CN100518750C - American ginseng effervescence tablet and its preparation method - Google Patents
American ginseng effervescence tablet and its preparation method Download PDFInfo
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- CN100518750C CN100518750C CNB2005100300929A CN200510030092A CN100518750C CN 100518750 C CN100518750 C CN 100518750C CN B2005100300929 A CNB2005100300929 A CN B2005100300929A CN 200510030092 A CN200510030092 A CN 200510030092A CN 100518750 C CN100518750 C CN 100518750C
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Abstract
The invention provides an American ginseng effervescent tablet and its preparing process, wherein the American ginseng effervescent tablet comprises American ginseng saponin and vitamin C as the principal raw materials, and edible auxiliary materials.
Description
Technical field:
The present invention relates to the health food technology field, be specifically related to a kind of American ginseng effervescence tablet and preparation method.
Background technology:
Radix Panacis Quinquefolii (Radix Panacis Quinquefolii) is the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L., originates in Bei Meizhou, claims Radix Panacis Quinquefolii, panacis quinquefolii radix again.China uses the existing hundreds of years history of Radix Panacis Quinquefolii." Bencao Congxin " record Radix Panacis Quinquefolii " lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst ".Modern study is the composition of clear and definite Radix Panacis Quinquefolii, think that the Radix Panacis Quinquefolii master contains ginsenoside ginsenoside R0, Rb1, Rb2, Rc, Rd, Re etc., can refresh oneself, beneficial brain, heart tonifying, anticoagulant, main health care is: 1) antifatigue effect: obviously eliminate organism fatigue, regain one's vigor; 2) anoxia enduring prolongs the body anoxia; 3) immunoregulation effect, health invigorating.Tumour patient, hepatitis patient, diabetes patient, coronary disease patient, chronic gastritis and health can be taken per capita.Radix Panacis Quinquefolii is all-ages, and the four seasons all can take, and can nourish for a long time, have been put into to can be used for health food regulation category.
Vitamin C is the human body essential vitamin, and the normal person then can cause avitaminosis as if Deficiency of Intake, increased capillary permeability, and severe patient causes vitamin C deficiency.
Therefore, be raw material how with Radix Panacis Quinquefolii and vitamin C, in order to replenish body vitamin C, mediator's body immunity function is the problem that everybody pays close attention to, and wishes that exploitation is easy to take the Radix Panacis Quinquefolii health food that is easy to carry about with one especially.
Summary of the invention:
Technical problem to be solved by this invention is research design Radix Panacis Quinquefolii and ascorbic novel formulation.
The invention provides a kind of American ginseng effervescence tablet.American ginseng effervescence tablet of the present invention is made up of Radix Panacis Quinquefolii saponin, vitamin C and edible adjuvant.
The proportioning of the each component of American ginseng effervescence tablet of the present invention sees the following form:
American ginseng effervescence tablet formula for a product table
The weight sum of above-mentioned each component is absolutely.
Another object of the present invention provides a kind of preparation method of American ginseng effervescence tablet, and this method comprises the following steps:
(1) get essence, 10 times of amounts of 75% ethanol dissolve the essence alcoholic solution;
(2) Radix Panacis Quinquefolii saponin and 60% diluent (60 order) mix homogeneously are wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 1;
(3) it is even to get the mixing diluents of effervescent carbon dioxide source and 40%, is wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 2;
(4) getting effervescent acid source, vitamin C, sweeting agent (being 60 orders) mix homogeneously, is wetting agent with 1/3 essence alcoholic solution and 95% ethanol of measuring, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate get granule 3;
(5), add lubricant, fine powder (60 order), mix homogeneously with granule 1,2,3 mix homogeneously;
(6) tabletting, packing;
(7) Co60 radiation sterilization.
Product of the present invention can be used for mediator's immunologic function, and the VitC of additional needed by human, and health and enhancement immunity are had bigger effect.In addition, because of product of the present invention is an effervescent tablet preparation formulation, taking convenience, the old and the young like, have broad application prospects.
Process chart of the present invention is seen accompanying drawing.
Produce " American ginseng effervescence tablet " according to prescription provided by the present invention and preparation technology and obtain good effect, Three batches of pilot scale setting-outs all reach the set goal.
By stipulating under Chinese Pharmacopoeia version appendix in 2000 the tablet item, to outward appearance, the tablet weight variation of this product three batch samples, collapse Solution time limit, microbial limit check that the result all meets the pharmacopeia regulation.
(1) outward appearance
(2) tablet weight variation
(3) disintegration time limited (60 ℃ of effervesces should be 3 minutes disintegration time limited)
(4) microorganism checking
The inventive method and other American Ginseng preparation relatively have following effect:
(1) effervescent tablet is to take with the solution form, and drug effect is rapid, has improved greatly bioavilability;
(2) enlarge the adaptation population, be particularly suitable for the patient of children, the elderly and the solid pharmaceutical preparation of can not swallowing;
(4) compare with liquid preparation easy to carry.
Example one
Preparation method:
(1) get essence, 10 times of amounts of 75% ethanol dissolve the essence alcoholic solution;
(2) Radix Panacis Quinquefolii saponin and 60% lactose (60 order) mix homogeneously are wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 1;
(3) getting the lactose mix homogeneously of sodium bicarbonate and 40%, is wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 2;
(4) getting tartaric acid, vitamin C, orange flavor essence (being 60 orders) mix homogeneously, is wetting agent with 1/3 essence alcoholic solution and 95% ethanol of measuring, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate get granule 3;
(5), add corn starch, fine powder (60 order), mix homogeneously with granule 1,2,3 mix homogeneously;
(6) tabletting, packing;
(7) Co60 radiation sterilization.
Example two
Preparation method:
(1) get essence, 10 times of amounts of 75% ethanol dissolve the essence alcoholic solution;
(2) Radix Panacis Quinquefolii saponin and 60% mannitol (60 order) mix homogeneously are wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 1;
(3) getting the mannitol mix homogeneously of sodium carbonate and 40%, is wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 2;
(4) getting fumaric acid, vitamin C, orange flavor essence (being 60 orders) mix homogeneously, is wetting agent with 1/3 essence alcoholic solution and 95% ethanol of measuring, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate get granule 3;
(5), add polyethylene glycol 6000, fine powder (60 order), mix homogeneously with granule 1,2,3 mix homogeneously;
(6) tabletting, packing;
(7) Co60 radiation sterilization.
Example three
Preparation method:
(1) get essence, 10 times of amounts of 75% ethanol dissolve the essence alcoholic solution;
(2) Radix Panacis Quinquefolii saponin and 60% sorbitol (60 order) mix homogeneously are wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 1;
(3) getting the sorbitol mix homogeneously of sodium bicarbonate and 40%, is wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 2;
(4) getting anhydrous citric acid, vitamin C, orange flavor essence (being 60 orders) mix homogeneously, is wetting agent with 1/3 essence alcoholic solution and 95% ethanol of measuring, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate get granule 3;
(5), add Macrogol 4000, fine powder (60 order), mix homogeneously with granule 1,2,3 mix homogeneously;
(6) tabletting, packing;
(7) Co60 radiation sterilization.
Claims (4)
1, a kind of American ginseng effervescence tablet is characterized in that this American ginseng effervescence tablet is that raw material and edible adjuvant are made by Radix Panacis Quinquefolii saponin and vitamin C, and the proportioning of each component is the mg/ sheet:
Content mg/ sheet
Radix Panacis Quinquefolii saponin 10.0-50.0
Vitamin C 30.0-70.0
Effervescent acid source 1000.0-1500.0
Effervescent carbon dioxide source 500.0-1000.0
Diluent 400.0-800.0
Sweeting agent 10.0-22.0
Essence 2.0-7.0
100.0500.0
Lubricant.
2, a kind of American ginseng effervescence tablet according to claim 1 is characterized in that wherein said effervescent acid source is anhydrous citric acid, tartaric acid or fumaric acid; The effervescent carbon dioxide source is sodium bicarbonate or sodium carbonate.
3, a kind of American ginseng effervescence tablet according to claim 1 is characterized in that wherein said diluent is mannitol, sorbitol or lactose; Sweeting agent is aspartame, stevioside or sucrose; Essence is orange flavor essence; Lubricant is polyethylene glycol 6000, Macrogol 4000 or corn starch.
4, a kind of preparation method of American ginseng effervescence tablet according to claim 1: it is characterized in that this method comprises the following steps:
(1) get essence, 10 times of amounts of 75% ethanol dissolve the essence alcoholic solution;
(2) Radix Panacis Quinquefolii saponin and 60% diluent 60 order mix homogeneously are wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 1;
(3) it is even to get the mixing diluents of effervescent carbon dioxide source and 40%, is wetting agent with essence alcoholic solution and 95% ethanol of 1/3 amount, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate must granule 2;
(4) getting effervescent acid source, vitamin C, sweeting agent and all cross 60 mesh sieve mix homogeneously, is wetting agent with 1/3 essence alcoholic solution and 95% ethanol of measuring, the system soft material, and 20 mesh sieves are granulated, 60 ℃ of dryings, 16 mesh sieve granulate get granule 3;
(5) with granule 1,2,3 mix homogeneously, add lubricant, sieve 60 order fine powders after, mix homogeneously;
(6) tabletting, packing;
(7) Co60 radiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100300929A CN100518750C (en) | 2005-09-28 | 2005-09-28 | American ginseng effervescence tablet and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100300929A CN100518750C (en) | 2005-09-28 | 2005-09-28 | American ginseng effervescence tablet and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1762399A CN1762399A (en) | 2006-04-26 |
| CN100518750C true CN100518750C (en) | 2009-07-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100300929A Expired - Fee Related CN100518750C (en) | 2005-09-28 | 2005-09-28 | American ginseng effervescence tablet and its preparation method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103462002A (en) * | 2013-08-13 | 2013-12-25 | 深圳市麦金利实业有限公司 | Vitamin c effervescent tablet and preparation method thereof |
| CN112546081A (en) * | 2021-01-26 | 2021-03-26 | 吉林农业科技学院 | Ginseng effervescent tablet and preparation method thereof |
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Granted publication date: 20090729 Termination date: 20130928 |