CN101019900A - Health product with auxiliary antilipemic function and its prepn - Google Patents
Health product with auxiliary antilipemic function and its prepn Download PDFInfo
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Abstract
The present invention discloses one kind of health product with auxiliary antilipemic function and its preparation process. The health product is prepared with black edible fungus extract 30-50 weight portions, ginkgo leaf extract 30-50 weight portions and fish oil 900-1000 weight portions as well as conventional supplementary material. It is prepared into oral preparation, and has obvious health functions of lowering blood fat, delaying senility, resisting oxidation, etc.
Description
Technical field
The present invention relates to a kind of health product, relate in particular to a kind of health product and preparation method thereof, belong to the health-care products field with auxiliary lipid-lowering function.
Background technology
Blood fat is the general name of various lipid materials in the blood, wherein the most important thing is cholesterol and triglyceride.Triglyceride i.e. fat.They are water insoluble, become lipoprotein with protein bound, cycle operation in blood.Also have a kind of high density lipoprotein that is called as, its effect is then opposite fully with beta Lipoprotein, has the arteriosclerotic effect of antagonism.
Healthy people's average cholesterolemia content is to have 160 milligrams in per 100 milliliters of blood, is too high as surpassing 220 milligrams; Triglyceride is 85 milligrams, is too high as surpassing 160 milligrams; Beta Lipoprotein is 400 milligrams, is too high as surpassing 600 milligrams; High density lipoprotein then is 55 milligrams, and certainly, this numerical value is high more good more, as is lower than 35 milligrams, and it is undesired to be considered as on the contrary.
Cholesterol slightly increases, may be because due to cholesterol and the animal fat Excessive Intake.Smoking, diabetes, hypothyroidism etc. can cause that also cholesterol increases.Surpass in the per 100 milliliters of blood of cholesterol level 300 milligrams be called the severe hypercholesterolemia, can be familial disease sometimes.Slight triglyceride increases, and may cause owing to factors such as polysaccharide food Excessive Intake, smoking, obesities.The high triglyceride of severe, how relevant with diabetes, hepatopathy, chronic nephritis etc.Comprise cholesterol and triglyceride in the beta Lipoprotein, all factors that causes that cholesterol or triglyceride increase all can make beta Lipoprotein raise.And high density lipoprotein is low excessively, then may be caused by factors such as heredity, malnutrition, hepatic lesions and shortage motions.
No matter be that cholesterol level increases, or the content of triglyceride increases, or both all increase, and are referred to as hyperlipemia.Hyperlipemia and coronary heart disease have confidential relation, and especially cholesterol and triglyceride all increase, and the danger of suffering from coronary heart disease is bigger.
Data show according to the modern medicine diseases monitoring: more than nearly 3600 people of cardiovascular and cerebrovascular disease death toll that whole world every day causes because of hyperlipidemia, the heart infarction that China causes because of hyperlipidemia every year, cerebral infarction, apoplexy, hemiplegia, disable, the number that causes death rises with the speed of average annual growth 12%.Adult's blood fat of China 1/3 is generally higher at present, nearly 3,500,000 people of patient that cause apoplexy every year.
Though existing health product with blood fat reducing function all have certain blood fat reducing function, all in various degree exist effect inadequately significantly, defectives such as poor stability, have much room for improvement.
Summary of the invention
The present invention's technical problem at first to be solved is to overcome the deficiencies in the prior art, and a kind of new significant blood fat reducing function that has is provided, safely, the health product that have no side effect.
The present invention's technical problem at first to be solved realizes by following technological approaches:
A kind of health product with auxiliary lipid-lowering function mainly are made up of the component of following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part and fish oil 900-1000 part.
Preferably, the weight portion of each component is: 40 parts of Auricularia extracts, 40 parts of Folium Ginkgo extract, 920 parts in fish oil.
Described Auricularia extract can prepare in accordance with the following methods:
(1) pre-treatment: will wet and taste with discrimination the Auricularia roguing, and clean; After the dry product Auricularia is soaked in water, roguing again, cleaning;
(2) Auricularia after will cleaning joins in the extraction pot of band agitating device, adds water, and 90-95 ℃ is stirred and extract 1-5 time; With merging filtrate behind the extracting liquid filtering, filtrate decompression concentrates, and centrifugal removal precipitation is got supernatant, continues concentrating under reduced pressure, and spray drying gets the Auricularia extract.
Preferably, after in the step (1) the dry product Auricularia being soaked in water 4-5 hour, roguing again, cleaning; Auricularia after will cleaning in the step (2) joins in the extraction pot of band agitating device, adds water, and 90-95 ℃ is stirred extraction 3 times, extracted 3 hours at every turn; Wherein, the 1st time is extracted amount of water is 40 times of weight, and the 2nd, 3 time is extracted amount of water is 20 times of weight; In the step (2) extracting solution is filtered according to 30 orders, 60 orders, 100 purpose size fractionations, merging filtrate, filtrate decompression be concentrated into volume be raw material weight 15-18 doubly, centrifugal removal precipitation is got supernatant, continues most 5 times of raw material raw material of concentrating under reduced pressure.
Preparation-obtained according to the method described above Auricularia extract, its polyoses content 〉=22%, adenosine content 〉=0.17%.
Folium Ginkgo extract and fish oil all can be bought from commercial channels and obtain, and its specification is a pharmaceutical grade.For example, Folium Ginkgo extract can be purchased in skill source, Henan natural health-care products company limited, and its trade name is " Folium Ginkgo extract ", wherein flavones content 〉=24%; Fish oil can be purchased in the foreign refreshing Biotec Marin GmbH of Shandong letter, and its commodity are called " fish oil ", DHA+EPA content 〉=30%.
Auricularia [Auricalaria auriculaCL.ex Hook) Underw.], be under the jurisdiction of Eumycota, Basidiomycotina, Hymenomycetes, Auriculariale Auriculariaceae, Auricularia.
Auricularia nature and flavor function: sweet, flat, nontoxic.Go into stomach liver large intestine channel.Can replenish blood, removing heat from blood, hemostasis, lung moistening stomach reinforcing, dryness moistening and intestine benefiting, relaxing muscles and tendons and activating QI and blood in the collateral, the strong will of making light of one's life by commiting suicide.Auricularia contains abundant high protein, high ferro, high calcium, multivitamin and trace element etc., is the very high edible health bacterium of nutritive value.
Auricularia mainly has the pharmacological effect of following several respects:
1, effect for reducing blood fat: polysaccharide (acid isodextran) is the Auricularia main active, and its main component is an xylose, glucuronic acid, mannose and a spot of glucose and fucose.Auricularia polycose can obviously reduce hyperlipidemia rats free serum cholesterol, cholesteryl ester, triacylglycerol and β one lipoprotein content, the formation of the mice hypercholesterolemia that the reduction hypercholesterolemia causes.Often edible Auricularia can reduce the blood of human body grumeleuse, relaxes coronary atherosclerosis, prevents thrombotic function.Auricularia also can promote cholesterol metabolism and discharge, makes it blood fat reducing, has lipoid peroxidization resistant again.
2, anticoagulant; The material of its anticoagulant is the adenosine class.Other composition has ergosterol, dihydroergosterol, lecithin, cephalin and sphingomyelins.Contained molecular weight in the Auricularia and be 1000 daltonian gland former times, this kind material can influence hematoblastic function, suppress phospholipid arachidonic acid on the platelet membrane, thereby also suppressed the synthetic of thromboxane (TXA2), and TXA2 be at present known to the strongest platelet aggregating agent and the vasoconstrictor of effect.Because hematoblastic aggregation reduces greatly, thereby thrombosis also alleviates.Experiment shows that the action effect of Auricularia and aspirin is close, also established atheromatous plaque is had regressive effect.
3, antithrombotic forms: Auricularia polycose can obviously prolong the formation time of rabbit specificity thrombosis and fibrinous thrombus, shortens thrombosis length.Alleviate platelet count, reduce platelet adhesion rate and blood viscosity, and can obviously shorten the Cavia porcellus euglobulin lysis time, reduce plasma fibrinogen content, the rising plasmin activity has obvious antithrombotic effect.
In addition, Auricularia also contains abundant colloid, has good clear sliding effect for digestive system, can wash in the intestines and stomach cellulose clearly and long-pendingly lose food, and certain antitumor action is arranged.The content of vitamin E and solarization is higher in the Auricularia in addition, and the content of ferrum is also very high, has peroxidating of lipotropism value and anti-radical action.So product of the present invention not only helps preventing and treating hyperlipemia and coronary heart disease, also help effects such as slow down aging, prevention senile dementia.
Active component has TC (serum total cholesterol) in the obvious reduction blood in the Auricularia extract, TG (triglyceride) LDL (low-density lipoprotein cholesterol) content.Reduce the lipid peroxidation product mda content.Improve the vigor of superoxide dismutase (SOD), dwindle atheromatous plaque, reduce cholesterol and the deposition of oxide on arterial wall thereof, promote the running of unsaturated fatty acid; Prolong thrombus formation time, shorten thrombosis length, alleviate wet weight of thrombus, dry weight, improve the fine enzymatic activity of living, produce anti thrombotic action; Anticoagulant reduces blood viscosity, alleviates thrombosis; Enhance SOD activity improves and removes the free radical ability, and immunocompetence and oxidation resistance, slow down aging.
Folium Ginkgo: be the Ginkgoaceae plant, the dried leaves of Semen Ginkgo (Ginkgo bilohaL.).Chemical constituent: contain flavonoid:, rutin, mountain naphthol-3-rhamnose, glucose earthenware, Flos Camelliae Japonicae phenol, Quercetin, isorhamnetin, ginkegetin (ginkgetin), different ginkegetin (isoginkgetin).Interior lipid: Semen Ginkgo endoenzyme A, the new lactone of B, C (ginkgolide A, B, C) Semen Ginkgo.
Flavor efficacy: sweet in the mouth, hardship, puckery, property is flat.Astringe the lung, relieving asthma, invigorating blood circulation paralysis, analgesic function.Be used for the treatment of cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, diseases such as hyperlipemia.
Folium Ginkgo extract can blood vessel dilating, regulate capillary fragility and permeability, prevent the dense long-pending and clot formation of blood, has the enhancing circulatory function, antioxidation, functions such as treatment circulation and enhancing central nervous system's blood flow, improvement circulation, especially can effectively improve cerebral circulation, memory reinforcing, prevention of stroke and senile dementia, potent removing free radical.
Fish oil: contain abundant omega-3 polyunsaturated fatty acids ten or twenty carbon 5 alkene acid and docosahexenoic acid, have effects such as blood fat reducing, cholesterol and blood pressure, inhibition platelet aggregation, can be used for angiocardiopathy preventing and senile dementia, can prevent thrombosis and apoplexy.Omega-3 polyunsaturated fatty acids has blood fat reducing, cholesterol and blood pressure, anticoagulant, have the thrombosis of preventing and apoplexy, the prevention senile dementia strengthens amphiblestroid reflectance, pre-myopia prevention is degenerated, and memory reinforcing improves effects such as learning capacity.Fish oil can strengthen prostatic synthetic, reduce endothelial cell surface thrombosis, suppress the thrombocytozyme activity, reduce thrombosis, reduce oxygen-derived free radicals, reduce monocytic chemotaxis, reduce endothelial cell damage and cell adhesion, increase fiber egg enzymolysis activity, prevent the thrombosis blood vessel blockage.
The Auricularia extract mainly acts on and is cholesterol reducing, triglyceride and low density lipoprotein, LDL and anticoagulant, by Folium Ginkgo extract blood vessel dilating and enhancing circulatory function, can promote the reverse of unsaturated fatty acid, get rid of external, Folium Ginkgo, fish oil and Auricularia extract three's antioxidation influences the peroxidating of lipid, reduces the deposition of lipid peroxidation product on arterial wall, dwindles atheromatous plaque.Folium Ginkgo, fish oil and Auricularia extract suppress thrombosis and reduce the thrombosis absorption affinity to suppress blood vessel blockage to the interaction of thrombosis, and the three coordinates mutually, not only blood fat reducing, atherosclerosis suppresses thrombosis, also has anti peroxidation of lipid, function in delaying senility.More than three kinds of compositions have the effect of Synergistic after organically combining, have significant blood fat reducing, cholesterol, prevention of arterial is atherosis, prevents thrombosis, effects such as angiocardiopathy preventing generation, slow down aging, prevention senile dementia.
Health product of the present invention are with Auricularia, Folium Ginkgo extract, fish oil is main component, has serum total cholesterol in the blood of reduction, triglyceride, low-density lipoprotein cholesterol, the high density lipoprotein increasing cholesterol, and minimizing lipid peroxidation product, improve the vigor of superoxide dismutase (SOD), dwindle the effect of established atheromatous plaque, having antithrombotic simultaneously forms and anticoagulant, prevent the dense long-pending formation clot of blood, strengthen circulatory function, strengthen effects such as central nervous system's blood flow, has auxiliary lipid-lowering function, especially at atherosclerosis and prevent that thrombosis from having unique effect, and have the effect of anti peroxidation of lipid, improve cerebral circulation, memory reinforcing, strengthen the retinal reflex ability, the prevention visual deterioration, prevention of stroke also has extraordinary effect to slow down aging and prevention senile dementia.
Another technical problem to be solved by this invention provides a kind of above-mentioned method with auxiliary lipid-lowering function health product for preparing.
Another technical problem to be solved by this invention realizes by following technological approaches:
A kind ofly prepare above-mentioned method, comprising with auxiliary lipid-lowering function health product:
(1) takes by weighing each component by following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part and fish oil 900-1000 part;
(2), get mixture 1 with above-mentioned each component mix homogeneously under 35-45 ℃ temperature;
(3) in mixture 1, add preparation adjuvant or carrier commonly used, make needed peroral dosage form (for example can be soft capsule, tablet, granule, pill, powder etc.) by this area conventional formulation method.
Preferably, a kind ofly prepare above-mentioned method, comprising with auxiliary lipid-lowering function health product:
(1) takes by weighing each component by following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part, fish oil 900-1000 part;
(2), get mixture 1 with above-mentioned each component mix homogeneously under 35-45 ℃ temperature;
(3) with behind gelatin, glycerol, ferrum oxide and the water mix homogeneously (wherein, those skilled in the art can be according to the Auricularia extract, the consumption of gelatin, glycerol, ferrum oxide and water is determined or allocated to the consumption of Folium Ginkgo extract and fish oil, consumption is more or a little lessly enforcement of the present invention is not constituted any substantial influence) make colloidal sol, colloidal sol is filtered, get glue;
(4) glue is mixed the back pelleting with mixture 1, make soft capsule, pass through shaping again, wash ball, drying, promptly.
The eating method of health product of the present invention and consumption: the consumption of health product of the present invention depends on concrete dosage form, and factor such as age of eater, body weight, health status.As guidance: soft capsule, oral, one time 2,2 times on the one, can take for a long time for one-period in 90 days.
The specific embodiment
The invention will be further described below by embodiment.Should be pointed out that these embodiment only are illustrations of the present invention, should not be construed as limitation of the present invention.
Embodiment 1
Take by weighing each raw material (unit: g): Auricularia extract 40 by following weight, Folium Ginkgo extract 40 (is purchased in skill source, Henan natural health-care products company limited, its trade name is " Folium Ginkgo extract "), fish oil (purchase in the foreign refreshing Biotec Marin GmbH of Shandong letter, its commodity are called " fish oil ") 920;
The preparation of Auricularia extract: dried Auricularia roguing, immersion 4-5 hour, clean; Auricularia after cleaning is joined in the extraction pot (equipment is purchased in Harbin nano medical equipment company limited) of band agitating device, 90-95 ℃ is stirred extraction 3 times, wherein it was 40 times of weight that the 1st extraction adds the water multiple in 3 hours in each extraction, and it is 20 times of weight that the 2nd, 3 extraction adds the water multiple; Classified filtering (30 orders, 60 orders, 100 orders) filters the back merging filtrate respectively, filtrate decompression be concentrated into volume be raw material weight 15-18 doubly, the 10000r/min continuous centrifugal is removed precipitation, gets supernatant, and continuing to be evaporated to raw material ratio is 1: 5, spray drying, promptly; After testing, in the prepared extract, its polyoses content 〉=22%, adenosine content 〉=0.17%;
With Auricularia extract, Folium Ginkgo extract and fish oil mix homogeneously under 35-45 ℃ temperature, get mixture; To make colloidal sol behind gelatin 800g, glycerol 400g, iron oxide black 6.4g and the water 800g mix homogeneously, colloidal sol is filtered, get glue; With after said mixture mixes, pelleting is made soft capsule with glue, again through typing, wash ball, drying, promptly.
Embodiment 2
Take by weighing each raw material (unit: g): Auricularia extract 30 by following weight, Folium Ginkgo extract (is purchased in skill source, Henan natural health-care products company limited, its trade name is " Folium Ginkgo extract ") 30, fish oil is purchased in the foreign refreshing Biotec Marin GmbH of Shandong letter, and its commodity are called " fish oil ") 900;
The preparation of Auricularia extract: the Auricularia roguing of will wetting, clean; Auricularia after the cleaning is joined in the extraction pot of band agitating device, 90-95 ℃ is stirred extraction 3 times, extracts 3 hours at every turn, and wherein, the 1st extraction adds 40 times of weight that the water multiple is a raw material, and the 2nd, 3 extraction adds 20 times of weight that the water multiple is a raw material; Classified filtering (30 orders, 60 orders, 100 orders) filters the back merging filtrate respectively, filtrate decompression be concentrated into volume be raw material weight 15-18 doubly, the 10000r/min continuous centrifugal is removed precipitation, gets supernatant, and continuing to be evaporated to raw material ratio is 1: 5, spray drying, promptly; After testing, in the prepared extract, its polyoses content 〉=22%, adenosine content 〉=0.17%;
With prepared Auricularia extract, Folium Ginkgo extract and fish oil mix homogeneously under 35-45 ℃ temperature, get mixture; To make colloidal sol behind gelatin 800g, glycerol 400g, iron oxide black 6.4g and the water 800g mix homogeneously, colloidal sol is filtered, get glue; With after said mixture mixes, pelleting is made soft capsule with glue, again through typing, wash ball, drying, promptly.
Embodiment 3
Take by weighing each raw material (unit: g): Auricularia extract 50 by following weight, Folium Ginkgo extract (is purchased in skill source, Henan natural health-care products company limited, its trade name is " Folium Ginkgo extract ") 50, fish oil is purchased in the foreign refreshing Biotec Marin GmbH of Shandong letter, and its commodity are called " fish oil ") 1000;
The preparation of Auricularia extract: dried Auricularia roguing, immersion 4-5 hour, clean; Auricularia after the cleaning is joined in the extraction pot of band agitating device, 90-95 ℃ is stirred extraction 3 times, extracts 3 hours wherein at every turn, and the 1st extraction adds 40 times of weight that the water multiple is a raw material, and the 2nd, 3 extraction adds 20 times of weight that the water multiple is a raw material; Classified filtering (30 orders, 60 orders, 100 orders) filters the back merging filtrate respectively, filtrate decompression be concentrated into volume be raw material weight 15-18 doubly, the 10000r/min continuous centrifugal is removed precipitation, gets supernatant, and continuing to be evaporated to raw material ratio is 1: 5, spray drying promptly gets the Auricularia extract;
With prepared Auricularia extract, Folium Ginkgo extract and fish oil mix homogeneously under 35-45 ℃ temperature, get mixture; To make colloidal sol behind gelatin 800g, glycerol 400g, iron oxide black 6.4g and the water 800g mix homogeneously, colloidal sol is filtered, get glue; With after said mixture mixes, pelleting is made soft capsule with glue, again through typing, wash ball, drying, promptly.
Test example 1 health product auxiliary lipid-lowering function human feeding trial of the present invention
Given the test agent: the soft capsule that the embodiment of the invention 1,2 and 3 is prepared.
1. the experimenter selects:
1.1 study subject: press the principle of voluntariness and select 18-65 year, hyperlipidemia person.
1.2 the person's of including in standard: simple dyslipidemia crowd, usual diet.Blood sampling is 2 times in half a year, twice serum total cholesterol (CTC) all 〉=5.2mmol/L or serum levels of triglyceride (TG) all 〉=1.65mmol/L, all can carry out test-meal and observe.
1.3 eliminator's standard:
1.3.1 the age, pregnancy or women breast-feeding their children were to these health product allergy sufferers under-18s or over-65s person.
1.3.2 be associated with serious diseases such as conscience kidney and hemopoietic system, the psychotic.
1.3.3 take the article relevant in a short time, have influence on judgement person to the result with being tried function.
1.3.4 do not meet the standard of including in,, can't judge effect or data not umbra sound effect or safety judgement person not in accordance with regulations with being tried thing.
1.4 EXPERIMENTAL DESIGN and grouping requirement; 100 routine experimenters are divided into test-meal group and blank group at random, adopt before and after self and contrast form between group.Keep on ordinary days life and dietary habit during being tried.Get the every biochemical indicator of hematometry on an empty stomach.
1.5 test-meal group taking dose and time: each 2, every day 2 times, continuous 90 days.
1.6 instrument and reagent: F-820 type blood counting instrument, ten analysers of (Japan produces) MIDIRON urine (Germany produces), RAI000 automatic clinical chemistry analyzer (U.S.'s product), the biochemical reagents box is all provided by middle living company.
2. observation index:
2.1 safety is observed:
2.1.1. ordinary circumstance:
Detailed medical history-taking is understood situations such as experimenter's spirit, diet, sleep, defecation, heart rate, blood pressure, observes main clinic symptoms: tired, uncomfortable in chest, dizzy, agitation etc.Before and after test-meal, add up integrated value by symptom weight (serious symptom 3 minutes, moderate 2 minutes, light disease 1 minute), and improve (2 fens produce effects of each doing well,improving are improved 1 and are divided into effectively), calculate the improvement rate with regard to its cardinal symptom.
2.1.2. blood and urinate just routine examination:
Red blood cell count(RBC), hemoglobin, numeration of leukocyte, routine urinalysis, just routine examination.
2.1.3 biochemical indicator is measured:
Serum albumin ALB, total protein TP, darling renal function (glutamic oxaloacetic transaminase, GOT AST, paddy third changes nitrogen enzyme ALT, carbamide UREA, flesh back of the body CRE), blood glucose GLU.
2.1.4. Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line.
2.1.5. untoward reaction is observed:
2.2 effect index
2.2.1 serum total cholesterol level and reduction percentage rate, sweet pool three lipid levels and reduction percentage rate, the horizontal ascensional range of HDL-C.
3 date processing and result judge:
3.1 date processing: with the STATE6.0 of statistical software computational analysis data.T check is in groups relatively adopted in check, two groups of means, and the latter need carry out variance test, and the data of nonnormal distribution or heterogeneity of variance are carried out suitable variable conversion, carries out the t check after waiting to satisfy the normal state homogeneity of variance; If translation data still can not satisfy the requirement of normal state homogeneity of variance, use t ' check or rank test instead; But the coefficient of variation is too big as (CV.＞50%) data is used rank test.Power index X
2Check.
3.2 effect criterion
3.2.1 effectively
Cholesterol descends＞10%, and glycerol three vinegar descend＞15%, HDL-C rising＞0.104mmol/L.Serum total cholesterol, sweet pool three enzymes, comparing difference has significance between test-meal group self comparison and matched group group, and HDL-C significantly is not lower than matched group.
3.2.2 invalid:
Do not reach above standard person.
4. experimental result:
4.1. general situation:
Observe hyperlipidemia experimenter 100 examples altogether, test-meal group male 17 examples, women's 33 examples, minimum 40 years old of age, maximum 65 years old, average 55.42 ± 6.75 years old, average course of disease 3.81 ± 3.21 years.Blank group male 11 examples, women's 39 examples, minimum 25 years old of age, maximum 65 years old, average 54.52 ± 8.61 years old, average course of disease 3.61 ± 3.07 years.Symptoms such as spirit, sleep, diet, defecation do not have obvious change before and after experimenter's test-meal.
Changes in heart rate before and after table 1 test-meal (unit: inferior/minute)
| The example number | Before the test-meal | After the test-meal | |
| The test-meal group | 50 | 72.24±5.71 | 72.08±5.60 |
| Matched group | 50 | 73.04±6.43 | 72.76±6.32 |
Blood pressure (unit: mmHg) before and after table 2 test-meal
| The example number | Systolic pressure | Diastolic pressure | |||
| Before the test-meal | After the test-meal | Before the test-meal | After the test-meal | ||
| The test-meal group | 50 | 123.30±8.96 | 123.76±9.16 | 79.00±7.07 | 79.24±7.32 |
| Matched group | 50 | 124.13±7.68 | 124.48±7.82 | 75.94±6.33 | 76.31±6.87 |
4.2 cholesterol changes
Cholesterol changes (unit: mmol/L) before and after table 3 test-meal
| The example number | Before the test-meal | After the test-meal | Difference | Effective percentage (%) | |
| The test-meal group | 50 | 6.09±0.75 | 5.58±0.96 | -0.51±0.90※ | 48 (24 examples) |
| Matched group | 50 | 6.13±0.71 | 6.00±0.84 | -0.13±0.67☆ | 12 (6 examples) |
Annotate: self is ※ P＜0.01 relatively; Compare ☆ P＜0.05. between group
4.3 triglyceride changes
Triglyceride changes (unit: mmol/L) before and after table 4 test-meal
| The example number | Before the test-meal | After the test-meal | Difference | Effective percentage (%) | |
| The test-meal group | 50 | 2.86±1.07 | 2.36±1.18 | -0.49±1.18※ | 58 (29 examples) |
| Matched group | 50 | 2.99±1.59 | 2.96±1.56 | -0.04±0.58☆ | 16 (8 examples) |
Annotate: self is ※ P＜0.01 relatively; Compare ☆ P＜0.05. between group
4.4 high density lipoprotein changes
High density lipoprotein changes (unit: mmol/L) before and after table 5 test-meal
| The example number | Before the test-meal | After the test-meal | Difference | Effective percentage (%) | |
| The test-meal group | 50 | 0.96±0.32 | 0.99±0.34 | 0.03±0.41※ | 34 (17 examples) |
| Matched group | 50 | 1.04±0.27 | 1.05±0.27 | 0.01±0.09 | 8 (4 examples) |
Annotate: compare ※ P＜0.05. between group
4.5 effect is judged
Table 6 effect is judged
| The example number | Effectively | Invalid | Total effective rate (%) | |
| The test-meal group | 50 | 18 | 32 | 36.00％☆ |
| Matched group | 50 | 3 | 47 | 6.00％ |
Annotate: compare ☆ P＜0.05. between group
4.6 cardinal symptom is improved situation
Table 7 cardinal symptom is improved situation
| Cardinal symptom | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Feeling of fatigue | 36(31) | 2(0) | 19(8) | 15(23) | 58.38(25.81) |
| Uncomfortable in chest | 28(23) | 2(0) | 16(5) | 10(18) | 64.29(21.74) |
| Dizzy | 30(18) | 1(0) | 17(5) | 12(13) | 60.00(27.78) |
| Irritated | 29(27) | 4(0) | 15(7) | 10(20) | 65.52(25.93) |
Annotate: () is matched group.
4.7 symptom integral changes
Table 8 symptom integral changes
| The example number | Before the test-meal | After the test-meal | After the test-meal | |
| The test-meal group | 50 | 7.78±4.67 | 6.92±4.68※ | 4.74±4.18※ |
| Matched group | 50 | 8.12±4.59 | 7.58±4.24※ | 7.16±3.91※ |
Annotate: ※ P＜0.01;
4.8 safety indexes detects
Table 9 safety indexes detects
| Project | The example number | The test-meal group | Matched group | ||
| Before the test-meal | After the test-meal | Before the test-meal | After the test-meal | ||
| TP(g/L) | 50 | 74.25±3.28 | 74.14±4.90 | 73.53±5.15 | 73.43±5.22 |
| ALB(g/L) | 50 | 45.03±3.72 | 46.12±4.01 | 43.47±4.08 | 43.90±3.77 |
| ALT(u/L) | 50 | 16.86±11.2 | 18.92±11.8 | 18.16±13.2 | 22.22±17.4 |
| AST(u/L) | 50 | 19.08±6.10 | 22.08±8.16 | 22.08±7.60 | 24.78±8.78 |
| GLU(mmol/L) | 50 | 5.75±2.03 | 6.05±1.60 | 5.57±2.42 | 5.49±2.16 |
| UREA(mmol/L) | 50 | 4.67±1.42 | 4.54±1.18 | 4.74±1.33 | 4.68±1.47 |
| CRE(umol/L) | 50 | 90.06±18.4 | 83.50±15.1 | 88.47±21.7 | 81.08±22.6 |
| HGB(g/L} | 50 | 144.46±15.7 | 142.3±15.3 | 139.48±12.6 | 138.66±12.5 |
| RBC(X10 12/L) | 50 | 4.64±0.52 | 4.57±0.41 | 4.53±0.43 | 4.58±0.46 |
| WBC(X10 9/L) | 50 | 6.59±1.27 | 6.32±1.17 | 6.41±1.32 | 6.64±1.39 |
| Routine urinalysis | 50 | Normally | Normally | Normally | Normally |
| Just conventional | 50 | Normally | Normally | Normally | Normally |
Before and after the test-meal, every index is substantially in normal range.
4.9 Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line is substantially in normal range.
4.10 case is taken off the mistake rate: test-meal group and matched group respectively are 60 examples, and the test-meal of wherein test-meal group has 4 examples not take in accordance with regulations when finishing to be tried thing, 6 routine detection data are incomplete, and matched group has 7 routine detection data incomplete, and 3 examples are check on time at the appointed time.Test-meal group and matched group respectively have 10 examples to meet experimenter's exclusion standard, effective every group 50 example of case, and case is taken off the mistake rate and is 16.67%.
5. conclusion (of pressure testing)
5.1 100 routine hyperlipidemia experimenters on request, the test-meal group is taken northern bacterium board 9 soft capsule, each 2, every day 3 times, matched group is the blank group, the result is subjected to the examination group cholesterol 0.51 ± 0.90mmol/L that on average descends, the triglyceride 0.49 ± 1.18mmol/L that on average descends, the high density lipoprotein 0.03 ± 0.41mmol/L that on average raises; In 50 examples, effective 18 examples, total effective rate is 35.00%; The blank group cholesterol 0.13 ± 0.67mmol/L that on average descends, the triglyceride 0.04 ± 0.58mmol/L that on average descends, the high density lipoprotein 0.01 ± 0.09mmol/L that on average raises; In 50 examples, effective 3 examples, total effective rate is 6.00%; Cholesterol and triglyceride self relatively reaches relatively significant difference between group.More variant between the high density lipoprotein group, illustrate that health product of the present invention have the effect of significant auxiliary antilipemic.
5.2 health product of the present invention have the improvement effect to symptoms such as hyperlipidemia experimenter's feeling of fatigue, uncomfortable in chest, dizzy, agitations.
5.3 the experimenter takes before and after the health product of the present invention, hemoglobin, erythrocyte, leukocyte, total serum protein, albumin, glutamate pyruvate transaminase, inosine, carbamide, blood glucose, routine urinalysis, just routine etc. detects index substantially in normal range, illustrate that health product of the present invention to human body safety, have no adverse reaction.
5.4 the experimenter takes before and after the health product of the present invention, heart rate, blood pressure are in normal range.
5.5 after the experimenter takes health product of the present invention, do not meet quick and other untoward reaction.
Claims (9)
1, a kind of health product with auxiliary lipid-lowering function mainly are made up of the component of following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part and fish oil 900-1000 part.
According to the health product of claim 1, it is characterized in that 2, the weight portion of each raw material is: 40 parts of Auricularia extracts, 40 parts of Folium Ginkgo extract, 920 parts in fish oil.
According to the health product of claim 1 or 2, it is characterized in that 3, described Auricularia extract prepares in accordance with the following methods:
(1) pre-treatment: will wet and taste with discrimination the Auricularia roguing, and clean; After the dry product Auricularia is soaked in water, roguing again, cleaning;
(2) Auricularia after will cleaning joins in the extraction pot of band agitating device, adds water, and 90-95 ℃ is stirred and extract 1-5 time; With merging filtrate behind the extracting liquid filtering, filtrate decompression concentrates, and centrifugal removal precipitation is got supernatant, continues concentrating under reduced pressure, and spray drying gets the Auricularia extract.
4, according to the health product of claim 3, it is characterized in that, after in the step (1) the dry product Auricularia being soaked in water 4-5 hour, roguing again, cleaning;
According to the health product of claim 3, it is characterized in that 5, the Auricularia after will cleaning in the step (2) joins in the extraction pot of band agitating device, adds water, 90-95 ℃ is stirred extraction 3 times, extracted 3 hours at every turn; Wherein, the 1st time is extracted amount of water is 40 times of weight, and the 2nd, 3 time is extracted amount of water is 20 times of weight.
6, according to the health product of claim 3, it is characterized in that, in the step (2) extracting solution is filtered according to 30 orders, 60 orders, 100 purpose size fractionations, merging filtrate, filtrate decompression be concentrated into volume be raw material weight 15-18 doubly, centrifugal removal precipitation is got supernatant, continues most 5 times of raw material raw material of concentrating under reduced pressure.
7, according to any one described health product of claim 1-6, it is characterized in that, be prepared into oral formulations according to this area conventional formulation method behind adjuvant that adding is conventional or the carrier.
According to the health product of claim 7, it is characterized in that 8, described oral formulations is soft capsule, tablet, granule, pill or powder.
9, a kind of method for preparing the health product of claim 1 comprises:
(1) takes by weighing each component by following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part, fish oil 900-1000 part;
(2), get mixture 1 with above-mentioned each component mix homogeneously under 35-45 ℃ temperature;
(3) in mixture 1, add preparation adjuvant or carrier commonly used, make needed peroral dosage form by this area conventional formulation method.
10, a kind of method for preparing the health product of claim 1 comprises:
(1) takes by weighing each component by following weight portion: Auricularia extract 30-50 part, Folium Ginkgo extract 30-50 part, fish oil 900-1000 part;
(2), get mixture 1 with above-mentioned each component mix homogeneously under 35-45 ℃ temperature;
(3) will make colloidal sol behind gelatin, glycerol, ferrum oxide and the water mix homogeneously, colloidal sol is filtered, get glue;
(4) glue is mixed the back pelleting with mixture 1, make soft capsule, pass through shaping again, wash ball, drying, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710086922 CN101019900A (en) | 2007-03-22 | 2007-03-22 | Health product with auxiliary antilipemic function and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710086922 CN101019900A (en) | 2007-03-22 | 2007-03-22 | Health product with auxiliary antilipemic function and its prepn |
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| CN101019900A true CN101019900A (en) | 2007-08-22 |
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| CN 200710086922 Pending CN101019900A (en) | 2007-03-22 | 2007-03-22 | Health product with auxiliary antilipemic function and its prepn |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579118B (en) * | 2009-03-26 | 2013-06-19 | 庆元大山合菌物科技有限公司 | Health food of black fungus soft capsule |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| CN103989176A (en) * | 2014-05-06 | 2014-08-20 | 宁波市成大机械研究所 | Deep sea fish oil soft capsule containing radix puerariae extract |
| CN104523770A (en) * | 2014-12-05 | 2015-04-22 | 黑龙江众生生物工程有限公司 | Auriculacin soft capsule and preparation method thereof |
| CN107411088A (en) * | 2017-06-20 | 2017-12-01 | 哈尔滨工业大学 | Special blueberry anthocyanin complex tablet of a kind of the elderly and preparation method thereof |
| CN109876022A (en) * | 2019-04-22 | 2019-06-14 | 黑龙江中医药大学 | Black fungus hypolipidemic activity position and its preparation method and application |
-
2007
- 2007-03-22 CN CN 200710086922 patent/CN101019900A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579118B (en) * | 2009-03-26 | 2013-06-19 | 庆元大山合菌物科技有限公司 | Health food of black fungus soft capsule |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| CN103238840B (en) * | 2013-05-16 | 2014-10-29 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| CN103989176A (en) * | 2014-05-06 | 2014-08-20 | 宁波市成大机械研究所 | Deep sea fish oil soft capsule containing radix puerariae extract |
| CN103989176B (en) * | 2014-05-06 | 2016-02-24 | 宁波市成大机械研究所 | Deep-sea fish oil soft capsules containing kudzu root extract |
| CN104523770A (en) * | 2014-12-05 | 2015-04-22 | 黑龙江众生生物工程有限公司 | Auriculacin soft capsule and preparation method thereof |
| CN107411088A (en) * | 2017-06-20 | 2017-12-01 | 哈尔滨工业大学 | Special blueberry anthocyanin complex tablet of a kind of the elderly and preparation method thereof |
| CN109876022A (en) * | 2019-04-22 | 2019-06-14 | 黑龙江中医药大学 | Black fungus hypolipidemic activity position and its preparation method and application |
| CN109876022B (en) * | 2019-04-22 | 2021-07-20 | 黑龙江中医药大学 | Black fungus blood fat reducing active part and preparation method and application thereof |
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