CN101006994A - Enteric-coated capsules of allimin and its preparation method - Google Patents
Enteric-coated capsules of allimin and its preparation method Download PDFInfo
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- CN101006994A CN101006994A CN 200610018273 CN200610018273A CN101006994A CN 101006994 A CN101006994 A CN 101006994A CN 200610018273 CN200610018273 CN 200610018273 CN 200610018273 A CN200610018273 A CN 200610018273A CN 101006994 A CN101006994 A CN 101006994A
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- cycloheptaamylose
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- clathrate
- bulbus allii
- starch
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Abstract
The invention relates to a kind of allicin capsulate enterosolubilis as well as its preparing method. The invention is composed by garlic oil, beta-schardinger dextrin and starches. The preparing procedure includes the following steps: putting purified water and beta-schardinger into the castration jar in turns and heating them; stirring to get the emulsified suspension; putting garlic oil into the jar and keeping stirring at a certain temperature for several hours; pumping the mentioned materials into the storage tank, stetting at low temperature; removing water through filtering; after heating, airblast drying, pulverizing and sieving the materials, mixing them with starches; getting the particles or micro pallets with 75% as the demulcent; cryodrying; polishing; loading the materials into the No. 1 capsulae enterosolubilis; packaging. The invention belongs to hard capsule dosage form; it's capsulae enterosolubilis (white or off-white color particles); its specification is 20mg/grain. The advantages of the invention includes: up-to-date idea, proper design, standard technology, simple preparing method, easily available medicine, low cost, convenient to take with, easy absorption by intestinal tract, no gastric irritation, excellent curative effect, good acceptability, no pollution and it's easy to realize production in quantity. The product is applicable to prevent and treat deep part fungus infection such as bellows and alimentary canal fungus infection; blastomyces alb cans bacteria, chronic and acute enteritis, whooping cough and so on.
Description
Technical field
The present invention relates to a kind of antibacterials, particularly relate to garlicin enteric coated capsule and the method for completing the square thereof of a kind of anti-deep mycete.
Background technology
As everyone knows, the kind of Liu Tong antibacterials, specification are various in the market, and its therapeutic effect is different, and the pain of slowing down or curing the patient is played effect for the moment really.Wherein, be applicable to the antibacterials of preventing and treating deep mycete infection, though there are many kinds to appear on the market, also effective in cure to the patient, as capsulae allitridi, but it is a kind of not dissolubility capsule, the patient takes the back has stimulation to stomach, and defective such as have side effects, so its application is restricted.
Summary of the invention
Purpose of the present invention exactly in order to remedy the prior art deficiency, in the defective of existing product, provides a kind of being applicable to prevent and treat deep mycete infection, easily by intestinal absorption, and the garlicin enteric coated capsule and the compounding method thereof of no gastric irritation.
To achieve these goals, technical scheme of the present invention is such: capsule involved in the present invention is sliding by Bulbus Allii, and cycloheptaamylose and starch are formed.Wherein, Oleum Bulbus Allii is a raw material, and content is 2 to 2.4kg; Cycloheptaamylose is the color condensation material, and its content is 18 to 22kg; Starch is inserts, and its content is 11.2 to 11.8kg.This product is made by following processing step, purified water, cycloheptaamylose is successively added color close a jar internal heating, stirs and makes equal emulsion suspension liquid, adds Oleum Bulbus Allii again, insulated and stirred 4h (hour); With in the above-mentioned color compound suction basin low temperature 2-6 ℃ left standstill 24 hours, remove clear water liquid through filter paper, will precipitate again the color compound heat forced air drying, pulverize, sieve, standby; After will pulverizing color compound and starch mix homogeneously then, reuse 75% ethanol becomes granule or micropill as wetting agent, and through cold drying, polishing, the enteric hollow capsule of packing into No. 1, packing promptly.
The garlicin enteric coated capsule that the present invention is alleged is characterized in that: Oleum Bulbus Allii content is that 2.2kg, cycloheptaamylose are that 20kg, content of starch are 11.5kg.
The compounding method of the garlicin enteric coated capsule that the present invention is alleged is characterized in that, its process is as follows:
A, 245L (liter) purified water is added in the enclose jar, be heated to 50 to 58 ℃ after, add 20kg, cycloheptaamylose, stir the emulsion suspension liquid of making homogeneous, add the 2.2kg Oleum Bulbus Allii again, insulated and stirred 4h (hour).
B, with in the above-mentioned clathrate suction basin, under 2 to 6 ℃ of conditions of low temperature, leave standstill 24h.
The clear water liquid of C, the above-mentioned clathrate of usefulness filter paper elimination.
D, with above-mentioned clathrate precipitation and forced air drying under 55 to 58 ℃ of conditions, after pulverizing 80 mesh sieves, standby again.
E, with behind above-mentioned spares and the 11.5kg starch mix homogeneously, reuse 75% ethanol is made the granule or the micropill of white or off-white color as wetting agent, then through cold drying, polishing, the enteric hollow capsule of packing into No. 1, packing promptly gets this product.
Garlicin enteric coated capsule and compounding method thereof involved in the present invention, novel, reasonable in design, technological specification, simple for production, medical material is easily got, non-environmental-pollution, be easy to form industrialized mass production; The garlicin enteric coated capsule made from the present invention; belong to the hard capsule dosage form, its character is an enteric coated capsule, and content is white or off-white color granule or micropill; after the patient takes easily by intestinal absorption, no gastric irritation, evident in efficacy, price suitable, easy to carry, patient takes like a shot.The present invention is a kind of novel antibacterials, this product meets " two appendix 1E of Chinese Pharmacopoeia board in 2000 " about every regulation relevant under the capsule item, be applicable to and prevent and treat deep mycete infection, as pulmonary and digestive tract fungal infection, Candida albicans bacteremia, acute and chronic epilepsy, acute chronic enteritis, pertussis etc.The invention belongs to Chinese medicine preparation, the universal antimicrobial drug, especially suitable old man, child patient use.
The specific embodiment
Garlicin enteric coated capsule and compounding method thereof involved in the present invention, the specific embodiment of its technical scheme is described in detail as follows:
At first, choose through the accreditation medical material: Oleum Bulbus Allii content is that 2.2kg, cycloheptaamylose 20kg and content of starch 115kg are standby, secondly, get purified water 245L and add in the enclose jar, be heated to 54 ℃ after, cycloheptaamylose 20kg is added in the enclose jar, the emulsion suspension liquid of homogeneous is made in stirring, again Oleum Bulbus Allii 2.2kg is added in the enclose jar, insulated and stirred 4h, standby; Its three, in above-mentioned clathrate suction basin, under 4 ℃ of conditions of low temperature, leave standstill 24h; Its four, with clear water liquid in the filter paper elimination above-mentioned clathrate; Its five, the clathrate of removing clear water liquid is precipitated and forced air drying under 56 ℃ of conditions, through pulverizing 80 mesh sieves, standby afterwards; At last, above-mentioned spares and content is 11.5kg starch mix homogeneously after, make the granule or the micropill of white or off-white color with 75% ethanol as wetting agent, again through cold drying, polishing, the enteric hollow capsule of packing into No. 1, packing promptly gets this product.This product specification: 20mg/ grain.
Claims (3)
1. garlicin enteric coated capsule is characterized in that: this capsule is by Oleum Bulbus Allii, and cycloheptaamylose and starch are formed, and wherein Oleum Bulbus Allii content is 2 to 2.4kg, and cycloheptaamylose content is 18 to 22kg, and content of starch is 11.2 to 11.8kg; This product is made by following processing step: purified water, cycloheptaamylose are successively added enclose jar internal heating, stir and to make emulsion suspension liquid, add Oleum Bulbus Allii, insulated and stirred a few hours again; With stand at low temperature in the above-mentioned clathrate suction basin, remove clear water liquid after filtration, will precipitate clathrate heating forced air drying again, pulverize, sieve, standby; After will pulverizing clathrate and starch mix homogeneously then, reuse 75% ethanol is made granule or micropill as wetting agent, and through cold drying, polishing, the enteric hollow capsule of packing into No. 1, packing promptly.
2. garlicin enteric coated capsule according to claim 1 is characterized in that: Oleum Bulbus Allii content is 2.2kg, and cycloheptaamylose 20kg, content of starch are 11.5kg.
3. the preparation method of a garlicin enteric coated capsule as claimed in claim 1, it is characterized in that: its process is as follows:
A, the 245L purified water is added in the enclose jar, be heated to 50 to 58 ℃ after, add the 20kg cycloheptaamylose, stir the emulsion suspension liquid of making homogeneous, add the 2.2kg Oleum Bulbus Allii again, insulated and stirred 4h;
B, will under 2 to 6 ℃ of conditions of low temperature, leave standstill 24h in the above-mentioned clathrate suction basin;
Clear water liquid in C, the above-mentioned clathrate of usefulness filter paper elimination;
D, with above-mentioned clathrate precipitation and forced air drying under 55 to 58 ℃ of conditions, after pulverizing 80 mesh sieves, standby again;
E, with behind above-mentioned spares and the 11.5kg starch mix homogeneously, reuse 70% ethanol is made the granule or the micropill of Bai Bao or off-white color as wetting agent, then through cold drying, polishing, the enteric hollow capsule of packing into No. 1, packing promptly gets this product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610018273 CN101006994A (en) | 2006-01-23 | 2006-01-23 | Enteric-coated capsules of allimin and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610018273 CN101006994A (en) | 2006-01-23 | 2006-01-23 | Enteric-coated capsules of allimin and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101006994A true CN101006994A (en) | 2007-08-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610018273 Pending CN101006994A (en) | 2006-01-23 | 2006-01-23 | Enteric-coated capsules of allimin and its preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN101006994A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804145B (en) * | 2009-02-12 | 2012-11-14 | 杭州赛利药物研究所有限公司 | Garlic oil enteric pellet capsule and preparation method thereof |
-
2006
- 2006-01-23 CN CN 200610018273 patent/CN101006994A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804145B (en) * | 2009-02-12 | 2012-11-14 | 杭州赛利药物研究所有限公司 | Garlic oil enteric pellet capsule and preparation method thereof |
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Open date: 20070801 |