CN101019914A - Soft capsule containing lutein and its prepn - Google Patents
Soft capsule containing lutein and its prepn Download PDFInfo
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- CN101019914A CN101019914A CNA2007102003269A CN200710200326A CN101019914A CN 101019914 A CN101019914 A CN 101019914A CN A2007102003269 A CNA2007102003269 A CN A2007102003269A CN 200710200326 A CN200710200326 A CN 200710200326A CN 101019914 A CN101019914 A CN 101019914A
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Abstract
The present invention discloses one kind of soft capsule containing lutein and its preparation process. The soft capsule has inclusion comprising lutein 62.4-109.2 weight portions, mountain mulberry fruit 3.12-9.36 weight portions, docosahexaenoic acid 156-218.4 weight portions, yeast astacin 6.24-21.84 weight portions, vitamin E 3.12-9.36 weight portions, vitamin B2 3.12 -9.36 weight portions and zinc gluconate3.12-9.36 weight portions. The soft capsule has the functions of protecting eyesight, regulating blood fat, reducing risk of heart diseases, etc.
Description
Technical field: the present invention relates to a kind of soft capsule that contains phylloxanthin and preparation method thereof, belong to the technical field of healthcare products.
Background technology: phylloxanthin has another name called " plant progesterone ", is a kind of natural pigment that extensively is present in the plants such as Fructus Musae, Fructus actinidiae chinensis, corn, Caulis et Folium Brassicae capitatae, Brassica Oleracea Var.Acephala, Herba Spinaciae and Flos Tagetis Erectae, belongs to a kind of of carotenoid.Phylloxanthin have lovely luster, strong coloring force, safety non-toxic, oxidation resistance strong, can prevent human senility, being rich in nutrition advantage such as have no side effect, more and more be subject to people's attention.In order to satisfy the needs that each health food is produced, research and development wide spectrum, efficient, safe natural function raw-food material become one of focus in the current functional food additives research field.Phylloxanthin has the wide development prospect as a kind of novel healthy food additive in health food processing.
The scientific research of series shows that phylloxanthin has effects such as the vision of raising, antioxidation, and eyes are had protective effect.Because phylloxanthin can absorb a large amount of blue lights, the wavelength and the ultraviolet light of blue visible light are approaching, are a kind of light that can reach potential hazard maximum in the amphiblestroid visible light.The lutein content at macula lutea place is abundant just to reduce to the injury of this light minimum if look.Phylloxanthin also can be used as oxidant and protects eyes except protecting the eyes as light filter.The intake that increases phylloxanthin in addition can reduce cataractous incidence rate.
Though a large amount of research has shown phylloxanthin and has had multiple physiological function and effect, is a kind of good food supplement, how rationally assembly, it is prepared into suitable dosage form, adopts certain route of administration contact or importing body competence exertion curative effect.
Summary of the invention:
The objective of the invention is to: a kind of soft capsule that contains phylloxanthin and preparation method thereof is provided.This soft capsule can be used for treatment and the auxiliary treatment because of ophthalmic diseasess such as the maculopathy that the phylloxanthin shortage causes, retinitis pigmentosa, cataract, diabetic renal papillary necrosis, myopia, muscae volitantes.
The present invention constitutes like this: a kind of soft capsule that contains phylloxanthin, form by capsule material and capsule content, calculate according to components by weight percent, the capsule content is by 62.4～109.2 parts of 5% phylloxanthins, 3.12～9.36 parts of bilberry, 156～218.4 parts of docosahexenoic acid (DHA), 6.24～21.84 parts of yeast 3,4,3',4'-tetraketo-.beta.-carotenes, 3.12～9.36 parts of vitamin Es, vitamin B
23.12 3.12～9.36 parts of～9.36 parts and zinc gluconate are made.
Say that exactly calculate according to components by weight percent, the capsule content is by 87.36 parts of 5% phylloxanthins, 6.24 parts of bilberry, 187.2 parts of docosahexenoic acid (DHA), 12.48 parts of yeast 3,4,3',4'-tetraketo-.beta.-carotenes, 6.24 parts of vitamin Es, vitamin B
26.24 part and 6.24 parts of zinc gluconate make.
The preparation of soft capsule method that contains phylloxanthin of the present invention is: with 5% phylloxanthin, bilberry, docosahexenoic acid (DHA), yeast 3,4,3',4'-tetraketo-.beta.-carotene, the vitamin B of recipe quantity
2Pulverize with zinc gluconate, cross 120 mesh sieves, fine powder; It is standby that medicated powder adds recipe quantity vitamin E, medicinal soybean oil 311.52～382.32 weight portions, Cera Flava 21.12～25.92 weight portions, Arlacel-80 5.5～6.75 weight portions, tween 80 5.5～6.75 weight portions are prepared into suspension; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight glue is made rubber, is pressed into soft capsule, typing, and drying, promptly.
Say exactly, with 5% phylloxanthin 87.36g, bilberry 6.24g, docosahexenoic acid (DHA) 187.2g, yeast 3,4,3',4'-tetraketo-.beta.-carotene 12.48g, vitamin B
26.24g and zinc gluconate 6.24g pulverizes, and crosses 120 mesh sieves, fine powder; It is standby that medicated powder adds vitamin E 6.24g, medicinal soybean oil 354g, Cera Flava 24g, Arlacel-80 6.25g, tween 80 6.25g is prepared into suspension; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight glue is made rubber, is pressed into soft capsule, typing, and drying, promptly.
Describedization adhesive process is: take by weighing gelatin, glycerol, titanium dioxide, purified water and brown pigment in proportion respectively, and standby; Water, glycerol are heated to 80 ℃, gelatin are added dissolve, titanium dioxide, brown pigment are dissolved with glycerol again, be uniformly dispersed, add in the glue again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, got final product.
The compound method of suspension is: with Cera Flava dissolve the back and vitamin E, Arlacel-80, tween 80 add in the lump in the medicinal soybean oil, dispersed with stirring is even, and medicated powder is added dispersed with stirring in the above-mentioned fluid, last colloid barreling is worn into finely dispersed suspension, promptly.
The pressing process of soft capsule is: the 12# mould is installed, behind the debugging encapsulating machine, the gelatin solution that is incubated is pressed into air compressor in the glue box of encapsulating machine, glue box temperature is controlled at 50～60 ℃, and the mould rotating speed is 2.6cm/min, 35～36 ℃ of sprinkler body temperature; Open chilled drum (coolant temperature is controlled at 10 ℃～14 ℃), regulate adhesive tape thickness between 0.7～0.9mm, after inspection adhesive tape toughness is qualified, get final product; Suspension is added in the material storing box of encapsulating machine, machine, adjust loading amount, observe the outward appearance and the sealed degree of soft capsule, formal then start compacting.
Described typing, dry run are: the soft capsule that suppresses imports in the typing rotating cage of having opened through track, through cold wind typing 1～1.5 hour, setting temperature was controlled at 16～20 ℃, and is preliminary hard solid to the soft capsule skin, discharging is carried out preliminarily dried to tray; Go-on-go then, the dehydrated alcohol flushing, drying, packing gets final product.
Used 5% phylloxanthin of the present invention is the commercially available prod, and Gong Ying phylloxanthin is natural extract in the market, is to extract refining forming from the petal of catananche's Flos Tagetis Erectae.
Phylloxanthin (lutein) is a kind of asymmetric dihydroxy carotenoid, and systematic name is 3,3 ' dihydroxy-β, alpha-carotene.It is human eye retina's macular pigment key component.Pure phylloxanthin is a rib trellis yellow crystals, and metallic luster is arranged, and fusing point is 183-190 ℃, to light and oxygen instability, need be stored in shady and cool dry place, and the lucifuge sealing is preserved.
Side of the present invention separates:
(1) phylloxanthin: the petal by feverfew Flos Inulae Marigold (also claiming Flos Tagetis Erectae, Tagetes erecta) extracts and gets, and belongs to carotenoid, has another name called " plant progesterone ", in occurring in nature and the common existence of zeaxanthin (Zeaxanthin).Phylloxanthin and zeaxanthin are the key components that constitutes plant pigment such as vegetable, fruit, flowers, are the only carotenoid of finding in the eyes, are present on the macula retinae of eyes.U.S. FDA is listed phylloxanthin in the dietary supplement ingredient list in nineteen ninety-five.
Phylloxanthin and maize ester are unique carotenoid that concentrates on the eye retina district, be known as macula lutea, macula lutea is positioned at the optical fundus retinal centre, in the retinal tissue layer of macula lutea body a large amount of phylloxanthins is arranged, macula lutea is the accumulative place of photoreceptor cell, is responsible for providing color and detail in visual field central authorities.Phylloxanthin absorbs blue light, antioxidation.Ultraviolet light in the sunlight, blue light enter eyes can produce a large amount of free radicals, causes cataract, macular area degeneration, or even cancer.Ultraviolet generally can be filtered out by cornea and crystalline lens, but through retina of the penetrable eyeball of blue light and macula lutea, and the phylloxanthin of crystalline lens and macula lutea can filter out blue light, avoids the infringement of blue light to eyes.The phylloxanthin of intake body is distributed to two positions of eyes: (1) retina and macular area; (2) crystalline lens.Studies show that and take in phylloxanthin amount height, help to delay aging, degeneration, the pathological changes of eyes, reduce the incidence rate of ophthalmic, can also protect retina to avoid the injury of light.
(2) bilberry: claim Pericarpium Citri tangerinae again, the bilberry fruit is rich in anthocyanidin, and (vaccinium myrtillusanthocyanosides VMA), belongs to flavone compound.Anthocyanidin has used for many years clinical, is widely used in treatment vein pathological changes and blood capillary pathological changes.Mainly concentrate on the retinopathy that diabetes and hypertension cause in the application of ophthalmology, and obtained practical curative effect.Along with deepening continuously to anthocyanidin research, researcheres find that anthocyanidin not only helps the prevention of senile cataract and the generation of diabetic cataract, and can be by the powerful antioxidation elimination or the sings and symptoms of relieving fatigue syndrome eye and/or whole body.
(3) docosahexenoic acid (DHA): DHA is that (docosahexaenoic acid DHA), is to belong to the serial polyunsaturated fatty acid of ω-3 (poly Shan nsatarated fattyacid, PUFA) a kind of to docosahexenoic acid.The main source of DHA is to absorb from Fish especially marine fishes.The intravital DHA of people mainly is distributed in retina, brain cell, breast milk and the seminal fluid.It all has very big influence to people's vision formation, cerebral activity, cardiovascular and cerebrovascular disease, immunologic function and alzheimer disease.Contain a large amount of DHA in people's the retina light perception device cell, DHA is very important to the photostimulation conduction of amphiblestroid photoreceptor cell.Find that in the research to the premature infant breast feeding or artificial feeding replenish the fish oil baby of (mainly containing EPA and DHA), its rod of the retina is grown normal; And artificial feeding lacks the baby of fish oil, and its rod of the retina is hypoevolutism then.Its mechanism is because DHA can pass through the blood retinal barrier, makes the retina cell softness, and then the excitement photo-cell, makes information be delivered to brain fast, thereby has improved visual performance.
(4) yeast 3,4,3',4'-tetraketo-.beta.-carotene: 3,4,3',4'-tetraketo-.beta.-carotene is a kind of of class Hu Luosu, has stronger anti-oxidation function (Naguib, 2000 years.Be 10 times of carotenoid, 100 times of vitamin E), antitumaous effect (Chewetal, 1999) is also arranged.Have the tumor of inhibition to take place, enhancing immunity is removed many-sided biological functions such as interior free yl, and UV-induced skin carcinoma is had good therapeutic effect, and the oculopathy that is caused by diabetes is also had the better prevention effect.
(5) vitamin E, vitamin B
2, zinc gluconate:
Vitamin E is to the oxygen sensitivity, and is very easily oxidized, can protect other easily oxidized material in vivo, strengthens the antioxidation of cell.Vitamin B2 is the metabolic important substance of neurocyte that participates in comprising optic nerve, and the effect of protection conjunctiva palpebrae, bulbar conjunctiva and cornea is arranged.When lacking in the body, symptoms such as eyes are dry and astringent, the hyperemia of knot pancreas, the inflammation of eye face, photophobia, blurred vision, fatiguability can occur, even optic neuritis takes place.Zinc can increase the sensitivity of optic nerve.
The prescription foundation: the present invention is a compound preparation, is mainly used in the treatment and the auxiliary treatment that lack ophthalmic diseasess such as the maculopathy cause, retinitis pigmentosa, cataract, diabetic renal papillary necrosis, myopia, muscae volitantes because of phylloxanthin.
Phylloxanthin and docosahexenoic acid (DHA) are main effect material in we.Phylloxanthin be ministry of Health of China approval have the vision of improvement effect material, a legal CAS[127-40-2 that is numbered], its major function is:
(1) phylloxanthin is the main component of macula lutea in the eyes, can prevent the aging of macula retinae, retina yellow multiple sick (a kind of senile corneal clouding) (AMD) is had preventive effect, to alleviate senile vision decline etc.
(2) blindness causing disease that prevents muscle deterioration disease (ARMD) to be caused: owing to old and feeble muscle deterioration disease of taking place can make the old people of over-65s cause irreclaimable blindness causing disease.Phylloxanthin is respond well aspect prevention muscle deterioration disease, because phylloxanthin can not produce in human body, therefore must absorb from food or extra replenishing.Especially the old people must often select for use and contain the abundant food of phylloxanthin.
(3) phylloxanthin in the eyes has filtration to ultraviolet, the injury effect to eyes and vision that ultraviolet caused that has protection to be launched by daylight, computer etc.
Docosahexenoic acid (DHA) has the memory function of an improvement material for ministry of Health of China approval, the legal CAS[6217-54-5 that is numbered], its natural product mainly are present in marine fishes, extra large beast and the shellfish, DHA content is directly relevant in DHA in the human body and the diet, and DHA is one of the most basic composition of people's cerebral nervous system.Content in cerebral tissue is about 15%, and 60% is the DHA phospholipid molecule around amphiblestroid vision staff cell.DHA is cerebral cortex and amphiblestroid important component part, with the function of neural and vision substantial connection is arranged.DHA enters liver and the brain of fetus by Placenta Hominis, fetus from later stage of pregnancy to back six months of birth, brain and retinal development are the fastest, competent DHA can promote the growth of optic nerve, improves visual acuity.Therefore, itself and phylloxanthin share can Synergistic, adapts to different crowd.
Main component anthocyanin in the bilberry (being Pericarpium Citri tangerinae), be the ministry of Health of China approval have the vision of an improvement effect material, can protect blood capillary, promote to look regeneration of erythrocytes, strengthen adaptive capacity to dark; The yeast 3,4,3',4'-tetraketo-.beta.-carotene is the auxiliary tumor function material that suppresses of the tool of ministry of Health of China approval, has the effect of very strong antioxidation and elimination free radical; Vitamin E is a tocopherol, is the tool function of delaying senility material of ministry of Health of China approval, the legal INS307 (b) that is numbered; CAS[59-02-9], can protect other easily oxidized material in vivo, strengthen the antioxidation of cell; Zinc is that the tool of ministry of Health of China approval promotes the growth promoter material, supplementary form is mainly organic zinc, it is zinc gluconate, it can strengthen the sensitivity of optic nerve, be the constituent of retinol reductase in the retinal tissue cell, directly influence vitamin A during shortage, influence the effect of retinal looking synthetic the and dysbolismus of quality, thereby weaken adaptive capacity, also can influence the chromatic discrimination power of cone cell on the retina during zinc deficiency the low light level; Vitamin B
2Be the important substance of protection eyelid, conjunctive bulbi and cornea, can cause blurred vision, photophobia, conjunctival congestion, eyelid inflammation etc. during shortage.
In sum, above-mentioned five kinds of materials and phylloxanthin, DHA share, and can effectively replenish the deficiency of main effect material among this side, improve the effect that it improves vision.
This soft capsule system is according to the modern nutriology theory, with phylloxanthin, bilberry, DHA, yeast 3,4,3',4'-tetraketo-.beta.-carotene, vitamin E, vitamin B
2And zinc gluconate is raw material, and that adopts that advanced machining technology makes a kind ofly has an eye protection health food that improves the vision effect, can take for a long time.In order to verify the effect of soft capsule of the present invention, the applicant has carried out improving vision test research according to Ministry of Public Health " the health food function assessment assessment process and the method for inspection ", and the result is as follows.
1 sample and method
1.1 sample
Sample is 1.: soft capsule of the present invention is applicant's own product; Sample is 2.: other provides outer package, the sensory properties placebo similar to preparation of the present invention, and its main component is starch and food coloring.
1.2 subjects selects the bore hole distant vision 〉=4.0～≤ 4.9, near vision normally reach the refraction of eye degree-more than the 1.0D, the age is that 15～45 years old crowd is subjects; Eliminating is to this health food of test-meal allergy, and eye part diseases such as infectious eye part disease, corneal nebula and keratoconus are taken other relevant medicine for a long time or used other Therapeutic Method person.
1.3 double-blind method is adopted in test grouping and this test of amount, at random the experimenter is divided into two groups, removes outside the experimenter who ends for some reason actual tests group 51 examples, matched group 50 examples midway.1. test group eats sample, and the edible sample of matched group 2..Each edible 1, divide early, middle and late respectively the food 1 time every day, and the test-meal test period is 30 days.
2 observation index
2.1 general index
2.1.1 the subjective sensation index mainly comprises diet, sleep, mental status and asthenopia sense (inspection index be ophthalmic bloated, ophthalmalgia, photophobia, blurred vision, eye dry and astringent etc.), adopts questioning to carry out.
2.1.2 the physical examination index comprises height, body weight, blood pressure, heart rate, skin, the heart, lung, liver and spleen inspection, health check-up method is routinely carried out.
2.1.3 blood parameters comprises hemoglobin, RBC counting, wBC counting, adopts the Clinical Laboratory method.
2.2 edible soft capsule of the present invention improves the vision characteristic index
2.2.1 vision criteria bore hole distant vision effect criterion
Effectively: the bore hole distant vision improves 〉=2 row; Invalid: as not reach aforementioned requirement.
2.2.2 refraction of eye degree index diopter (D).
2.3 data statistical approach
Vision and diopter are changed to measurement data, adopt the t check.Mean relatively adopts in groups the t check between group, carries out homogeneity test of variance before relatively, and the data of nonnormal distribution or heterogeneity of variance are carried out suitable variable conversion, wait to satisfy the normal state variance neat after, carry out the t check with data converted.
It is enumeration data that eyesight improving effective percentage and diopter reduce (more than the 0.5D) rate, checks with x.
3 results
3.1 the edible general index situation of change of soft capsule of the present invention
3.1.1 the edible soft capsule of the present invention of subjective sensation index situation of change experimenter all had no adverse reaction after 30 days, its diet situation, sleep state and mental status do not have significant change.
3.1.2 physical examination index result of variations shows: all examination trencherman heights, body weight, blood pressure do not have significant change, after the test-meal before test-meal group and the test-meal and matched group relatively be (P＞0.05) difference and do not have significance, physical examination results such as its heart rate, skin, the heart, lung, liver, spleen are no change also.
3.1.3 the blood parameters result of variations shows: hemoglobin, RBC counting, WBC counting comparing difference do not have significance (P＞0.05) before and after test-meal group and the matched group test-meal, and all in normal range.
3.1.4 eye asthenopia sense situation of change
The result shows: test-meal group and matched group eye asthenopia sense incidence rate difference do not have significance (P＞0.05) before the test-meal.Test-meal group asthenopia number obviously reduces after the test-meal, with before the test-meal and the matched group comparing difference highly significant (P＜0.01) is arranged.
3.2 improve vision characteristic index situation of change
3.2.1 the distant vision situation of change is the result show: before the test-meal, the distant vision of test-meal group and matched group comparing difference do not have significance (P＞0.05).Test-meal group distant vision improves obviously after the test-meal, and with test-meal before and the matched group comparing difference highly significant (P＜0.01) is arranged, wherein test-meal group eyesight improving effective percentage is 68.37, with matched group relatively (P＜0.01), difference has highly significant.
3.2.2 (D) the situation of change result shows the refraction of eye degree; The experimenter of test-meal group after test-meal, its refraction of eye degree (D) present obvious decline, and with matched group and test-meal before relatively (P＜0.01) difference highly significant is arranged.Wherein the above person of refraction of eye degree reduction-0.5D reaches 67.35; And with matched group relatively (P＜0.01) difference highly significant is arranged.
4 brief summaries
The experimenter who meets the test-meal condition is divided into test-meal group and matched group, and the test-meal group eats soft capsule of the present invention, and matched group eats placebo.After all experimenters eat 30 continuously, reach matched group before test-meal group and the test-meal relatively, the touching number of eye asthenopia obviously reduces (P＜0.01); Distant vision obviously improves, and its eyesight improving effective percentage reaches 68.37 (P＜0.01).(D) descend to some extent, the above person of reduction-0.5D is 67.35 (P＜0.01) to the refraction of eye degree, and its statistical procedures result shows that difference has highly significant.Experimenter's subjective sensation is good, all no abnormal variation before and after the blood parameters test-meal.
Compared with prior art, soft capsule of the present invention has the following advantages:
1. protection eye eyesight
(1) phylloxanthin is the main component of macula lutea in the eyes, and senile macula retinae degeneration (AMD) is had preventive effect, can improve old people's vision decline.
(2) the prevention blindness causing disease that senile degeneration of macula caused.Owing to old and feeble muscle deterioration disease of taking place can make the old people of over-65s cause irreclaimable blindness causing disease.And phylloxanthin is respond well aspect prevention muscle deterioration disease, because it can not produce in human body, therefore must replenish from food or additionally, and especially the old people must often select for use and contain the abundant food of phylloxanthin.The U.S. need replenish phylloxanthin 6mg in the people in suggestion 60-65 year in 1996 every day.
(3) phylloxanthin in the eyes has filtration to ultraviolet, the injury effect to eyes and vision that ultraviolet caused that has protection to be launched by daylight, computer etc.
2. in the ameliorate body and the danger of skin degeneration senile plaque,, reduce the formation of lipid peroxide by antioxidation.
3. blood lipid regulation.Prevent that low density lipoprotein, LDL is oxidized, thereby alleviate cardiopathic danger.
The specific embodiment:
Embodiments of the invention 1:5% phylloxanthin 87.36g, bilberry 6.24g, docosahexenoic acid (DHA) 187.2g, yeast 3,4,3',4'-tetraketo-.beta.-carotene 12.48g, vitamin E 6.24g, vitamin B
26.24g, zinc gluconate 6.24g
5% phylloxanthin, bilberry, docosahexenoic acid (DHA), yeast 3,4,3',4'-tetraketo-.beta.-carotene, vitamin B2 and the zinc gluconate that take by weighing recipe quantity are pulverized, and cross 120 mesh sieves, fine powder; Get Cera Flava 24g dissolve the back and vitamin E 6.24g, Arlacel-80 6.25g, tween 80 6.25g add in the lump among the medicinal soybean oil 354g, dispersed with stirring is even, medicated powder is added dispersed with stirring in the above-mentioned fluid, and last colloid barreling is worn into finely dispersed suspension, and is standby; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight takes by weighing gelatin, glycerol, titanium dioxide, purified water and brown pigment respectively, and is standby; Water, glycerol are heated to 80 ℃, gelatin are added dissolve, titanium dioxide, brown pigment are dissolved with glycerol again, be uniformly dispersed, add in the glue again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, made rubber.
The compacting of soft capsule: the 12# mould is installed, behind the debugging encapsulating machine, the gelatin solution that is incubated is pressed into air compressor in the glue box of encapsulating machine, glue box temperature is controlled at about 55 ℃, and the mould rotating speed is 2.6cm/min, 35～36 ℃ of sprinkler body temperature; Open chilled drum (coolant temperature is controlled at 10 ℃～14 ℃), regulate adhesive tape thickness between 0.7～0.9mm, after inspection adhesive tape toughness is qualified, get final product; Suspension is added in the material storing box of encapsulating machine, machine, adjust loading amount, observe the outward appearance shall be rounded up of soft capsule, do not have deformity, plush copper; Observe the sealed degree of soft capsule simultaneously, soft capsule is sealed should be tightly, neatly, no nib, leakage phenomenon.Formal then start compacting.The soft capsule that suppresses imports in the typing rotating cage of having opened through track, and through cold wind typing 1.2 hours, setting temperature was controlled at 18 ℃, and preliminary hard solid to the soft capsule skin, discharging is carried out preliminarily dried to tray; Go-on-go then, the dehydrated alcohol flushing, drying, packing, promptly.
Embodiments of the invention 2:5% ten flavin 62.4g, bilberry 3.12g, docosahexenoic acid (DHA) 156g, yeast 3,4,3',4'-tetraketo-.beta.-carotene 6.24g, vitamin E 3.12g, vitamin B
23.12g, zinc gluconate 3.12g
Take by weighing 5%0 flavin, bilberry, docosahexenoic acid (DHA), yeast 3,4,3',4'-tetraketo-.beta.-carotene, the vitamin B of recipe quantity
2Pulverize with zinc gluconate, cross 120 mesh sieves, fine powder; Get Cera Flava 21.12g dissolve the back and vitamin E 3.12g, Arlacel-80 5.5g, tween 80 5.5g add in the lump among the medicinal soybean oil 311.52g, dispersed with stirring is even, medicated powder is added dispersed with stirring in the above-mentioned fluid, and last colloid barreling is worn into finely dispersed suspension, and is standby; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight takes by weighing gelatin, glycerol, titanium dioxide, purified water and brown pigment respectively, and is standby; Water, glycerol are heated to 80 ℃, gelatin are added dissolve, titanium dioxide, brown pigment are dissolved with glycerol again, be uniformly dispersed, add in the glue again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, made rubber.
The compacting of soft capsule: install 12
#Mould behind the debugging encapsulating machine, is pressed into the gelatin solution that is incubated in the glue box of encapsulating machine with air compressor, glue box temperature is controlled at about 50 ℃, and the mould rotating speed is 2.6cm/min, 35～36 ℃ of sprinkler body temperature; Open chilled drum (coolant temperature is controlled at 10 ℃～14 ℃), regulate adhesive tape thickness between 0.7～0.9mm, after inspection adhesive tape toughness is qualified, get final product; Suspension is added in the material storing box of encapsulating machine, machine, adjust loading amount, observe the outward appearance shall be rounded up of soft capsule, do not have deformity, plush copper; Observe the sealed degree of soft capsule simultaneously, soft capsule is sealed should be tightly, neatly, no nib, leakage phenomenon.Formal then start compacting.The soft capsule that suppresses imports in the typing rotating cage of having opened through track, and through cold wind typing 1 hour, setting temperature was controlled at 16 ℃, and preliminary hard solid to the soft capsule skin, discharging is carried out preliminarily dried to tray; Go-on-go then, the dehydrated alcohol flushing, drying, packing, promptly.
Embodiments of the invention 3:5% ten flavin 109.2g, bilberry 9.36g, docosahexenoic acid (DHA) 218.4g, yeast 3,4,3',4'-tetraketo-.beta.-carotene 21.84g, vitamin E 9.36g, vitamin B
29.36g, zinc gluconate 9.36g
Take by weighing 5%0 flavin, bilberry, docosahexenoic acid (DHA), yeast 3,4,3',4'-tetraketo-.beta.-carotene, the vitamin B of recipe quantity
2Pulverize with zinc gluconate, cross 120 mesh sieves, fine powder; Get Cera Flava 25.92g dissolve the back and vitamin E 9.36g, Arlacel-80 6.75g, tween 80 6.75g add in the lump among the medicinal soybean oil 382.32g, dispersed with stirring is even, medicated powder is added dispersed with stirring in the above-mentioned fluid, and last colloid barreling is worn into finely dispersed suspension, and is standby; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight takes by weighing gelatin, glycerol, titanium dioxide, purified water and brown pigment respectively, and is standby; Water, glycerol are heated to 80 ℃, gelatin are added dissolve, titanium dioxide, brown pigment are dissolved with glycerol again, be uniformly dispersed, add in the glue again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, made rubber.
The compacting of soft capsule: install 12
#Mould behind the debugging encapsulating machine, is pressed into the gelatin solution that is incubated in the glue box of encapsulating machine with air compressor, glue box temperature is controlled at about 60 ℃, and the mould rotating speed is 2.6cm/min, 35～36 ℃ of sprinkler body temperature; Open chilled drum (coolant temperature is controlled at 10 ℃～14 ℃), regulate adhesive tape thickness between 0.7～0.9mm, after inspection adhesive tape toughness is qualified, get final product; Suspension is added in the material storing box of encapsulating machine, machine, adjust loading amount, observe the outward appearance shall be rounded up of soft capsule, do not have deformity, plush copper; Observe the sealed degree of soft capsule simultaneously, soft capsule is sealed should be tightly, neatly, no nib, leakage phenomenon.Formal then start compacting.The soft capsule that suppresses imports in the typing rotating cage of having opened through track, and through cold wind typing 1.5 hours, setting temperature was controlled at 20 ℃, and preliminary hard solid to the soft capsule skin, discharging is carried out preliminarily dried to tray; Go-on-go then, the dehydrated alcohol flushing, drying, packing, promptly.
Claims (8)
1. soft capsule that contains phylloxanthin, form by capsule material and capsule content, it is characterized in that: calculate according to components by weight percent, the capsule content is made for 3.12～9.36 parts by 62.4～109.2 parts of 5% phylloxanthins, 3.12～9.36 parts of bilberry, 156～218.4 parts of docosahexenoic acid, 6.24～21.84 parts of yeast 3,4,3',4'-tetraketo-.beta.-carotenes, 3.12～9.36 parts of vitamin Es, 3.12～9.36 parts of vitamin Bies and zinc gluconate.
2. according to the described soft capsule that contains phylloxanthin of claim 1, it is characterized in that: calculate according to components by weight percent, the capsule content is made for 6.24 parts by 87.36 parts of 5% phylloxanthins, 6.24 parts of bilberry, 187.2 parts of docosahexenoic acid, 12.48 parts of yeast 3,4,3',4'-tetraketo-.beta.-carotenes, 6.24 parts of vitamin Es, 6.24 parts of vitamin Bies and zinc gluconate.
3. contain the preparation of soft capsule method of phylloxanthin according to claim 1, it is characterized in that: 5% phylloxanthin of recipe quantity, bilberry, docosahexenoic acid, yeast 3,4,3',4'-tetraketo-.beta.-carotene, vitamin B2 and zinc gluconate are pulverized, are crossed 120 mesh sieves, fine powder; It is standby that medicated powder adds recipe quantity vitamin E, medicinal soybean oil 311.52～382.32 weight portions, Cera Flava 21.12～25.92 weight portions, Arlacel-80 5.5～6.75 weight portions, tween 80 5.5～6.75 weight portions are prepared into suspension; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight glue is made rubber, is pressed into soft capsule, typing, and drying, promptly.
4. according to the described preparation of soft capsule method that contains phylloxanthin of claim 3, it is characterized in that: 5% phylloxanthin 87.36g, bilberry 6.24g, docosahexenoic acid 187.2g, yeast 3,4,3',4'-tetraketo-.beta.-carotene 12.48g, vitamin B2 6.24g and zinc gluconate 6.24g are pulverized, cross 120 mesh sieves, fine powder; It is standby that medicated powder adds vitamin E 6.24g, medicinal soybean oil 354g, Cera Flava 24g, Arlacel-80 6.25g, tween 80 6.25g is prepared into suspension; By gelatin: glycerol: water: titanium dioxide: brown pigment=100: 50: 100: 0.3: 0.05 part by weight glue is made rubber, is pressed into soft capsule, typing, and drying, promptly.
5. according to claim 3 or the 4 described preparation of soft capsule methods that contain phylloxanthin, it is characterized in that: describedization adhesive process is: take by weighing gelatin, glycerol, titanium dioxide, purified water and brown pigment in proportion respectively, and standby; Water, glycerol are heated to 80 ℃, gelatin are added dissolve, titanium dioxide, brown pigment are dissolved with glycerol again, be uniformly dispersed, add in the glue again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, got final product.
6. according to claim 3 or the 4 described preparation of soft capsule methods that contain phylloxanthin, it is characterized in that: the compound method of suspension is: with Cera Flava dissolve the back and vitamin E, Arlacel-80, tween 80 add in the medicinal soybean oil in the lump, dispersed with stirring is even, medicated powder is added dispersed with stirring in the above-mentioned fluid, last colloid barreling is worn into finely dispersed suspension, promptly.
7. according to claim 3 or the 4 described preparation of soft capsule methods that contain phylloxanthin, it is characterized in that: the pressing process of soft capsule is: the 12# mould is installed, behind the debugging encapsulating machine, be pressed into the gelatin solution of insulation in the glue box of encapsulating machine with air compressor, glue box temperature is controlled at 50～60 ℃, the mould rotating speed is 2.6cm/min, 35～36 ℃ of sprinkler body temperature; Open chilled drum, regulate adhesive tape thickness between 0.7～0.9mm, after inspection adhesive tape toughness is qualified, get final product; Suspension is added in the material storing box of encapsulating machine, machine, adjust loading amount, observe the outward appearance and the sealed degree of soft capsule, formal then start compacting.
8. according to claim 3 or the 4 described preparation of soft capsule methods that contain phylloxanthin, it is characterized in that: described typing, dry run are: the soft capsule that suppresses imports in the typing rotating cage of having opened through track, through cold wind typing 1～1.5 hour, setting temperature is controlled at 16～20 ℃, preliminary hard solid to the soft capsule skin, discharging is carried out preliminarily dried to tray; Go-on-go then, the dehydrated alcohol flushing, drying, packing gets final product.
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