CN100534418C

CN100534418C - Capsule for treating rhinitis and preparation method thereof

Info

Publication number: CN100534418C
Application number: CNB2005100031918A
Authority: CN
Inventors: 陈沙
Original assignee: Individual
Current assignee: ANKANG PHARMACEUTICAL Co Ltd GUIZHOU
Priority date: 2005-08-29
Filing date: 2005-08-29
Publication date: 2009-09-02
Anticipated expiration: 2025-08-29
Also published as: CN1739667A

Abstract

The capsule for treating rhinitis is prepared with seven kinds of Chinese medicinal materials, including cordate houttuynia, Japanese spiraea, Setose thistle, sweetgum fruit, Japanese pearlwort herb, etc. as well as cyclodextrin, oily liquid and supplementary material. The present invention has the functions of clearing away heat and toxic material, dispelling wind evil, eliminating swelling, etc. and is used in treating acute and chronic rhinitis, nasosinusitis and laryngopharyngitis. The present invention coats extracted volatile oil inside cyclodextrin and adds oily matter, and compared with available technology, the medicine of the present invention has the advantages of high curative effect, short disintegrating time, fast leaching out and absorption, high bioavailability, etc.

Description

Capsule of treatment rhinitis and preparation method thereof

Technical field:

The present invention relates to a kind of capsule for the treatment of rhinitis and preparation method thereof, belong to technical field of medicaments.

Background technology:

Rhinitis and sinusitis are a kind of common diseases.The patient of rhinitis, sinusitis is nasal obstruction, rhinorrhea, headache, giddy, hypomnesis often, pus spreads towards periphery, can cause the infection of surrounding tissue, even can cause serious consequences such as blind, meningitis, brain abscess, become and have a strong impact on the healthy disease of people.The nasopharyngeal carcinoma in the whole world 80% occurs in China, and about ninety percent nasopharyngeal carcinoma, is because of due to the rhinitis obstinate worsens.Aspect work and study, the patient can make work efficiency low because of headache, the giddy that rhinitis causes.Other complication that rhinitis caused also have: because of the stuffiness of long-time nasal obstruction, dyspnea can cause sleep apnea syndrome; Patient's hypertrophic inferior turbinate, oxygen deficiency during sleep can cause cerebral infarction, hypertension, heart attack etc. under the serious situation, individual patient even meeting sudden death at night.

At present, in the medicine of numerous treatment rhinitis, to the therapeutic effect of rhinitis slightly at the medicine of " national standard for traditional Chinese medicines compilation Chinese patent medicine provincial standard rising national standard part ophthalmology department of otorhinolaryngology skin fascicle " the 168th page of a kind of BIKANG PIAN of applauding of recording of National Drug Administration promulgation.It is that main formula is prepared from by Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris and Herba Centipedae.But, shortcoming such as because its dosage form is tablet, exist that disintegration time is long, stripping and absorption are not ideal enough.And it is that volatile oil with medical material extracts earlier in the preparation, extracts the water soluble ingredient of medical material then, concentrate, dry, be ground into fine powder, at last the volatile oil that extracts is sprayed into, compacting in flakes, coating.Because the volatilization oil mass of extracting is little, appearance mixes uneven situation spraying often, directly causes the difference of drug effect; And volatile oil is sprayed at the material surface, makes the quick volatilization of volatile oil easily and drug effect is reduced; Though and it adopts method loss that can slow down volatile oil of parcel sugar-coat, owing to the cold and Warm Changes in Northern of weather, the volumetric expansion of being heated of volatile oil molecule makes coated tablet generation sliver, directly influences product quality.In addition, because volatile oil, pure soluble components and water soluble ingredient are blended directly in together, the disintegrative of medicine is reduced, deadlocked mutually between various compositions, absorption slows down, declined bioavailability of oral administration.

Summary of the invention:

The object of the present invention is to provide a kind of capsule for the treatment of rhinitis and preparation method thereof, medicine of the present invention not only good drug efficacy, acute and chronic rhinitis, sinusitis and pharyngolaryngitis due to the wind heat are had curative effect preferably, and its disintegration time weak point, stripping and absorption are fast, the bioavailability height is to solve the problem that prior art exists.

The present invention is achieved in that according to weight and calculates that it is prepared into capsule by Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g active component and cyclodextrin, oil-based liquid material and the suitable adjuvant after extracting.Wherein said active component is the volatile ingredient and the water soluble ingredient of medical material; Described active component also can be the volatile ingredient and the pure soluble components of medical material; Described active component also can be volatile ingredient and the pure soluble components and the water soluble ingredient of medical material.

Described cyclodextrin is alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, hydroxypropyl-alpha-cyclodextrin, HP-, hydroxypropyl-gamma-cyclodextrin, methyl-beta-schardinger dextrin-, a kind of or mixture more than 2 kinds in carboxymethyl-beta-cyclodextrin, the one chlorotriazine-beta-schardinger dextrin-.Best cyclodextrin is a beta-schardinger dextrin-.

Described oil-based liquid material is liquid paraffin, methyl-silicone oil or vegetable oil.Best oil-based liquid material is a liquid paraffin.

The capsule that the present invention treats rhinitis is preparation like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris and Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 1～3 time, and each 1～3 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 80～98% ethanol, stir evenly, left standstill 12～36 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 50～70 order fine powders, get the water soluble ingredient material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil that extracts, stirred 0.5～2 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 1～5% weight the oil-based liquid material, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, be to prepare like this: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 2 times, and each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 95% ethanol, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 3% weight white oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The capsule that the present invention treats rhinitis also can prepare like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris and Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 1～3 time, each 1～3 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 2～80,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 50～70 order fine powders, get the water soluble ingredient material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 0.5～2 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 1～5% weight the oil-based liquid material, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, be to prepare like this: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 2 times, each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 50,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 3% weight white oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The capsule that the present invention treats rhinitis can also prepare like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris and Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae alcohol reflux 1～3 time, each 1～2 hour, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50～70 order fine powders, get pure soluble components material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, ultrasonic 0.5～2 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction pure soluble components material 1～5% weight the oil-based liquid material, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, be to prepare like this: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae alcohol reflux 2 times, each 1.5 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, ultrasonic 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction pure soluble components material 3% weight white oil, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The capsule that the present invention treats rhinitis also can prepare like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris, Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 12～36 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50～70 order fine powders, get pure soluble components material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil that extracts, ultrasonic 0.5～2 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the oil-based liquid material of pure soluble components material 1～5% weight of extraction, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, be to prepare like this: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 24 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, ultrasonic 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the white oil of pure soluble components material 3% weight of extraction, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The capsule that the present invention treats rhinitis also can also prepare like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris, Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder carbon dioxide supercritical fluid extraction volatile oil, 30～70 ℃ of extraction temperature, extracting pressure 20～40MPa collects volatile oil; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae were with alcohol reflux 1～3 time, each 1～2 hour, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50～70 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the ethanol extraction decoct with water 1～3 time, each 1～3 hour, merge decoction liquor, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 80～98% ethanol, making concentration of alcohol is 50～70%, stirs, and leaves standstill 12～36 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50～70 order fine powders, get the water soluble ingredient material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 0.5～2 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the oil-based liquid material of mixture 1～5% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, be to prepare like this: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder carbon dioxide supercritical fluid extraction volatile oil, 65 ℃ of extraction temperature, extracting pressure 35MPa collects volatile oil; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae were with alcohol reflux 2 times, each 1.5 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the ethanol extraction decoct with water 2 times, each 2 hours, merge decoction liquor, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 95% ethanol, making concentration of alcohol is 65%, stirs, and leaves standstill 24 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the white oil of mixture 3% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The capsule that the present invention treats rhinitis can also prepare at last like this: take by weighing medical material Herba Inulae cappae, Herba Houttuyniae, Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae, Fructus Liquidambaris and Herba Centipedae and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition received preservation; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under 2005 editions appendix I of Chinese Pharmacopoeia O fluid extract and the extractum item with alcohol dipping after 12～36 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50～70 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the percolation decoct with water 1～3 time, each 1～3 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 2～80,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 50～70 order fine powders, get the water soluble ingredient material, standby; Get the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, colloid mill ground 0.5～2 hour, and is dry below 40 ℃, is ground into fine powder, gets cyclodextrin clathrate, standby; Get the oil-based liquid material of mixture 1～5% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

Specifically, its best preparation method is: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition received preservation; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 24 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the percolation decoct with water 2 times, each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 50,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, colloid mill ground 1 hour, and is dry below 40 ℃, is ground into fine powder, gets cyclodextrin clathrate, standby; Get the white oil of mixture 3% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

The present invention is with the volatile oil of medical material, water soluble ingredient extracts, and the volatile oil that extracts wrapped up with cyclodextrin, make volatile oil and cyclodextrin form the clathrate of molecule capsula interna, improved the stability of volatile oil, make the volatile oil powdered, increased the dissolubility of volatile oil at gastric, improved bioavailability of medicament, reduced the toxic and side effects of medicine, zest, covered the bad smell of volatile oil, directly sprayed volatile oil when having avoided production and cause mixing inhomogeneous, made curative effect of medication the scarce limit of difference occur, prevented that volatile oil from reduce bioavailability because of volatilizing easily, the drawback that causes curative effect of medication to descend; Add the oil-based liquid material in the active component extract powder that the present invention simultaneously extracts in by medical material, because the oil-based liquid material has higher permeability, can be penetrated into the extract powder surface, form one deck hydrophobic layer, medicine and water in air branch have been isolated, make capsule 's content keep higher drying property, prevented that extractum from luming because of absorbing moisture, make medicine disintegrate rapidly, improved the speed that discharges medicine, overcome owing to various compositions and deadlocked disintegration decline, the problem that causes drug absorption to be slowed down of making of moisture mixing appearance.

Therefore, compared with prior art, the present invention has that good effect, disintegration time are short, stripping and absorption are fast, and bioavailability is high and to be difficult for the moisture absorption rotten, stay-in-grade advantage.

For confirming the seal effect of the present invention to cyclodextrin parcel volatile oil, the applicant adopts L ₉(3 ³) orthogonal experiment, studied the technology of beta-cyclodextrin inclusion compound volatile oil.By the investigation to clathrate yield and two indexs of bag branch rate, optimizing clathrate process is A ₂B ₃C ₁, promptly with 2 times of beta-schardinger dextrin-amount enclose to volatile oil, the enclose temperature is 60 ℃, the enclose time is 1h, and verifies by the optimised process that experiment obtains.Test as follows:

Beta-schardinger dextrin-wraps up the L that seals of volatile oil ₉(3 ³) orthogonal test:

1 material and instrument:

1.1 material: medical material meets " regulation under 2005 editions one each medicine item of Chinese pharmacopoeia through evaluation; Beta-schardinger dextrin-, Suzhou Gourmet Powder Factory produces, purity＞98%; Reagent is analytical pure.

1.2 equipment: electronic thermostatic water-bath, Bei Jingjing are defended scientific instrument factory; SXJQ-1 type motor stirrer; Scout 11 electronic balances, Ao Haosi International Trading Company Ltd; 101-2 type drying baker, Shanghai City experimental apparatus head factory.

2 methods and result:

2.1 the medical material pulverize separately becomes coarse grain, in prescription ratio mixing, adds 10 times of water gagings, soaks 1h, by " an appendix determination of volatile oil of Chinese pharmacopoeia version in 2005 method is extracted into oil to the greatest extent, uses anhydrous sodium sulfate dehydration, and is standby.Total volatile oil is a yellow liquid, and relative density is 0.954.

Mainly contain host and guest's molecular proportion, enclose temperature and enclose time 2.2 Orthogonal Experiment and Design, influences the factor of this product clathrate process according to trial test, as evaluation index, carry out L with the comprehensive grading of clathrate yield and inclusion rate ₉(3 ⁴) orthogonal test.Factor level sees Table 1.

Table 1: enclose experimental factor water-glass

2.3 the clathrate preparation: press the experimental condition that table 2 is arranged, precision takes by weighing beta-schardinger dextrin-and puts in the conical flask, adds water and is made into saturated solution.Precision is measured 1.0mL volatile oil, with the dilution of equivalent dehydrated alcohol, with dropper the volatile oil diluent is injected the beta-schardinger dextrin-saturated aqueous solution, constant temperature is stirred to the stipulated time, take out, cooling is put refrigerator and cooled and is hidden 24h, sucking filtration, use a small amount of distilled water and absolute ethanol washing clathrate respectively, to there not being the volatile oil abnormal smells from the patient, 40 ℃ of dryings, promptly.

2.4 clathrate yield and inclusion rate are measured: by " an appendix determination of volatile oil of Chinese pharmacopoeia version in 2005 method is carried out.The dry inclusion complex precision of gained is weighed, put in the round-bottomed flask that zeolite is housed, the about 400mL of adding distil water connects volatile oil determination apparatus, littlely boils and keeps 6h, when no longer increasing, oil mass stops to heat, and placement 30min, reading obtains the volatile oil volume.Calculate clathrate recovery rate and inclusion rate, comprehensive grading=clathrate yield * 0.5+ inclusion rate * 0.5 (the results are shown in Table 2,3).

Table 2:L ₉(3 ³) the enclose orthogonal test table

Table 3 analysis of variance table

F _0.05(2，2)＝19.00，F _0.01(2，2)＝99.*00

2.5 result: respectively investigate the R value of index and the The results of analysis of variance of table 3 in the table 2 and show that influence factor's primary and secondary is B＞A＞C.Because the C factor is a secondary cause, and test is not made significant difference, and for enhancing productivity, selects C ₁Level, so optimum process condition is decided to be: volatile oil is 1: 2 with the ratio of beta-schardinger dextrin-, and the enclose temperature is 60 ℃, and the enclose time is 1.0h.

3. clathrate checking: whether clathrate forms and can adopt the several different methods checking, as microscopic method, phase solubility method, thin layer chromatography, UV-VIS spectrophotometry, infrared spectrophotometer, thermal analysis system or the like, this product adopts the infrared spectrophotometer checking.

Method: prepare four duplicate samples respectively: beta-schardinger dextrin-, Benexate Hydrochloride, beta-schardinger dextrin-and mixture of volatile oil, pure volatile oil, adopting the KBr pressed disc method to measure its infrared spectrum absorbs, relatively the enclose front and back are in the variation of ultrared absworption peak, position and the power that can see the absworption peak of four duplicate samples have nothing in common with each other, and show that clathrate forms.

4. discuss: this experiment adopts saturated water solution method to carry out enclose, and simple to operate, equipment requirements is not high, is convenient to commercial production.In present new drug research,, use the beta-cyclodextrin inclusion compound after drying, again with extract powder and adjuvant molding for preserving the comparatively effective and practical method of volatile ingredient.Adopt the beta-cyclodextrin inclusion compound technology, can reduce the loss of oil, the volatile oil powdered, and increase dissolubility, be convenient to make various dosage forms.

In order to confirm that the extract extract powder adds the oil-based liquid material, to the hygroscopic influence of extract powder, the applicant adopts accelerated tests comparison distinct methods to prepare the moisture situation of capsule content, proves the effectiveness of this method, tests as follows:

The capsule high humility test of several preparation method preparations

1 material and instrument

1.1 material:

1.1.1 medical material is handled: get by weight ratio Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g, Herba Centipedae 780g, be ground into coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, volatile oil in addition device is collected, and volatile oil, medicinal liquid, medicinal residues are standby; Medicinal residues behind Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, the Herba Centipedae extraction volatile oil and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 2 times, each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, being condensed into relative density is the clear paste of 1.05～1.15 (60 ℃), cooling, by 1: 1.5 adding 95% ethanol, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), aeration-drying below 70 ℃ is ground into 60 order fine powders, gets the water soluble ingredient material.

1.1.2 get said extracted performance oil, spray in the above-mentioned water soluble ingredient material, mix homogeneously, filled capsules gets sample 1.

1.1.3 get above-mentioned water soluble ingredient material, add the calcium hydrogen phosphate of water soluble ingredient material 5% percentage by weight, mix homogeneously sprays into said extracted performance oil, mix homogeneously, filled capsules gets sample 2.

1.1.4 get the beta-schardinger dextrin-of 2 times of amounts of said extracted volatile oil, make saturated solution, add the volatile oil that extracts, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate; Add in the above-mentioned water soluble ingredient material, mix homogeneously, filled capsules gets sample 3.

1.1.5 get 2 times of amounts of extraction volatile oil beta-schardinger dextrin-, make saturated solution, add the volatile oil that extracts, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate; Other gets the white oil of water soluble ingredient material 3% percentage by weight of extraction, and add by the equivalent method of progressively increasing and extract the water soluble ingredient material, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, filled capsules gets sample 4.

1.2 equipment: Scout 11 electronic balances, Ao Haosi International Trading Company Ltd;

2 methods and result:

2.1 the test sample opening is put in the constant-temperature enclosed container, places 10 days under respectively at relative humidity 90 ± 5% conditions at 25 ℃, in the 5th day and sampling in the 10th day, accurate test sample weight before and after the weighing test was with investigation test sample moisture pick-up properties.

2.2 the results are shown in Table 4

Each sample high humility test of table 4

As can be seen from the table, sample 1 its weightening finish when the 5th day detects surpasses 5%, though and sample 2,3 did not surpass 5% at the 5th day, and at the 10th day also all above 5%; Have only sample 4 not surpass 5% its weightening finish in the 10th day.Show that thus sample 1,2,3 has higher hygroscopicity, and sample 4 moisture resistances are stronger, can keep the relatively dry of capsule 's content.Sample 4 is according to the capsule of the inventive method preparation, illustrates that the present invention can effectively solve the problem that Chinese medicine is got the object height moisture absorption, and the preparation of making can be guaranteed the stability of product quality.

For the effectiveness of effective ingredient on pharmacology that confirms that this method is extracted, the applicant has carried out relevant pharmacological evaluation relatively, and its experimental result is as follows:

The research of this product nose recovering capsule pharmacodynamic experiment:

1. experiment material

1.1 medicine: this product nose recovering capsule: 0.4/ (hereinafter to be referred as capsule); BIKANG PIAN: 0.35g/ sheet (hereinafter to be referred as tablet), Ankang Pharmaceutical Co., Ltd., Guizhou produces.

1.2 animal: Kunming mouse, 18.0-22.0g, ♂ ♀ is regardless of; The SD rat, 150-250g, ♂ ♀ is regardless of; Cavia porcellus, 400-500g, ♂ ♀ is regardless of.

1.3 strain: beta hemolytic streptococcus, golden Portugal bacterium, Pseudomonas aeruginosa, shigella dysenteriae, colon bacillus.

2. experimental technique and result

2.1 the influence of inflammatory swelling due to the on Carrageenan:

Get body weight 180-220g SD rat, press table 5 dosage gastric infusion, continuous 3d presses capillary tube and amplifies improved method and survey rat toes volume, survey get for 2 times its average as administration before normal volume.0.5h is in rat toes subcutaneous injection 0.05% carrageenin 0.1ml after the last administration, measures 0.5,1,3,5 later on respectively, rat foot volume behind the 7h, and deducting before the administration after the normal volume divided by normal volume with measured value is the swelling rate, the results are shown in Table 5.

The sensible nose recovering capsule of table 5 to the influence of rat carrageenan reaction (X ± S, n=10)

Annotate: compare * P＜0.05, * * P＜0.01 (down together) with the NS group

2.2 influence to the mouse peritoneal capillary permeability:

Get mice by the gastric infusion of dosage shown in the table 6, matched group gavages with the volume normal saline, tail vein injection 0.5%Evans blue 0.2ml behind the administration 30min, lumbar injection 0.2ml 0.12mol/LHac divides the flushing abdominal cavity 2 times with the 10ml normal saline simultaneously, collects washing liquid, add 0.1mol/LNaOH 0.1ml, centrifugal behind the placement 20min, survey trap in ultraviolet spectral photometer 590nm place, the results are shown in Table 6.

The sensible nose recovering capsule of table 6 causes the influence that the abdominal cavity capillary permeability increases (X ± S) to H

2.3 influence to the mice granuloma induced by implantation of cotton pellets:

Get mice, press the gastric infusion of dosage shown in the table 7 respectively, the medicinal hydrocortisone of positive control, 0.5h etherization after the administration, strange portion imbeds the aseptic cotton balls of a 10mg about every Mus, (gentamycin of cotton balls usefulness 1600u/ml concentration soaks aseptic) later every day, gastric infusion was 1 time, continuous 7d, 1h puts to death animal after the last administration, get the granuloma induced by implantation of cotton pellets tissue, put 60 ℃ of dry 3h, two granuloma induced by implantation of cotton pellets tissues about every Mus are merged weigh, and organize a statistical, the results are shown in Table 7.

The sensible nose recovering capsule of table 7 is to the influence of mice granuloma induced by implantation of cotton pellets (X ± S)

2.4 influence to isolated tracheal:

Get Cavia porcellus, shoot dead, immediately outside of belly medisection skin of neck and subcutaneous tissue, cut whole tracheas and put into the culture dish that fills gram one Xiang Shi nutritional solution, wipe out knot and form fatty tissue, the trachea longitudinal incision, current in the crosscut at interval of 3～4 cartilaginous rings, the trachea sheet is strung, with DC-001 type isolated organ analyzer record, bath 25ml, zero-bit pulling force 2.5g in the middle of the monitor, fill 100% oxygen, treat that trachea steadily after, trace one section correct tension curve.Add following medicine successively: 1. add 0.2% histidine (His) 0.1ml, add 18% scorching capsule (or sheet) 0.1ml again; 2. add 0.1 acetylcholine (Ach) 0.1ml, add 18% capsule (or sheet) 0.1ml again, add a kind of medicine after, treat that its pull-up curve tends to be steady after, add a kind of medicine down again, the results are shown in Table 8.

The sensible nose recovering capsule of table 8 is to the tensile influence of isolated tracheal (X ± S)

Annotate: * * represents to contrast before and after the step His (or Ach), P＜0.01; △ △ represents to contrasting P＜0.01 with giving His (or Ach) back behind the medicine.

2.5 vitro antibacterial activity:

Routine operation adopts two times of method dilution medicines, and the plate punch method is surveyed the medicine inhibition zone, and (aperture is 5mm) the results are shown in Table 9.

The sensible nose recovering capsule of table 9 vitro antibacterial activity (unit: mm)

3. brief summary:

Above-mentioned experiment shows that this product nose recovering capsule can significantly resist the foot swelling that carrageenin causes, and then effect reinforcement of dosage increasing, points out this medicine that acute inflammation is had certain antiinflammation; Can significantly suppress mouse peritoneal capillary permeability and mice granuloma induced by implantation of cotton pellets, show that this medicine can reduce oozing out of secretions and prevent the hypertrophy of inflammation tissue, this is used for the treatment of secretions increase that rhinitis causes and the effect of nasal obstruction conforms to clinical; External isolated tracheal chain experiment shows, this product nose recovering capsule can be significantly to anti-inflammatory mediator histamine, the in-vitro antibacterial test shows, this product nose recovering capsule has obvious inhibitory action to golden Portugal bacterium, group B streptococcus, Pseudomonas aeruginosa, shigella dysenteriae, colon bacillus, these antiinflammatories, antibacterial, to suppress the rheuminess effect may be this product nose recovering capsule heat-clearing and toxic substances removing, dispelling wind and eliminating swelling, one of pharmacological basis that sore-throat relieving is sensible.

The specific embodiment:

Embodiments of the invention 1: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and be ground into coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition received preservation; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 24 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the percolation decoct with water 2 times, each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 50,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, colloid mill ground 1 hour, and is dry below 40 ℃, is ground into fine powder, gets cyclodextrin clathrate, standby; Get the white oil of mixture 3% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 2: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition received preservation; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 12 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the percolation decoct with water 1 time, each 3 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 20,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 50 order fine powders, get the water soluble ingredient material, standby; Get the alpha-cyclodextrin that extracts 1 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, colloid mill ground 0.5 hour, and is dry below 40 ℃, is ground into fine powder, gets cyclodextrin clathrate, standby; Get the methyl-silicone oil of mixture 1% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 3: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition received preservation; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 36 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 70 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the percolation decoct with water 3 times, each 1 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 80,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 70 order fine powders, get the water soluble ingredient material, standby; Get the gamma-cyclodextrin that extracts 3 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, colloid mill ground 2 hours, and is dry below 40 ℃, is ground into fine powder, gets cyclodextrin clathrate, standby; Get the vegetable oil of mixture 5% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 4: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder carbon dioxide supercritical fluid extraction volatile oil, 65 ℃ of extraction temperature, extracting pressure 35MPa collects volatile oil; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae were with alcohol reflux 2 times, each 1.5 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the ethanol extraction decoct with water 2 times, each 2 hours, merge decoction liquor, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 95% ethanol, making concentration of alcohol is 65%, stirs, and leaves standstill 24 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the white oil of mixture 3% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 5: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder carbon dioxide supercritical fluid extraction volatile oil, 30 ℃ of extraction temperature, extracting pressure 20MPa collects volatile oil; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae were with alcohol reflux 1 time, each 2 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the ethanol extraction decoct with water 1 time, each 3 hours, merge decoction liquor, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 80% ethanol, making concentration of alcohol is 50%, stirs, and leaves standstill 12 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50 order fine powders, get the water soluble ingredient material, standby; Get the hydroxypropyl-alpha-cyclodextrin that extracts 1 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 0.5 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the methyl-silicone oil of mixture 1% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 6: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder carbon dioxide supercritical fluid extraction volatile oil, 70 ℃ of extraction temperature, extracting pressure 40MPa collects volatile oil; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae were with alcohol reflux 3 times, each 1 hour, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 70 order fine powders, get pure soluble components material, standby; The medicinal residues of getting behind the ethanol extraction decoct with water 3 times, each 1 hour, merge decoction liquor, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 98% ethanol, making concentration of alcohol is 70%, stirs, and leaves standstill 36 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 70 order fine powders, get the water soluble ingredient material, standby; Get the HP-of extracting 3 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 2 hours, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the vegetable oil of mixture 5% weight of the pure soluble components material of extraction and water soluble ingredient material, add the pure soluble components material of said extracted and the mixture of water soluble ingredient material by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 7: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 24 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, ultrasonic 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the white oil of pure soluble components material 3% weight of extraction, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 8: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 12 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 50 order fine powders, get pure soluble components material, standby; Get the hydroxypropyl-gamma-cyclodextrin that extracts 1 times of amount of volatile oil, make saturated solution, add the volatile oil that extracts, ultrasonic 0.5 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the methyl-silicone oil of pure soluble components material 1% weight of extraction, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 9: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae carry out percolation according to the percolation under Chinese Pharmacopoeia 2005 editions appendix IO fluid extract and the extractum item with alcohol dipping after 36 hours, collect percolate to colourless, merge percolate, filter, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 70 order fine powders, get pure soluble components material, standby; Get the methyl-beta-schardinger dextrin-that extracts 3 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, ultrasonic 2 hours, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get the methyl-silicone oil of pure soluble components material 5% weight of extraction, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 10: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae alcohol reflux 2 times, each 1.5 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, aeration-drying below 70 ℃, be ground into 60 order fine powders, get pure soluble components material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, ultrasonic 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction pure soluble components material 3% weight white oil, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 11: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae alcohol reflux 1 time, each 2 hours, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 50 order fine powders, get pure soluble components material, standby; Get the carboxymethyl-beta-cyclodextrin that extracts 1 times of amount of volatile oil, make saturated solution, add the volatile oil of said extracted, ultrasonic 0.5 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction pure soluble components material 1% weight liquid paraffin, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 12: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae alcohol reflux 3 times, each 1 hour, merge reflux extracting liquid, filter, the survey relative density was 1.30～1.35 thick paste when filtrate decompression was concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 70 order fine powders, get pure soluble components material, standby; Get the one chlorotriazine-beta-schardinger dextrin-that extracts 3 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, ultrasonic 2 hours, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction pure soluble components material 5% weight methyl-silicone oil, add the pure soluble components material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 13: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 2 times, each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 50,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil of said extracted, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 3% weight white oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 14: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 1 time, each 3 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 20,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 50 order fine powders, get the water soluble ingredient material, standby; Get the alpha-cyclodextrin of 1 times of amount of extraction volatile oil and the mixture of beta-schardinger dextrin-, make saturated solution, add the volatile oil of said extracted, stirred 0.5 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 1% weight vegetable oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 15: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris, Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 3 times, each 1 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, separate with the ultrafilter membrane that can hold back 80,000 molecular weight, getting when liquid is concentrated into 60 ℃ under the film and surveying relative density is 1.30～1.35 thick paste, and aeration-drying below 70 ℃ is ground into 70 order fine powders, get the water soluble ingredient material, standby; Get the gamma-cyclodextrin of 3 times of amounts of extraction volatile oil and the mixture of hydroxypropyl-alpha-cyclodextrin, make saturated solution, add the volatile oil of said extracted, stirred 2 hours, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 5% weight methyl-silicone oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 16: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 2 times, and each 2 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 95% ethanol, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 60 order fine powders, get the water soluble ingredient material, standby; Get the beta-schardinger dextrin-that extracts 2 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, stirred 1 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 3% weight white oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 17: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 1 time, and each 3 hours, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 80% ethanol, stir evenly, left standstill 12 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 50 order fine powders, get the water soluble ingredient material, standby; Get the methyl-beta-schardinger dextrin-of 1 times of amount of extraction volatile oil and the mixture of carboxymethyl-beta-cyclodextrin, make saturated solution, add the volatile oil that extracts, stirred 0.5 hour, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 1% weight methyl-silicone oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Embodiments of the invention 18: take by weighing medical material Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately and become coarse powder, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decoct with water 3 times, and each 1 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 98% ethanol, stir evenly, left standstill 36 hours, filter, filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, and aeration-drying below 70 ℃ is ground into 70 order fine powders, get the water soluble ingredient material, standby; Get the mixture of the alpha-cyclodextrin, beta-schardinger dextrin-and the gamma-cyclodextrin that extract 3 times of amounts of volatile oil, make saturated solution, add the volatile oil that extracts, stirred 2 hours, dry below 40 ℃, be ground into fine powder, get cyclodextrin clathrate, standby; Get extraction water soluble ingredient material 5% weight vegetable oil, add the water soluble ingredient material of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, make 1000, promptly.

Claims

1, a kind of capsule for the treatment of rhinitis, calculate according to weight, it becomes coarse powder by Herba Inulae cappae 610g, Herba Houttuyniae 780g, Ramulus et Folium Spiraeae Salicifolia 780g, cirsii japonici,radix 780g, Herba Saginae Japonicae 520g, Fructus Liquidambaris 780g and Herba Centipedae 780g and pulverize separately, get Herba Inulae cappae, Herba Houttuyniae, Fructus Liquidambaris and Herba Centipedae coarse powder steam distillation, extract volatile oil, collect volatile oil, medicinal liquid device is in addition preserved; Medicinal residues and Ramulus et Folium Spiraeae Salicifolia, cirsii japonici,radix, Herba Saginae Japonicae decocts with water 1～3 time, each 1～3 hour, remaining medicinal liquid behind merging decoction liquor and the said extracted volatile oil, the survey relative density is 1.05～1.15 clear paste when being concentrated into 60 ℃, and cooling adds 80～98% ethanol, stir evenly, left standstill 12～36 hours, and filtered filtrate recycling ethanol, the survey relative density is 1.30～1.35 thick paste when being concentrated into 60 ℃, aeration-drying below 70 ℃ is ground into 50～70 order fine powders, gets the cyclodextrin that extracts 1～3 times of amount of volatile oil, make saturated solution, add the volatile oil that extracts, stirred 0.5～2 hour, dry below 40 ℃, be ground into fine powder, cyclodextrin clathrate, it is characterized in that: get extraction extract powder 1～5% weight the oil-based liquid material, add the extract powder of said extracted by the equivalent method of progressively increasing, mix homogeneously, last and cyclodextrin clathrate mix homogeneously, encapsulated, promptly.

2. according to the capsule of the described this treatment rhinitis of claim 1, it is characterized in that the oil-based liquid material is liquid paraffin, methyl-silicone oil or vegetable oil.

3, according to the capsule of the described treatment rhinitis of claim 1, it is characterized in that: described cyclodextrin is alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, hydroxypropyl-alpha-cyclodextrin, HP-, hydroxypropyl-gamma-cyclodextrin, methyl-beta-schardinger dextrin-, a kind of or mixture more than 2 kinds in carboxymethyl-beta-cyclodextrin, the one chlorotriazine-beta-schardinger dextrin-.