CN1006383B - 新的噻吩取代的烯丙基胺类的制备方法 - Google Patents

新的噻吩取代的烯丙基胺类的制备方法

Info

Publication number
CN1006383B
CN1006383B CN85109434A CN85109434A CN1006383B CN 1006383 B CN1006383 B CN 1006383B CN 85109434 A CN85109434 A CN 85109434A CN 85109434 A CN85109434 A CN 85109434A CN 1006383 B CN1006383 B CN 1006383B
Authority
CN
China
Prior art keywords
preparation
acid
compound
dbh
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN85109434A
Other languages
English (en)
Chinese (zh)
Other versions
CN85109434A (zh
Inventor
巴格·索马斯·M
布罗里斯马·罗伯特
麦克卡思·詹姆斯·R
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Merrell Dow Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Ltd filed Critical Merrell Dow Pharmaceuticals Ltd
Publication of CN85109434A publication Critical patent/CN85109434A/zh
Publication of CN1006383B publication Critical patent/CN1006383B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN85109434A 1984-12-31 1985-12-30 新的噻吩取代的烯丙基胺类的制备方法 Expired CN1006383B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68762884A 1984-12-31 1984-12-31
US687,628 1984-12-31

Publications (2)

Publication Number Publication Date
CN85109434A CN85109434A (zh) 1986-09-24
CN1006383B true CN1006383B (zh) 1990-01-10

Family

ID=24761167

Family Applications (1)

Application Number Title Priority Date Filing Date
CN85109434A Expired CN1006383B (zh) 1984-12-31 1985-12-30 新的噻吩取代的烯丙基胺类的制备方法

Country Status (21)

Country Link
US (1) US4788301A (enExample)
EP (1) EP0187390B1 (enExample)
JP (1) JPS61197576A (enExample)
KR (1) KR900003373B1 (enExample)
CN (1) CN1006383B (enExample)
AR (1) AR241137A1 (enExample)
AT (1) ATE55386T1 (enExample)
AU (1) AU587591B2 (enExample)
CA (1) CA1258264A (enExample)
DE (1) DE3579145D1 (enExample)
DK (1) DK164504C (enExample)
ES (1) ES8703866A1 (enExample)
FI (1) FI81794C (enExample)
GR (1) GR853149B (enExample)
HU (1) HU193619B (enExample)
IE (1) IE58187B1 (enExample)
NO (1) NO168581C (enExample)
NZ (1) NZ214698A (enExample)
PH (1) PH21649A (enExample)
PT (1) PT81772B (enExample)
ZA (1) ZA859888B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847288A (en) * 1986-12-23 1989-07-11 Merrell Dow Pharmaceuticals Inc. Allenyl amines
US5112852A (en) * 1986-12-23 1992-05-12 Merrell Dow Pharmaceuticals Inc. Allenyl amines
CA1293511C (en) * 1986-12-23 1991-12-24 James R. Mccarthy Allenyl amines
CA1309719C (en) * 1987-02-26 1992-11-03 Thomas M. Bargar Heterocycly1-2-propyn-1-amines
WO2009139855A2 (en) * 2008-05-14 2009-11-19 Ipsen Pharma S.A.S. Pharmaceutical compositions of somatostatin-dopamine conjugates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454158A (en) * 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
FR2508456A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines

Also Published As

Publication number Publication date
AU5173085A (en) 1986-07-10
PT81772A (en) 1986-01-02
FI855158A0 (fi) 1985-12-27
DK164504C (da) 1992-11-23
CN85109434A (zh) 1986-09-24
AU587591B2 (en) 1989-08-24
DK607785D0 (da) 1985-12-30
EP0187390A3 (en) 1987-03-25
ZA859888B (en) 1986-09-24
PT81772B (pt) 1987-10-20
HUT40099A (en) 1986-11-28
IE853326L (en) 1986-06-30
FI81794C (fi) 1990-12-10
EP0187390A2 (en) 1986-07-16
NZ214698A (en) 1988-08-30
NO855353L (no) 1986-07-01
US4788301A (en) 1988-11-29
IE58187B1 (en) 1993-07-28
NO168581B (no) 1991-12-02
DE3579145D1 (en) 1990-09-13
ES550570A0 (es) 1987-03-01
NO168581C (no) 1992-03-11
HU193619B (en) 1987-11-30
KR900003373B1 (ko) 1990-05-16
PH21649A (en) 1988-01-13
GR853149B (enExample) 1986-04-20
EP0187390B1 (en) 1990-08-08
AR241137A1 (es) 1991-11-29
DK164504B (da) 1992-07-06
ES8703866A1 (es) 1987-03-01
DK607785A (da) 1986-07-01
KR860004874A (ko) 1986-07-14
CA1258264A (en) 1989-08-08
FI81794B (fi) 1990-08-31
ATE55386T1 (de) 1990-08-15
FI855158L (fi) 1986-07-01
AR241137A2 (es) 1991-11-29
JPS61197576A (ja) 1986-09-01

Similar Documents

Publication Publication Date Title
US5354885A (en) Process for preparing ethyl ester of L-DOPA
US5607969A (en) L-DOPA ethyl ester to treat Parkinson's disease
EP0072014B1 (en) Combination of 2-substituted penems with dipeptidase inhibitors
FR2502153A1 (fr) Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
EP0010460B1 (fr) Nouveaux dérivés de pyrrolidine-2-méthanol, procédé pour leur préparation et médicaments les contenant
EP0219961B1 (en) Irreversible dopamine-b-hydroxylase inhibitors
US4743618A (en) Substituted 2-aminotetralins
US4428959A (en) 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
CN85109434A (zh) 新的烯丙基胺类的制备方法
KR950001040B1 (ko) 티오우레아 유도체 및 이를 함유하는 항균제 및 항궤양제
BE897843A (fr) Derives biologiquement actifs de 2, 5-piperazinediones, procede pour leur preparation et compositions pharmaceutique en contenant
US4465692A (en) Selective D-2 dopamine receptor agonist
CN1007247B (zh) 新的呋喃取代的烯丙基胺类的制备方法
US4957909A (en) Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents
EP0218356B1 (en) Phenylalanine derivatives and uses thereof
WO1984002908A1 (fr) Carbostyriloximinopropanolamines utiles comme medicaments et procede pour leur preparation
SU904516A3 (ru) Способ получени производных дифенилметана или смеси их изомеров
US3658958A (en) Method of inhibiting gastric acid secretion with 2 - (2 6 - dichlorophenylimino) pyrrolidines
US4703058A (en) β-methylene furanethanamines and use as anti-hypertensive agents
CA2015665A1 (fr) Derive d'hydroxyphenethylamine et ses sels, procede de preparation, application a titre de medicaments et utilisation comme outil pharmacologique specifique
FR3020810A1 (fr) Nouveau sel de l'ivabradine et son procede de preparation.
HU203474B (en) Process for producing pharmaceutical compositions for treating ulcus ventriculi
BE827990A (fr) Derives de thienylurees et de thiethylurees, leur preparation et compositions pharmaceutiques les contenant
BE827989A (fr) Derives de cyclohexenylurees
NO145839B (no) Analogifremgangsmaate for fremstilling av hypolipidemiske p-aminobenzoesyrer

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee