CN100518723C - Composition for capsule film, capsule film, and capsule made with the same - Google Patents
Composition for capsule film, capsule film, and capsule made with the same Download PDFInfo
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- CN100518723C CN100518723C CNB200580012782XA CN200580012782A CN100518723C CN 100518723 C CN100518723 C CN 100518723C CN B200580012782X A CNB200580012782X A CN B200580012782XA CN 200580012782 A CN200580012782 A CN 200580012782A CN 100518723 C CN100518723 C CN 100518723C
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Abstract
A composition for capsule film formation which is effective in more highly inhibiting a gelatin film from decreasing in solubility with time and which, when applied especially to a soft capsule, imparts sufficient strength to the capsule simultaneously therewith; and a capsule film and a capsule each formed from or with the composition. The composition is characterized by comprising gelatin (A) and an inositol phosphate (B) represented by the general formula C<SUB>6</SUB>H<SUB>12-n</SUB>(H<SUB>2</SUB>PO<SUB>4</SUB>)<SUB>n</SUB> (wherein n is an integer of 1-6).
Description
Technical field
The capsule that the present invention relates to contain capsule shell film composition, the film, capsule of gelatin and use it.
The spy that the application requires on July 30th, 2004 to file an application is willing to 2004-No. 223745 and the spy that filed an application on April 27th, 2005 is willing to 2005-129968 priority, and here cites its content.
Background technology
At medicine and field of food, consider that from safety and intravital instant capacity equal angles using has the gelatine capsule agent of gelatin to be widely adopted in epithelium.Yet, the gelatine capsule agent owing to gelatin molecule and the interaction of filling content or its analyte produce crosslinked etc., the dissolubility of the epithelium that is associated with the bioavailability of effective ingredient has the trend that reduces along with the time easily.This problem particularly contains under the situation of senior unsaturated fatty acid such as crude drug, DHA, EPA, the oils and fats that contains the unsaturated fatty acid residue, mineral, the yeast that contains mineral and vitamin C etc. more serious in filling content.
In order to address the above problem, propose following scheme: (1) adds aminoacid, citric acid, tartaric acid or fumaric acid (patent documentation 1 and 2) to the gelatin epithelium; (2) add amylopectin and polypeptide (patent documentation 3) etc. to the gelatin epithelium.
In addition, as the general issue of soft capsule, known: can not get epithelium adhesion portion and adhere to thickness fully when capsule shaping, the result is that capsular intensity becomes insufficient, content occurs from situations such as the leakage of adhesion portion, capsule breakages.
Patent documentation 1: special public clear 57-No. 30088 communiques
Patent documentation 2: the spy opens clear 59-No. 39834 communiques
Patent documentation 3: the spy opens flat 05-No. 65222 communiques
Summary of the invention
Yet in above-mentioned prior art (1) and (2), the dissolubility that can not fully suppress epithelium reduces.
In addition, improve the effect of soft capsule intensity, also may not be fully satisfied.
The present invention finishes in view of described situation, purpose provide suppress better gelatin epithelium dissolubility in time reduce, particularly under the situation of soft capsule, give the capsule shell film composition of capsule with abundant intensity and the film, capsule and the capsule that use it simultaneously.
Discoveries such as the inventor by cooperate inositol monophosphate in film, capsule, can solve above-mentioned problem, thereby finish the present invention.
That is, being characterized as of capsule shell film composition of the present invention contains gelatin (A) and uses general formula C
6O
6H
12-n(H
2PO
3)
nThe inositol monophosphate (B) of (n represents 1～6 integer in the general formula) expression.
Being characterized as of film, capsule of the present invention contained gelatin (A) and used general formula C
6O
6H
12-n(H
2PO
3)
nThe inositol monophosphate (B) of (n represents 1～6 integer in the general formula) expression.In film, capsule of the present invention, (B) composition preferably contains phytic acid.
Being characterized as of capsule of the present invention has the film, capsule of the invention described above.The filling content of capsule of the present invention contain the oils and fats, the mineral that are selected from crude drug, unsaturated fatty acid, contain the unsaturated fatty acid residue, effective especially when containing the yeast of mineral and in the vitamin C one or more and planting.In addition, as capsule of the present invention, preferably in filling content, cooperate one or more kinds that are selected from phospholipid, amino sugar and the organic acid.And then capsule of the present invention is effective especially when being soft capsule.
Capsule of the present invention can be a soft capsule.
Being characterized as of the manufacture method of above-mentioned soft capsule comprises that modulation contains gelatin (A) at least and uses general formula C
6O
6H
12-n(H
2PO
3)
nThe operation of the capsule shell film composition of the inositol monophosphate (B) of (n represents 1～6 integer in the general formula) expression; By capsule shell film composition modulation film, capsule, between film, capsule, sandwich the filling content, roll, encapsulated operation.
In addition, above-mentioned manufacture method may further include the operation that modulation contains the filling content of one or more kinds that are selected from phospholipid, amino sugar and the organic acid.
By the present invention, can provide suppress better gelatin epithelium dissolubility in time reduce, particularly under the situation of soft capsule, give the capsule shell film composition of capsule with abundant intensity and the film, capsule and the capsule that use it simultaneously.
The specific embodiment
Below, describe the present invention in detail.
" capsule shell film composition, film, capsule "
Capsule shell film composition of the present invention is the compositions that is used to make film, capsule, it is characterized by, and contains gelatin (A) at least and uses general formula C
6O
6H
12-n(H
2PO
3)
nThe inositol monophosphate (B) of (n represents 1～6 integer in the general formula) expression.
Being characterized as of film, capsule of the present invention contained gelatin (A) and used general formula C
6O
6H
12-n(H
2PO
3)
nThe inositol monophosphate (B) of (n represents 1～6 integer in the general formula) expression.
Discoveries such as the inventor, by in the gelatin epithelium, adding inositol monophosphate, can suppress significantly that the epithelium dissolubility in time that causes such as crosslinked reduces because gelatin molecule and the interaction of filling content or its analyte produce, particularly when being soft capsule, because epithelium adhesion portion adheres to thickness sufficient, can give capsule with full intensity, can prevent that content is from situations such as the leakage of epithelium adhesion portion, capsule breakages.
As the gelatin (A) of main component without limits, the known gelatin that can use acid treatment gelatin, alkali treated gelatin, both sexes to handle gelatin, chemical modification gelatin etc., in general capsule, use.These gelatin can use a kind or two or more.
To be collagen protein extract through hydrolysis process gelatin, as hydrolytic reagent, be " acid treatment gelatin " when using hydrochloric acid or sulphuric acid etc. sour, is " alkali treated gelatin " when using alkali such as Calx, is " both sexes processing gelatin " when use acid and alkali.In addition, " chemical modification gelatin " is with organic acid reactions such as the amino of gelatin and succinic acid, fumaric acid and the material that obtains.Wherein, preferably use acid treatment gelatin, alkali treated gelatin.
Inositol monophosphate (B) represents with above-mentioned general formula, and is corresponding with number n=1～6 of the phosphate that imports, and inositol monophosphate, inositol diphosphate, inositoltriphosphoric acid, inositol tetrakisphosphate, inositol five phosphoric acid and phytic acid (phytic acid) are arranged.These materials can use a kind or two or more.
Wherein, reduce and give the better angle of intensity effect and consider, preferably use the material (phytic acid) of material, particularly n=6 of number n=3～6 of phosphate from suppressing dissolubility.
The addition of inositol monophosphate (B) without limits.But, (B) amount of composition is very few, the then possible insufficient performance of the additive effect of this composition (suppressing the effect that dissolubility reduces and give intensity), if too much, particularly when being soft capsule, might occur because the pH of epithelium reduces or the use level of gelatin reduces the situation that waits adhesion between the capsule intensity reduction that caused or the capsule relatively.Therefore, with respect to gelatin (A), preferred 0.05～15 quality % of the amount of the inositol monophosphate in the film, capsule (B), further preferred 1～10 quality %, preferred especially 2～8 quality %.
In capsule shell film composition of the present invention and the film, capsule, except (A) composition with (B) the composition, as required, can also be engaged in normally used various additives in the film, capsule, for example coloring agent such as plasticizer, antiseptic, pigment or titanium oxide, organic acid etc. such as glycerol outside (B) composition of aminoacid, citric acid etc. or Sorbitol.
The capsule shell film composition, for example, can be under the room temperature or the condition of heating by composition and then the various additive mixed dissolutions that add are as required made in water with (A) composition with (B).
Film, capsule roughly can be made by the following, that is, with above-mentioned capsule shell film composition epitheliumization, be configured as the regulation shape, and carry out drying.In the dried film, capsule amount of moisture without limits, preferred 5～20 quality %, preferred especially 7～15 quality %.
The opportunity that the shaping of film, capsule and content are filled is according to the type of capsule and different.The present invention goes for any one in soft capsule, the hard capsule, but preferred especially soft capsule.
When " soft capsule ", cooperate plasticizers such as glycerol and Sorbitol, with the softer film like film, capsule that has increased plasticity, the filling content that is covered, in lining or after the lining, be configured as the regulation shape, thereby make capsule (coating forming).When " hard capsule ", in the harder film, capsule of preprocess established practice setting shape, will fill the content former state and fill, or simple shaping the after filling, thereby capsule made.
Crosslinked etc. soft capsule is effective because gelatin molecule and the interaction of filling content or its analyte produce for relatively easily causing in the present invention.
During soft capsule, for example can make capsule as follows: use rotary soft capsule filling machine, the capsule shell film composition is processed into film like, it is supplied in the roller die from the left and right sides, before striking out the regulation shape, be pressed into the filling content, form and drying.
During hard capsule, for example can use following infusion process to wait and make capsule, promptly, in pure water, dissolve gelatin while stirring, and then add inositol monophosphate, the modulation impregnation liquid, the shaping pin of stainless steel is dipped in this impregnation liquid, and then, the limit is rotated this shaping pin limit and is made its drying.
In capsule shell film composition of the present invention and film, capsule, by cooperating inositol monophosphate (B), significantly having suppressed gelatin epithelium dissolubility in time reduces, particularly under the situation that is soft capsule, by improving the thickness of film, capsule adhesion portion simultaneously, thereby can give the capsule full intensity.
By technology of the present invention, owing to only cooperate inositol monophosphate (B) to get final product in compositions at general known epithelium, thereby can not change manufacture method in the past, just can make capsule, so be preferred.
" capsule "
Being characterized as of capsule of the present invention has the film, capsule of the invention described above.As mentioned above, the present invention goes for any one in soft capsule, the hard capsule, preferred especially soft capsule.
The form of filling content can be a form arbitrarily such as aqueous, suspension, pasty state, Powdered, graininess without limits.During graininess, can be the material that applies the preparation epithelium with the smears.
Capsule of the present invention can be used for various uses such as pharmaceuticals, medical exterior-applied article, health food, normal food, cosmetics, and the composition of filling content can suitably determine according to purposes.
The present invention is by cooperating inositol monophosphate (B) to film, capsule, significantly suppressing epithelium dissolubility in time reduces, particularly under the situation that is soft capsule, the thickness of the adhesion portion by improving film, capsule simultaneously, give capsule with full intensity, no matter which kind of composition of filling content all plays a role.
And then the inventor finds, by cooperate a kind or the more kinds of material that is selected from phospholipid, amino sugar and the organic acid in filling content, can reduce the influence to the film, capsule of filling content, further suppresses epithelium dissolubility in time and reduces.
" phospholipid " is unqualified, can enumerate Phosphatidylserine, phosphatidylcholine (lecithin), phosphatidylinositols, PHOSPHATIDYL ETHANOLAMINE (cephalin), cuorin, phosphatidic acid, (nerve) sphingomyelins and their derivant etc.These materials can use a kind or two or more.
Wherein, from suppressing the angle consideration that dissolubility reduces the effect excellence, preferred PHOSPHATIDYL ETHANOLAMINE and derivant thereof.As the derivant of PHOSPHATIDYL ETHANOLAMINE, monoacyl type (haemolysis type), alkene fundamental mode and then the base portion that can enumerate the PHOSPHATIDYL ETHANOLAMINE that belongs to the diacyl type be by methylated N-methyl type, N, N-diformazan fundamental mode, N-acyl group type etc.
Contain goods as containing one or more phospholipid of planting above-mentioned phospholipid, commercially available have soybean phospholipid (soybean lecithin), lecithin (yolk lecithin) etc., because these materials obtain easily, and the effect excellence, thereby preferred the use.These materials can be that highly finished product also can be semifinished products, also can be hydride or powdery material.
" amino sugar " is unqualified, can exemplify out glycosamine, N-acetyl-glucosamine, galactosamine, N-acetylgalactosamine, N-n acetylneuraminic acid n etc. and have the amino saccharide or the polymer of glycosamine.The chemical compound of the structure that the hydroxyl that particularly, can enumerate chitosan and derivant thereof, poly-galactosamine and derivant thereof etc., has sugar has been replaced by amino.As the derivant of chitosan, can enumerate low-molecular-weight chitosan, high-molecular weight chitosan, chitosan oligosaccharide etc., the material that obtains after chitin is deacetylated can preferably use.Amino sugar can use a kind or two or more.
" organic acid " is unqualified, can enumerate aminoacid such as tryptophan, aspartic acid, glutamic acid, glycine, phenylalanine, arginine, lysine, citric acid, succinic acid, fumaric acid, tartaric acid, lactic acid, malic acid, inositol monophosphate etc.These materials can use a kind or two or more.
Wherein, from suppressing the angle consideration that dissolubility reduces the effect excellence, preferably myo-inositol phosphoric acid, citric acid.Can use above-mentioned material as inositol monophosphate, but especially preferably use phytic acid.
As mentioned above, in filling content, can cooperate at least one in phospholipid, amino sugar, the organic acid, but especially preferably cooperate phospholipid and organic acid.The addition of these materials without limits, if can not give full play to additive effect at least but cross, if too much, then the amount of effective ingredient such as medicine can reduce relatively, therefore, with respect to the total amount of filling content, preferred 0.05～20 quality % of total addition level, further preferred 0.1～10 quality %, preferred especially 0.5～10 quality %.
The composition of which kind of filling content of the present invention all plays a role, because to reduce problem serious for gelatin epithelium dissolubility in the past, therefore to contain in oils and fats, the mineral that is selected from crude drug, unsaturated fatty acid, contains the unsaturated fatty acid residue, the yeast that contains mineral and the vitamin C a kind or more kinds of situation effective especially filling content.
So-called " crude drug ", be with part or all former state of animals and plants mineral etc. or with the degree that does not change character cut off, simple processing modulation such as fragmentation, drying, be used for the material of pharmaceuticals raw material (comprising Chinese medicine, medicine among the people), cosmetic perfume, hot flavorings etc.At this, capsule can also use with the form of its extract, extracting solution or tincture etc. except the crude drug end.
Object lesson as crude drug, can enumerate Cortex malloti japonici, catechu, Aloe, Herba Epimedii, Fructus Foeniculi, Fructus Mume, the Radix Linderae, Folium Vaccinii vitis-idaeae, Radix Curcumae, Fructus rosae multiflorae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Corydalis, prolong the life grass, the Radix Astragali, Radix Scutellariae, Rhizoma Polygonati, Cortex Phellodendri, bark of cherry, Rhizoma Coptidis, Radix Polygalae, Testis et penis callorhini, Hippocampus, Radix Polygoni Multiflori, Rhizoma Curcumae, Radix Puerariae, Rhizoma et radix valerianae, Paullina Cupana (ガ ラ Na), Radix Glycyrrhizae, Radix Platycodonis, Fructus Aurantii Immaturus, Semen Armeniacae Amarum, Fructus Lycii, Herba Schizonepetae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Cassiae, Radix Gentianae, Herba Erodii, Radix Ginseng Rubra, Cortex Magnoliae Officinalis, Calculus Bovis, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Fructus Evodiae, Fructus Schisandrae Chinensis, Radix Bupleuri, Herba Asari, Herba thymi vulgaris, Salvia farinacea, Rhizoma Smilacis Chinensis, crab apple, SHANZHIZI, Fructus Corni, Pericarpium Zanthoxyli, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Rehmanniae, Zibethum, Radix Paeoniae, Fructus Cnidii, Herba Plantaginis, Herba Houttuyniae, sand contracts, Rhizoma Zingiberis Recens, Elettaria cardamomum (L.) Maton, Fructus Ligustri Lucidi, Pheretima, Flos Magnoliae, ground centaury (セ ネ ガ), Rhizoma Chuanxiong, Radix Peucedani, work as medicine, Rhizoma Atractylodis, Cortex Mori, Folium Perillae, Radix Et Rhizoma Rhei, Fructus Jujubae, Flos Caryophylli, uncariae uncis cure ramulus, Pericarpium Citri Reticulatae, Fructus Capsici, Radix Angelicae Sinensis, Radix Codonopsis, Semen Persicae, Pericarpium Citri junoris, hippo, Semen Cuscutae, the Cortex Eucommiae, the Fructus Nandinae Domesticae fruit, Stigma Maydis, Herba Cistanches, Bulbus Allii, Radix Ophiopogonis, the shore Radix Saposhnikoviae, the Rhizoma Pinelliae, anti-nose, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Stephaniae Tetrandrae, Fructus Psoraleae, Cortex Moutan, Flos lupuli (Flos Humuli Lupuli), Herba Ephedrae, Ramulus et Folium Actinidiae Polygamae, Brazil's heavy curtain heavy curtain wood (system イ ラ プ ア マ), the Radix Aucklandiae, Semen Coicis, Arillus Longan, Radix Gentianae, Radix Hyoscyami, Cornu Cervi Pantotrichum, Flos Chrysanthemi, the wheat tender leaf, Flos Carthami, Salacia prinoides (Willd.) DC., Radix Ophiopogonis, ginseng for medicinal use (koryo insam, Tienchi-Ginseng etc.), Folium Artemisiae Argyi, green tea, medicinal herbs class (Folium Ginkgo, Herba Hyperici Monogyni, Flos Matricariae chamomillae, kawa, blue berry, bilberry, plug profit palmitic acid, Sarah west Ya Bu Longjia (サ ラ シ ア オ Block ロ Application ガ), Fructus Resina garciniae, Herba Rosmarini Officinalis, Citrus, periwinkle, Echinacea purpurea Moench etc.) etc. plant, its extract, extracting solution or tincture; With bacterium (sporophore) former state drying and crushing such as the bacterium of Agaricus, Phellinus igniarius (L. ex Fr.) Quel., Ganoderma, JINZHENGU, Schizophyllum commune Franch, Lentinus Edodes, Grifola frondosa, Inonqqus obliquus, Agaricus bisporus, Lyophyllum decastes, Corilus versicolor Quel., oriental cherry bacterium, polypor, Cordyceps, Ganoderma and powder, with the extracting solution of hot water extraction bacterium and extract powder etc.; The animal extract, the hydrolysate after perhaps it being handled, (for example Fel Bovis seu Bubali, chrondroitin, glycosamine, collagen protein, the propolis etc.) such as materials taked from animal nest cave with acid, alkali or enzyme; With wheat bacterium, red wheat bacterium, lactobacillus, acetic acid bacteria, Bacillus natto, yeast etc. make fermentation such as corn, plant, marine products and the extracting solution of fermented product; The Chinese medicine that contains the crude drug combination, for example GEGEN TANG (Radix Puerariae, Fructus Jujubae, Radix Paeoniae, Rhizoma Zingiberis Recens, Herba Ephedrae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Glycyrrhizae), Radix Angelicae Sinensis Radix Paeoniae (Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae, Poria, Rhizoma Atractylodis, Rhizoma Alismatis), eight flavor Radix Rehmanniae (Radix Rehmanniae, Rhizoma Dioscoreae, Poria, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Corni, Rhizoma Alismatis, Cortex Moutan, gun additioner), XIAOQINGLONG TANG (Herba Ephedrae, Rhizoma Zingiberis Recens, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Schisandrae Chinensis, Radix Paeoniae, Radix Glycyrrhizae, Herba Asari, the Rhizoma Pinelliae), Maimendong Tang (Radix Ophiopogonis, Semen oryzae sativae, Radix Dauci Sativae, the Rhizoma Pinelliae, Fructus Jujubae, Radix Glycyrrhizae), JIAWEI XIAOYAO SAN (Radix Angelicae Sinensis, Rhizoma Atractylodis, Radix Bupleuri, SHANZHIZI, Rhizoma Zingiberis Recens, Radix Paeoniae, Poria, Cortex Moutan, Radix Glycyrrhizae, Herba Menthae) etc.
Fill content and can contain in these crude drugs a kind or two or more.
The angle that the effect that reduces from the dissolubility that suppresses epithelium is big considers, the present invention fill content contain Herba Rosmarini Officinalis, the situation of bacterium, Phellinus igniarius (L. ex Fr.) Quel., Lentinus Edodes, Ganoderma and their extracting solution etc. of Citrus, blue berry, bilberry, propolis, Tienchi-Ginseng, koryo insam, Agaricus is effective especially.
" unsaturated fatty acid " without limits, the angle that the effect that reduces from the dissolubility that suppresses epithelium is big considers, the present invention fill content contain carbon number be 14 or more and then carbon number be that the situation of 14～22 long-chain unsaturated fatty acid is effective especially.
Carbon number is 14 or more long-chain unsaturated fatty acid, can enumerate DHA (docosahexenoic acid), EPA (eicosapentaenoic acid), linoleic acid, arachidonic acid, oleic acid, pinolenic acid, eicosatrienoic acid (Δ-5c, 11c, 14c), eicosatetraenoic acid (Δ-5c, 11c, 14c, 17c), jeceric acid (Δ-5t, 9c, 12c), conjugated linoleic acid, eleostearic acid, octadecenoic acid, octadecadienoic acid, docosenoic acid, ricinoleic acid, alpha-linolenic acid, gamma-linolenic acid, behenic acid etc.Fill content and can contain in these unsaturated fatty acids a kind or two or more.Particularly to contain the situation of DHA and/or EPA effective filling content in the present invention.
At this, unsaturated fatty acid can cooperate with the form of the independent products of separated of unsaturated fatty acid, also can cooperate with the form of the oil that contains it.
" oils and fats that contains the unsaturated fatty acid residue " is meant that at least 1 of the greasy fatty acid residue of formation is the oils and fats of unsaturated fatty acid residue.
The greasy oil that contains a kind or two or more unsaturated fatty acid residues, can enumerate soybean oil, Oleum Brassicae campestris, Testa oryzae oil, Oleum Gossypii semen, Oleum sesami, Oleum helianthi, mustard oil, safflower oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, olive oil, Petiolus Trachycarpi oil, Cortex cocois radicis wet goods vegetable oil, animal oil such as fish oil, haco oil, Adeps Bovis seu Bubali, Adeps Sus domestica, butterfat.Fill content and can contain in these oil a kind or two or more.
The oils and fats that contains the unsaturated fatty acid residue also contains a large amount of above-mentioned unsaturated fatty acids (DHA and EPA), and the angle that the effect that reduces from the dissolubility that suppresses epithelium is big considers that the present invention is effective especially in the situation that the filling content contains fish oil.
" mineral " is not particularly limited, and is meant inorganic substances useful on the threpsology, can exemplify out calcium, phosphorus, ferrum, sodium, potassium, magnesium, zinc, selenium and copper etc.Wherein, when element of multivalence was used as the filling content of capsule of the present invention, the thawless angle of the epithelium that obviously produces from can suppress capsule in the past considered that the present invention is more effective under the situation that contains calcium, phosphorus, ferrum, magnesium, zinc, selenium or copper.At this, these mineral can be as the inorganic salt or the organic salt that use in common food.
" yeast that contains mineral " is not particularly limited, and can exemplify out the yeast, the yeast that contains zinc that contain magnesium, contain selenic yeast, contains the yeast of ferrum and contain yeast of copper etc.At this, the yeast that contains mineral is meant the yeast of taking in mineral in the yeast thalline.
In filling content, except mentioned component, can also suitably cooperate normally used additive, for example excipient, bonding agent, disintegrating agent, stabilizing agent, dispersant, coloring agent, flavouring agent, middle carbon chain fatty acid monoglyceride, middle carbon chain fatty acid triglyceride, polyethylene glycols, surfactant (fatty acid glyceride etc.), antioxidant (vitamin E, astaxanthin, catechuic acid etc.) etc. in pharmaceuticals, the food etc. as required.
Capsule of the present invention is owing to have film, capsule of the present invention, and the dissolubility that can significantly suppress in time reduces, and particularly under the situation that is soft capsule, can also give capsule simultaneously with full intensity.
Particularly, by cooperate a kind of being selected from phospholipid, amino sugar and the organic acid or more kinds of in filling content, can further suppress deliquescent reduction, be preferred therefore.Embodiment
Below, enumerate experimental example of the present invention, but the present invention is not limited thereto.
The effect that suppresses the dissolubility reduction of epithelium
" experimental example 1 " (embodiment 1-1,1-2, comparative example 1-1～1-3)
(modulation of gelatin epithelium)
In the 100g pure water, add 100g gelatin and 45g glycerol, make its suction swelling, then at about 80 ℃ of dissolvings down, modulation gelatin solution.In this solution, add the kind shown in the table 1 and the organic acid (concentration in the table is represented for the concentration of constituent total amount (quality %)) of amount, deaeration under reduced pressure after the mixing, modulation capsule shell film composition.
The compositions that obtains is poured on the TLC plate, evenly diffuse into the about 1mm of thickness, drying is 24 hours under 30 ℃, obtains the film like gelatin epithelium of moisture content about 9%.The epithelium that obtains in each example is cut into the small pieces of 1 * 1cm, for following evaluation.
(evaluation)
In serpentine pipe, add DHA (fish oil) 15ml, flood in each example each 2 of synthetic gelatin leather diaphragms, 50 ℃ of preservations.After 1 day and after 2 days, take out the gelatin leather diaphragm, wipe the content that adheres to after, join in 60 ℃ of warm water of 200ml, stirred 2 minutes with agitator.Visualization under static state is by following standard evaluation.
Criterion
(-): the gelatin leather diaphragm dissolves fully, and it is residual to cannot see dissolving fully.
(±): visible minute quantity dissolving is residual.
(+): visible minimal amounts of dissolved is residual.
(++): visible moderate dissolving is residual.
(+++): visible a large amount of dissolving is residual.
(++ ++): the gelatin leather diaphragm does not dissolve fully, and is insoluble fully.
(result)
The result is integrated display in table 1.
In comparative example 1-1～1-3, the gelatin epithelium is insoluble fully after 2 days, relative therewith, be added with the embodiment 1-1 of phytic acid (phytic acid), in 1-2, the gelatin epithelium dissolves fully after 2 days, shows by adding phytic acid, can significantly suppress gelatin epithelium dissolubility in time and reduce.
Table 1
" experimental example 2 " (embodiment 2-1～2-13)
(modulation of soft capsule)
To contain the inositol monophosphate (concentration in the table is represented the concentration (quality %) for total composition) of kind shown in gelatin 45 quality %, glycerol 18 quality %, the table 2 and amount and the film, capsule compositions of water (remainder), similarly modulate with experimental example 1, after the deaeration, left standstill about 10 hours, and supplied manufacturing then in capsule.
With rotary soft capsule filling machine (oval 5 types), fill with the kind that shows in the table and the composition of amount.After the filling, under 27 ℃ of temperature, humidity 50% or lower condition, it is 8% that film, capsule is dried to moisture, makes soft capsule.
Table 2
| Embodiment | The inositol monophosphate that is added with in the epithelium (quality %) | Fill content (amount) |
| 2—1 | Phytic acid (1%) | DHA (fish oil) (300mg) |
| 2—2 | Phytic acid (2%) | DHA (fish oil) (300mg) |
| 2—3 | Phytic acid (5%) | DHA (fish oil) (300mg) |
| 2—4 | Phytic acid (8%) | DHA (fish oil) (300mg) |
| 2—5 | Phytic acid (10%) | DHA (fish oil) (300mg) |
| 2—6 | Phytic acid (4%) | Ganoderma (130mg) Semen Tritici aestivi germ oil (150mg) |
| 2—7 | Phytic acid (4%) | Radix Notoginseng (100mg) propolis (150mg) |
| 2—8 | Phytic acid (2%) | (150mg) EPA (fish oil) is (80mg) for DHA (fish oil) |
| 2—9 | Phytic acid (2%) | Blue berry (120mg) DHA (fish oil) (150mg) |
| 2—10 | Inositol five phosphoric acid (2%) | DHA (fish oil) (300mg) |
| 2—11 | Inositoltriphosphoric acid (2%) | DHA (fish oil) (300mg) |
| 2—12 | Phytic acid (4%) | Vitamin C (100mg) Semen Tritici aestivi germ oil (150mg) |
| 2—13 | Phytic acid (4%) | Heme iron (100mg) contains zinc yeast (50mg) Semen Tritici aestivi germ oil (150mg) |
Give the effect of capsule with intensity
" experimental example 3 " (embodiment 3, comparative example 3)
(modulation of gelatin epithelium and soft capsule)
Modulation contains the gelatin solution (A) of gelatin 45 quality %, glycerol 18 quality %, phytic acid (phytic acid) 1 quality % and water 36 quality %, contain gelatin 45%, glycerol 18 quality %, and the gelatin solution (B) of water 37 quality %, under 80 ℃, dissolve respectively, deaeration, left standstill then about 10 hours.Use gelatin solution (A) reaches (B), is the gelatin epithelium of 0.90mm with rotary soft capsule filling machine (oval 5 types) modulation thickness, fills the DHA (fish oil) of 300mg, and the modulation soft capsule supplies in following evaluation.
(evaluation)
After filling beginning respectively, the filled capsules of filling the No.1～No.7 of mould No.1, No.4, No.7 (back in preceding) from capsule takes out as sample immediately, take out content after, be cut into disk, with having the graduated measurement microscope adhesion portion thickness of thin part, compare.And then, use gelatin solution separately, with filled capsules and above-mentioned similarly the make sample of filling machine work after 1 hour, measure the thickness of the thinnest adhesion portion, compare.Then, calculate adhesion rate, compare by the thickness of this adhesion portion.
(result)
The results are shown in table 3 and the table 4.
With respect to using gelatin solution (B) to modulate capsular comparative example 3, use the gelatin solution (A) that is combined with phytic acid (phytic acid) to modulate capsular embodiment 3 and demonstrate high adhesion rate, confirmed that capsule intensity uprises.
Table 3
The thickness of adhesion portion
(unit: mm)
Table 4
Adhesion rate
(unit: %)
※ adhesion rate (%)=(on average adhere to thickness (mm)/0.90mm) * 100
Industrial applicability
Technology of the present invention can preferably be applicable to the capsule that uses in the fields such as pharmaceuticals, medical exterior-applied article, healthy food, normal food, cosmetics.
Claims (11)
1. the capsule shell film composition is characterized by, and contains gelatin (A) and uses general formula C
6O
6H
12-n(H
2PO
3)
nThe inositol monophosphate (B) of expression, n represents 3,5 or 6 in the general formula, with respect to gelatin (A), the amount of the inositol monophosphate in the film, capsule (B) is 0.05～15 quality %.
2. film, capsule is characterized by, and contains the described capsule shell film composition of claim 1.
3. film, capsule according to claim 2 is characterized by, and (B) composition is a phytic acid.
4. capsule is characterized by, and will fill content and be filled in claim 2 or the 3 described film, capsules and form.
5. capsule according to claim 4 is characterized by, and described filling content contains the oils and fats that is selected from crude drug, unsaturated fatty acid, contains the unsaturated fatty acid residue, contain the yeast of mineral and in the vitamin C one or more.
6. capsule according to claim 4 is characterized by, and described filling content contains mineral.
7. according to claim 4 or 5 described capsules, it is characterized by, fill to contain in the content and be selected from phospholipid, amino sugar and the organic acid one or more.
8. according to each the described capsule in the claim 4～6, it is characterized by, is soft capsule.
9. capsule according to claim 7 is characterized by, and is soft capsule.
10. the manufacture method of the described capsule of claim 8 is characterized by, and comprises the operation of the described capsule shell film composition of modulation claim 1; By described capsule shell film composition modulation film, capsule, between described film, capsule, sandwich the filling content, roll, encapsulated operation.
11. the manufacture method of capsule according to claim 10 is characterized by, and comprises that further modulation contains one or more the operation of filling content that is selected from phospholipid, amino sugar and the organic acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004223745 | 2004-07-30 | ||
| JP223745/2004 | 2004-07-30 | ||
| JP129968/2005 | 2005-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1960717A CN1960717A (en) | 2007-05-09 |
| CN100518723C true CN100518723C (en) | 2009-07-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200580012782XA Active CN100518723C (en) | 2004-07-30 | 2005-07-29 | Composition for capsule film, capsule film, and capsule made with the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100518723C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103059348A (en) * | 2011-10-24 | 2013-04-24 | 三生医药株式会社 | Capsule skin membrane composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0409494A2 (en) * | 1989-07-14 | 1991-01-23 | Sanwa Kagaku Kenkyusho Co., Ltd. | Stabilized composition of phytic acid |
| JP2003169632A (en) * | 2001-12-08 | 2003-06-17 | Sapuri:Kk | Health food containing rice germ oil, yolk oil and phosphatidylserine |
-
2005
- 2005-07-29 CN CNB200580012782XA patent/CN100518723C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0409494A2 (en) * | 1989-07-14 | 1991-01-23 | Sanwa Kagaku Kenkyusho Co., Ltd. | Stabilized composition of phytic acid |
| JP2003169632A (en) * | 2001-12-08 | 2003-06-17 | Sapuri:Kk | Health food containing rice germ oil, yolk oil and phosphatidylserine |
Non-Patent Citations (2)
| Title |
|---|
| 植酸制取工艺研究现状与展望. 杨文玉.中国油脂，第28卷第4期. 2003 |
| 植酸制取工艺研究现状与展望. 杨文玉.中国油脂，第28卷第4期. 2003 * |
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| CN1960717A (en) | 2007-05-09 |
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