CN100563711C - 一种抗癌缓释注射剂 - Google Patents
一种抗癌缓释注射剂 Download PDFInfo
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- CN100563711C CN100563711C CNB2006102000463A CN200610200046A CN100563711C CN 100563711 C CN100563711 C CN 100563711C CN B2006102000463 A CNB2006102000463 A CN B2006102000463A CN 200610200046 A CN200610200046 A CN 200610200046A CN 100563711 C CN100563711 C CN 100563711C
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Abstract
Description
试验组(n) | 给药方式 | 第一天肿瘤内药物量 | 第三天肿瘤内药物含量 | 第7天肿瘤内药物含量 |
1(3) | 尾静脉注射普通注射剂 | 0.65 | 0.35 | 0.12 |
2(3) | 腹腔注射普通注射剂 | 0.58 | 0.3 | 0.08 |
3(3) | 瘤周注射普通注射剂 | 2.8 | 1.2 | 0.3 |
4(3) | 瘤周注射缓释注射剂 | 10 | 18 | 20 |
5(3) | 瘤周放置缓释植入剂 | 20 | 30 | 32 |
6(3) | 瘤内注射普通注射剂 | 4 | 2 | 1 |
7(3) | 瘤内注射缓释注射剂 | 90 | 80 | 60 |
8(3) | 瘤内放置缓释植入剂 | 94 | 90 | 84 |
试验组(n) | 给药方式 | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | - | 70 | |
2(6) | 尾静脉注射普通注射剂 | 65 | 0.06 |
3(6) | 腹腔注射普通注射剂 | 66 | 0.06 |
4(6) | 瘤周注射普通注射剂 | 58 | 0.03 |
5(6) | 瘤周注射缓释注射剂 | 32 | <0.01 |
6(6) | 瘤周放置缓释植入剂 | 22 | <0.01 |
7(6) | 瘤内注射普通注射剂 | 54 | 0.04 |
8(6) | 瘤内注射缓释注射剂 | 22 | <0.001 |
9(6) | 瘤内放置缓释植入剂 | 16 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | 对照 | 72±10 | |
2(6) | 5-FU | 48±5.4 | <0.05 |
3(6) | 阿霉素 | 46±2.2 | <0.01 |
4(6) | 表柔比星 | 46±2.2 | <0.01 |
5(6) | 依达比星 | 48±3.2 | <0.01 |
6(6) | 戊柔比星 | 42±3.0 | <0.01 |
7(6) | 5-FU+阿霉素 | 22±2.0 | <0.001 |
8(6) | 5-FU+表柔比星 | 30±3.4 | <0.001 |
9(6) | 5FU+依达比星 | 32±3.4 | <0.001 |
10(6) | 5-FU+戊柔比星 | 18±2.0 | <0.001 |
瘤细胞 | 5-FU | 丝裂霉素C | 放线菌素D | 米托蒽醌 | 5-FU+丝裂霉素C | 5-FU+放线菌素D | 5-FU+米托蒽醌 |
CNS | 64% | 56% | 64% | 66% | 92% | 86% | 86% |
C6 | 64% | 64% | 60% | 64% | 94% | 84% | 94% |
SA | 56% | 62% | 56% | 62% | 88% | 92% | 92% |
BC | 54% | 64% | 54% | 64% | 94% | 84% | 82% |
BA | 52% | 60% | 62% | 60% | 98% | 90% | 90% |
LH | 60% | 58% | 62% | 58% | 90% | 88% | 84% |
PAT | 66% | 58% | 62% | 56% | 92% | 88% | 86% |
试验组(n) | 所受治疗 | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | 对照 | 70±10 | |
2(6) | 5-FU | 46±5.0 | <0.05 |
3(6) | 尼莫司汀 | 50±2.0 | <0.01 |
4(6) | 5-FU+尼莫司汀 | 30±2.2 | <0.001 |
5(6) | 卡莫司汀 | 48±3.2 | <0.01 |
6(6) | 卡莫司汀+5-FU | 32±3.0 | <0.001 |
7(6) | 福莫司汀 | 32±2.6 | <0.01 |
8(6) | 福莫司汀+5-FU | 22±2.6 | <0.001 |
9(6) | 萨莫司汀 | 46±4.8 | <0.01 |
10(6) | 萨莫司汀+5-FU | 20±2.0 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | - | |
2(6) | 5-FU | 42 | <0.05 |
3(6) | 司莫司汀 | 48 | <0.01 |
4(6) | 洛莫司汀 | 42 | <0.01 |
5(6) | 甲基洛莫司汀 | 52 | <0.01 |
6(6) | 链佐星 | 40 | <0.01 |
7(6) | 5-FU+司莫司汀 | 86 | <0.001 |
8(6) | 5-FU+洛莫司汀 | 88 | <0.001 |
9(6) | 5-FU+甲基洛莫司汀 | 92 | <0.001 |
10(6) | 5-FU+链佐星 | 92 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | - | |
2(6) | 5-FU | 56 | <0.05 |
3(6) | 加莫司汀 | 54 | <0.01 |
4(6) | 雷莫司汀 | 46 | <0.01 |
5(6) | 环磷酰胺 | 48 | <0.01 |
6(6) | 美法仑 | 46 | <0.01 |
7(6) | 5-FU+加莫司汀 | 86 | <0.001 |
8(6) | 5-FU+雷莫司汀 | 88 | <0.001 |
9(6) | 5-FU+环磷酰胺 | 94 | <0.001 |
10(6) | 5-FU+美法仑 | 90 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | - | |
2(6) | 5-FU | 54 | <0.05 |
3(6) | 紫杉醇 | 58 | <0.05 |
4(6) | 多西他赛 | 54 | <0.05 |
5(6) | 2’-羟基紫杉醇 | 60 | <0.05 |
6(6) | 7-表-紫杉醇 | 62 | <0.01 |
7(6) | 5-FU+紫杉醇 | 84 | <0.01 |
8(6) | 5-FU+多西他赛 | 88 | <0.01 |
9(6) | 5-FU+2’-羟基紫杉醇 | 92 | <0.01 |
10(6) | 5-FU+7-表-紫杉醇 | 90 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | - | |
2(6) | 5-FU | 58 | <0.05 |
3(6) | 长春新碱 | 48 | <0.01 |
4(6) | 长春花碱 | 56 | <0.01 |
5(6) | 长春瑞滨 | 48 | <0.01 |
6(6) | 长春地辛 | 48 | <0.01 |
7(6) | 5-FU+长春新碱 | 88 | <0.001 |
8(6) | 5-FU+长春花碱 | 86 | <0.001 |
9(6) | 5-FU+长春瑞滨 | 94 | <0.001 |
10(6) | 5-FU+长春地辛 | 96 | <0.001 |
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CN200910300878A Division CN101837002A (zh) | 2006-01-18 | 2006-01-18 | 一种抗癌缓释注射剂 |
CN2009103008790A Division CN101904851A (zh) | 2006-01-18 | 2006-01-18 | 抗癌缓释注射剂 |
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CN1923173B (zh) * | 2006-02-24 | 2010-05-19 | 济南康泉医药科技有限公司 | 一种同载抗癌抗生素及其增效剂的抗癌药物缓释剂 |
CN1957920B (zh) * | 2006-09-28 | 2010-05-19 | 山东蓝金生物工程有限公司 | 一种同载氟尿嘧啶及其增效剂的抗癌缓释剂 |
CN102342919A (zh) * | 2011-10-14 | 2012-02-08 | 上海交通大学 | 一种5-氟尿嘧啶/plga载药微球的制备方法 |
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