CN101543511A - Pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol - Google Patents
Pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol Download PDFInfo
- Publication number
- CN101543511A CN101543511A CN200810084201A CN200810084201A CN101543511A CN 101543511 A CN101543511 A CN 101543511A CN 200810084201 A CN200810084201 A CN 200810084201A CN 200810084201 A CN200810084201 A CN 200810084201A CN 101543511 A CN101543511 A CN 101543511A
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- China
- Prior art keywords
- medicinal charcoal
- polyethylene glycol
- medicinal
- polyethyleneglycol
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention provides a pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol, which is characterized in that the medicinal charcoal accounts for 65 to 75 percent of the composition, and the polyethyleneglycol of which the molecular weight is between 1,500 and 6,000 accounts for 15 to 25 percent of the composition. The pharmaceutical composition is applied to correcting a digestive symptom of intestinal constipation caused by the medicinal charcoal while being applied to a clinical nonspecific antidote. People are surprised to find that the composition, such as solid colored film coat tablet, has more acceptable perceptive and clinical curative effects compared with the prior medicinal charcoal tablet.
Description
Technical field
The present invention relates to clinical nonspecific medicinal charcoal antidote, eliminate or correct constipation, feces that medicinal charcoal produces and be detained a kind of compressed pharmaceutical compositions that contains medicinal charcoal and Polyethylene Glycol of constipation gastrointestinal symptom that improved intestinal in therapeutic process.The present invention also further relates to the preparation method of said composition.
Background technology
Has the absorption medicine medicinal charcoal sheet of using clinically in " Drug Standard of Ministry of Public Health of the Peoples Republic of China " (first of chemical medicine).As a kind of non-specific antidote, medicinal charcoal enters in its aperture at gastrointestinal tract internal adsorption vivotoxin material, directly excretes from intestinal.Because medicinal charcoal strong absorptive, clinical patients in using the medicinal charcoal treatment, use patient's fecund to give birth to the constipation untoward reaction for a long time or in a large number.Feces is trapped in colon and/or rectum causes uncomfortable and headache, and under extreme case, scybalum that exists in the rectum or argol piece can cause long constipation and dyschizia.
At the drawback of medicinal charcoal, the present invention eliminates or corrects intestinal constipation gastrointestinal symptom after aiming to provide medicinal charcoal for oral use, and medicine without any side effects.The present invention utilizes polyethylene glycol 1500～6000 physicochemical characteristicss and medicinal charcoal compatibility to be pressed into the non-specific antidote that contains medicinal charcoal and Polyethylene Glycol for achieving the above object.
In the combination of new proportioning its long-chain polymer of high-molecular weight polyethylene glycol 1500～6000 can by hydrogen bond fixedly hydrone increase local penetration and press, moisture is retained in the colon enteric cavity, increase the recoverable amount of liquid in the intestinal, thereby stool softened.Stool is softening can and then to promote its promotion and drainage in intestinal with the water content increase.The effect that Polyethylene Glycol is good not only overcomes the defective of existing kind, and high-molecular weight Macrogol 4000-6000 also has and is difficult for being adsorbed by medicinal charcoal, not in intestinal by bacterial degradation, do not produce organic acid or gas yet, do not change the Acidity of Aikalinity of feces, to not influence of the PH of intestinal, genotoxic potential is extremely low, and this is that chemicals and Chinese medicine and medicinal plants are not available.
The discovery that people are surprised, the compressed pharmaceutical compositions of a kind of medicinal charcoal and Polyethylene Glycol, for example, solid coloured film garment piece is obviously better than previous commodity sensory effects, and it is fine to take effect.Fact proved that the present invention has more acceptant outward appearance and therapeutic effect.
The component medicinal charcoal of medicinal charcoal and Polyethylene Glycol accounts for the 65-75% of compositions in the compressed pharmaceutical compositions of the present invention, and molecular weight is the 15-25% that 1500～6000 Polyethylene Glycol account for compositions.All the other materials of compositions are optional excipient, contain one or more components in natural and the synthetic food color coating solution.
The mean molecule quantity that the Polyethylene Glycol that uses in compositions of the present invention has is preferably 1500 or bigger, and the mean molecule quantity that Polyethylene Glycol has is preferably 6000 or littler.
In the present invention, Polyethylene Glycol has the effect of cathartic by the osmosis at enteral, the component medicinal charcoal of medicinal charcoal and Polyethylene Glycol accounts for the 65-75% of compositions, and molecular weight is the 15-25% that 1500～6000 Polyethylene Glycol account for compositions, and the good treatment of performance curative effect complements each other.
Medicine pharmacy compositions of the present invention is oral medicine.Compressed pharmaceutical compositions of the present invention is preferably the coloured film garment piece.
Compressed pharmaceutical compositions of the present invention further also has can be easy to the advantage of producing and packing.Compressed pharmaceutical compositions of the present invention normally mixes with dried powder or particulate form, suppresses, is colored as required face shaping then.Suitable drug excipient comprises hard magnesium, cellulose and cellulose derivative, starch and starch derivatives, lactose and lactose derivatives.
Prepare the technology of the method for compressed pharmaceutical compositions, known by people.Can be referring to the pharmaceutics textbook.
Beneficial effect of the present invention
The compressed pharmaceutical compositions that contains medicinal charcoal and Polyethylene Glycol is used for the gastrointestinal symptom that the intestinal constipation that is produced by medicinal charcoal is treated in the clinical nonspecific detoxifcation simultaneously, has increased patient's compliance, improves clinical therapeutic efficacy.
The specific embodiment
In conjunction with most preferred embodiment the present invention is described in further detail.Those skilled in the art can carry out various modifications and improvement to various aspects of the present invention, and these modifications and improvement also belong to protection scope of the present invention.
Example formulations
Medicinal charcoal 0.3 gram
Macrogol 4000 0.1 gram
The drug powder mixing is suppressed bag coloured film clothing according to the technology of the method for preparing compressed pharmaceutical compositions.
But clinical acceptance test:
Select the medicinal carbon plate of listing product for use, specification 0.3 gram/sheet and compositions of the present invention are relatively.
In test, six healthy volunteers all take each 100 of listing product and pharmaceutical composition coloured film garment pieces of the present invention, 10 days cycles, every day twice, each 5.Off-test each experimenter all think, they are more prone to take by the present invention and suppress the formulated product of thing.
Claims (2)
1. contain the compressed pharmaceutical compositions of medicinal charcoal and Polyethylene Glycol, comprise:
Medicinal charcoal accounts for the 65-75% of compositions, and molecular weight is the 15-25% that 1500～6000 Polyethylene Glycol account for compositions.
Described compressed pharmaceutical compositions is corrected the gastrointestinal symptom that medicinal charcoal causes the intestinal constipation as the clinical nonspecific antidote simultaneously.
2. one kind prepares compressed pharmaceutical compositions method as claimed in claim 1, may further comprise the steps:
1. medicinal charcoal and 1500～6000 Polyethylene Glycol, one or more excipient and other optional components are mixed;
2. this mixing is pressed into the oblate morph sheet of diameter 5～14mm, it is the compacting medicinal mixture that 5～15 μ m have one or more color film-coats of humidity resistance that the surface coats thickness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810084201A CN101543511A (en) | 2008-03-26 | 2008-03-26 | Pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810084201A CN101543511A (en) | 2008-03-26 | 2008-03-26 | Pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101543511A true CN101543511A (en) | 2009-09-30 |
Family
ID=41191053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810084201A Pending CN101543511A (en) | 2008-03-26 | 2008-03-26 | Pressed pharmaceutical composition containing medicinal charcoal and polyethyleneglycol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101543511A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108883130A (en) * | 2016-04-01 | 2018-11-23 | 株式会社吴羽 | Contain the tablet and its manufacturing method that spherical adsorbent charcoal is administered orally |
| CN112386577A (en) * | 2019-08-16 | 2021-02-23 | 北京天衡药物研究院有限公司 | Composition for treating constipation |
-
2008
- 2008-03-26 CN CN200810084201A patent/CN101543511A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108883130A (en) * | 2016-04-01 | 2018-11-23 | 株式会社吴羽 | Contain the tablet and its manufacturing method that spherical adsorbent charcoal is administered orally |
| CN108883130B (en) * | 2016-04-01 | 2021-06-22 | 株式会社吴羽 | Tablet containing spherical adsorbent carbon for oral administration and method for producing same |
| CN112386577A (en) * | 2019-08-16 | 2021-02-23 | 北京天衡药物研究院有限公司 | Composition for treating constipation |
| CN112386577B (en) * | 2019-08-16 | 2024-01-23 | 北京天衡药物研究院有限公司 | Composition for treating constipation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090930 |