CN100546660C - A kind of Wound suturing-free tissue adhesive - Google Patents
A kind of Wound suturing-free tissue adhesive Download PDFInfo
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- CN100546660C CN100546660C CNB2006100355606A CN200610035560A CN100546660C CN 100546660 C CN100546660 C CN 100546660C CN B2006100355606 A CNB2006100355606 A CN B2006100355606A CN 200610035560 A CN200610035560 A CN 200610035560A CN 100546660 C CN100546660 C CN 100546660C
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Abstract
Wound suturing-free tissue adhesive of the present invention belongs to pharmaceutical sanitary field, the α-Qing Jibingxisuanwanjizhi tissue glue that is specifically related to contain antibacterial He subtracts smelly dose.The present invention contains 40.0-85.0 part α-Qing Jibingxisuanwanjizhi, 0.7-6.5 part intensity modifying agent, 0.5-7.5 part plasticity modifying agent, 0.1-22.5 part antibacterial, 0.02-9.5 part and subtracts smelly dose.Wherein, antibacterial is one or more in cefmotazole, erythromycin ethylsuccinate, acetylspiramycin, the chlorhexidinium iodine; Subtracting smelly dose is in angelica essential oil, Oleum Cinnamomi, the Myrrha quintessence oil one or more.Wound suturing-free tissue adhesive of the present invention has anti-microbial property, can obviously alleviate its peculiar stink, is widely used in Wound suturing-free and closes the field.
Description
Technical field
The invention belongs to the medical and health field, be specifically related to a kind of α-Qing Jibingxisuanwanjizhi class Wound suturing-free tissue adhesive that contains the high-efficiency antimicrobial composition and subtract smelly composition.
Background technology
Surgical wound and trauma wounds adopt three kinds of methods to close usually: sewing, staple stitching method and tissue glue's Method for bonding.
Tissue glue's Method for bonding is that α-Qing Jibingxisuanwanjizhi tissue glue closes the bonding wound characteristics that the wound method has uniqueness.α-Qing Jibingxisuanwanjizhi tissue glue is widely applied to and closes surgical wound and trauma wounds aspect as exempting to stitch tissue glue, especially to adopting sewing to be difficult to satisfied wound of closing, have and save time and energy, the bonding tissue that is difficult to sew up of energy, the wound closure environment of relative sealing can be provided, and postoperative needn't be changed dressings, and anastalsis is arranged, more attractive in appearance behind the wound healing, must be indispensable when the wound first aid etc. advantage.Chinese patent CN200310103799.9 provides-kind contain 50-70 part α-Qing Jibingxisuanwanjizhi, the tissue glue of 2.5-6.5 part plasticizer, 0.5-2.5 part flexibilizer.Chinese patent CN02113554.1 use a-cyanoacrylate and PTMC prepare a kind of medical surgical adhesive and are used for wound suture.Mention in U.S. Pat 5928661, U.S. Pat 5665817 and the U.S. Pat 5328687 and use a-cyanoacrylate as tissue glue's primary raw material.But the antimicrobial acivity of α-Qing Jibingxisuanwanjizhi tissue glue comprises the scarce capacity of microorganism spore, therefore can not guarantee to suppress the breeding of buttoned-up skin wound below or wound circumference microorganism, may cause wound infection.In addition, α-Qing Jibingxisuanwanjizhi tissue glue after being applied to wound for a long time in all can give out a kind of stink, use clinically thereby influenced tissue glue to a certain extent.In order to improve the anti-microbial property of α-Qing Jibingxisuanwanjizhi tissue glue, Chinese patent 00814024.1 uses xeothermic, radiation method to carry out disinfection and improve the anti-microbial property of tissue in preparation.But can not be suppressed at the microbial activity during the Wound healing and bone regeneration.In order to reduce the stink that wound distributes, adding spice etc. in α-Qing Jibingxisuanwanjizhi tissue glue, to subtract smelly dose be the method for using always.Among U.S. Pat 5807563, US5730994, US5665817, the Chinese patent CN00809625.2 spice is added to the stink of reduction generation in α-Qing Jibingxisuanwanjizhi tissue glue.But the antibacterial of above-mentioned adding, subtract smelly dose and have following shortcoming: 1. under the room temperature (being 20-25 ℃) dissolubility is little in α-Qing Jibingxisuanwanjizhi; 2. cause easily at the too early polymerization reaction take place of α-Qing Jibingxisuanwanjizhi; 3. quicken tissue glue at the skin wound polymerization reaction take place, thereby have little time tissue glue is applied on the whole wound; 4. prolong the shortcomings such as suitable polymerization time of tissue glue's polymeric membrane on skin wound.
Summary of the invention
The object of the present invention is to provide a kind of have strong anti-microbial property and obviously alleviate its peculiar stink, the Wound suturing-free that can close all kinds of wounds closes tissue glue.
For achieving the above object, the component of Wound suturing-free tissue adhesive of the present invention and content (weight portion) are:
α-Qing Jibingxisuanwanjizhi 40.0-85.0
Intensity modifying agent 0.7-6.5
Plasticity modifying agent 0.5-7.5
Antibacterial 0.1-22.5
Subtract smelly dose of 0.02-9.5.
Wound suturing-free tissue adhesive among the present invention, described α-Qing Jibingxisuanwanjizhi are at least a in ethyl, alpha-cyanoacrylate propyl ester, alpha-cyanoacrylate butyl ester, alpha-cyanoacrylate pentyl ester, alpha-cyanoacrylate ester in the last of the ten Heavenly stems, alpha-cyanoacrylate ester in the ninth of the ten Heavenly Stems or the α-Qing Jibingxisuanzhengxinzhi.α-Qing Jibingxisuanwanjizhi of the present invention better is one or more in ethyl, alpha-cyanoacrylate propyl ester, alpha-cyanoacrylate butyl ester, the α-Qing Jibingxisuanzhengxinzhi.α-Qing Jibingxisuanwanjizhi of the present invention is one or more in alpha-cyanoacrylate butyl ester and the α-Qing Jibingxisuanzhengxinzhi preferably.
α-Qing Jibingxisuanwanjizhi consumption of the present invention better is 40-70 part, preferably 55 parts.
Wound suturing-free tissue adhesive among the present invention, described intensity modifying agent are one or more in polymethyl methacrylate, polyethyl methacrylate, polybutyl methacrylate, polymethylacrylic acid monooctyl ester, polyvinyl acetate, acrylate rubber, neoprene, butadiene rubber, butadiene-styrene rubber, acrylonitrile-butadiene rubber, vinyl chloride-vinyl acetate copolymer or the acrylate copolymer.Intensity modifying agent of the present invention is one or more in polymethyl methacrylate, polyethyl methacrylate, polybutyl methacrylate, the vinyl chloride-vinyl acetate copolymer preferably.
Intensity modifying agent consumption of the present invention better is 2-5 part, preferably 3 parts.
Wound suturing-free tissue adhesive among the present invention is characterized in that: described intensity modifying agent is at least a in polymethyl methacrylate, polyethyl methacrylate, polybutyl methacrylate, polymethylacrylic acid monooctyl ester, polyvinyl acetate, acrylate rubber, neoprene, butadiene rubber, butadiene-styrene rubber, acrylonitrile-butadiene rubber, vinyl chloride-vinyl acetate copolymer or the acrylate copolymer.α-Qing Jibingxisuanwanjizhi of the present invention better is one or more in ethyl, alpha-cyanoacrylate propyl ester, alpha-cyanoacrylate butyl ester, the α-Qing Jibingxisuanzhengxinzhi.α-Qing Jibingxisuanwanjizhi of the present invention is one or more in alpha-cyanoacrylate butyl ester and the α-Qing Jibingxisuanzhengxinzhi preferably.
α-Qing Jibingxisuanwanjizhi consumption of the present invention better is 40-70 part, preferably 55 parts.
Wound suturing-free tissue adhesive among the present invention is characterized in that: described plasticity modifying agent is at least a in diethyl phthalate, dibutyl phthalate, dinoctyl phthalate, dipropyl sebacate, dibutyl sebacate, di-n-octyl sebacate, trioctyl trimellitate (TOTM), PMA four butyl esters or the n-butyl cyanoacetate.Plasticity modifying agent of the present invention is one or more in diethyl phthalate, dibutyl phthalate, dinoctyl phthalate, the dipropyl sebacate preferably.
This described plasticity modifying agent consumption better is 2-6 part, preferably 4 parts.
Wound suturing-free tissue adhesive among the present invention, described antibacterial are one or more in cefmotazole, cefixime, tobramycin, erythromycin, erythromycin ethylsuccinate, midecamycin, clarithromycin, acetylspiramycin, Iodophors, the chlorhexidinium iodine.Antibacterial of the present invention is one or more in cefmotazole, erythromycin ethylsuccinate, acetylspiramycin, the chlorhexidinium iodine preferably.
Wound suturing-free tissue adhesive of the present invention, wherein antibacterial better is 1-15 part, preferably 5-10 part.
Wound suturing-free tissue adhesive among the present invention describedly subtracts smelly dose of at least a in the rose essence, jasmine flower essence, herbal essence, orchid compound, Flos Rosae Rugosae quintessence oil, tea tree oil, Oleum lavandula angustifolia, Jasmin oil, angelica essential oil, Myrrha quintessence oil, Oleum Cinnamomi.Of the present inventionly subtract smelly dose of preferably one or more in angelica essential oil, Oleum Cinnamomi, the Myrrha quintessence oil.
Wound suturing-free tissue adhesive of the present invention, wherein subtracting smelly dose of consumption better is 1-10 part, preferably 3-7 part.
Wound suturing-free tissue adhesive preparation method of the present invention adopts tissue glue's preparation method commonly used.Wound suturing-free tissue adhesive preparation method of the present invention be by a certain percentage with α-Qing Jibingxisuanwanjizhi monomer, intensity modifying agent, plasticity modifying agent, subtract smelly dose and antibacterial mix homogeneously promptly.
For a better understanding of the present invention, with antibacterial effect its effect is described with subtracting of Wound suturing-free tissue adhesive of the present invention is smelly below.
Tissue glue's basis is: (wherein alpha-cyanoacrylate butyl ester pure monomer accounts for 70% weight to α-Qing Jibingxisuanwanjizhi pure monomer 60 grams, alpha-cyanoacrylate pentyl ester pure monomer accounts for 30% weight), intensity modifying agent polyethyl methacrylate 6.4 grams, plasticity modifying agent dibutyl phthalate 4.3 restrain, subtract smelly dose of angelica essential oil 2.0 gram and antibacterial chlorhexidinium iodinies.Wherein antibacterial chlorhexidinium iodine consumption is 0% (0 gram), 7% (5.3 gram), 14% (7.1 gram), 20% (17.7 gram).
To in the same old way: (wherein alpha-cyanoacrylate butyl ester pure monomer accounts for 70% weight to α-Qing Jibingxisuanwanjizhi pure monomer 60 grams, alpha-cyanoacrylate pentyl ester pure monomer accounts for 30% weight), intensity modifying agent polyethyl methacrylate 6.4 grams, plasticity modifying agent dibutyl phthalate 4.3 grams.
Wound suturing-free tissue adhesive of the present invention subtracts smelly effect measuring: in (each 4 of the male and female of the Cavia porcellus of preserved skin, every about 400 grams of body weight, be divided into four groups according to contained antibacterial difference, 1 Cavia porcellus of every group of each male and female) the other about 6mm of both sides, back spinal column place, each is done one and is parallel to spinal column straight cut out of shape, be about 2.5cm respectively, reach subcutaneous tissue deeply.Behind the bloodstain of wiping wound with toothed forceps respectively with each wound to holding together, antibacterial content is identical but contain or do not contain two kinds of deodorizer and exempt to stitch tissue glue and evenly be applied to respectively on two wounds of same Cavia porcellus, the nose about 10cm of the wound distance of moving close to is smelt the stink of organizing glued membrane, and record.Check each guinea pig back wound 10 day after surgery every day, smells its stink.Result: the equal first phase healing of wound, wound healing rate 100%.The distinctive stink of experimental group tissue glue all obviously alleviates.Experimental result is that Wen Xiang experiment was about 8 minutes, and matched group 0 minute, full marks 10 minutes.
The antibacterial effect experimental technique of Wound suturing-free tissue adhesive of the present invention is as follows.
1. inoculated bacteria: experimental strain staphylococcus aureus (ATCC25923), staphylococcus epidermidis (ATCC26101), Candida albicans are inoculated in respectively in MH fluid medium or the Ah's Vickers culture medium, in 37 ℃ of water isolation type electro-heating standing-temperature cultivators, hatch 6h, according to K-B method drug sensitive test standard coated test bacterium.Only inoculate a kind of pathogenic microorganism in each sterile petri dish, bacterial concentration is adjusted to 0.5 wheat formula standard opacity tube---(McFarland Standard) 1 * 10
8CFU/ml.Place the aseptic filter paper sheet of one piece of diameter 6mm in the central authorities of each culture dish, extract 10 μ l tissue glues with micropipettor respectively and drip on the filter paper, each bacterial strain is respectively inoculated 3 culture dishs, and each culture dish is put into 1 piece of filter paper.Culture dish is placed in 37 ℃ of water isolation type electro-heating standing-temperature cultivators hatches 24h.
2. observation index: aseptic or the zone of indivedual bacteria growings is arranged is antibacterial ring around the filter paper.Each culture dish is taken out measurement to be organized the inhibition zone diameter of glued membrane diameter and each bacterial strain and writes down the result.
3. bacteriostatic experiment result
Antibacterial district shows as two zones in the culture dish, i.e. I district and II district.The I district is the zone of integral asepsis growth near filter paper; The II district is outer in the I district, and is aseptic or a small amount of pathogenic microorganism growth is arranged, and inhibition zone diameter is: II district diameter-I district diameter.As Fig. 1.
Table 1. pathogenic microorganism: staphylococcus aureus (diameter units: mm)
Table 2. pathogenic microorganism: staphylococcus epidermidis (diameter units: mm)
Table 3. pathogenic microorganism: Candida albicans (diameter units: mm)
The tissue glue that the The above results explanation has added antibacterial can effectively bring into play antibacterial action after polymerization reaction take place forms the polymer thin film.
Wound suturing-free tissue adhesive solidification effect assay method of the present invention: in (each 4 of the male and female of the Cavia porcellus of preserved skin, every about 400 grams of body weight, be equally divided into four groups, every group has 1 of male and female Mus) the other about 6mm of both sides, back spinal column place, each is done one and is parallel to spinal column straight cut out of shape, be about 2.5cm respectively, reach subcutaneous tissue deeply.Behind the bloodstain of wiping wound with toothed forceps respectively with each wound to holding together, will exempt to stitch tissue glue and evenly be applied to respectively and respectively organize on the Cavia porcellus wound, be determined at wound surface and form the used time of solidified tissue glue thin film.
The solidification effect of Wound suturing-free tissue adhesive of the present invention is as shown in table 4.
The hardening time of table 4 Wound suturing-free tissue adhesive
Description of drawings
Fig. 1 is the antibacterial area schematic of Wound suturing-free tissue adhesive of the present invention.
The specific embodiment
The following example is used for specifying content of the present invention, but this does not limit the scope of the invention.Content described in the embodiment all is weight portion.
Embodiment 1
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate pentyl ester 10
Alpha-cyanoacrylate ester in the last of the ten Heavenly stems 20
Polybutyl methacrylate 0.5
Dibutyl phthalate 1.0
Angelica essential oil 0.05
Chlorhexidinium iodine 0.1
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 2
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Ethyl 40
Polyethyl methacrylate 2
Polymethylacrylic acid monooctyl ester 0.5
Diethyl phthalate 1.0
Dibutyl phthalate 1.0
Angelica essential oil 0.4
Oleum Cinnamomi 0.6
Erythromycin ethylsuccinate 0.5
Acetylspiramycin 0.5
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 3
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Ethyl 20
Alpha-cyanoacrylate propyl ester 20
Alpha-cyanoacrylate butyl ester 20
α-Qing Jibingxisuanzhengxinzhi 20
Polymethyl methacrylate 2.5
Polyethyl methacrylate 2.5
Polyvinyl acetate 2.5
Diethyl phthalate 1.5
Dibutyl phthalate 2.5
Dinoctyl phthalate 1
Dipropyl sebacate 1.5
Angelica essential oil 6
Oleum Cinnamomi 5
Myrrha quintessence oil 2
Cefmotazole 7
Cefixime 6
Tobramycin 6
Erythromycin 3.5
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 4
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Ethyl 20
Alpha-cyanoacrylate pentyl ester 20
Alpha-cyanoacrylate butyl ester 30
Polyethyl methacrylate 2.5
Vinyl chloride-vinyl acetate copolymer 2.5
Dipropyl sebacate 2
Dibutyl phthalate 2
Di-n-octyl sebacate 2
Angelica essential oil 4
Rose essence 3
Flos Rosae Rugosae quintessence oil 3
Erythromycin ethylsuccinate 1.5
Midecamycin 2.5
Clarithromycin 0.5
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 5
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 30
α-Qing Jibingxisuanzhengxinzhi 10
Polyethyl methacrylate 4
Dibutyl phthalate 2
Angelica essential oil 5
Acetylspiramycin 10
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 6
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 30
α-Qing Jibingxisuanzhengxinzhi 10
Alpha-cyanoacrylate ester in the ninth of the ten Heavenly Stems 15
Polyethyl methacrylate 4
Butadiene rubber 2
Dibutyl phthalate 0.2
PMA four butyl esters 0.2
Angelica essential oil 3
Oleum lavandula angustifolia 1
Jasmin oil 1
Iodophors 7.5
Chlorhexidinium iodine 7.5
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 7
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 30
α-Qing Jibingxisuanzhengxinzhi 10
Alpha-cyanoacrylate ester in the ninth of the ten Heavenly Stems 20
Polyethyl methacrylate 2
Acrylate rubber 1.5
Dibutyl phthalate 2.5
Dibutyl sebacate 1
Trioctyl trimellitate (TOTM) 1
Angelica essential oil 5
Tea tree oil 1
Orchid compound 1
Cefmotazole 5
Chlorhexidinium iodine 5
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 8
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 30
α-Qing Jibingxisuanzhengxinzhi 10
Ethyl 30
Polyethyl methacrylate 2
Acrylonitrile-butadiene rubber 0.5
Dibutyl phthalate 1
Trioctyl trimellitate (TOTM) 1
N-butyl cyanoacetate 1
Angelica essential oil 1
Jasmine flower essence 1
Herbal essence 1
Erythromycin ethylsuccinate 2
Chlorhexidinium iodine 3
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 9
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 41
α-Qing Jibingxisuanzhengxinzhi 14
Polyethyl methacrylate 4.5
Dibutyl phthalate 3.5
Angelica essential oil 6.5
Acetylspiramycin 6
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 10
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 25
α-Qing Jibingxisuanzhengxinzhi 10
Polyethyl methacrylate 1.5
Dibutyl phthalate 7
Angelica essential oil 8.5
Erythromycin ethylsuccinate 8
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 11
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 30
α-Qing Jibingxisuanzhengxinzhi 40
Polyethyl methacrylate 6.5
Dibutyl phthalate 7
Angelica essential oil 9.5
Cefmotazole 7
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 12
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 50
α-Qing Jibingxisuanzhengxinzhi 10
Polyethyl methacrylate 2.5
Dibutyl phthalate 3
Angelica essential oil 3.5
Cefmotazole 2
Erythromycin ethylsuccinate 3
Acetylspiramycin 3
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Embodiment 13
It is as follows that Wound suturing-free of the present invention closes the component and the content of tissue glue:
Alpha-cyanoacrylate butyl ester 25
α-Qing Jibingxisuanzhengxinzhi 25
Polyethyl methacrylate 3
Dibutyl phthalate 4
Oleum Cinnamomi 6
Chlorhexidinium iodine 6
The preparation method that Wound suturing-free of the present invention closes tissue glue is that said components is obtained according to the content uniform mixing.
Claims (10)
1. medical glue of Wound suturing-free, the component of this medical glue and weight portion content are:
α-Qing Jibingxisuanwanjizhi 40.0-85.0
Intensity modifying agent 0.7-6.5
Plasticity modifying agent 0.5-7.5
Antibacterial 0.1-22.5
Subtract smelly dose of 0.02-9.5;
Wherein,
Described intensity modifying agent is one or more in polymethyl methacrylate, polyethyl methacrylate, polybutyl methacrylate, the vinyl chloride-vinyl acetate copolymer;
Described plasticity modifying agent is one or more in diethyl phthalate, dibutyl phthalate, dinoctyl phthalate, the dipropyl sebacate;
Described antibacterial is one or more in cefmotazole, cefixime, tobramycin, erythromycin, erythromycin ethylsuccinate, midecamycin, clarithromycin, acetylspiramycin, Iodophors, the chlorhexidinium iodine;
Describedly subtract smelly dose and be in the rose essence, jasmine flower essence, herbal essence, orchid compound, Flos Rosae Rugosae quintessence oil, tea tree oil, Oleum lavandula angustifolia, Jasmin oil, angelica essential oil, Myrrha quintessence oil, Oleum Cinnamomi one or more.
2. the medical glue of the described a kind of Wound suturing-free of claim 1, it is characterized in that α-Qing Jibingxisuanwanjizhi is one or more in ethyl, alpha-cyanoacrylate propyl ester, alpha-cyanoacrylate butyl ester, the α-Qing Jibingxisuanzhengxinzhi, consumption is 40-70 part.
3. the medical glue of the described a kind of Wound suturing-free of claim 2 is characterized in that α-Qing Jibingxisuanwanjizhi is one or both in alpha-cyanoacrylate butyl ester and the α-Qing Jibingxisuanzhengxinzhi, and consumption is 55 parts.
4. the medical glue of the described a kind of Wound suturing-free of claim 1, the consumption that it is characterized in that the intensity modifying agent is 2-5 part.
5. the medical glue of the described a kind of Wound suturing-free of claim 1, the consumption that it is characterized in that the plasticity modifying agent is 2-6 part.
6. the medical glue of the described a kind of Wound suturing-free of claim 1 is characterized in that antibacterial is one or more in cefmotazole, erythromycin ethylsuccinate, acetylspiramycin, the chlorhexidinium iodine.
7. claim 1 or the medical glue of 6 described a kind of Wound suturing-frees is characterized in that the antibacterial consumption is 1-15 part.
8. the medical glue of the described a kind of Wound suturing-free of claim 7 is characterized in that the antibacterial consumption is 5-10 part.
9. the medical glue of the described a kind of Wound suturing-free of claim 1, it is characterized in that subtracting smelly dose is in angelica essential oil, Oleum Cinnamomi, the Myrrha quintessence oil one or more.
10. the medical glue of the described a kind of Wound suturing-free of claim 1, it is characterized in that subtracting smelly dose of consumption is 3-7 part.
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| CNB2006100355606A CN100546660C (en) | 2006-05-23 | 2006-05-23 | A kind of Wound suturing-free tissue adhesive |
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| CNB2006100355606A CN100546660C (en) | 2006-05-23 | 2006-05-23 | A kind of Wound suturing-free tissue adhesive |
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| CN100546660C true CN100546660C (en) | 2009-10-07 |
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| RU2468824C1 (en) * | 2011-08-11 | 2012-12-10 | Леплянина Елена Геннадьевна | Biological adhesive and method for preparing it |
| CN105412980B (en) * | 2015-12-28 | 2018-09-28 | 任新界 | A kind of outpatient service minor operation notch medical glue and preparation method |
| CN110575561B (en) * | 2019-09-16 | 2022-04-22 | 浙江派菲特新材料科技有限公司 | Medical n-butyl ester adhesive with high impact resistance and high hydrophilicity |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807563A (en) * | 1997-01-10 | 1998-09-15 | Medlogic Global Corporation | Methods for draping surgical incision sites |
| CN1362982A (en) * | 1999-06-30 | 2002-08-07 | 科乐医药有限公司 | Flavored cyanoacrylate compositions |
| CN1524520A (en) * | 2003-09-12 | 2004-09-01 | 裴国献 | Emergency protective agent for wound |
| US6797107B1 (en) * | 2001-06-29 | 2004-09-28 | Chemence, Inc. | Solid cyanoacrylate adhesive composition and method for its use |
-
2006
- 2006-05-23 CN CNB2006100355606A patent/CN100546660C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807563A (en) * | 1997-01-10 | 1998-09-15 | Medlogic Global Corporation | Methods for draping surgical incision sites |
| CN1362982A (en) * | 1999-06-30 | 2002-08-07 | 科乐医药有限公司 | Flavored cyanoacrylate compositions |
| US6797107B1 (en) * | 2001-06-29 | 2004-09-28 | Chemence, Inc. | Solid cyanoacrylate adhesive composition and method for its use |
| CN1524520A (en) * | 2003-09-12 | 2004-09-01 | 裴国献 | Emergency protective agent for wound |
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| CN1850290A (en) | 2006-10-25 |
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