CN100998667A - Medicine composition for lowering blood-fat - Google Patents
Medicine composition for lowering blood-fat Download PDFInfo
- Publication number
- CN100998667A CN100998667A CN 200610148749 CN200610148749A CN100998667A CN 100998667 A CN100998667 A CN 100998667A CN 200610148749 CN200610148749 CN 200610148749 CN 200610148749 A CN200610148749 A CN 200610148749A CN 100998667 A CN100998667 A CN 100998667A
- Authority
- CN
- China
- Prior art keywords
- compositions
- fructus crataegi
- perilla oil
- crataegi extract
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A hypoglycemic composition contains perilla oil and haw extract as its active components. Its preparing process and the medicine or food containing it are also disclosed.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically, the invention relates to a kind of is the blood-fat reducing composition of main component with Fructus Crataegi extract and perilla oil.
Background technology
Hyperlipidemia is a kind of common frdquently encountered disease of middle-aged and elderly people, is atherosclerotic main reason, also is the main pathological basis that causes cardiovascular and cerebrovascular disease.Obvious with the side effect of western medicine hyperlipidemia, easily bounce-back after the drug withdrawal, and do not have prevention, regulating action.Therefore, the blood fat reducing of research Chinese medicine is with the control blood lipid level, and anti-curing hyperlipemia has significance to safeguarding human beings'health and longevity.
Fructus Crataegi is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataeguspinnatifida Bge., be a kind of conventional Chinese medicine, have that removing food stagnancyization stagnates, spleen reinforcing is good for the stomach, the effect of blood circulation promoting and blood stasis dispelling.Compendium of Material Medica record this product " sour sweet tepor, removing food stagnancy food, spleen reinforcing ".Modern study proves, Fructus Crataegi has many-sided pharmacological action to cardiovascular and cerebrovascular vessel, has blood fat reducing, expansion hat dress tremulous pulse, improves myocardial metabolism, reduction hematuria, arrhythmia, heart tonifying, atherosclerosis, fat-reducing and complexation or catch free radical, prevents effects such as body lipid peroxidation.Fructus Crataegi and Fructus Crataegi flavone can significantly reduce serum and liver malonaldehyde (MDA) content, strengthen the activity of erythrocyte and liver superoxide dismutase (SOD).Strengthen whole blood glutathion reductase (GSH-Px) activity simultaneously.Can also significantly suppress to feed high fat high cholesterol diet rat blood serum T-CHOL (TC), low density lipoprotein, LDL-cholesterol (LDL-C) and ApoB concentration, remarkable high density lipoprotein increasing-cholesterol (HDL-C) and ApoAl concentration, but little to triglyceride (TG) influence.RT-polymerase chain reaction (RT-PCR) experiment shows that high fat high cholesterol diet can significantly reduce rat liver low density lipoprotein receptor (LDLR) mRNA level.Fructus Crataegi and the Fructus Crataegi flavone rat liver LDLR protein level that can significantly raise, significantly increased rat liver LDLR number, and it is not obvious to the affinity influence, illustrate that Fructus Crataegi and Fructus Crataegi flavone are by regulating LDLR transcription level and improving oxidation resistance and suppress lipid peroxide prevention lipid metabolic disorder (Lin Qiushi, Chen Jidi, the Study on Molecular Mechanism of Fructus Crataegi and the disorder of Fructus Crataegi flavone prevention lipid metabolism in rats, Journal of Nutrition, 2000,22 (2): 131).
Fructus Perillae is the dry mature fruit of labiate Folium Perillae Perilla frutescens (L.) Britt., perilla oil is that Fructus Perillae is through squeezing and the refining vegetable oil that obtains, the alpha-linolenic acid that is rich in the perilla oil can significantly reduce content of triglyceride higher in the serum, suppressed the synthetic of endogenous cholesterol by the activity that suppresses the HMC-Co reductase in the liver, also can be increased effective hdl concentration with cholesterol reducing.Zoopery is found, the rat blood serum triglyceride (TG) of perilla oil feeding, T-CHOL (TC), low density lipoprotein, LDL sterin (LDL-C) all are lower than high fat rat matched group with the ratio (LDL-C)/(HDL-C) of high density lipoprotein sterin (HDLC), illustrate that perilla oil has adjustment blood fat (Wang Weidong, Xie Wei to the hyperlipidemia rat, the health care of perilla oil, China's food and nutrition, 2004, (5): 50).
Though the food of above-mentioned two kinds of single component preparations and/or medicine are used for the existing report of blood fat reducing treatment or use, better blood lipid-lowering medicine of development effectiveness or food are still attractive problem.
Summary of the invention
Purpose of the present invention just is to provide a kind of blood-fat reducing composition, and said composition is compared existing blood fat reducing food and/or medicine has better effect.
Another object of the present invention is to provide a kind of preparation method of described blood-fat reducing composition.
Another purpose of the present invention is to provide a kind of medicine or food, contains described blood-fat reducing composition in this medicine or the food.
Blood-fat reducing composition of the present invention is an effective ingredient with perilla oil and Fructus Crataegi extract.
According to the present invention, preferred, the weight ratio of perilla oil and Fructus Crataegi extract is 1: 0.1～1: 10 in the described compositions; It more preferably is 1: 0.1～1: 1; Optimum, the weight ratio of described perilla oil and Fructus Crataegi extract is 1: 0.25～1: 1.
According to the present invention, described perilla oil can be commercially available commodity, wherein the content of alpha-linolenic acid usually 〉=50% (w/w), generally in 50～90% scopes; Also can be to be prepared voluntarily according to prior art by corresponding natural material: Fructus Perillae reaches decortication through cleaning, drying, cooling and the core skin separates, Fructus Perillae core obtains squeezing crude oil through low temperature pressing, then sedimentation and filtration, come unstuck, deacidification, decolouring, deodorize, fine straining obtains refining perilla oil again; Or obtain refining perilla oil according to document [Wang Jing etc., the application of perilla oil and extraction, Food Science, 1996,17 (6), 59]; Or according to document [Tan Xiaohua etc., the supercritical CO of perilla oil
2Extraction and pharmacodynamic study thereof, Chinese crude drug, 1999,22 (10), 520] obtain refining perilla oil.
According to the present invention, described Fructus Crataegi extract (Hawthorn Fruit Extract) is meant any product that extracts through water or ethanol equal solvent from haw berry, wherein general flavone content usually 〉=2% (w/w), generally in 2～90% scopes.It can be commercially available commodity; Also can be by corresponding natural material according to prior art as according to document [Liu Chunyu etc., Different Extraction Method is to the influence of flavone content of hawthorn, the Suzhou Medical College journal, 1998,18 (12), 1266] prepare voluntarily: exsiccant haw berry lamellar medical material, add 75% alcoholic solution reflux, extract, twice, 10 times of amounts that add for the first time medical material weight, reflux, extract, 1.5 hours is filtered extracting solution, second this add 8 times of amounts of medical material weight, reflux, extract, 1 hour is filtered extracting solution, merges extracted twice liquid, after reclaiming ethanol, adopt vacuum 0.8MPa concentrating under reduced pressure, concentrated solution proportion reaches 1.02-1.04, blowing, at inlet temperature 160-180 ℃, under the condition that outlet temperature is 80 ℃, spray drying obtains the haw berry extract.
The above-mentioned two kinds of effective ingredient that comprise effective dose in the blood-fat reducing composition of the present invention.So-called " effective dose " means in the medical science of generally approval and judges in the category that the consumption of effective ingredient is enough to improve feelings to be cured the disease, and do not occur serious adverse during treatment; The effective dose of described effective ingredient should determine that these should be known to those skilled in the art according to concrete feelings to be cured the disease, the patient's that receives treatment age and physiological situation, the degree that is in a bad way, course of treatment factor such as length, pharmaceutical carrier and route of administration.According to the present invention, the total amount of perilla oil of selecting for use (content of alpha-linolenic acid is 50～90%) and Fructus Crataegi extract (general flavone content is 2～90%) is preferably 93～99% of composition total weight.
Can also contain receivable auxiliary additive on one or more pharmacology in the blood-fat reducing composition of the present invention, comprise antioxidant, suspending agent and surfactant etc., wherein antioxidant can be for example butylated hydroxyarisol, vitamin E and two fourth cresols, suspending agent can be for example Cera Flava, Cera Flava and oily wax mixture, and surfactant can be for example PEG (Polyethylene Glycol) 400, PEG6000 and tween 80.
The preparation method of blood-fat reducing composition of the present invention comprises mixes acceptable auxiliary additive on perilla oil, Fructus Crataegi extract and one or more pharmacology, grinds evenly then.
Of the present invention is that the compositions of effective ingredient has remarkable role in synergy with perilla oil and Fructus Crataegi extract, has even more ideal effect for reducing blood fat.
Studies show that, compositions of the present invention can significantly reduce TG, TC, the LDL-C of hyperlipidemia rat, the perilla oil and the Fructus Crataegi extract that all obviously are better than only containing single component at aspect triglyceride reducing, the high density lipoprotein increasing and clinical efficacy aspect show between two kinds of effective ingredient of blood-fat reducing composition of the present invention to have obvious role in synergism.
The specific embodiment
Be described in further detail of the present invention below in conjunction with embodiment, but it should be interpreted as restriction scope of the present invention.Do not breaking away under the above-mentioned technological thought situation of the present invention, various replacements or change according to ordinary skill knowledge and customary means are made include within the scope of the invention.
Employed perilla oil is available from the biochemical article company limited of the auspicious virtue in Dalian in following examples, and the content of alpha-linolenic acid is 50～90% in this product; Fructus Crataegi extract is available from the four seas, Haimen City plant essence company limited, and general flavone content is 2～90% in this product.
Embodiment 1, preparation of compositions
Get perilla oil and Fructus Crataegi extract respectively, by the listed Different Weight of following table 1 than (perilla oil: Fructus Crataegi extract) mix, and add acceptable auxiliary additive on one or more an amount of pharmacology (comprising antioxidant, suspending agent and/or surfactant), mixture is ground evenly, and it is standby to be prepared into pharmaceutical composition.Percentage ratio in the table accounts for the percentage by weight of total composition for each composition components.
Table 1, preparation of compositions
| Sample number | 1 | 2 | 3 | 4 |
| Total effective ingredient (perilla oil: Fructus Crataegi extract) | 98.99％ (1∶0.1) | 95.8％ (1∶0.25) | 93.98％ (1∶0.5) | 93.8％ (1∶1) |
| Antioxidant | 0.01% tertiarybutylhydroquinone | 0.2% vitamin E | 0.02% butylated hydroxyarisol | 0.2% vitamin E |
| Suspending agent | - | 4% Cera Flava | 5% Cera Flava | 5% oily wax mixture |
| Surfactant | 1％PEG400 | - | 1% tween 80 | 1％PEG6000 |
Embodiment 2, zoopery
Below the composition sample for preparing with the method according to embodiment 1 is respectively carried out rat experiment hyperlipidemia preventive and therapeutic effect test, and is contrast with the perilla oil and the Fructus Crataegi extract of the one-component of same product simultaneously.
Animal grouping: 80 of the SD rats that body weight 160～190g male and female have concurrently (Chinese Academy of Sciences's Shanghai Experimental Animal Center), be divided into 5 groups at random, be respectively normal control group, hyperlipidemia model group, perilla oil matched group, Fructus Crataegi extract matched group and compositions test group.
Rats in normal control group gives normal diet, and other each group gives high lipid food, normal diet and high lipid food composed as follows:
Normal feedstuff: meet State Standard of the People's Republic of China GB 14924.3-2001.
High lipid food: 79% normal feedstuff, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica.
Perilla oil matched group, Fructus Crataegi extract matched group and compositions rats in test groups are pressed the amount of 5.0mg/kg (administration/weight) respectively, feeding perilla oil, Fructus Crataegi extract and compositions of the present invention, administration every day 1 time, continuous 30 days.
Each treated animal respectively at administration before, got venous blood on an empty stomach after the administration in the 15th day and the 30th day, separation of serum, content with enzymatic assays (health industry standard " enzymatic assays of serum total cholesterol " (WS/T 120-1999)) triglyceride (TG), T-CHOL (TC), low-density lipoprotein cholesterol (LDL-C) and HDL-C (HDL-C), and adopt variance analysis and paired t-test to take statistics to result of the test and learn processing, the result as shown in the following Table 1.
Table 1, perilla oil, Fructus Crataegi extract and compositions to the influence of rat fat (n=10,
Mmol/L
| TC | TG | |||||
| Before the administration | The 15th day | The 30th day | Before the administration | The 15th day | The 30th day | |
| The normal control group | 1.64±0.21 | 1.62±0.23 | 1.67±0.28 | 0.66±0.09 | 0.63±0.11 | 0.67±0.12 |
| The hyperlipidemia model group | 1.65±0.29 | 8.89±0.57 ▲ | 10.61±1.92 ▲ | 0.69±0.14 | 1.04±0.09 ▲ | 1.22±0.11 ▲ |
| Perilla oil | 1.73±0.35 | 7.11±1.04 ** | 6.96±0.93 ** | 0.70±0.10 | 0.88±0.15 * | 0.81±0.13 ** |
| Fructus Crataegi extract | 1.68±0.27 | 7.65±0.96 ** | 7.02±1.14 ** | 0.63±0.12 | 0.93±0.08 * | 0.87±0.14 ** |
| Test group | 1∶0.1 | 1.61±0.23 | 7.12±1.08 ** | 6.62±1.17 ** | 0.65±0.11 | 0.87±0.13 * | 0.78±0.08 ** |
| 1∶0.25 | 1.75±0.34 | 5.71±0.95 **☆ | 4.94±0.85 **☆ | 0.68±0.08 | 0.79±0.14 **☆ | 0.68±0.10 **☆ | |
| 1∶0.5 | 1.65±0.32 | 5.54±0.97 **☆ | 4.87±0.97 **☆ | 0.71±0.13 | 0.77±0.12 **☆ | 0.66±0.09 **☆ | |
| 1∶1 | 1.69±0.36 | 5.83±0.82 **☆ | 5.11±0.88 **☆ | 0.67±0.07 | 0.81±0.11 ** | 0.72±0.12 ** | |
| LDL-C | HDL-C | ||||||
| Before the administration | The 15th day | The 30th day | Before the administration | The 15th day | The 30th day | ||
| The normal control group | 0.44±0.04 | 0.42±0.05 | 0.45±0.07 | 1.38±0.32 | 1.37±0.30 | 1.38±0.22 | |
| The hyperlipidemia model group | 0.41±0.06 | 5.07±1.08 ▲ | 5.41±2.14 ▲ | 1.41±0.27 | 1.31±0.38 | 1.21±0.25 | |
| Perilla oil | 0.46±0.09 | 4.45±1.43 | 3.48±1.14 * | 1.40±0.29 | 1.47±0.50 | 1.51±0.46 | |
| Fructus Crataegi extract | 0.43±0.07 | 4.63±1.95 | 3.67±0.96 * | 1.43±0.33 | 1.40±0.43 | 1.43±0.43 | |
| Test group | 1∶0.1 | 0.45±0.10 | 4.22±1.08 | 3.15±1.44 * | 1.39±0.28 | 1.46±0.51 | 1.45±0.62 |
| 1∶0.25 | 0.41±0.08 | 3.66±1.43 * | 2.21±0.68 **☆ | 1.41±0.36 | 1.42±0.37 | 1.63±0.51 ** | |
| 1∶0.5 | 0.44±0.05 | 3.58±1.37 * | 2.13±0.74 **☆ | 1.40±0.34 | 1.47±0.42 | 1.61±0.54 ** | |
| 1∶1 | 0.42±0.04 | 3.95±1.02 * | 2.35±0.87 **☆ | 1.42±0.42 | 1.44±0.35 | 1.60±0.46 ** | |
Annotate: compare with the normal control group:
▲P＜0.01;
Compare with the hyperlipidemia model group:
*P＜0.01,
*P＜0.05;
Compare with matched group (perilla oil, Fructus Crataegi extract):
☆P＜0.05.
By the result of table 1 as seen, compare with the rats in normal control group of feeding normal diet, the hyperlipidemia model group rat of feeding high lipid food is giving high lipid food the 15th day and the 30th day, serum TG, TC, LDL-C are all than normal matched group obviously raise (P＜0.01), though HDL-C has reduction slightly, not statistically significant (P＞0.05).
By contrast, when giving high lipid food, three groups of rats of feeding perilla oil, Fructus Crataegi extract and compositions of the present invention respectively, after administration the 30th day, serum TC, TG and LDL-C all obviously reduced; Wherein, for the 15th day (P＜0.01 that promptly begin to play a role behind TC and the TG self administration of medication, P＜0.05), and compositions of the present invention (weight ratio of perilla oil and Fructus Crataegi extract 1: 0.1～1: 1) is compared single perilla oil and the Fructus Crataegi extract effect is more obvious, wherein better with 1: 0.25～1: 1 the compositions effect of weight ratio of perilla oil and Fructus Crataegi extract especially; Same, compositions of the present invention (weight ratio of perilla oil and Fructus Crataegi extract 1: 0.1～1: 1) compares single perilla oil and Fructus Crataegi extract is more obvious for the effect of LDL-C, and after medication the 15th day just play a role (P＜0.05) have only compositions of the present invention (weight ratio of perilla oil and Fructus Crataegi extract 1: 0.25～1: 1).
The HDL-C of matched group (perilla oil, Fructus Crataegi extract) and test group all has rising in various degree, and compositions of the present invention (weight ratio of perilla oil and Fructus Crataegi extract 1: 0.1～1: 1) is compared single perilla oil and Fructus Crataegi extract is more obvious for the effect of HDL-C, but 1: 0.25～1: 1 the compositions of weight ratio of having only perilla oil and Fructus Crataegi extract demonstrated obviously rising effect of HDL-C (P＜0.01) on the 30th day after administration.
From above zooperal result as can be seen, (perilla oil: effect for reducing fat Fructus Crataegi extract=1: 0.1～1: 1) all is better than single perilla oil or Fructus Crataegi extract for the perilla oil of proper proportion and Fructus Crataegi extract compositions.Wherein, perilla oil: most of indexs of the compositions of Fructus Crataegi extract=1: 0.25～1: 1 are compared with single perilla oil or Fructus Crataegi extract, notable difference (P＜0.05) is arranged, demonstrate perilla oil and Fructus Crataegi extract with after the proper proportion combination, aspect blood fat reducing, can produce obvious synergistic and potentiation.
Blood-fat reducing composition of the present invention can be prepared into medicine or the food that has blood fat by the conventional means of this area; this is conspicuous for a person skilled in the art; therefore, medicine or the food that contains blood-fat reducing composition of the present invention should belong to protection scope of the present invention equally.
Claims (12)
1, a kind of blood-fat reducing composition is characterized in that, said composition is an effective ingredient with perilla oil and Fructus Crataegi extract.
2, compositions as claimed in claim 1 is characterized in that, and the weight ratio of described perilla oil and Fructus Crataegi extract is 1: 0.1～1: 10.
3, compositions as claimed in claim 2 is characterized in that, the weight ratio of described perilla oil and Fructus Crataegi extract is 1: 0.25～1: 1.
4, compositions as claimed in claim 1 is characterized in that, the content of alpha-linolenic acid is 50～90% in the described perilla oil.
5, compositions as claimed in claim 1 is characterized in that, general flavone content is 2～90% in the described Fructus Crataegi extract.
6, as each described compositions in the claim 1～5, it is characterized in that, also contain one or more auxiliary additives.
7, compositions as claimed in claim 6 is characterized in that, described auxiliary additive comprises antioxidant, suspending agent and surfactant.
8, compositions as claimed in claim 7 is characterized in that, described antioxidant comprises butylated hydroxyarisol, vitamin E and tertiarybutylhydroquinone.
9, compositions as claimed in claim 7 is characterized in that, described suspending agent comprises Cera Flava, Cera Flava and oily wax mixture.
10, compositions as claimed in claim 7 is characterized in that, described surfactant comprises PEG400, PEG6000 and tween 80.
11, as each described preparation of compositions method in the claim 1～10, it is characterized in that, comprise each constituent is mixed, grind evenly then.
12, a kind of blood lipid-lowering medicine or food is characterized in that, this medicine or food product packets contain each described blood-fat reducing composition in the claim 1～10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610148749 CN100998667A (en) | 2006-12-30 | 2006-12-30 | Medicine composition for lowering blood-fat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610148749 CN100998667A (en) | 2006-12-30 | 2006-12-30 | Medicine composition for lowering blood-fat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN100998667A true CN100998667A (en) | 2007-07-18 |
Family
ID=38257538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610148749 Pending CN100998667A (en) | 2006-12-30 | 2006-12-30 | Medicine composition for lowering blood-fat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100998667A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524276A (en) * | 2014-12-17 | 2015-04-22 | 北华大学 | Composition for reducing blood fat and preparation and preparation method thereof |
| CN107137473A (en) * | 2017-05-09 | 2017-09-08 | 江磊 | A kind of hawthorn lipid nanometer preparation and preparation method and application |
| CN107232602A (en) * | 2017-06-08 | 2017-10-10 | 华子昂 | It is a kind of that there is the health food for aiding in three high drop function |
| CN116019217A (en) * | 2021-10-26 | 2023-04-28 | 内蒙古蒙牛乳业（集团）股份有限公司 | Stomach strengthening composition, nutrition composition and nutrition bar |
-
2006
- 2006-12-30 CN CN 200610148749 patent/CN100998667A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524276A (en) * | 2014-12-17 | 2015-04-22 | 北华大学 | Composition for reducing blood fat and preparation and preparation method thereof |
| CN104524276B (en) * | 2014-12-17 | 2017-11-10 | 北华大学 | Blood-fat reducing composition and its preparation and preparation method |
| CN107137473A (en) * | 2017-05-09 | 2017-09-08 | 江磊 | A kind of hawthorn lipid nanometer preparation and preparation method and application |
| CN107232602A (en) * | 2017-06-08 | 2017-10-10 | 华子昂 | It is a kind of that there is the health food for aiding in three high drop function |
| CN116019217A (en) * | 2021-10-26 | 2023-04-28 | 内蒙古蒙牛乳业（集团）股份有限公司 | Stomach strengthening composition, nutrition composition and nutrition bar |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5284097B2 (en) | Anti-obesity composition | |
| CN101612362B (en) | Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof | |
| CN101862367B (en) | Cassia seed soft capsule for reducing fat and losing weight and preparation method | |
| CN107334908A (en) | A kind of extracting method of aloe extract | |
| TWI640317B (en) | Uses ofporia cocosextract and its active ingredients in protecting skin and/or promoting wound healing | |
| CN104383315A (en) | Chinese herbal medicinal composition for protecting liver and sobering and drink containing Chinese herbal medicinal composition | |
| KR20120003693A (en) | Anti-obesity composition comprising red grape extracts, green tea extracts, soybean extracts, and l-carnitine | |
| CN100998667A (en) | Medicine composition for lowering blood-fat | |
| KR20120124608A (en) | Health-aid food used the ginseng seed oil by main raw material | |
| EP2891496B1 (en) | PHARMACEUTICAL COMPOSITION CONTAINING COMPLEX EXTRACT OF CRATAEGI FRUCTUS and CITRI PERICARPIUM AS AN ACTIVE INGREDIENT FOR TREATING OR PREVENTING OBESITY OR LIPID-RELATED METABOLIC DISEASES | |
| WO2010054470A1 (en) | Pumpkin and rose hips weight loss composition | |
| CN108785370B (en) | A pharmaceutical composition for treating hyperlipidemia and atherosclerosis | |
| KR20150057333A (en) | Composition comprising extract of korean fir for preventing and improving obesity | |
| CN103006922A (en) | Composition having function of relieving alcoholism to protect liver | |
| JP4486096B2 (en) | Natural tea effective in eliminating drunkenness and restoring liver function and method for producing the same | |
| CN102715322A (en) | Food skin nourishing tea granule | |
| CN104706553A (en) | Extraction method and application of myrrh leaf cell extract | |
| CN110538311A (en) | Pure traditional Chinese medicine composition for controlling hypertension and preparation method thereof | |
| CN100551396C (en) | A kind of Chinese patent medicine for the treatment of fatty liver and preparation method thereof | |
| CN1985917A (en) | Medicine composition for reducing blood sugar, reducing blood fat and controlling diabetes complication | |
| CN102133306B (en) | Health-care medicine or medicine composition for reducing blood fat to prevent and cure heart cerebrovascular diseases and application thereof | |
| CN102613655A (en) | Gingko, garlic and broadleaf holly leaf compound particle drink | |
| KR101957664B1 (en) | Composition for improving memory comprising Stachys sieboldii MIQ extract and green tea extract | |
| KR20200061285A (en) | Food Composition for blood circulation and for Preventing blood vessel disease Comprising Extract of Galangal | |
| CN104473992B (en) | A kind of Radix Platycodonis extract and the new application in medicine and health products are prepared |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20070718 |