CN100531751C - External plaster for treating child cold diarrhea and preparing method - Google Patents
External plaster for treating child cold diarrhea and preparing method Download PDFInfo
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- CN100531751C CN100531751C CNB2006100986961A CN200610098696A CN100531751C CN 100531751 C CN100531751 C CN 100531751C CN B2006100986961 A CNB2006100986961 A CN B2006100986961A CN 200610098696 A CN200610098696 A CN 200610098696A CN 100531751 C CN100531751 C CN 100531751C
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Abstract
The present invention discloses a kind of externally applied plaster for treating children's cold type diarrhea and its preparation process. The externally applied plaster is developed based on children's physiological and pathological characteristics and the pathogenesis of cold type diarrhea, and is prepared with ten kinds of Chinese medicinal materials, including atractylodes rhizome, schizonepeta, bupleurum root, etc. and through decoction, concentration, crushing and other steps. It has the functions of invigorating spleen, eliminating wetness, regulating qi, etc. It has obvious curative effect on children's cold type diarrhea, use safety and convenient quality control.
Description
Technical field
The present invention relates to the outer plaster of a kind of treatment diarrheal, particularly a kind of outer plaster for the treatment of child cold diarrhea also relates to the preparation method of above-mentioned outer plaster.
Background technology
Children's's physiological and pathological feature: children's's internal organs are tender and lovely, and shape gas does not fill, adding cold warm can not self-regulated, newborn food can not be from joint, in case nurse inappropriately, the breast food is improper, is then easily hindered by pathogenic factor, so morbidity easily on the pathology.Children's's's " the spleen tending to insufficiency usually, a little less than the fortuneization power, stomach is little and crisp, and is tolerant few " characteristics have determined the spleen and stomach in children to be received the fortuneization function to get muddled easily and suffer from diarrhoea.
The child cold diarrhea etiology and pathogenesis: children's's being invaded by exogenous pathogen or internal damage caused by infantile dyspepsia, all can impairing the spleen and stomach, dysfunction of the stomach and spleen in receiving and transporting, the lifting imbalance, clear QI being mixed up with turbid QI, and walk large intestine, and suffer from diarrhoea.
The normal drainage of food waste matter and the keying degree of having of anus, not only with the taking good care of oneself of kidney qi, the fortuneization of temper and the lucid yang sending up, the becoming thoroughly decomposed and the turbid descending of gastric qi, the conduction of large intestine is closely related, and with the catharsis of irritability, the respectful degradation of lung qi all has substantial connection.
Liver controlling conveyance and dispersion, harmonizing the functional activities of vital QI, the tonneau three warmers are dredged function of gallbladder promoting juice, fail in intestinal, both can help the fortuneization of the spleen, and the gas lift of sun is sent out, and belong to lung on the essence of water and grain; Fail in intestinal; Can help being received of stomach to become thoroughly decomposed again, promote the gas of turbid yin to descend, chyme is assigned in small intestinal.As seen the fortuneization of spleen depends on the catharsis of liver, and the catharsis of liver is normal, and then the fortuneization of spleen is healthy and vigorous.If the liver failing to maintain the normal flow of QI is violated spleen gram stomach, it is not normal to cause the taste ascending or descending movement of vital Qi, and formation is had loose bowels.
Lung governing qi, a surname of lung falls and regulating fluid apssage, helps the spleen transformation of body flaud, when damage of the spleen is wet contain in, lung also can not solely be good for, and must lose its defeated function down, logical accent is obstructed and then wetly must stops to hold and increase the weight of to suffer from diarrhoea.The lung being the upper source of fluids, main Xuan Fasu falls, regulating fluid apssage, a surname opens part of the body cavity above the diaphragm housing the heart and lungs lung qi, helps the tonneau of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels water channel, so be called " source is clearly then flowed self-cleaning ".
Because of children's's physiology and pathological characteristic and adult different, so child cold diarrhea has following characteristics:
1。Easily insufficiency of the spleen, easily stagnant: as during the spleen and stomach in children characteristics decision infantile diarrhea, both to be prone to syndrome of spleen-deficiency, and to have seen that the loose stool color was white, indigestion is done to rush down more than the food back, outbreak repeatedly, clear urine in large amounts, lack of appetite is indigestion and loss of appetite, and food back gastral cavity abdominal distention is vexed does not relax, and shallow complexion is tired etc., be prone to stagnant card again, see loose stool, accompany newborn sheet or indigestible food debris, increased frequency, abdominal distention is desired to rush down during pain, rushes down the back alleviation of pain, and stool acid is smelly, or as losing ovum, belch acid is turned sour, vomiting, lack of appetite or refusing to eat etc.Spleen is void more, and breast is eaten difficult fortuneization and more stagnated; Otherwise, stagnant more hinder the strong fortune of spleen and spleen is more empty, form vicious cycle.
2. easily sick " trembling with fear ", easily sick " wetting ": children's is in pathogenic process, because body belongs to " pure sun ", " young the moon " easily shows the card marquis of " heat ", belongs to " young the moon " again, so easily show the card marquis of " trembling with fear " again.Damp being a kind of YIN pathogen, deep viscous, taste after all.Because the easiest disease of the spleen and stomach in children characteristics decision children's " wets ".Greedy cool cold drink of children's Duo Yin or eating cold and uncooked food excessively melon and fruit, or misapplied and use cold and cool medicine, easy damaged taste yang-energy, excess of YIN due to YANG-insufficiency makes in the cold-damp and gives birth to; The damp pathogenic characteristic: (1) damp pathogen being heavy and turbid in nature is sticky, easily checks mechanism of qi, makes ascending or descending movement of vital Qi not normal; Retention of damp leading to blockage of QI, the stagnation of QI are added with heavily wet resistance; Deadlocked being difficult to resolve, difficult speed is gone; (2) damp being a kind of YIN pathogen, excess of YIN is YANG disease then, so damp causes harm easy damaged yang-energy.Wet because of wet evil of spleen fortune again, so the damp impairment of YANG, the easiest stagnating spleen-YANG makes hypoactivity of spleen-YANG, failure of the spleen to transport and transform, and water is wet to stop gathering, and sends out to having loose bowels.So during child cold diarrhea, be prone to cold-damp syndrome, see that stool is rare clearly, in addition as water sample, the stomachache borborygmus, the vexed lack of appetite of gastral cavity, nausea, tongue is greasy in vain, cards such as relaxed and soft pulse.
3. susceptible wind and cold, the spleen lung is with sick: children's's physiological and pathological feature, decision infant influenza wind and cold, during the wind and cold invasion and attack, (1) easily attacks taste, and it is rare clearly stool to occur, increased frequency, color is light, the folder foam, or color is clear, or color such as duck excrement, foul smell is not very; Just stomachache borborygmus before, paroxysm is cry and screamed, and tongue is white etc.; (2) lung being a delicate viscus, so wind and cold when invasion and attack, lung is got involved more, the nasal obstruction watery nasal discharge occurs, micro evil wind is cold, cough, itching throat, head-body-pain, light red tongue, cards such as white and thin fur.Because the spleen lung be the dirty of mothers and sons, female disease pass in or illness of child viscera affecting mother one, on pathology, influence each other, often the spleen lung is with disease.
The medicine commonly used of commercially available treatment infantile diarrhea: " dioctahedral smectite ", " R-1132 ", " children's is rushed down speed and is stopped " etc., its weak point is: one is to use inconvenience, and compliance is poor, and children's refuses clothes and cries and screams, and often affects the treatment because of the food dose is not enough; The 2nd, can not be preferably at the etiology and pathogenesis of children's's physiological and pathological feature and child cold diarrhea, such as not preferably in depressed liver-energy dispersing and QI regulating, dispersing obstructed lung-QI, expelling wind and cold, invigorating spleen to remove dampness, activating the spleen intestinal stasis relieving, medication is come at the characteristics of child cold diarrhea specially in aspects such as whole adjustment.
The outer plaster of the treatment infantile diarrhea that all kinds of documents are contained, weak point is: the one, can not come medication at the etiology and pathogenesis characteristics of children's's physiological and pathological feature and child cold diarrhea preferably; The 2nd, preparation technology is simple, and at quality control, the preparation stability aspect is unfavorable for the heavy industrialization continuous production.
The outer plaster of commercially available treatment infantile diarrhea, control plaster outside the diarrheal as " DINGHUIER QITIE ", " ERXIEKANG TIEMO " etc., its weak point is: only be conceived to drugs for dispelling internal cold such as Flos Caryophylli, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Evodiae, Fructus Piperis, spleen invigorating warming middle-JIAO, cold expelling antidiarrheal, and the ignorance depressed liver-energy dispersing and QI regulating, dispersing obstructed lung-QI, expelling wind and cold, invigorating spleen to remove dampness, the activating the spleen intestinal stasis relieving, aspects such as whole adjustment.Can not come medication at the etiology and pathogenesis characteristics of children's's physiological and pathological feature and child cold diarrhea preferably.
Summary of the invention
The present invention has overcome the deficiencies in the prior art, provides a kind of easy to use, and accurate measurement is with strong points, and the outer plaster of treatment child cold diarrhea evident in efficacy also provides a kind of preparation method capable of being industrialized for preparing described outer plaster.
At children's's physiological and pathological feature and child cold diarrhea etiology and pathogenesis, the present invention is the outer plaster that is primarily aimed at child cold diarrhea, and component and weight proportion thereof that its material medicine is included are:
Rhizoma Atractylodis 0.5-2, Flos Caryophylli 0.5-2, Herba Schizonepetae 0.3-1, the Rhizoma Atractylodis Macrocephalae 0.3-1.5, Poria 0.3-1.5,, Radix Bupleuri 0.2-1, Radix Platycodonis 0.2-1, the Radix Aucklandiae 0.1-0.5, Herba Bidentis Bipinnatae 0.1-0.5, Folium eucalypti globueli (Eucalyptus globulus Labill.) 0.01-0.1.
In the side: Rhizoma Atractylodis, draw the spleen channel medicine, hot, bitter, warm, function is: a fragrance is pleased stomach, and be amusing and help fortune, the dissipating depression of QI alleviating distention in middle-JIAO, dispersing and eliminating the turbid dampness is just accord with the habit of spleen, ascending the clear and descending the turbid and spleen invigorating activating the spleen; Two diaphoresis expelling cold and relieving exterior syndromes; Modern pharmacological research proves: be good for the stomach (1); (2) regulate the intestines and stomach; (3) antibiotic; Flos Caryophylli, hot, temperature, fragrant, both warming spleen and stomach for dispelling cold, warming the kidney to activate YANG again, modern pharmacological research proves: (1) stimulates gastric mucosa hyperemia, increases to divide secretly, promotes appetite, regulates the intestinal activity; Increase gastric acid and pepsinia and vigor, promote calm (5) broad-spectrum antiseptic of bile secretion (2) antidiarrheal (3) emesis (4), resisiting influenza virus, antifungal; Herba Schizonepetae, fragrance, hot, loose, both expelling pathogenic wind from the body surface, expelling pathogenic factors from the exterior reaches outward, again with wind prevailing over dampness; Modern pharmacological research proves: (1) analgesic, diaphoresis, improve that skin blood circulation (2) is calm, analgesia (3) antiinflammatory (4) is antibiotic, antiviral; Bai Intraoperative, bitter, sweet, warm, air making-up and spleen enlivening, the dampness diuretic is broken off damp and is become the source of life and be good for Jiao in the fortune, gas in the mediation; Modern pharmacological research proves: (1) is regulated gastrointestinal smooth muscle motion (2) diuresis (3) and is regulated sugar and protein metabolism (4) enhancing human body immunity function; Poria, sweet, light, promoting diuresis to eliminate damp pathogen and middle antidiarrheal, spleen invigorating and not feeling frustrated; Modern pharmacological research proves: (1) antipathogen microorganism (2) myenteron (3) diuresis (4) enhancing human body immunity function that relaxes; Radix Bupleuri, hardship, suffering is slightly cold, and is liver, gallbladder, three warmers, percardium is all through guiding drug, one through main gas to reach yang-energy, to reach cloudy gas, declare smooth QI and blood at dirty main blood, rotation important department, smooth Yu Yang and to change the moon that stagnates be can dispersing the stagnated live-QI to relieve the stagnation of QI reaches the irritability bar and smooth; The gas of two sending up the lucid YANG; Three restriction Zhu Xinwen medicines, anti-its warm-dryness syndrome too blocks the heat-transformation patient's condition; Modern pharmacological research proves: (1) is analgesic, and analgesia (2) suppresses antibacterial, virus (3) antiinflammatory (4) strengthens enterokinesia (5) and promotes body's immunological function; Radix Platycodonis, priming is gone into lung meridian, has both opened lung qi dispersing gas, multiple its logical accent, yang invigorating gas and lift sunken again; Modern pharmacological research proves: (1) is analgesic, analgesia (2) antiinflammatory; The Radix Aucklandiae, bitter in the mouth, gas fragrance and the hot temperature of loosing is logical, its function is: the intestines and stomach of manage it stagnate gas declare in transferring stagnant, promoting the circulation of QI to relieve pain; Two energy dampness are controlled and are let out real large intestine; Three energy dispersing the stagnated live-QI to relieve the stagnation of QI; Modern pharmacological research proves: (1) is excited and suppress the two-ways regulation gastrointestinal motility; (2) facilitating digestion liquid secretion; (3) antibiotic; Herba Bidentis Bipinnatae, bitter, warm, both heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling again; Modern pharmacological research proves: (1) is antibiotic; (2) antiulcer, hemostasis; Folium eucalypti globueli (Eucalyptus globulus Labill.), hardship, hot, cool, function is: one, can ease pain by wind dispelling the damp eliminating detoxifcation; Two, anticorrosion, the deodorization of energy, sterilization, parasite killing; Three, anti-its warm-dryness syndrome of assistant system Zhu Xinwen medicine too blocks the heat-transformation patient's condition; Modern pharmacological research proves: (1) contains tannic acid, and the hypostypsis effect is arranged; (2) analgesic, analgesia; (3) decoct has wider antimicrobial spectrum; (4) enhancing human body immunity function; (5) its volatile oil can promote drug transdermal to absorb.All medicine phases 5, warming spleen and stomach for dispelling cold, dispelling wind leads to lung, depressed liver-energy dispersing and QI regulating, invigorating spleen to remove dampness, the activating the spleen intestinal stasis relieving removes wind and cold, and humidity hysteresis is dispelled, and makes and rises turbid falling clearly, the unobstructed and all card spontaneous recovery of mechanism of qi.
The raw material of described outer plaster can also comprise: substrate, as: vaseline, lanoline etc., plasticizer, as: glycerol etc., surfactant, as: Arlacel-20 etc., transdermal enhancer, as: azone, propylene glycol, Borneolum Syntheticum, Mentholum etc.In preparation process, also comprise the medicine carrying body of forcing on, as: medical gluing non-woven fabrics, antiseepage film and antiseepage circle paster, separate paper etc.
The preparation method of described outer plaster may further comprise the steps:
(1). add the volatile oil of water distillation and extraction part Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor, concrete steps are: the eucalyptus globulus charge ratio takes by weighing described each medicine, get 1/5 to 4/5 of the required weight of Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor respectively, add the water distillation and collect volatile oil, distillatory purpose mainly is to collect volatile oil, described volatile oil not only has the obvious treatment effect, and is good rapid transdermal promoter.Preferably 5-10 hour distillatory time; It is standby to distill remaining medicinal liquid in back and medicinal residues separation back;
(2). decoct the full dose of Herba Bidentis Bipinnatae, Poria, Radix Platycodonis 3 flavor medicines, behind described decocting liquid and the medicinal liquid mixing in (1) step, be condensed into clear paste, concrete steps are: get the full dose of Herba Bidentis Bipinnatae, Poria, Radix Platycodonis 3 flavor medicines, also can add the medicinal residues in (1) step, decoct with water twice, collecting decoction, each preferably 1-1.5 hour time that decocts is with described decocting liquid and the medicinal liquid mixing in (1) step, simmer down to clear paste; The relative density of described clear paste is preferably 1.21-1.30 (50-60 ℃);
(3). get 7 each medicine remainder of flavor in (1) step, it is ground into fine powder A, as: pulverize and be 80-200 purpose fine powder A;
(4). clear paste in (2) step and the fine powder A in (3) step are in harmonious proportion, dry, pulverize again and be the acceptable fine powder B of poultice, concrete steps are: evenly admix the fine powder A in (3) step in the clear paste in (2) step, put into drying baker, carrying out drying below 60 ℃, water content is reached below 6%, after discharging is cooled to room temperature, is ground into 80-200 purpose fine powder B, and weighs;
(5). get an amount of substrate heat fused, again with the fine powder B in (4) step, plasticizer, surfactant, transdermal enhancer and collect in (1) step the volatilization wet goods, gradation adds gradually, the limit edged stirs, and makes poultice behind the mix homogeneously, loads on the plaster medicine carrying body to get final product.Described system cream process is common process, the best approach is: get the vaseline that accounts for fine powder B weight 42-90% and lanoline heat fused in water-bath of 8-10%, filter, when being chilled to 58-82 ℃, constantly stir, silk ribbon attached to an official seal or a medal adds fine powder B slowly, under 45-55 ℃ of condition, constantly stirs, add the glycerol that accounts for fine powder B weight 1-2% respectively, account for the Arlacel-20 of fine powder B weight 1-2%, account for the azone of fine powder B weight 1-2%, account for the propylene glycol of fine powder B weight 5-8% and the volatile oil of collection, when waiting to be chilled to 35-42 ℃, add Borneolum Syntheticum that accounts for fine powder B weight 1-2% and the Mentholum that accounts for fine powder B weight 1-2% (the two grinds the liquefaction back and adds) again, constantly stir, fully mixing, after being the uniform paste of color and luster, the stand is applied on the antiseepage film of the intermediary antiseepage circle of gluing nonwoven base fabric, covers separate paper, and packing promptly gets product.
In above-described prescription and the preparation method, described Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, Poria, this Chinese medicine of the five flavours of the Radix Aucklandiae can be replaced with following traditional Chinese medicines, can reach identical curative effect: the Rhizoma Atractylodis of 0.5-2 weight portion can be used any one replacement in Herba Pogostemonis, Fructus Amomi, Bai Fructus Amomi Rotundus, Cao Fructus Amomi Rotundus, Fructus Tsaoko or the Folium Perillae of equivalent; 0.5-2 the Flos Caryophylli of weight portion can be used any one replacement in Cortex Cinnamomi, Radix orixae japonicae, Fructus Evodiae, Fructus Piperis Longi, Pericarpium Zanthoxyli, Rhizoma Alpiniae Officinarum, Rhizoma Zingiberis or the Folium Artemisiae Argyi of equivalent; 0.3-1 the Herba Schizonepetae of weight portion can be with any one replacement in Herba Ephedrae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae or the Rhizoma Et Radix Notopterygii of 0.1-0.3 weight portion; 0.3-1.5 the Poria of weight portion can be replaced with the Semen Coicis of 0.6-3 weight portion; 0.1-0.5 the Radix Aucklandiae of weight portion can be used any one replacement in equivalent Herba Asari, Rhizoma Kaempferiae, Radix Et Rhizoma Nardostachyos or the Lignum Santali Albi.
In order to the outer plaster of the treatment child cold diarrhea of top method preparation, specification is: every subsides dose is the 1.5-3 gram, and the best is 2 grams.
In order to the outer plaster of the treatment child cold diarrhea of top method preparation, character: this product is the circular ointment of sepia, fragrant odour.
The outer plaster of the present invention's prescription also can be by cataplasma, and the infrared ray nanometer is pasted, rubber plaster, electronic medicinal plaster, the Different Preparation production of different exterior patch such as magnet therapeutic plaster.
The outer plaster of treatment child cold diarrhea of the present invention, its function is: invigorating spleen to remove dampness, in the accent of regulating the flow of vital energy, cold expelling antidiarrheal.Cure mainly: the defecation frequency that children's's being invaded by exogenous pathogen or internal damage caused by infantile dyspepsia etc. cause increases, and excrement matter is thin or rush down down as water sample, stomachache, and abdominal distention, poor appetite, Mental fatigue, light red tongue, Tai Bai or companion's nasal obstruction watery nasal discharge, micro evil wind is trembled with fear, cards such as head-body-pain.
The outer plaster of treatment child cold diarrhea of the present invention, wet partially in the time of also can be at child cold diarrhea, cold partially, different characteristics such as stagnant, inclined to one side void partially increases and decreases other relevant herbal raw materials, comprises the increase and decrease drug dose.
Usage and dosage: be affixed on umbilical part, one time one subsides, per 24 hours are once, once-a-day.Also can be affixed on caves such as the middle part of gastric cavity, Tianshu, tsu san li, Zhangmen, described acupuncture point is the treatment diarrheal and wants the cave, not only can make the efficacy of a drug sick institute that goes directly, also can make the efficacy of a drug from outward appearance to inner essence, under the dual function of medicine and meridians effect, play, with regulating YIN and YANG, internal organs, QI and blood and cure diseases.
Advantage of the present invention:
1. show by pharmacodynamics test that our medicine has the promotion gastric secretion, regulate gastrointestinal motility, spasmolytic, analgesia, the effect that improves immunologic function.
2. show our medicine avirulence performance by animal acute toxicity test.
3. by skin irritation, mucous membrane irritation and sensitization of skin test show, our medicine nonirritant, no sensitization.
4. pass through 800 routine administration clinical observations, our medicine was treated in 3 days, cure rate 91.25%, total effective rate 98.25%, evident in efficacy, medication is easy, and is safe and reliable, solve children's and feared the problem that pin is refused to take medicine, but also be convenient to control of quality, helped the heavy industrialization continuous production.
5. find in the clinical practice: to just at quiet or intramuscular injection treatment diarrheal infant, dialectical accurately after, paste treatment with this diarrhoea, can effectively shorten the course of disease, reduces by quiet or intramuscular injection number of times, raising cure rate, minimizing relapse rate.
The specific embodiment:
Below, come the outer plaster and the preparation method of treatment child cold diarrhea of the present invention are further specified by specific embodiment:
Embodiment 1:
The raw material of outer plaster of the present invention is formed and consumption is: Rhizoma Atractylodis 50 grams, Flos Caryophylli 200 grams, Herba Schizonepetae 30 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Poria 30 grams, Radix Bupleuri 60 grams, Radix Platycodonis 70 grams, the Radix Aucklandiae 30 grams, Herba Bidentis Bipinnatae 10 grams, Folium eucalypti globueli (Eucalyptus globulus Labill.) 1 gram.
Preparation method is:
(1) the eucalyptus globulus charge ratio takes by weighing described each medicine, gets 4/5 of the required weight of Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor respectively, adds water distillation 5 hours, collects volatile oil, will distill the separation of remaining medicinal liquid in back and medicinal residues after, standby;
(2) get the full dose of Poria, Radix Platycodonis, Herba Bidentis Bipinnatae 3 flavor medicines, add the medicinal residues in (1) step, decoct with water twice, collecting decoction, each time that decocts is 1 hour, the medicinal liquid mixing during described decocting liquid is gone on foot with (1), simmer down to clear paste; The relative density of described clear paste is 1.21 (50-60 ℃);
(3). get 7 each medicine remainder of flavor in (1) step, it is ground into 80 purpose fine powder A;
(4). in the clear paste in (2) step, evenly admix the fine powder A in (3) step, put into drying baker, under 55-60 ℃ of conditions, carry out drying, make water content reach discharging in 5.8% o'clock, be ground into 80 purpose fine powder B after being cooled to room temperature, and 158 grams of weighing;
(5) get 66.4 gram vaseline, 12.7 gram lanolines heat fused in water-bath filters, when being chilled to 58-82 ℃, constantly stir, slowly add fine powder B, under 44-55 ℃ of ℃ of conditions, constantly stir, add 1.6 gram glycerol respectively, 1.6 gram Arlacel-20s, 1.6 gram azones, the volatile oil of 8 gram propylene glycol and collection, wait to be chilled to 35-42 ℃, add the 1.6 gram Borneolum Syntheticums and the 1.6 gram Mentholums that have ground liquefaction again, constantly stir, abundant mixing, after being the uniform paste of color and luster, get 2 grams for a, the stand is applied on the interior antiseepage film of the intermediary antiseepage circle of gluing nonwoven base fabric, cover separate paper, packing promptly gets product.
Embodiment 2:
The raw material of outer plaster of the present invention is formed and consumption is: Rhizoma Atractylodis 100 grams, Flos Caryophylli 100 grams, Herba Schizonepetae 100 grams, the Rhizoma Atractylodis Macrocephalae 150 grams, Poria 150 grams, Radix Bupleuri 100 grams, Radix Platycodonis 20 grams, the Radix Aucklandiae 50 grams, Herba Bidentis Bipinnatae 50 grams, Folium eucalypti globueli (Eucalyptus globulus Labill.) 5 grams.
Preparation method is:
(1) the eucalyptus globulus charge ratio takes by weighing described each medicine, gets 1/2 of the required weight of Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor respectively, adds water distillation 7 hours, collects volatile oil, will distill the separation of remaining medicinal liquid in back and medicinal residues after, standby;
(2) get the full dose of Poria, Radix Platycodonis, Herba Bidentis Bipinnatae 3 flavor medicines, add the medicinal residues in (1) step, decoct with water twice, collecting decoction, each time that decocts is 1.2 hours, the medicinal liquid mixing during described decocting liquid is gone on foot with (1), simmer down to clear paste; The relative density of described clear paste is 1.24 (50-60 ℃);
(3). get 7 each medicine remainder of flavor in (1) step, it is ground into 140 purpose fine powder A;
(4). in the clear paste in (2) step, evenly admix the fine powder A in (3) step, put into drying baker, under 55-60 ℃ of conditions, carry out drying, make water content reach discharging in 5.5% o'clock, be ground into 140 purpose fine powder B after being cooled to room temperature, and 282 grams of weighing;
(5) get 197 gram vaseline, 25.1 gram lanolines heat fused in water-bath filters, when being chilled to 58-82 ℃, constantly stir, slowly add fine powder B, under 44-55 ℃ of ℃ of conditions, constantly stir, add 4.2 gram glycerol respectively, 4.2 gram Arlacel-20s, 4.2 gram azones, 16.9 the volatile oil of gram propylene glycol and collection, wait to be chilled to 35-42 ℃, add the 4.2 gram Borneolum Syntheticums and the 4.2 gram Mentholums that have ground liquefaction again, constantly stir, abundant mixing, after being the uniform paste of color and luster, get 2 grams for a, the stand is applied on the interior antiseepage film of the intermediary antiseepage circle of gluing nonwoven base fabric, cover separate paper, packing promptly gets product.
Embodiment 3
The raw material of outer plaster of the present invention is formed and consumption is: Rhizoma Atractylodis 200 grams, Flos Caryophylli 50 grams, Herba Schizonepetae 65 grams, the Rhizoma Atractylodis Macrocephalae 76 grams, Poria 70 grams, Radix Bupleuri 20 grams, Radix Platycodonis 100 grams, the Radix Aucklandiae 10 grams, Herba Bidentis Bipinnatae 36 grams, Folium eucalypti globueli (Eucalyptus globulus Labill.) 10 grams.
Preparation method is:
(1) the eucalyptus globulus charge ratio takes by weighing described each medicine, gets 1/5 of the required weight of Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor respectively, adds water distillation 10 hours, collects volatile oil, will distill the separation of remaining medicinal liquid in back and medicinal residues after, standby;
(2) identical with (2) among the embodiment 1, be each decocting time be 1.5 hours, the relative density of the clear paste after concentrating is 1.30 (50-60 ℃);
(3). get 7 each medicine remainder of flavor in (1) step, it is ground into 200 purpose fine powder A;
(4). in the clear paste in (2) step, evenly admix the fine powder A in (3) step, put into drying baker, under 55-60 ℃ of conditions, carry out drying, make water content reach discharging in 5.2% o'clock, be ground into 200 purpose fine powder B after being cooled to room temperature, and 235 grams of weighing;
(5) get 211.5 gram vaseline, 23.5 gram lanolines heat fused in water-bath filters, when being chilled to 58-82 ℃, constantly stir, slowly add fine powder B, under 44-55 ℃ of ℃ of conditions, constantly stir, add 4.7 gram glycerol respectively, 4.7 gram Arlacel-20,4.7 the gram azone, the volatile oil of 18.8 gram propylene glycol and collection waits to be chilled to 35-42 ℃, add the 4.7 gram Borneolum Syntheticums and the 4.7 gram Mentholums that have ground liquefaction again, other steps are identical with (5) among the embodiment 1.
Embodiment 4:
Change 50 gram Rhizoma Atractylodis among the embodiment 1 into the equivalent Herba Pogostemonis, 30 gram Herba Schizonepetae change 10 gram Herba Ephedraes into, and the 30 gram Radix Aucklandiae change the equivalent Herba Asari into, and all the other raw materials and preparation method are with embodiment 1.
Embodiment 5:
Change 100 gram Flos Caryophyllis among the embodiment 2 into the equivalent Cortex Cinnamomi, or Radix orixae japonicae, Fructus Evodiae, Fructus Piperis Longi, Pericarpium Zanthoxyli, Rhizoma Alpiniae Officinarum, Rhizoma Zingiberis, Folium Artemisiae Argyi, 150 gram Poria change 300 gram Semen Coiciss into, and all the other raw materials and preparation method are with embodiment 2.
Embodiment 6:
Change 200 gram Rhizoma Atractylodis among the embodiment 3 into the equivalent Fructus Amomi, all the other raw materials and preparation method are with embodiment 3.
Embodiment 7:
The outer plaster of above embodiment shows by pharmacodynamics test that all our medicine has the promotion gastric secretion, regulates gastrointestinal motility, spasmolytic, analgesia, the effect that improves immunologic function.Show our medicine avirulence performance by animal acute toxicity test.By skin irritation, mucous membrane irritation and the test of sensitization of skin degree show our medicine nonirritant, no sensitization.
By to 800 routine administration clinical observations, in the our medicine treatment 3 days, cure rate 91.25%, total effective rate 98.25%, evident in efficacy, medication is easy, and is safe and reliable, solve children's and feared the problem that pin is refused to take medicine, but also be convenient to control of quality, helped the heavy industrialization continuous production.
Clinical report
With year June in August, 1996 to 2006, adopt the outer plaster treatment of the present invention child cold diarrhea 800 examples, and set up matched group 400 examples to carry out observation of curative effect, get and imitate well, now report as follows:
1, clinical data
1.1 physical data adopts single at random blind method to be divided into treatment in proper order by prescription on individual diagnosis and organizes 800 examples and matched group 400 examples, general clinical data sees following each table for details:
Table 1 liang group sex, age distribution
The two groups of diarrhoea natural law and the number of times situation of suffering from diarrhoea when table 2 is admitted to hospital
1.2 clinical manifestation sees for details down in the tabulation:
Two groups of diarrhoea, vomiting, poor appetite, cases of dehydration when table 1 is admitted to hospital
| Group | The example number | Abdominal distention | Vomiting | Poor appetite | Dehydration |
| The treatment group | 800 | 279 | 185 | 714 | 192 |
| Matched group | 400 | 136 | 94 | 353 | 98 |
Two groups of Chinese medical discrimination pattern of syndrome distribution situations when table 2 is admitted to hospital
| Group | The example number | Damp syndrome is arranged | Syndrome of spleen-deficiency is arranged | Stagnant card is arranged | Wind-cold syndrome is arranged |
| The treatment group | 800 | 673 | 418 | 495 | 342 |
| Matched group | 400 | 331 | 207 | 249 | 169 |
Two groups of general clinical datas compare, and no difference of science of statistics (P〉0.05), have comparability.
2, during the treatment of two groups of Therapeutic Method,, give oral rehydration saline solution or vein fluid infusion for dehydrator is arranged.
2.1 the treatment group was changed dressings once with the outer plaster treatment of the present invention in 24 hours.
2.2 matched group with commercially available DINGHUIER QITIE treatment, was changed dressings once two groups of equal 3 days one courses of treatment in 24 hours without exception
3, efficacy analysis
3.1 criterion of therapeutical effect is with reference to " People's Republic of China's Chinese medicine industry standard traditional Chinese medical science disease diagnosis criterion of therapeutical effect " related content.Cure: stool is shaped, and just time recovery is normal, clinical symptom disappearance, and the stool microscopy is no abnormal; Take a turn for the better; Times of defecation and moisture reduce, but it is shapeless to defecate, and General Symptoms improves, stool visible Oil globule of microscopy or accidental leukocyte; Invalid; Treatment back times of defecation and moisture does not improve or sx.
3.2 therapeutic outcome sees the following form
The two group of 1 curative effect comparison course of treatment
| Group | The example number | Cure (%) | Take a turn for the better (%) | Invalid (%) | Total effective rate (%) |
| The treatment group | 800 | 730 (91.25) | 56 (7.05) | 14(1.75) | 98.25 |
| Matched group | 400 | 316(79.0) | 43(10.75) | 41(10.25) | 89.75 |
Above result learns by statistics and handles P＜0.01, shows that treatment group and matched group all have significant difference on 1 course cure rate and total effective rate, and treatment group curative effect obviously is better than matched group.Treatment is organized and is not all found toxic and side effects in 800 examples.
4, model case:
Example one: Lee * *, the woman, 2 years old, because of surplus prescription on individual diagnosis the in diarrhoea January, the plain body weakness of the spleen and stomach of infant, every because of the flu or the improper diarrhoea of bringing out of taking food.All will can alleviate behind infusion treatment more than 5 days, this is suffered from diarrhoea and caused behind the cold, fever before January at every turn, through elisa, finds the rotavirus positive in certain higher level hospital, is diagnosed as rotavirus enteritis.Be quiet Andrographolide pin successively, virazole pin etc., Chinese medicine and western medicine such as intramuscular injection interferon and oral dioctahedral smectite, the existing loose stool, every day 5 of still rushing down---7 times.Existing symptom: yellowish complexion shape is thin, and is tired, and lack of appetite is indigestion and loss of appetite, more than food back diarrhoea, and loose stool, indigestion, every day 5---7 times.Health check-up: 36.8 ℃ of axil temperature, the anus color is light, not red pneumonedema, the gauffer tide is sticking, and pale tongue with white fur is greasy, relaxed and soft pulse.Auscultation: cardiopulmonary are no abnormal, bowel sounds active, and stool microscopy: Oil globule ++, leukocyte 1-2/ visual field, erythrocyte (-).Diagnosis: cold-dampness type diarrhoea, syndrome of spleen-deficiency is obvious.Single with the outer plaster external application umbilical part of the present invention.The very night, times of defecation reduced.Check in second day, times of defecation obviously reduces, and stool gradually is shaped, and infant appetite strengthens to some extent, and logotype 3 was pasted afterwards and was gone to a doctor, and stool is shaped, and chromaticness is normal, and 1-2 times/days, the stool microscopy is normal, all disease recoveries from illness.Follow up a case by regular visits to after 3 months, infant diarrhoea is recurrence more not.
Example two: Zhao * *, the man, 9 months, because of infant diarrhoea companion nasal mucus thin nasal discharge was gone to a doctor over 2 days.Existing symptom: paroxysm is cry and screamed, and is diarrhea with loose stool after the borborygmus, and it is rare clearly to defecate, every day 8---and 9 times, the light folder foam of color, indigestion and loss of appetite, lack of appetite, nasal obstruction watery nasal discharge, cough.Health check-up: 36.9 ℃ of axil temperature, the anus color is light, and the gauffer tide is sticking, and abdomen is soft, light red tongue, white and thin fur.Auscultation: cardiopulmonary are no abnormal, bowel sounds active, stool routine examination (-).Diagnosis: wind-cold type diarrhoea.Single the very night, number of times reduced with the outer plaster external application ZHONGWAN acupoint of the present invention, and check in second day has been lined up the shape stool once, and the nasal obstruction watery nasal discharge alleviates, after pasting with 1 again, and all disease recoveries from illness.Follow up a case by regular visits to behind the first quarter moon, infant diarrhoea does not have recurrence.
Example three: a left side * *, the man, 5 years old, the plain body weakness of the spleen and stomach of infant, ate Citrullus vulgaris because of being satiated with food in the feast again after excessive last night, vomits this morning 2 times, suffers from diarrhoea 3 times.Loose stool accompanies the indigestion food debris.Existing symptom: shallow complexion, emaciated physique, spiritlessness and weakness, anorexia.Health check-up: 36.9 ℃ of axil temperature, distension and fullness in the abdomen pain, the anus color is light, the lip pale tongue, tongue is greasy in vain, thready pulse and sliding.Auscultation: cardiopulmonary are no abnormal, bowel sound hyperaction.The stool microscopy has fat drop.Diagnosis: cold diarrhea, insufficiency of the spleen stagnant proof shows.It is single that the very night, times of defecation reduced with the outer plaster external application TIANSHU acupoint (ST25) (bilateral) of the present invention, vomiting, and stomachache disappears.Check in second day has been lined up the shape stool once, and appetite increases, and abdominal distention disappears.After pasting with 2 again, all disease recoveries from illness, the stool microscopy is normal.Follow up a case by regular visits to after 2 months, infant diarrhoea does not have recurrence.
Claims (8)
1. outer plaster for the treatment of child cold diarrhea, the component and the weight portion thereof of its material medicine are:
Rhizoma Atractylodis 0.5-2, Flos Caryophylli 0.5-2, Herba Schizonepetae 0.3-1, the Rhizoma Atractylodis Macrocephalae 0.3-1.5, Poria 0.3-1.5, Radix Bupleuri 0.2-1, Radix Platycodonis 0.2-1, the Radix Aucklandiae 0.1-0.5, Herba Bidentis Bipinnatae 0.1-0.5, Folium eucalypti globueli (Eucalyptus globulus Labill.) 0.01-0.1.
2. outer plaster according to claim 1 is characterized in that, described outer plaster is to prepare by the preparation method that may further comprise the steps:
(1) adds 1/5 to 4/5 Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae of the required weight of water distillation and extraction, the volatile oil of Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor;
(2) full dose of decoction Radix Platycodonis, Poria, Herba Bidentis Bipinnatae 3 flavor medicines behind decocting liquid and the medicinal liquid mixing in (1) step, is condensed into clear paste;
(3) get 7 each medicine remainder of flavor in (1) step, it is ground into fine powder A;
(4) clear paste in (2) step and the fine powder A in (3) step are in harmonious proportion, drying, pulverizing is the acceptable fine powder B of poultice again;
(5) get an amount of substrate heat fused, again with the fine powder B in (4) step, plasticizer, surfactant, transdermal agent and the volatile oil of collecting in (1) step, gradation adds gradually, and the limit edged stirs, and behind the mix homogeneously, makes poultice.
3. outer plaster according to claim 2 is characterized in that, in described (2) step, when medicines were distinguished the flavor of in decoction described 3, the medicinal residues that add in (1) step decocted jointly.
4. according to the preparation method of the arbitrary described outer plaster of claim 1 to 3, may further comprise the steps successively:
(1) adds 1/5 to 4/5 Rhizoma Atractylodis, Flos Caryophylli, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, the Radix Aucklandiae of the required weight of water distillation and extraction, the volatile oil of Folium eucalypti globueli (Eucalyptus globulus Labill.) 7 each medicine of flavor;
(2) full dose of decoction Radix Platycodonis, Poria, Herba Bidentis Bipinnatae 3 flavor medicines behind decocting liquid and the medicinal liquid mixing in (1) step, is condensed into clear paste;
(3) get 7 each medicine remainder of flavor in (1) step, it is ground into fine powder A;
(4) clear paste in (2) step and the fine powder A in (3) step are in harmonious proportion, drying, pulverizing is the acceptable fine powder B of poultice again;
(5) get an amount of substrate heat fused, again with the fine powder B in (4) step, plasticizer, surfactant, transdermal agent and the volatile oil of collecting in (1) step, gradation adds gradually, and the limit edged stirs, and behind the mix homogeneously, makes poultice.
5. preparation method according to claim 4 is characterized in that, in described (2) step, when medicines are distinguished the flavor of in decoction described 3, adds (1) step Chinese medicine slag and decocts jointly.
6. preparation method according to claim 4 is characterized in that,
In described (1) step, the distillatory time is 5-10 hours;
Decoction process in described (2) step is: decoct with water twice, and collecting decoction, each decocting time is 1-1.5 hours, the relative density of described clear paste is 1.21-1.30 in the time of 50-60 ℃.
7. preparation method according to claim 4 is characterized in that,
In described (3) step, described fine powder A is 80-200 purpose fine powders;
In described (4) step, baking temperature is below 60 ℃, and water content is reached below 6%, and discharging is ground into 80-200 purpose fine powder B after being cooled to room temperature.
8. preparation method according to claim 4 is characterized in that,
In described (5) step, described substrate is to account for the vaseline of fine powder B weight 42-90% and 8-10% lanoline, described plasticizer is the glycerol that accounts for fine powder B weight 1-2%, described surfactant is the Arlacel-20 that accounts for fine powder B weight 1-2%, described transdermal enhancer is to account for fine powder B weight 1-2% azone, account for the propylene glycol of fine powder B weight 5-8%, account for the Mentholum of fine powder B weight 1-2% and 1-2% Borneolum Syntheticum; Get described substrate heat fused in water-bath, filter, when being chilled to 58-82 ℃, constantly stir, slowly add fine powder B, under 45-55 ℃ of conditions, constantly stir, add described plasticizer, surfactant respectively, the azone in the transdermal agent and the volatile oil of collection are when waiting to be chilled to 35-42 ℃, add Borneolum Syntheticum and Mentholum in the transdermal agent again, the two grinds the liquefaction back and adds continuous stirring the, fully mixing, after being the uniform paste of color and luster, the stand is applied on the interior antiseepage film of the intermediary antiseepage circle of gluing nonwoven base fabric, covers separate paper, and packing promptly gets product.
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| CN101199599B (en) * | 2007-12-13 | 2011-03-23 | 胡红芳 | Powders medicament for treating paediatrics laxness |
| CN102038750B (en) * | 2010-11-16 | 2013-04-24 | 王志强 | Medicine for treating diarrhea |
| CN102139000B (en) * | 2011-04-02 | 2012-05-09 | 封秀花 | External medicament for treating simple indigestion of children and preparation method thereof |
| CN103479938A (en) * | 2013-09-13 | 2014-01-01 | 李金梅 | Traditional Chinese composition for treating cold-damp affecting spleen diarrhea |
| CN103751685B (en) * | 2013-12-21 | 2016-06-15 | 吴军 | A kind of Chinese medicine treating gastrointestinal cold accumulated gastroenteropathy |
| CN104013756B (en) * | 2014-06-12 | 2017-10-31 | 上海中医药大学附属曙光医院 | A kind of Chinese medicine composition for preventing and treating diarrhoea and application thereof |
| CN104225559B (en) * | 2014-09-29 | 2017-06-27 | 国家电网公司 | A kind of warm navel conditioning navel patch |
| CN109512990A (en) * | 2018-12-17 | 2019-03-26 | 广州英和医疗科技有限公司 | A kind of strong doctor's healthful moxibustion and its preparation method and application for cold sense |
| CN109395012A (en) * | 2018-12-17 | 2019-03-01 | 广州英和医疗科技有限公司 | A kind of strong doctor's healthful moxibustion and its preparation method and application for diarrhea |
| CN109771602A (en) * | 2019-03-07 | 2019-05-21 | 张春梅 | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of diarrhea |
| CN116509824B (en) * | 2023-06-28 | 2023-09-15 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine gel and preparation process thereof |
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