CN100551988C - Not the aerosol safety in fluorine-containing Lyons, efficient complex spreading system - Google Patents
Not the aerosol safety in fluorine-containing Lyons, efficient complex spreading system Download PDFInfo
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- CN100551988C CN100551988C CNB2007100204348A CN200710020434A CN100551988C CN 100551988 C CN100551988 C CN 100551988C CN B2007100204348 A CNB2007100204348 A CN B2007100204348A CN 200710020434 A CN200710020434 A CN 200710020434A CN 100551988 C CN100551988 C CN 100551988C
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- propellent
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- 239000000443 aerosol Substances 0.000 title claims abstract description 25
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 15
- 239000011737 fluorine Substances 0.000 title claims abstract description 15
- 238000003892 spreading Methods 0.000 title claims abstract description 11
- 239000006185 dispersion Substances 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 23
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 239000002904 solvent Substances 0.000 claims abstract description 22
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims abstract description 10
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims abstract description 8
- MWDWMQNTNBHJEI-UHFFFAOYSA-N 1,1,2,3,3-pentafluoropropane Chemical compound FC(F)C(F)C(F)F MWDWMQNTNBHJEI-UHFFFAOYSA-N 0.000 claims abstract description 4
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 abstract description 14
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 abstract description 7
- 238000001704 evaporation Methods 0.000 abstract description 4
- 230000008020 evaporation Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 239000007921 spray Substances 0.000 abstract description 2
- 239000000470 constituent Substances 0.000 description 23
- 230000000694 effects Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000009835 boiling Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- XWCDCDSDNJVCLO-UHFFFAOYSA-N Chlorofluoromethane Chemical compound FCCl XWCDCDSDNJVCLO-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- MSSNHSVIGIHOJA-UHFFFAOYSA-N pentafluoropropane Chemical compound FC(F)CC(F)(F)F MSSNHSVIGIHOJA-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000010285 flame spraying Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of aerosol safety of not fluorine-containing Lyons, efficient complex spreading system, belong to the aerosol spray technique field.It is made up of propellent and latent solvent, dispersion agent or expanding material basically, it is characterized in that: described propellent is 1,1,1,2-Tetrafluoroethane or 1,1,1,2,3,3, the 3-heptafluoro-propane, described latent solvent, dispersion agent or expanding material are 1,1,1,3,3-3-pentafluorobutane, 1,1,2,3,3-pentafluoropropane, pentamethylene or iso-pentane.Applied range of the present invention, not fluorine-containing Lyons, security is good, evaporation rate is fast.
Description
Technical field
The present invention relates to the complex spreading system in a kind of aerosol products component.Belong to the aerosol spray technique field.
Background technology
Aerosol is served various fields such as individual, family, industry, agricultural, pharmaceutical sector, construction industry, livestock industry, fire-fighting, safety at present widely as the important Industrial products of a class.Aerosol is made up of effective constituent and complex spreading system.The complex spreading system is its important component part except that effective constituent, generally is made up of propellent and latent solvent, dispersion agent or expanding material.Requirement has certain impelling pressure to guarantee atomizing effect, and the noresidue of gasifying rapidly after the ejection is in order to avoid influence the result of use of effective constituent.Different in the past aerosol products often uses freon hydro carbons (fluorine Lyons) or hydrocarbon polymer, pressurized gas etc. to produce as the compound system of latent solvent as propellent and ethanol, volatile silicone oils, methylal, acetone or Virahol etc.These products play that fluorine Lyons has nontoxicity, no anaphylaxis and pungency because of it in the raw material of propellent effect; Non-explosive, colourless, odorless, tasteless, with medicine etc. chemical reaction does not take place, do not influence stability of drug, in many aerosol products of the industry, used more extensive in the past, but, soon all eliminate according to the Montreal Protocol on Substances that Deplete the Ozone Layer regulation of signature because of it can damage the ozone layer.Hydrocarbon polymer just has suitable danger as inflammable and explosive raw material as mixing its product of back with same relatively more dangerous latent solvents such as acetone.And pressurized gas is big owing to its pressure, and leakage rate height and pressure release speed are too fast, and the utmost point short period of time has promptly sprayed, and product is used also have suitable limitation.And as ethanol, volatile silicone oils, methylal, acetone or the Virahol etc. of latent solvent because boiling point is higher, in the aerosol jar ejection back volatilization time longer, prolonged operating time and efficient.Therefore, press for a kind of aerosol safety of not fluorine-containing Lyons in the prior art, efficient complex spreading system substitutes original complex spreading system.
Summary of the invention
The objective of the invention is to overcome above-mentioned deficiency, a kind of applied range, not fluorine-containing Lyons, security is good, evaporation rate is fast aerosol safety, complex spreading system efficiently are provided.
The object of the present invention is achieved like this: a kind of aerosol safety of not fluorine-containing Lyons, efficient complex spreading system, and it is made up of propellent and latent solvent, dispersion agent or expanding material basically, it is characterized in that:
Described propellent is 1,1,1,2-Tetrafluoroethane or 1,1,1,2,3,3, and the 3-heptafluoro-propane, such propellent boiling point is lower, the effect that in the impelling system, utilizes its pressure to produce thrust power,
Described latent solvent, dispersion agent or expanding material are 1,1,1,3,3-3-pentafluorobutane, 1,1,2,3,3-pentafluoropropane, pentamethylene or iso-pentane, dispersion agent, expanding material are meant the solvent that is used for increasing the dispersed of aerosol system solid effective constituent and reduces the concentration of solid effective constituent, latent solvent is meant and is used for promoting the mutual deliquescent solvent of other component of aerosol system, such dispersion agent, expanding material or latent solvent have suitable boiling point, are generally 10 ℃ to 50 ℃, the noresidue of gasifying rapidly after the ejection atomizing in the aerosol jar.
The weight proportion of above-mentioned propellent and latent solvent, dispersion agent or expanding material is:
2～8 parts of propellents, 1～7 part of latent solvent, dispersion agent or expanding material.
The present invention has good effect:
1, with the not fluorine-containing Lyons of aerosol propellent of the present invention's preparation, helps environment protection.
2, have good mutual solubility between each component of this compound system, be good solvent, all can dissolve or form good dispersion system many effective constituents.
3, because as 1,1,1 of propellent, 2-Tetrafluoroethane or 1,1,1,2,3,3, the 3-heptafluoro-propane has stronger cooling effect, so this system has non-combustible characteristics, security is good.
4, because as 1,1,1 of latent solvent, dispersion agent or expanding material, 3,3-3-pentafluorobutane, 1,1,2,3,3-pentafluoropropane, pentamethylene or iso-pentane are the boiling point appropriate liquid, and mix and fill operations can be volatilized rapidly when being distributed in body surface during use after the atomizing ejection at normal temperatures, accelerate the onset time of effective constituent, improved service efficiency.
Embodiment
Embodiment 1:
Propellent adopts 1,1,1, the 2-Tetrafluoroethane, and dispersion agent or expanding material are chosen as 1,1,1,3, and the 3-3-pentafluorobutane substitutes 1,1,1 ,-three chloro-1-fluoromethane (fluorine Lyons F11), and proportioning is 1,1,1,2-Tetrafluoroethane 2kg, 1,1,1,3,3-3-pentafluorobutane 7kg.
1,1,1,3, the 3-3-pentafluorobutane is liquid because of it has suitable boiling point (40.2 ℃) under the room temperature, production operations such as conventional batching, stirring, packing are very easily controlled, use always in main physicochemical property and the former aerosol 1,1,1 ,-three chloro-1-fluoromethane (fluorine Lyons F11) are near (seeing Table one), and material compatibility is (seeing Table two) extensively, can substitute 1,1,1,-three application of chloro-1-fluoromethane (F11) in aerosol need not scrap build in the production process and big processing condition change.
Table one: 1,1,1,3,3-3-pentafluorobutane and fluorine Lyons F11 materialization data synopsis
| Project | 1,1,1,3, the 3-3-pentafluorobutane | 1,1,1 ,-three chloro-1-fluoromethane |
| Molecular weight | 186 | 137.4 |
| Boiling point | 40.2℃ | 23.82℃ |
| 20 ℃ of fluid densities | 1.27 | 1.487 |
| State | Volatile liquid | Volatile liquid |
| Outward appearance | Colourless | Colourless |
| Smell | Slight ether flavor | Slight ether flavor |
| Destroy ozone latent energy value ODP | 0 | 1 |
| Global warming coefficient value GWP | 0.17 | 1 |
| Acidity mg/kg | ≤1 | ≤1 |
| Purity %WL | ≥99.7 | ≥99.5 |
| Moisture mg/kg | ≤100 | ≤100 |
| Evaporation residue mg/kg | ≤100 | ≤1000 |
Table two: 1,1,1,3, the compatibility of 3-3-pentafluorobutane and thermoplastics, rubber
Based on above theoretical condition, we do a series of test and verify:
1) 1,1,1,3,3-3-pentafluorobutane and propellent 1,1,1,2-Tetrafluoroethane dissolubility test:
Test method: with 1,1,1,3,3-3-pentafluorobutane and 1,1,1,2-Tetrafluoroethane (providing by German Su Wei fluorine chemistry company limited) mixes in vial by 7: 2 (weight ratio), shakes after 1 minute and leaves standstill, and observes whether layering of solution.
Test-results: the solution homogeneous transparent fuses does not fully have layering.
2) production technique checking: during the production can, producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. is effective constituent, and weight is 1kg.With effective constituent and 1,1,1,3,7 kilograms of 3-3-pentafluorobutanes dispersed with stirring under 10 ℃ room temperature is even, pours into after the metering in the vial, seals then, installs valve.With 1,1,1 in the steel cylinder, the 2-Tetrafluoroethane quantitatively is pressed in the bottle by the valve on the bottle through filling machine in proportion again.Because of 1,1,1,3, the 3-3-pentafluorobutane both can disperse, dilute effective constituent, and the solubilized propellent 1,1,1 again, the 2-Tetrafluoroethane, thus make the De Molin aerosol.
Test-results: existing normal temperature production technique is feasible fully, and effective constituent is dispersed in the solution.
3) atomizing effect and jeting effect checking
Test method: with above-mentioned usefulness 1,1,1,3,3-3-pentafluorobutane and 1,1,1, the 2-Tetrafluoroethane shakes even back apart from the injection of body surface 15cm place as the aerosol products of impelling system, observes to have or not dropping liquid, effective constituent skewness phenomenon.
Test-results: atomizing is no dropping liquid evenly, and effective constituent is at the body surface uniform distribution.
4) checking of evaporation rate
Test method: with above-mentioned usefulness 1,1,1,3,3-3-pentafluorobutane and 1,1,1, the 2-Tetrafluoroethane shakes even the injection in body surface greater than 100cm as the aerosol products of impelling system
2, measure and write down the required time that volatilizees fully.
Test-results: can in 5 times in second, volatilize fully, cannot see other residue except that effective constituent.
5) security verification
Test method: light a candle, with above-mentioned usefulness 1,1,1,3,3-3-pentafluorobutane and 1,1,1, the 2-Tetrafluoroethane is aimed at flame spraying as the aerosol products of impelling system, observes combustion case.
Test-results: the candle breath goes out.
Embodiment 2:
Propellent adopts 1,1,1,2,3,3, the 3-heptafluoro-propane, and dispersion agent or expanding material are chosen as 1,1,1,3, the 3-3-pentafluorobutane, proportioning is 1,1,1,2,3,3,3-heptafluoro-propane 2kg, 1,1,1,3,3-3-pentafluorobutane 7kg.
Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 3:
Propellent adopts 1,1,1, the 2-Tetrafluoroethane, and dispersion agent or expanding material are chosen as 1,1,2,3, the 3-pentafluoropropane, proportioning is 1,1,1,2-Tetrafluoroethane 2kg, 1,1,1,3,3-pentafluoropropane 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 4:
Propellent adopts 1,1,1,2,3,3, the 3-heptafluoro-propane, and dispersion agent or expanding material are chosen as 1,1,2,3, the 3-pentafluoropropane, proportioning is 1,1,1,2,3,3,3-heptafluoro-propane 2kg, 1,1,1,3,3-pentafluoropropane 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 5:
Propellent adopts 1,1,1, the 2-Tetrafluoroethane, and dispersion agent or expanding material are chosen as pentamethylene, and proportioning is 1,1,1,2-Tetrafluoroethane 2kg, pentamethylene 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 6:
Propellent adopts 1,1,1,2,3,3, the 3-heptafluoro-propane, and dispersion agent or expanding material are chosen as pentamethylene, and proportioning is 1,1,1,2,3,3,3-heptafluoro-propane 2kg, pentamethylene 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 7:
Propellent adopts 1,1,1, the 2-Tetrafluoroethane, and dispersion agent or expanding material are chosen as iso-pentane, and proportioning is 1,1,1,2-Tetrafluoroethane 2kg, iso-pentane 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 8:
Propellent adopts 1,1,1,2,3,3, the 3-heptafluoro-propane, and dispersion agent or expanding material are chosen as iso-pentane, and proportioning is 1,1,1,2,3,3,3-heptafluoro-propane 2kg, iso-pentane 7kg.Producing the De Molin pulvis with Jiangsu Yangsheng Biological Engineering Co., Ltd. in the can is effective constituent, and weight is 1kg.All the other are substantially the same manner as Example 1.
Embodiment 9:
Propellent adopts 1,1,1, the 2-Tetrafluoroethane, and latent solvent is chosen as 1,1,1,3, the 3-3-pentafluorobutane, proportioning is 1,1,1,2-Tetrafluoroethane 2kg, 1,1,1,3,3-3-pentafluorobutane 7kg.Producing lignocaine with Fourth Ring, Jiangsu biotechnology company limited in the can is effective constituent, and weight is 0.16kg.All the other are substantially the same manner as Example 1.
Embodiment 10:
Propellent adopts 1,1,1,2,3,3, the 3-heptafluoro-propane, and latent solvent is chosen as 1,1,1,3, the 3-3-pentafluorobutane, proportioning is 1,1,1,2,3,3,3-heptafluoro-propane 2kg, 1,1,1,3,3-3-pentafluorobutane 7kg.Producing lignocaine with Fourth Ring, Jiangsu biotechnology company limited in the can is effective constituent, and weight is 0.16kg.All the other are substantially the same manner as Example 1.
Obviously, can put into practice the present invention not according to the specific description of being done among above specification sheets and the embodiment.
Might make many changes and improvements to the present invention based on above-mentioned instruction, therefore can in the claim scope is awaited the reply in the present invention, needn't put into practice the present invention according to these specific descriptions.
Claims (1)
1, a kind of aerosol safety of not fluorine-containing Lyons, efficient complex spreading system, it is made up of propellent and latent solvent, dispersion agent or expanding material basically, it is characterized in that:
Described propellent is 1,1,1,2-Tetrafluoroethane or 1,1,1,2,3,3, and the 3-heptafluoro-propane,
Described latent solvent, dispersion agent or expanding material are 1,1,2,3,3-pentafluoropropane or pentamethylene,
The weight proportion of described propellent and latent solvent, dispersion agent or expanding material is: 2 parts of propellents, 7 parts of latent solvent, dispersion agent or expanding materials.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100204348A CN100551988C (en) | 2007-02-27 | 2007-02-27 | Not the aerosol safety in fluorine-containing Lyons, efficient complex spreading system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100204348A CN100551988C (en) | 2007-02-27 | 2007-02-27 | Not the aerosol safety in fluorine-containing Lyons, efficient complex spreading system |
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| Publication Number | Publication Date |
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| CN101050351A CN101050351A (en) | 2007-10-10 |
| CN100551988C true CN100551988C (en) | 2009-10-21 |
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| CN103920183A (en) * | 2014-04-16 | 2014-07-16 | 江苏阳生生物工程有限公司 | Compound propelling system for Dermlin skin dressing |
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| DE102005023334A1 (en) * | 2005-05-17 | 2006-11-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Propellant-containing aerosol suspension useful for treating diseases e.g. asthma, pain contains active substance with chemically bound water, propellant gas or its mixture |
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2007
- 2007-02-27 CN CNB2007100204348A patent/CN100551988C/en not_active Expired - Fee Related
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|---|---|---|---|---|
| CN1259386A (en) * | 1999-12-24 | 2000-07-12 | 丛繁滋 | Isoniazid synergistic compound aerosol and its prepn. method |
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| Publication number | Publication date |
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| CN101050351A (en) | 2007-10-10 |
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