CN100569200C - Semiconductor laser apparatus for treating amblyopia - Google Patents
Semiconductor laser apparatus for treating amblyopia Download PDFInfo
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- CN100569200C CN100569200C CNB200610082229XA CN200610082229A CN100569200C CN 100569200 C CN100569200 C CN 100569200C CN B200610082229X A CNB200610082229X A CN B200610082229XA CN 200610082229 A CN200610082229 A CN 200610082229A CN 100569200 C CN100569200 C CN 100569200C
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Abstract
Semiconductor laser apparatus for treating amblyopia, it comprises control unit and voltage regulator circuit, current regulating circuit, intervalometer, semiconductor laser; Described control unit is connected with voltage regulator circuit, current regulating circuit, intervalometer, semiconductor laser and voltage regulator circuit, and current regulating circuit, time switch K is connected in series.The present invention has overcome that existing therapeutic instrument therapeutic effect is poor, the deficiency of poor stability, have volume little, from heavy and light, be easy to carry, safe in utilization; The advantage that treatment time is short, therapeutic effect is good.
Description
Technical field
The present invention relates to a kind of semiconductor laser apparatus for treating amblyopia, (wavelength is a macular area cone cell at the bottom of 630～650nm) exciting eyes to adopt the semiconductor laser of cone sensitivity, make cone cell be subjected to optimal stimulation, activate the function of cone cell, reach the purpose of effective treatment amblyopia.
Background technology
Amblyopia is that non-organic disease causes, does not reach 0.9 based on correcting defects of vision of functional factor and is called amblyopia.The Therapeutic Method of amblyopia is a lot, comprises covering method, penalization, grating therapy, after image method and red optical filtering therapy, fine manipulation training and synoptophore training or the like,
At present, amblyopia treatment instrument on the market all is to be dispersed light source as red green or utilized common colourless or colored light sources to do the visual stimulus source by light emitting diode, yet these light sources are light sources of dispersing, the optical source wavelength scope is bigger, the shared ratio of the light wave of effective stimulus cone cell is less, can not make cone cell produce effective excitatory stimulation, not reach the purpose of treatment; Also have a kind ofly by the amblyopia treatment instrument of He-Ne laser as light source on the market, this laser is a kind of pulse laser, and for mean power that can the effective stimulus cone cell, the instantaneous power of laser is inevitable bigger, easily cornea is caused to a certain degree damage.
Summary of the invention
The objective of the invention is to overcome above-mentioned existing disadvantages of background technology part, and provide a kind of semiconductor laser apparatus for treating amblyopia, it utilizes the effect of physiological stimuli of optical fundus macular area cone cell, be that cone cell is responsive especially to the HONGGUANG of 630～650nm, under necessarily the rayed of this wave band of energy stimulates, the cone cell of human eye is activated easily, thereby improves the visual performance of human eye, reaches the purpose of treatment amblyopia.
To achieve these goals, technical scheme of the present invention is: semiconductor laser apparatus for treating amblyopia is characterized in that it comprises control unit and voltage regulator circuit, current regulating circuit, intervalometer, semiconductor laser; Described control unit is connected with voltage regulator circuit, current regulating circuit, intervalometer respectively, and semiconductor laser, voltage regulator circuit, current regulating circuit, time switch K are connected in series successively; One end of intervalometer is connected with control unit, and the other end of intervalometer is connected with time switch K; Described control unit is the single-chip microcomputer that plays the Accommodation of laser output power specificity analysis and laser operating voltage value, current value, intervalometer plays a part time detecting and control laser works situation, voltage regulator circuit, current regulating circuit is according to the running voltage and the electric current of the instruction adjusting laser instrument of 89C2051 one chip microcomputer, to reach the purpose of regulating laser output power.
In technique scheme, the output wavelength of described semiconductor laser is 630-650nm, and output is 2-3mW.
In technique scheme, the working procedure of described control unit control voltage regulator circuit, current regulating circuit, intervalometer is: beginning 01 → initialization 02 → power calculation 03 → voltage-regulation 04 → Current Regulation 05 → timing ratio is than 06, if the time does not arrive, then return 03; If the time arrives, K switch disconnects 07 → end 08.
In technique scheme, the output wavelength of described semiconductor laser is 640nm.
(optical maser wavelength is 630～650nm) conduct thorn lasing light emitters to adopt semiconductor laser, 89C2051 type one chip microcomputer is as the core cell of laser output control, applied voltage regulating circuit, current regulating circuit, timing control circuit are formed the electric part of this therapeutic instrument jointly.Realize providing 630～650nm red laser light source, can effectively control output power of laser and output time.
The schematic block circuit diagram of this therapeutic instrument as shown in Figure 1,89C2051 directly is connected with voltage regulator circuit, current regulating circuit, intervalometer as key control unit; Semiconductor laser and voltage regulator circuit, current regulating circuit, time switch K is connected in series.The software flow pattern of this control circuit as shown in Figure 2, characteristic is as shown in Figure 3 over time for output power of laser.In conjunction with Fig. 1, Fig. 2, Fig. 3, the work process of this therapeutic instrument is as follows:
When therapeutic instrument is started working, 89C2051 is according to property calculation output power of laser shown in Figure 3, calculate running voltage, the electric current of laser instrument, send instructions to voltage regulator circuit, current regulating circuit, the laser of the output corresponding power of laser instrument, intervalometer is judged the laser work time simultaneously, when the working time reaches three minutes, intervalometer sends instruction and turn-offs time switch K, and therapeutic instrument quits work.
The characteristics of this therapeutic instrument are: the semiconductor laser that 1. 630～650nm is provided, because laser has high directivity, the coherence is good, advantages such as wavelength unicity, the pure red laser of monochromaticity can make optical fundus macular area cone cell effectively be stimulated, thereby activates visual performance; 2. strict according to " the safe part 1 of GB7247.1-2001 laser product; Device class requires and users' guidebook ", control output power of laser and output time are to guarantee the safety of therapeutic process; 3. the laser output power of this therapeutic instrument is 2～3mW, and the laser therapy time is three minutes; 4. this therapeutic instrument laser is output as continuous laser; 5. this therapeutic instrument can use battery powered can use portable DC power supply again, has guaranteed the safety of using;
Description of drawings
Fig. 1 is a semiconductor laser apparatus for treating amblyopia schematic block circuit diagram of the present invention;
Fig. 2 is a semiconductor laser apparatus for treating amblyopia software flow pattern of the present invention;
Fig. 3 is a semiconductor laser apparatus for treating amblyopia laser output waveform figure of the present invention;
Fig. 4 is semiconductor laser apparatus for treating amblyopia control panel figure of the present invention.
The specific embodiment
Below in conjunction with the performance of accompanying drawing detailed description semiconductor laser apparatus for treating amblyopia of the present invention, but they do not constitute the qualification to patent protection of the present invention, and advantage of the present invention will become apparent and understands easily simultaneously.
Consult accompanying drawing as can be known: semiconductor laser apparatus for treating amblyopia of the present invention, it comprises control unit and voltage regulator circuit, current regulating circuit, intervalometer, semiconductor laser; Described control unit is connected with voltage regulator circuit, current regulating circuit, intervalometer respectively, and semiconductor laser, voltage regulator circuit, current regulating circuit, time switch K are connected in series successively; One end of intervalometer is connected with control unit, and the other end of intervalometer is connected with time switch K; Described control unit is the single-chip microcomputer that plays the Accommodation of laser output power specificity analysis and laser operating voltage value, current value, intervalometer plays a part time detecting and control laser works situation, voltage regulator circuit, current regulating circuit is according to the running voltage and the electric current of the instruction adjusting laser instrument of 89C2051 one chip microcomputer, to reach the purpose of regulating laser output power.
The output wavelength of semiconductor laser is 630-650nm, and power is 2～3mV; If output wavelength is 640nm, effect is better.
The working procedure of described control unit control voltage regulator circuit, current regulating circuit, intervalometer is: beginning 01 → initialization 02 → power calculation 03 → voltage-regulation 04 → Current Regulation 05 → timing ratio if the time does not arrive, then returns 03 than 06; If the time arrives, K switch disconnects 07 → end 08.
As shown in Figure 1,89C2051 directly is connected with voltage regulator circuit, current regulating circuit, intervalometer as key control unit; Semiconductor laser and voltage regulator circuit, current regulating circuit, time switch K is connected in series.89C2051 plays the Accommodation of laser output power specificity analysis and laser operating voltage value, current value as the key control unit of therapeutic instrument, intervalometer plays a part time detecting and control laser works situation, voltage regulator circuit, current regulating circuit is regulated the running voltage and the electric current of laser instrument according to the instruction of 89C2051, to reach the purpose of regulating laser output power, make laser output satisfy the requirement of Fig. 3.
The using method of this therapeutic instrument is: turn on the power switch, power supply indicator is bright, patient's eyes are near watching window attentively, press " laser " key (as Fig. 4) on the therapeutic instrument control panel, laser indicator lamp is bright, and laser window is transmitted into suffers from eye (if the patient only has eyes to suffer from amblyopia, please block normal eye) with opaque disk, the patient finishes up to Laser emission with suffering from eye direct-view laser, and therapeutic process finishes.
It below is this therapeutic instrument clinical verification report.
45 routine amblyopia semiconductor laser therapeutic efficacy analysis
Amblyopia sickness rate at home is high year by year, and its sickness rate in the child is 2.83% in China, and is and increases trend.Chinese Medical Association whole nation children's myopia using stravismus is anti-, and the group of making a study of subjects for the definition of amblyopia is: eye does not have the significant organic pathological changes, with correcting defects of vision of causing of functional factor≤0.8.Many scholars think that the pathogenesis basis of amblyopia is the abnormal interaction of form deprivation or eyes, cause looking cortex hormone function bad or suppress due to, the electrophysiologic study of zoopery and clinical patients is also supported this viewpoint.At present to amblyopia treatment based on traditional covering therapy, the helium neon laser looking irritation therapy (CAM), after image method, penalization, red filter film therapy, Drug therapy and occur in recent years.Treat 45 routine children with amblyopia with semiconductor laser apparatus for treating amblyopia, obtain obvious curative effects the shortest March in the longest June course of treatment, now report as follows:
1, object
Accept children with amblyopia 45 examples from 2005.7-2006.3 for medical treatment in outpatient service and amount to 81 eyes, wherein male 23 examples, women 22 examples, maximum 16 years old age, minimal ages 3 years old, 6.3 years old mean age.By amblyopia type 61 of ametropics wherein, 10 of anisometropies, 8 of stravismus property, 2 of form deprivations.Slight 40,35 of moderates, 6 of severes.Wherein optic atrophy is 1, oozes out 6,1 of posterior capsule opacification around the optic nerve.And have 14 to be paracentral fixation, 67 is central fixation.39 PVEP check and show P
100The ripple prolongation of latency, 37 emmetropia are not looked into for 6.
2, method
Semiconductor laser apparatus for treating amblyopia emission wavelength 630-650nm of the present invention, output 2.5 ± 0.5mW, retina spot diameter 5mm.Far away, the near vision of routine examination before the treatment, and do anterior ocular segment and examination of ocular fundus.Use 1% atropine below 8 years old, use compound recipe N-ethyl-N-(.gamma.-picolyl)tropamide mydriasis/retinoscopy optometry more than 8 years old, and wear the treatment eyeglass.With semiconductor laser apparatus for treating amblyopia through the pupil irradiation treatment, once a day-three time, each 3 minutes, treated continuously 3 months, if vision is brought up to more than 1.0, change into gradually and keeping once a day three months.Each laser therapy finishes, and can select for use supporting after image training, red sudden strain of a muscle training, software to look method training such as thorn is trained, the paracentral fixation patient can select the center training for use several minutes.No eyes stereopsis person cooperates binocular stereoscopic to look training; If 3 months persons of failing to respond to any medical treatment stop treatment, use other therapies instead.
3, therapeutic evaluation
Prevent making a study of subjects group (1996.4) effect of amblyopia evaluation criterion according to Chinese Medical Association's whole nation children's myopia using stravismus:
(1) invalid: treatment back vision improves＜2 row or constant
(2) progressive; Treatment back vision is promoted＞=2 row
(3) the basic healing: vision brings up to＞=and 0.9
(4) recovery from illness: followed up a case by regular visits to vision maintenance＞=1.0 through 3 years
4, statistical method
Adopt x for therapeutic evaluation
2Check, touchstone α=0.05.
Table 1 is the amblyopia treatment curative effect in various degree
Annotate: do in the X 2 test, the basic healing with progressive merged into effective row, below roughly the same.
The dissimilar treatment curative effects of table 2
The different ill time limit treatment curative effects of table 3
Table 4 all ages and classes treatment curative effect
The different nature of fixation treatment of table 5 curative effect
Amblyopia be owing to causing by multiple reason at the children's vision sensitive developmental period: one or both sides retina photostimulation reduces, the hypometabolism of retina photoreceptor cell, the active reduction, nerve synapse forms and reduces in the pathways for vision, and then brain is looked cortical areas's inhibition, cause the Ipsilateral visual deterioration, cause amblyopia to form.
Abroad have to be reported in the zoopery that visual deprivation causes amblyopia, neuronal quantity reduces pathological changes such as lateral geniculate body shrinkage to find have in various degree at visual cortex.Simultaneously, in the amblyopia patient, exist going down of meticulous vision to want much obvious more, thereby prove that also the amblyopia main damage occurs in the X-cell system based on cone cell than space sense.Therefore amblyopia treatment concentrates on the photostimulation that strengthens the amblyopia eye, thereby activates cone cell.And cone cell is that the light of 630-650nm is the most responsive for wavelength.
The semiconductor laser apparatus for treating amblyopia optical maser wavelength 630-650nm that this clinical experiment is adopted, power 2.5 ± 0.5mW can easily penetrate cornea and seldom is absorbed, thereby can fully act on central fovea of macula, activate cone cell, promote the foundation of normal vision path; On the one hand, the partial photo-thermal of laser irradiation, galvanomagnetic-effect can promote the circulation of retina blood, improve the photoreceptor cell metabolism, promote the recovery of photoreceptor cell function, thereby suitable various types of amblyopia treatments; On the other hand, red laser only acts on cone cell, and rod cell is insensitive to it, so can correct the paracentral fixation that the amblyopia eye is followed simultaneously; At last, the laser of this wavelength can penetrate muddy refractive media, so also effective in theory to the form deprivation amblyopia due to the acquired dispositions such as congenital cataract or corneal nebula.
Clinical experiment statistical analysis as a result shows that total effective rate can reach 71.60%, and its mild or moderate effective percentage is 82.50%, and the moderate effective percentage is 68.57%.Amblyopia observation of curative effect in various degree has significant difference: slight therapeutic effect is best, and moderate is taken second place, and severe is the poorest.The amblyopia observation of curative effect of the different ill time limits also has significant difference: the course of disease is best less than 1 year person's curative effect, and the person takes second place within 4 years, and effect is relatively poor more than 4 years.Dissimilar observation of curative effect shows: no obvious significant difference (P＞0.05) between ametropic, anisometropy and the stravismus property.The observation of curative effect of all ages and classes does not have obvious significant difference (P＞0.05) yet.There is not obvious significant difference (P＞0.05) between paracentral fixation and central fixation's curative effect yet.
Make regular check in the therapeutic process, do not see obvious anterior ocular segment and optical fundus injury response, macula lutea is normal, the unusual person P of 39 routine PVEP
100Obvious shortening is all arranged incubation period, and wherein 18 examples are reduced to below the 100ms.Have following several respects reason for invalid case analysis: (1) infant compliance is poor, deliberately closes one's eyes in irradiation process or shifts and watch attentively, thereby make irradiation light can not act on macula lutea position, optical fundus, influences therapeutic effect.(2) patient's length of the time limit of falling ill, disease time is long more, and therapeutic effect is poor more.(3) degree of amblyopia, the amblyopia vision is low more, and curative effect is poor more.(4) have or not other sick damages of optical fundus of occurring together, have other sick damage person's therapeutic effect of optical fundus relatively poor.
Experimental result shows that the semiconductor laser therapeutic amblyopia is safely and effectively in a short time relatively, and simplifies treatment, has shortened treatment cycle; Compare with He-Ne Lasers, its operational approach is simple, and the family therapy of being more convenient for can comparatively fast improve visual acuity in child patient, has better clinical value.Be used in combination after image training, red sudden strain of a muscle training, software and look combined training method better effects if such as thorn training.For its late result, and at a specified future date for refracting media and amphiblestroid injury response, and we will do further observation and report.
Need to prove that for these professional those skilled in the art under the situation that does not change the principle of the invention, can also make suitable change and distortion to the present invention, this belongs to protection scope of the present invention equally.
Claims (3)
1, semiconductor laser apparatus for treating amblyopia is characterized in that it comprises control unit and voltage regulator circuit, current regulating circuit, intervalometer, semiconductor laser; Described control unit is connected with voltage regulator circuit, current regulating circuit, intervalometer respectively, and semiconductor laser, voltage regulator circuit, current regulating circuit, time switch K are connected in series successively; One end of intervalometer is connected with control unit, and the other end of intervalometer is connected with time switch K; Described control unit is the single-chip microcomputer that plays the Accommodation of laser output power specificity analysis and laser operating voltage value, current value, intervalometer plays a part time detecting and control laser works situation, voltage regulator circuit, current regulating circuit is regulated the running voltage and the electric current of laser instrument according to the instruction of 89C2051 one chip microcomputer, to reach the purpose of regulating laser output power, the output wavelength of described semiconductor laser is 630-650nm, and output is 2-3mW.
2, semiconductor laser apparatus for treating amblyopia according to claim 1, the working procedure that it is characterized in that described control unit control voltage regulator circuit, current regulating circuit, intervalometer is: beginning (01) → initialization (02) → power calculation (03) → voltage-regulation (04) → Current Regulation (05) → timing ratio is (06), if the time does not arrive, then return (03); If the time arrives, K switch disconnects (07) → end (08).
3, semiconductor laser apparatus for treating amblyopia according to claim 1, the output wavelength that it is characterized in that described semiconductor laser is 640nm.
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| RU95512U1 (en) * | 2008-12-03 | 2010-07-10 | Алексей Витальевич Нестеренко | DEVICE FOR TREATING AMBLIOPIA |
| CN106823158A (en) * | 2017-02-27 | 2017-06-13 | 崔秀丽 | A kind of application method of amblyopia therapeutic equipment and amblyopia therapeutic equipment |
| CN110237432A (en) * | 2019-06-06 | 2019-09-17 | 中山大学中山眼科中心 | A method of increasing eyeground blood flow and metabolic rate |
| CN111813014A (en) * | 2020-06-08 | 2020-10-23 | 苏州市敏康医疗设备有限公司 | Eye axis control integrated circuit |
| CN111658307A (en) * | 2020-07-02 | 2020-09-15 | 重庆视力派眼镜连锁有限公司 | Therapeutic instrument for oblique amblyopia |
| CN113208804B (en) * | 2021-06-01 | 2022-03-18 | 江西中蓝电子制造有限公司 | Comprehensive therapeutic instrument for amblyopia and myopia |
| CN114209991B (en) * | 2022-01-25 | 2024-08-23 | 视谷大健康产业有限公司 | Laser physiotherapy instrument control method and laser physiotherapy instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU511079A1 (en) * | 1974-11-15 | 1976-04-25 | Московский научно-исследовательский институт глазных болезней им. Гельмгольца | Method of treating amblyoli |
-
2006
- 2006-05-12 CN CNB200610082229XA patent/CN100569200C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU511079A1 (en) * | 1974-11-15 | 1976-04-25 | Московский научно-исследовательский институт глазных болезней им. Гельмгольца | Method of treating amblyoli |
Non-Patent Citations (2)
| Title |
|---|
| 低强度半导体激光治疗少年儿童弱视逐米观察法的疗效检验. 杨中伟，孙桂英，杨家太，马桂芬，丁昆，王艳博.中国激光医学杂志，第12卷第2期. 2003 |
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