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GB0412301D0 (en) | 2004-07-07 |
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DK1766056T3 (da) | 2011-03-14 |
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AU2005250219A1 (en) | 2005-12-15 |
AP2006003862A0 (en) | 2006-12-31 |
NO20065939L (no) | 2007-02-08 |
ZA200610644B (en) | 2008-07-30 |
JP2008501332A (ja) | 2008-01-24 |
EP1766056B1 (en) | 2010-12-29 |
SI1766056T1 (sl) | 2011-05-31 |
WO2005118851A1 (en) | 2005-12-15 |
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