CN100553659C - A kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii) - Google Patents
A kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii) Download PDFInfo
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- CN100553659C CN100553659C CNB2006100484062A CN200610048406A CN100553659C CN 100553659 C CN100553659 C CN 100553659C CN B2006100484062 A CNB2006100484062 A CN B2006100484062A CN 200610048406 A CN200610048406 A CN 200610048406A CN 100553659 C CN100553659 C CN 100553659C
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Abstract
The present invention is a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii), can effectively solve the problem by Rhizoma Typhonium Gigantei (Rhizoma Typhonii) preparation " system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) ", the concrete technical scheme of its solution is: get Rhizoma Typhonium Gigantei (Rhizoma Typhonii) and use the Alumen aqueous solution soaking to the interior no dried heart, add the fresh ginger fragment again, pressure cooking, taking-up cools, and cuts sheet, oven dry, this method is simple, easy operating for system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) processing procedure provides concrete technical data, is convenient to control of quality, gained system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) color is light brown, cutin, matter is crisp, no numb feeling in the tongue, also applicable other the preparation of Rhizoma Typhonii of the present invention, can satisfy clinical different demands to Rhizoma Typhonii (processed), improve clinical efficacy, be a creation on the Chinese medicine processing.
Description
One, technical field
The present invention relates to a kind of concocting method of Chinese medicine, particularly a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii).
Two, background technology
Rhizoma Typhonium Gigantei (Rhizoma Typhonii) is one of Henan Province's authentic medicinal herbs, pharmacopeia is called Rhizoma Typhonii, and it is originated to the tuber of Araeceae colter platymiscium Herba Typhonii gigantei (Typhonium giganteum Engler), has the expectorant of dispeling the wind, arresting convulsion is jerked, detoxifcation, the effect of removing obstruction for relieving pain is clinical conventional Chinese medicine, cultivate in a large number at ground municipalizations such as Yuzhous, Henan Province, the inside and outside Chinese medicine market of medical material and decoction pieces supply country (because of producing white attached in the Yuzhou) for mostly being good, so title Rhizoma Typhonium Gigantei (Rhizoma Typhonii) or RHIZOMA TYPHONII claim the system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) through concocting.Rhizoma Typhonii little suffering of distinguishing the flavor of, temperature; Poisonous.Return stomach, Liver Channel.Give birth to the general external of Rhizoma Typhonii.Have the expectorant of dispeling the wind, arresting convulsion is jerked, detoxifcation analgesic function.Be used for facial hemiparalysis, tetanus, external treatment scrofula productive cough, venom.The toxicity that Rhizoma Typhonii is given birth to product shows as " spicy thorn tongue ", concocts the back numb feeling in the tongue and reduces or disappearance, and Rhizoma Typhonii is concocted can reduce toxicity, eliminates spicy flavor, strengthens the effect of the expectorant that dispels the wind.Be used for migraine, headache due to phlegm-damp, cough with copious phlegm more.The concocting method of state-promulgated pharmacopoeia and " national Chinese medicine processing standard " regulation Rhizoma Typhonii (processed) is a duplicating method.Specific requirement is: " get clean Rhizoma Typhonii, size is separately soaked with clear water, changes water every day 2～3 times; after a few days, as spume, and adds Alumen (every 100kg Rhizoma Typhonii use Alumen 2kg) after changing water; steep and change water again after one day, to mouthful tasting little numb feeling in the tongue degree of being that has, taking-up.Other gets Alumen and ginger slice adds suitable quantity of water, after boiling, pour into Rhizoma Typhonii boil altogether to the interior no dried heart for degree, pull out, remove ginger slice, dry in the air to 6～7 one-tenths dried, cut sheet, drying.Sieve removes chip.Every 100kg Rhizoma Typhonii is with Rhizoma Zingiberis Recens, each 12.5kg of Alumen ".Concocting method is not only loaded down with trivial details, and complex process the more important thing is that long-time immersion changes water, causes a large amount of losses of effective ingredient, and along with toxic reduction, drug effect also decreases, so processing procedure continues to improve and standard; In addition, traditional process of preparing Chinese medicine degree is only tasted with mouth and is felt and control, and not only falls behind, and varies with each individual.So need badly and will study improvement, and the Chinese medicine processing technique excavated and protect, especially after country's accession to WTO, the prepared slices of Chinese crude drugs are concocted the standardized study of production technology, are that country wishes the important topic that solves always, are paid much attention to.
Three, summary of the invention
The purpose of this invention is to provide a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii), can effectively solve problem (or problem of solution Rhizoma Typhonii (processed)) by Rhizoma Typhonium Gigantei (Rhizoma Typhonii) preparation " system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) ", the concrete technical scheme of its solution is: get Rhizoma Typhonium Gigantei (Rhizoma Typhonii), the size stepping, with mass concentration be 6% Alumen aqueous solution soaking to the interior no dried heart, the solution addition be Rhizoma Typhonium Gigantei (Rhizoma Typhonii) (Rhizoma Typhonii) weight 1-2 doubly, add the fresh ginger fragment again, addition is the 12-15% of the attached weight of white Yu, is 0.7kg/cm at 115 ℃, pressure
2Pressurization was boiled 30 minutes, taking-up cools, cut sheet, dry or get Rhizoma Typhonium Gigantei (Rhizoma Typhonii), different by size steppings, adding mass concentration according to per 100 kilograms of Rhizoma Typhonium Gigantei (Rhizoma Typhonii) is 100～200 kilograms of 6% Alumen aqueous solutions, soaked 3～10 days according to the volume size, to cutting the no dried heart in the inspection (soaking is degree), the ratio in 12～15 kilograms of per 100 kilograms of Rhizoma Typhonium Gigantei (Rhizoma Typhonii) adds broken fresh ginger sheet again, be transferred in the high steam container, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, let off steam, and took out Rhizoma Typhonium Gigantei (Rhizoma Typhonii) and cooled, and did to 6 seventy percent, cut 2～4mm sheet, and 60～80 ℃ of bakings 6～10 hours pack promptly after the drying.
This method is simple, and easy operating for system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) processing procedure provides concrete technical data, is convenient to control of quality.Gained system Rhizoma Typhonium Gigantei (Rhizoma Typhonii) color is light brown, cutin, and matter is crisp, no numb feeling in the tongue.Also applicable other the preparation of Rhizoma Typhonii of the present invention.The Rhizoma Typhonii (processed) that the present invention prepares shows through acute toxicity test, to the mouse peritoneal injection, does not all find dead mouse with adult 125 times of consumption.Reducing the toxic while, guaranteed drug effect.Can satisfy clinical different demands to Rhizoma Typhonii (processed), improve clinical efficacy, be a creation on the Chinese medicine processing.
Four. the specific embodiment
Below in conjunction with practical situation the specific embodiment of the present invention and embodiment are elaborated.
1. winters of embodiment, 5 ℃ of temperature, get individual diameter 10 kilograms of the Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of 2.5～4cm, add mass concentration and be 15 kilograms of 6% Alumen aqueous solutions, soaked 10 days, and checked the interior no dried heart, add 1.25 kilograms of broken fresh ginger sheets again to cutting, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to fifty percent to do, and rotary medicine cutter is cut the 3mm sheet, and 80 ℃ of dryings 7 hours pack promptly.
In 2. summers of embodiment, 30 ℃ of temperature are got individual diameter 5 kilograms of 1.5～2.5cm Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of uniform size, add mass concentration and be 5 kilograms of 6% Alumen aqueous solutions, soaked 3 days, add 0.6 kilogram of broken fresh ginger sheet again, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to sixty percent to do, and rotary medicine cutter is cut the 2mm sheet, and 80 ℃ of dryings 6 hours pack promptly
In 3. summers of embodiment, 30 ℃ of temperature are got individual diameter 5 kilograms of 2.5～4cm Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of uniform size, add mass concentration and be 7 kilograms of 6% Alumen aqueous solutions, soaked 5 days, add 0.6 kilogram of broken fresh ginger sheet again, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to sixty percent to do, and rotary medicine cutter is cut the 2mm sheet, and 80 ℃ of dryings 6 hours pack promptly.
Product of the present invention obviously is better than the product that traditional handicraft is concocted after measured, and bottom provides the situation that new technology is concocted Rhizoma Typhonium Gigantei (Rhizoma Typhonii) (Rhizoma Typhonii) acute toxicity test.
Experimental technique: choose 30 of body weight 18～22g Kunming mouses, male and female half and half give the different processed product decocting of Rhizoma Typhonii liquid 30g/kg respectively, make blank with 2% tween 80-normal saline solution, lumbar injection is observed dead mouse situation in 72 hours after the administration.
Result of the test: see the following form:
In all administration groups, dead mouse does not all appear in pharmacopeia method processed product and new technology processed product.Illustrate to concoct and to reduce toxicity.
The different concocting method goods of Rhizoma Typhonii are to the influence of pentobarbital sodium sub-threshold dose syngignoscism
Experimental technique:
Choose 30 of body weight 18～22g Kunming mouses, male and female half and half, be divided into 3 groups at random by sex, every group 10, give Rhizoma Typhonii each processed product infusion 25g/kg respectively, 1 lumbar injection is behind the 40min, the pentobarbital sodium 25mg/kg of lumbar injection sub-threshold dose observes the sleeping number of elements of mice in the 25min respectively.
Experimental result: see the following form:
Annotate: compare with matched group, ※ ※ represents p＜0.01, and ※ represents p＜0.05.
The above results shows that Rhizoma Typhonii new technology processed product effect is best, is the pharmacopeia goods secondly.
This technology is not subjected to the restriction of weather conditions, not restricted by the region, any time, can make the production of Rhizoma Typhonium Gigantei (Rhizoma Typhonii) (Rhizoma Typhonii (processed)) Anywhere.This process reform China's Rhizoma Typhonium Gigantei (Rhizoma Typhonii) and other Rhizoma Typhonii concocting method and technology fall behind, it is unsecured and influence the problem that it effectively uses to have overcome traditional processing procedure Rhizoma Typhonii (processed) prepared slice quality that causes lack of standardization, tcm clinical practice decoction and preparation curative effect have been guaranteed, solved and guaranteed the toxic while of reduction, prevented the loss of effective ingredient again, this technical barrier, it also is the problem of China's desired solution always, the present invention is the science regulationization more, convenient production is convenient to control prepared slice quality.It is applied and will make creationary contribution for China's Chinese medicine processing production.
Claims (4)
1, a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii), it is characterized in that, get Rhizoma Typhonium Gigantei (Rhizoma Typhonii), the size stepping, with mass concentration be 6% Alumen aqueous solution soaking to the interior no dried heart, the solution addition be Rhizoma Typhonium Gigantei (Rhizoma Typhonii) weight 1-2 doubly, add the fresh ginger fragment again, addition is the 12-15% of the attached weight of white Yu, is 0.7kg/cm at 115 ℃, pressure
2Pressurization was boiled 30 minutes, taking-up cools, and cuts sheet, oven dry, or get Rhizoma Typhonium Gigantei (Rhizoma Typhonii), it is 100～200 kilograms of 6% Alumen aqueous solutions that different by size steppings, per 100 kilograms of Rhizoma Typhonium Gigantei (Rhizoma Typhonii) add mass concentration, soaks 3～10 days, check the interior no dried heart to cutting, the broken fresh ginger sheet that adds 12～15 kilograms again by per 100 kilograms of Rhizoma Typhonium Gigantei (Rhizoma Typhonii), to the high pressure vapor vessel, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, let off steam, and took out Rhizoma Typhonium Gigantei (Rhizoma Typhonii) and cooled, and did to 6 seventy percent, cut 2～4mm sheet, and 60～80 ℃ of bakings 6～10 hours pack after the drying.
2, a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii) according to claim 1, it is characterized in that being, under 5 ℃ of temperature, get individual diameter 10 kilograms of the Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of 2.5～4cm, add mass concentration and be 15 kilograms of 6% Alumen aqueous solutions, soaked 10 days, check the interior no dried heart to cutting, add 1.25 kilograms of broken fresh ginger sheets again, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to fifty percent to do, and rotary medicine cutter is cut the 3mm sheet, and 80 ℃ of dryings 7 hours pack.
3, a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii) according to claim 1, it is characterized in that being, under 30 ℃ of temperature, get individual diameter 5 kilograms of 1.5～2.5cm Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of uniform size, add mass concentration and be 5 kilograms of 6% Alumen aqueous solutions, soaked 3 days, add 0.6 kilogram of broken fresh ginger sheet again, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to sixty percent to do, and rotary medicine cutter is cut the 2mm sheet, and 80 ℃ of dryings 6 hours pack.
4, a kind of concocting method of making Rhizoma Typhonium Gigantei (Rhizoma Typhonii) according to claim 1, it is characterized in that being, under 30 ℃ of temperature, get individual diameter 5 kilograms of 2.5～4cm Rhizoma Typhonium Gigantei (Rhizoma Typhonii) of uniform size, add mass concentration and be 7 kilograms of 6% Alumen aqueous solutions, soaked 5 days, add 0.6 kilogram of broken fresh ginger sheet again, to high-pressure bottle, controlling 115 ℃, pressure is 0.7kg/cm
2, pressurization was boiled 30 minutes, dried in the air to sixty percent to do, and rotary medicine cutter is cut the 2mm sheet, and 80 ℃ of dryings 6 hours pack.
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| CN103479745A (en) * | 2013-08-10 | 2014-01-01 | 田克力 | Preparation method of radix aconiti decoction pieces |
| CN104510790A (en) * | 2013-09-26 | 2015-04-15 | 四川江油中坝附子科技发展有限公司 | Processed monkshood product and fermentation method thereof |
| CN104147275A (en) * | 2014-07-31 | 2014-11-19 | 王秀华 | Traditional Chinese medicine processing method of typhonium giganteum |
| CN113750168A (en) * | 2020-08-26 | 2021-12-07 | 北京康仁堂药业有限公司 | Processing method for preparing rhizoma typhonii |
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Non-Patent Citations (4)
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| 中药关白附现代研究概况. 毛淑杰等.基层中药杂志，第9卷第2期. 1995 |
| 中药关白附现代研究概况. 毛淑杰等.基层中药杂志，第9卷第2期. 1995 * |
| 关白附炮制历史沿革研究. 吴连英.中国中药杂志，第23卷第2期. 1998 |
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