CN100534453C - Production process of five-ester droplet - Google Patents
Production process of five-ester droplet Download PDFInfo
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- CN100534453C CN100534453C CNB2006101519340A CN200610151934A CN100534453C CN 100534453 C CN100534453 C CN 100534453C CN B2006101519340 A CNB2006101519340 A CN B2006101519340A CN 200610151934 A CN200610151934 A CN 200610151934A CN 100534453 C CN100534453 C CN 100534453C
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Abstract
The invention adopts the limited diameter circular cylinder with concave canal orifice emitter dropping preparation method to produce five-ester dropping pills which has better rate of qualified products in pills weight and pills roundness degree than that produced by the current production method using circular cylinder with plane canal orifice emitter, what is more, five-ester dropping pills weighed ranging 30mg-100mg can also be produced using the present invention.
Description
Technical field
The present invention relates to method for producing five-ester dropping pills, it is characterized in that it is to adopt the cylindric concave mouth of pipe of limited diameter water dropper dropping preparation method production WUZHI DIWAN.
Background technology
The main component of WUZHI DIWAN is a Fructus Schisandrae Sphenantherae ethanol extractum, can reduce the serum aminotransferase, and the clinical demonstration of application result for many years is used for chronic, chronic persistent hepatitis Glutamate pyruvate transaminase rises person safety, effective.
At present wide clinical application is the five-ester capsule, but because long, poor stability of molten diffusing time of its disintegrate, and bed, dysphagia, the gerontal patient defectives such as inconvenience of taking medicine influence giving full play to of its curative effect.
WUZHI DIWAN not only production technology and working condition is simple; easy to operate; operation is few; with short production cycle; the automaticity height; labor intensity is low; workshop does not have dust; help labor protection; the production efficiency height, production cost is low, and disintegrate is molten looses and medicine stability obviously improves; bed; dysphagia; the gerontal patient takes medicine conveniently; compliance improves, especially at chronic; the easy characteristics of knock-on of glutamate pyruvate transaminase after the chronic persistent hepatitis patient drug withdrawal, WUZHI DIWAN can make the patient accomplish to reduce gradually dose to keep maintenance dose to reach that the treatment glutamate pyruvate transaminase continues not fall or the purpose of rising repeatedly easily; component uses more convenient, and the therapeutical effect of medicine is more given full play to.
But, WUZHI DIWAN in process of production, when Fructus Schisandrae Sphenantherae ethanol extractum be added to make uniform medicinal liquid in fused Polyethylene Glycol and/or the sodium lauryl sulphate substrate after, when adopting the cylindric plane mouth of pipe water dropper drop pill machine production drop pill of present suitability for industrialized production extensive use, because the influence of factors such as dropper bore, dropper pipe thickness, medicinal liquid interfacial tension, make different and roundness pill of the ball method of double differences wayward, accepted product percentage is low, and can only produce ball and focus on the following drop pill of 30mg.
Goal of the invention
The present invention is directed to the problem that existing dropping-pill machine head exists, adopt the cylindric concave mouth of pipe of limited diameter water dropper, the contact area of the medicinal liquid drop and the water dropper mouth of pipe is increased, increase interfacial tension, overcome the cylindric plane mouth of pipe water dropper mouth of pipe that present drop pill machine uses and medicinal liquid drop contact area is little, interfacial tension causes the different and uppity problem of pill roundness of the ball method of double differences for a short time, improve accepted product percentage, can also increase ball and heavily reduce dose.
Summary of the invention
For achieving the above object, the present invention adopts following method production WUZHI DIWAN: get 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum and be added in fused 2～10 weight portion Polyethylene Glycol and/or 0.1～3 weight portion sodium lauryl sulphate substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, drip system with the cylindric concave mouth of pipe of limited diameter water dropper dropping preparation method, dimethicone degree of passing cooling with 35 ℃～0 ℃, the oil ball separates, in temperature is that 30 ℃, relative humidity are under 50% condition dry 60 minutes, the sieve ball selects ball, check, packing, promptly.
The cylindric concave mouth of pipe of limited diameter of the present invention water dropper as shown in drawings, comprises screw thread silk post 1, prism 2, water dropper post 3, medicinal liquid hopper 4, water dropper pipe 5 and the water dropper concave mouth of pipe 6, and the angle α of water dropper concave surface vertical line and horizontal plane is 0-180 °.
The WUZHI DIWAN that the present invention produces has following beneficial effect:
1. the cylindric plane mouth of pipe water dropper with existing drop pill machine use compares, and the present invention can effectively control the different and pill roundness of the ball method of double differences, improves accepted product percentage.
2. can produce the heavy WUZHI DIWAN of 30mg～100mg ball.
The specific embodiment
Getting 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum is added in the substrate of 2～5 weight portion polyethylene glycol 6000s and 1～4 weight portion Macrogol 4000 mixed melting, stir evenly, make uniform medicinal liquid, under 85 ℃ of heat-retaining conditions, drip system, with 35 ℃～0 ℃ dimethicone degree of passing cooling with the cylindric concave mouth of pipe of limited diameter water dropper dropping preparation method, the oil ball separates, in temperature is that 30 ℃, relative humidity are under 50% the condition dry 60 minutes, and the sieve ball selects ball, check, packing, promptly.
Compare the different and pill roundness accepted product percentage raising 27% of the product ball method of double differences that the present invention produces with cylindric plane mouth of pipe water dropper.
Getting 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum is added in the fused polyethylene glycol 6000 substrate of 2～6 weight portions, stir evenly, make uniform medicinal liquid, under 90 ℃ of heat-retaining conditions, drip system, with 35 ℃～5 ℃ dimethicone degree of passing coolings with the cylindric concave mouth of pipe of limited diameter water dropper dropping preparation method, the oil ball separates, in temperature is that 30 ℃, relative humidity are under 50% the condition dry 30 minutes, and the sieve ball selects ball, check, packing, promptly.
Compare the different and pill roundness accepted product percentage raising 36% of the product ball method of double differences that the present invention produces with cylindric plane mouth of pipe water dropper.
Getting 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum is added in the substrate of 1～3 weight portion polyethylene glycol 6000,2～6 weight portion Macrogol 4000s and 0.1～3 weight portion sodium lauryl sulphate mixed melting, stir evenly, make uniform medicinal liquid, under 75 ℃ of heat-retaining conditions, drip system with the cylindric concave mouth of pipe of limited diameter water dropper dropping preparation method, with 35 ℃～5 ℃ dimethicone degree of passing coolings, the oil ball separates, in temperature is that 30 ℃, relative humidity are under 55% the condition dry 60 minutes, the sieve ball selects ball, check, packing, promptly.
Compare the different and pill roundness accepted product percentage raising 33% of the product ball method of double differences that the present invention produces with cylindric plane mouth of pipe water dropper.
Claims (1)
1. method for producing five-ester dropping pills, it is characterized in that it is to get 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum to be added in fused 2～10 weight portion Polyethylene Glycol and/or 0.1～3 weight portion sodium lauryl sulphate substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions with comprising screw thread silk post (1), prismatic (2), water dropper post (3), medicinal liquid hopper (4), drip pipe (5), the water dropper dropping preparation method of the water dropper concave mouth of pipe (6) drips system, dimethicone gradient cooling with 35 ℃～0 ℃, the oil ball separates, in temperature is 30 ℃, relative humidity is under 50% the condition dry 60 minutes, checks after the sieve ball selects ball, WUZHI DIWAN is made in packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101519340A CN100534453C (en) | 2006-09-04 | 2006-09-04 | Production process of five-ester droplet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101519340A CN100534453C (en) | 2006-09-04 | 2006-09-04 | Production process of five-ester droplet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1927270A CN1927270A (en) | 2007-03-14 |
| CN100534453C true CN100534453C (en) | 2009-09-02 |
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ID=37857500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101519340A Active CN100534453C (en) | 2006-09-04 | 2006-09-04 | Production process of five-ester droplet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100534453C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433588B (en) * | 2008-12-19 | 2010-12-22 | 南昌弘益科技有限公司 | Method for producing five-ester dropping pills |
| CN103285084A (en) * | 2012-03-05 | 2013-09-11 | 上海中药制药技术有限公司 | Production method for fructus schizandrae extract dripping pills |
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2006
- 2006-09-04 CN CNB2006101519340A patent/CN100534453C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN1927270A (en) | 2007-03-14 |
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| C06 | Publication | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20070314 Assignee: Nanchang Helioeast Pharmaceutical Co., Ltd. Assignor: Hongyi Science and Technology Co., Ltd., Nanchang Contract record no.: 2015360000050 Denomination of invention: Production process of five-ester droplet Granted publication date: 20090902 License type: Exclusive License Record date: 20150527 |
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| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Nanchang Helioeast Pharmaceutical Co., Ltd. Assignor: Hongyi Science and Technology Co., Ltd., Nanchang Contract record no.: 2015360000050 Date of cancellation: 20190902 |
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| EC01 | Cancellation of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20070314 Assignee: Nanchang Helioeast Pharmaceutical Co., Ltd. Assignor: Hongyi Science and Technology Co., Ltd., Nanchang Contract record no.: X2019360000001 Denomination of invention: Production process of five-ester droplet Granted publication date: 20090902 License type: Exclusive License Record date: 20190925 |
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| EE01 | Entry into force of recordation of patent licensing contract |