CN100998632A - Method for processing Chinese herb medicine-cornel - Google Patents
Method for processing Chinese herb medicine-cornel Download PDFInfo
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- CN100998632A CN100998632A CN 200610130888 CN200610130888A CN100998632A CN 100998632 A CN100998632 A CN 100998632A CN 200610130888 CN200610130888 CN 200610130888 CN 200610130888 A CN200610130888 A CN 200610130888A CN 100998632 A CN100998632 A CN 100998632A
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Abstract
A process for refining dogwood fruit to increase the contents of its primary active components includes such steps as immersing dogwood fruit in yellow wine until the yellow wine is sufficiently absorbed, steaming for 2-4 hr, and baking.
Description
Technical field
The present invention relates to a kind of concocting method of Chinese medicine Fructus Corni, belong to technical field of Chinese medicines.
Technical background
Fructus Corni, another name another name for Sichuan Province Fructus Jujubae, Mus arrow, chicken foot, Fructus Corni, real Fructus Jujubae, Fructus Corni and Fructus Corni etc., dry mature fruit for Cornaceae plant Fructus Corni (Cornus officinalis Sieb.et Zucc.), the picking fruit when time of the year when autumn changes into winter, peel reddened, with slow fire baking or put after the boiling water part omitted scalds, in time remove removal core, drying.All there are distribution and cultivation in ground such as China Zhejiang, Henan, Shandong, Anhui, Jiangsu, Shanxi, Shaanxi, Sichuan.Its sour in the mouth of Fructus Corni, puckery, slightly warm in nature is returned the Liver and kidney warp, and the effect of liver and kidney tonifying, essence astringing and desertion stemming is arranged.Cure mainly vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse, interior-heat is quenched one's thirst.Effect with liver and kidney tonifying, essence astringing and desertion stemming is one of tcm clinical practice famous and precious traditional medical material commonly used.Think that at present ursolic acid, oleanolic acid, gallic acid, loganin, cornin, polysaccharide etc. are the main effective ingredient of Fructus Corni, have blood sugar lowering, pharmacological actions such as raise immunity, antiinflammatory.
Since ancient times, Fructus Corni have give birth to and make and be used as medicine with multiple decoction pieces specification.But it is clinical more with the goods use.All emphasize the enucleation use at all times.Northern and Southern Dynasties' Lei Gong's Treatise on Preparation and Broiling of Materia Medica carries: " make Fructus Corni, must remove kernel.Whenever repair one jin of thing enucleation, get meat skin usefulness, a scale becomes four liang with the end, and slow fire is endured it, and the side uses.Energy primordial qi strengthening gas, secret essence, nuclear energy spermatorrhea." the successive dynasties concocting method is washed, discarding stalk, must remove kernel, the method for enucleation has warm water to soak, get meat enucleation, washing enucleation, the enucleation of hot soup maceration etc.; Breaking methods such as breaking, smash, smash to pieces, get meat system end, steeping in wine pestle, pestle cream is arranged; Endure, parched with bran, little stir-fry, dry, big gun, burning, steaming, Adeps Caprae seu ovis are processed, concocting methods such as salt is fried, processed with wine, wherein the processed with wine method comprises different operation requirements such as steeping in wine, wine steam, wine is washed.The modern times of Chinese medicine Fructus Corni concoct, and inherit former worthies' experience, and stewed, multiple concocting methods such as yellow wine is stewed, wine steaming are arranged.Pharmacopoeia of the People's Republic of China version in 2005 is recorded the concocting method of Fructus Corni and two kinds of decoction pieces specifications of wine Fructus Corni.The regulation Fructus Corni is promptly removed impurity and residual pit; The concocting method of wine Fructus Corni is to get clean Fructus Corni, stewes or steam to wine according to stewed with wine method or wine steaming method to exhaust.The processed product appearance surfaces shows atropurpureus, and matter is moistened soft, and little have fume.But all there is factors such as being subjected to climatic effect is big, the operation field area is big, production cost height in original concocting method and is unfavorable for automated production, and how to be judged the process of preparing Chinese medicine and to be dried degree that unstable product quality is difficult to control by experience.
The Chinese medicine Fructus Corni is given birth to product and is won with astringing YIN to stop sweating power, is used for the treatment of spontaneous perspiration, night sweat more, seminal emission, and diseases such as the enuresis, as it is diffusing to control the Fructus Corni of the frequent micturition incontinence of suffering from a deficiency of the kidney.It steams the back with the kidney invigorating arresting seminal emission, and controlling nocturnal emission with astringent drugs reducing urination power is strong, is used for the treatment of the vertigo more, waist cold type of pain, frequent urination and enuresis, diseases such as impotence and premature ejaculation.Borrow capacity for liquor temperature logical behind its stewed with wine, help the medicine gesture, reduce its acidity, as control the LIUWEI DIHUANG WAN of emission due to deficiency of the kidney, the grass of the positive rising for the treatment of the liver, the vertigo is pellet etc. also.
Summary of the invention
The concocting method that the purpose of this invention is to provide a kind of Chinese medicine Fructus Corni.
Main component organic acid and esters thereof, pentacyclic triterpene and esters thereof, iridoids, tannin class, saccharide etc. in the Chinese medicine Fructus Corni.Modern pharmacology studies show that the process of preparing Chinese medicine iridoid glycosides material of Fructus Corni Chinese medicine Fructus Corni is the main active site of blood sugar lowering.Loganin is wherein topmost a kind of iridoid glycoside.Ursolic acid is except the effect with clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, and all right speckle dispelling, inhibition melanin form, and have the effect of anticancer.Oleanolic acid has good hepatoprotective effect.That gallic acid has is antibiotic, antiviral, antitumor action.One aspect of the present invention by with the Chinese medicine Fructus Corni product of giving birth to put that moistening to yellow wine is fully absorbed by the Chinese medicine Fructus Corni product of giving birth in the yellow wine, utilize yellow wine can impel specific examples of such components or dissociate type or increased stripping because of the ester type is acidity because of the salt type is to the specific examples of such components fine solubility; The long-time heating of Duning is destroyed the medical material histiocyte on the other hand, is beneficial to the stripping of specific examples of such components.And then increased content of effective, played synergic effect.By to the yellow wine consumption, stew determining of system time, bake out temperature and drying time, help the stripping of effective ingredient, can fully satisfy the needs that the Chinese medicine Fructus Corni is concocted, can realize modern production.
It is as follows to implement technical scheme of the present invention:
At normal temperatures, place container moistening to the yellow wine that fills yellow wine to be given birth to fully absorption of product by the Chinese medicine Fructus Corni Chinese medicine Fructus Corni product of giving birth to, put in the marmite stewing out of water 2～4 hours, the mass ratio of the living product of yellow wine and Chinese medicine Fructus Corni is 15: 100～25: 100; Take out to put in the baking oven after stewing and dry, promptly get yellow wine and stew the Fructus Corni processed product.
Get the Chinese medicine Fructus Corni of concocting without this method give birth to product and through the yellow wine that this method is concocted gained stew the Fructus Corni processed product powder (crossing sieve No. four) each 2 restrain, be dipped in an amount of methanol ultrasonic extraction 20 minutes.Dilute with methanol, by the Chinese medicine Fructus Corni of concocting without this method being given birth to product and studies show that, give birth in the product consistent with main component kind in the stewed Fructus Corni processed product of yellow wine of this method process of preparing Chinese medicine gained without the Chinese medicine Fructus Corni that this method is concocted through the Electrospray Mass Spectrometry (ESI/MS) that the yellow wine that this method is concocted gained is stewed the Fructus Corni processed product.Sample liquid is analyzed through high performance liquid chromatography (HPLC), measures the content of ursolic acid, oleanolic acid, gallic acid, loganin.Studies show that the quality percentage composition of giving birth to these four kinds of main components in the product without the Chinese medicine Fructus Corni of this method process of preparing Chinese medicine is: ursolic acid (0.233%), oleanolic acid (0.215%), gallic acid (0.0197%), loganin (0.620%); The quality percentage composition of stewing these four kinds of main components in the Fructus Corni processed product through the yellow wine of this method process of preparing Chinese medicine gained is: ursolic acid (0.290%), oleanolic acid (0.250%), gallic acid (0.0785%), loganin (0.897%); The yellow wine of concocting gained through this method is stewed compare with the Chinese medicine Fructus Corni life product of concocting without this method content of effective wherein of Fructus Corni processed product in various degree rising.Therefore, the invention provides a kind of concocting method of effective Chinese medicine Fructus Corni.
Implement
Embodiment 1:
At normal temperatures, the Chinese medicine Fructus Corni is given birth to product 500 grams to be immersed in after moistening to yellow wine is given birth to the abundant absorption of product by the Chinese medicine Fructus Corni in the 100 gram yellow wine, put in the marmite stewing out of water 4 hours, pick up counting after opening with water, take the dish out of the pot postcooling to room temperature, shop thickness is about 10～15 millimeters in the tray, puts into 40 ℃ of baking taking-ups after 3.5 hours down of baking oven, promptly gets stewed with wine Fructus Corni processed product.This method of learning from else's experience is concocted powder (crossing sieve No. four) 2 grams of the stewed Fructus Corni processed product of yellow wine of gained, is dipped in an amount of methanol ultrasonic extraction 20 minutes.With the methanol dilution, to analyze through high performance liquid chromatography (HPLC), four kinds of main component quality percentage compositions are: ursolic acid (0.290%), oleanolic acid (0.250%), gallic acid (0.0785%), loganin (0.897%).
Embodiment 2:
At normal temperatures, the Chinese medicine Fructus Corni is given birth to product 500 grams to be immersed in after moistening to yellow wine is given birth to the abundant absorption of product by the Chinese medicine Fructus Corni in the 75 gram yellow wine, put in the marmite stewing out of water 4 hours, pick up counting after opening with water, take the dish out of the pot postcooling to room temperature, shop thickness is about 10～15 millimeters in the tray, puts into 60 ℃ of baking taking-ups after 4 hours down of baking oven, promptly gets stewed with wine Fructus Corni processed product.This method of learning from else's experience is concocted powder (crossing sieve No. four) 2 grams of the stewed Fructus Corni processed product of yellow wine of gained, is dipped in an amount of methanol ultrasonic extraction 20 minutes.With the methanol dilution, to analyze through high performance liquid chromatography (HPLC), four kinds of main component quality percentage compositions are: ursolic acid (0.283%), oleanolic acid (0.253%), gallic acid (0.0692%), loganin (0.837%).
Embodiment 3:
At normal temperatures, the Chinese medicine Fructus Corni is given birth to product 500 grams to be immersed in after moistening to yellow wine is given birth to the abundant absorption of product by the Chinese medicine Fructus Corni in the 100 gram yellow wine, put in the marmite stewing out of water 2 hours, pick up counting after opening with water, take the dish out of the pot postcooling to room temperature, shop thickness is about 10～15 millimeters in the tray, puts into 50 ℃ of baking taking-ups after 4 hours down of baking oven, promptly gets stewed with wine Fructus Corni processed product.This method of learning from else's experience is concocted powder (crossing sieve No. four) 2 grams of the stewed Fructus Corni processed product of yellow wine of gained, is dipped in an amount of methanol ultrasonic extraction 20 minutes.With the methanol dilution, to analyze through high performance liquid chromatography (HPLC), four kinds of main component quality percentage compositions are: ursolic acid (0.238%), oleanolic acid (0.195%), gallic acid (0.0341%), loganin (0.682%).
Embodiment 4:
At normal temperatures, the Chinese medicine Fructus Corni is given birth to product 500 grams to be immersed in after moistening to yellow wine is given birth to the abundant absorption of product by the Chinese medicine Fructus Corni in the 125 gram yellow wine, put in the marmite stewing out of water 3 hours, pick up counting after opening with water, take the dish out of the pot postcooling to room temperature, shop thickness is about 10～15 millimeters in the tray, puts into 40 ℃ of baking taking-ups after 4 hours down of baking oven, promptly gets stewed with wine Fructus Corni processed product.This method of learning from else's experience is concocted powder (crossing sieve No. four) 2 grams of the stewed Fructus Corni processed product of yellow wine of gained, is dipped in an amount of methanol ultrasonic extraction 20 minutes.With the methanol dilution, to analyze through high performance liquid chromatography (HPLC), four kinds of main component quality percentage compositions are: ursolic acid (0.249%), oleanolic acid (0.217%), gallic acid (0.053%), loganin (0.709%).
Embodiment 5:
At normal temperatures, the Chinese medicine Fructus Corni is given birth to product 500 grams to be immersed in after moistening to yellow wine is given birth to the abundant absorption of product by the Chinese medicine Fructus Corni in the 125 gram yellow wine, put in the marmite and stewed 4 hours, pick up counting after opening with water, take the dish out of the pot postcooling to room temperature, shop thickness is about 10～15 millimeters in the tray, puts into 50 ℃ of baking taking-ups after 3 hours down of baking oven, promptly gets stewed with wine Fructus Corni processed product.This method of learning from else's experience is concocted powder (crossing sieve No. four) 2 grams of the stewed Fructus Corni processed product of yellow wine of gained, is dipped in an amount of methanol ultrasonic extraction 20 minutes.With the methanol dilution, to analyze through high performance liquid chromatography (HPLC), four kinds of main component quality percentage compositions are: ursolic acid (0.289%), oleanolic acid (0.247%), gallic acid (0.0748%), loganin (0.764%).
Claims (1)
1. the concocting method of a Chinese medicine Fructus Corni, it is characterized in that: at normal temperatures, place container moistening to the yellow wine that fills yellow wine fully to be absorbed the Chinese medicine Fructus Corni product of giving birth to by the Chinese medicine Fructus Corni product of giving birth to, put in the marmite stewing out of water 2～4 hours, the mass ratio that yellow wine and Chinese medicine Fructus Corni are given birth to product is 15: 100～25: 100; Take out to put in the baking oven after stewing and dry, promptly get yellow wine and stew the Fructus Corni processed product.
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| CN 200610130888 CN100998632A (en) | 2006-12-29 | 2006-12-29 | Method for processing Chinese herb medicine-cornel |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106892A (en) * | 2011-02-25 | 2011-06-29 | 江苏省中医院 | Process for preparing Chinese herbal slices of dogwood fruit pulp prepared for decoction |
| CN103446222A (en) * | 2013-07-17 | 2013-12-18 | 当涂县黄池蔬菜产销专业合作社 | Liver nourishing and eyesight improving cornus decoction piece and preparation method thereof |
| CN104586919A (en) * | 2015-02-04 | 2015-05-06 | 安徽省万生中药饮片有限公司 | Method for processing dogwood with wine |
| CN105136965A (en) * | 2015-06-04 | 2015-12-09 | 南京中医药大学 | Quality control method of cornus officinalis medicinal material and extract and preparation thereof and application of method |
| CN105193897A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing cornus officinalis decoction pieces |
-
2006
- 2006-12-29 CN CN 200610130888 patent/CN100998632A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106892A (en) * | 2011-02-25 | 2011-06-29 | 江苏省中医院 | Process for preparing Chinese herbal slices of dogwood fruit pulp prepared for decoction |
| CN103446222A (en) * | 2013-07-17 | 2013-12-18 | 当涂县黄池蔬菜产销专业合作社 | Liver nourishing and eyesight improving cornus decoction piece and preparation method thereof |
| CN104586919A (en) * | 2015-02-04 | 2015-05-06 | 安徽省万生中药饮片有限公司 | Method for processing dogwood with wine |
| CN105136965A (en) * | 2015-06-04 | 2015-12-09 | 南京中医药大学 | Quality control method of cornus officinalis medicinal material and extract and preparation thereof and application of method |
| CN105136965B (en) * | 2015-06-04 | 2017-06-20 | 南京中医药大学 | The method of quality control of Fructus Corni and its extract with preparation and application |
| CN105193897A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing cornus officinalis decoction pieces |
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