CN100516026C - preparation process of amino acid-calcium chelate - Google Patents
preparation process of amino acid-calcium chelate Download PDFInfo
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- CN100516026C CN100516026C CNB2006100962399A CN200610096239A CN100516026C CN 100516026 C CN100516026 C CN 100516026C CN B2006100962399 A CNB2006100962399 A CN B2006100962399A CN 200610096239 A CN200610096239 A CN 200610096239A CN 100516026 C CN100516026 C CN 100516026C
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- calcium
- amino acid
- preparation
- acid chelate
- leucine
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Abstract
The present invention discloses preparation process of amino acid-calcium chelate. Through converting strong acid type cationic exchange resin into calcium type with calcium ion, reacting in column with mixed solution of leucine and sodium hydroxide in the molar ratio of 1 to 0.5-2 at normal temperature, collecting the effluent at the flow rate of 0.05-1 BV/hr, and vacuum concentration to crystallize leucine-calcium chelate. The leucine-calcium chelate has high water solubility, high absorption rate, no stimulation to gastrointestinal tract and other features, and can meet the requirement of human body in replenishing calcium and amino acid. The preparation process has the advantages of low production cost, high conversion rate and high product purity, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of is main raw material with leucine and calcium chloride, produces a kind of method of calcium amino acid chelate, and it belongs to the synthetic organic calcium method of ion exchange method of using.
Background technology
Calcium is the abundantest mineral element of content in the organism, its effect is except the composition as body bone and tooth, also participate in multiple physiological activity, the vital movement of biology is played an important role, especially animals such as chicken, duck, goose need to replenish a large amount of calcium between the spawning time.At present calcium class additive is formed from the calcium source and mainly contained following three classes on the domestic market: (1) is based on the product of inorganic salt, as mineral products lime carbonate, chemosynthesis lime carbonate, secondary calcium phosphate, calcium chloride etc.; (2) based on the product of common organic salt, as calcium lactate, calcium acetate, calisanin, citrate of lime and calcium maleate etc.; (3) amino acid calcium of biologically active.Preceding two class calcium additives exist and absorb and biochemical function is poor, have defectives such as antagonistic action between certain toxic side effect, the organism interior element is obvious, can not satisfy the needs of biological growth.The 3rd class calcium additive is calcium and amino acid whose complex compound, it have stable chemical properties, high biological value, nontoxic, have no stimulation, advantage such as good palatability, especially can play supplementing calcium element and amino acid whose dual function as fodder additives, can reduce feed intake, improve the feed conversion utilization ratio, improving the bioavailability of calcium simultaneously, reduce the competitive antagonism between each element in the organism, is ideal humans and animals calcium complement agent comparatively.
At present the production method of calcium amino acid chelate mainly contains two kinds: shortcomings such as a kind of is directly amino acid and calcium source to be mixed to carry out complex reaction and obtain calcium amino acid chelate in water, and this method exists the complexing rate low, and product purity is low; Another kind method is to add merit in above-mentioned mixing process, for example adds the microwave of certain frequency or ultrasonic wave etc., and this method has improved the complexing rate of reaction, but limits its industrialization ground production in enormous quantities owing to the technology cost is higher.
Summary of the invention
The objective of the invention is to improve the deficiencies in the prior art, a kind of preparation method of calcium amino acid chelate is provided, it can improve amino-acid complex rate and product purity, reduces production costs, and simplifies technology, but industrialized mass chelating amino acids calcium product.
For achieving the above object, the preparation method of calcium amino acid chelate of the present invention is achieved by the following scheme:
At first prepare the inorganic calcium solution of 0.5～1.0mol/L, the ratio of pressing inorganic calcium liquor capacity (L) and Zeo-karb quality (Kg) is greater than 4, it is standby that Zeo-karb is converted to the calcium type fully, then according to mol ratio 1: 0.5～2 preparation amino acid and sodium hydroxide mixing solutionss, this mixing solutions is injected the ion exchange resin column of above-mentioned processing, in the upper prop process, resin with the mixed solution of calcium ion in sodium ion exchange, and continuous the combination with the amino acid radical generates calcium amino acid chelate, with flow velocity is that 0.05～1BV/h collects effluent liquid down, to collect the liquid vacuum concentration, crystallization, refining, finally obtain the chelating amino acids calcium product.
Above-mentioned inorganic calcium is a kind of in calcium chloride or calcium oxide or the calcium hydroxide.
Above-mentioned inorganic calcium is a calcium chloride.
Above-mentioned Zeo-karb is 732 type strongly acidic cation-exchanges.
Above-mentioned amino acid is leucine.
After adopting such scheme, the advantage of using ion exchange method provided by the invention to prepare the method for calcium amino acid chelate is the renewable use of ion exchange resin, and amino-acid complex rate and product purity have been improved, the production technique cost is lower, the conversion rate of products height, the product purity height of preparing can be at industrial production in enormous quantities chelating amino acids calcium product.
Embodiment
Embodiment 1:
Preparation 1mol/L calcium chloride solution 1L, it is standby to convert the 200g732 strongly acidic cation-exchange to calcium type resin fully.The accurate weighing leucine of difference and each 52.472g of sodium hydroxide and 8g, prepared leucine and sodium hydroxide mixing solutions 1.5L in 2: 1 in molar ratio, this mixing solutions is gone up above-mentioned calcium type cation exchange resin column at normal temperatures, the post specification is Φ 2.5cm, high 50cm, collect with flow velocity 0.17BV/h that the effluent liquid final vacuum concentrates, crystallization, final white leucine chelating calcium product.
Embodiment 2:
Preparation 1mol/L calcium chloride solution 2L, it is standby to convert the 300g732 strongly acidic cation-exchange to calcium type resin fully.The accurate weighing leucine of difference and each 39.354g of sodium hydroxide and 12g, prepared leucine and sodium hydroxide mixing solutions 3L in 1: 1 in molar ratio, this mixing solutions is gone up above-mentioned calcium type cation exchange resin column at normal temperatures, the post specification is Φ 3.5cm, high 50cm, collect with flow velocity 0.25BV/h that the effluent liquid final vacuum concentrates, crystallization, final white leucine chelating calcium product.
Claims (5)
1, the preparation method of calcium amino acid chelate is characterized in that: be achieved by the following scheme:
At first prepare the inorganic calcium solution of 0.5～1.0mol/L, the ratio of pressing inorganic calcium liquor capacity L and Zeo-karb quality Kg is greater than 4, it is standby that Zeo-karb is converted to the calcium type fully, then according to mol ratio 1: 0.5～2 preparation amino acid and sodium hydroxide mixing solutionss, this mixing solutions is injected the ion exchange resin column of above-mentioned processing, in the upper prop process, resin with the mixed solution of calcium ion in sodium ion exchange, and continuous the combination with the amino acid radical generates calcium amino acid chelate, with flow velocity is that 0.05～1BV/h collects effluent liquid down, to collect the liquid vacuum concentration, crystallization, refining, finally obtain the chelating amino acids calcium product.
2, the preparation method of calcium amino acid chelate according to claim 1 is characterized in that: above-mentioned inorganic calcium is a kind of in calcium chloride or the calcium hydroxide.
3, the preparation method of calcium amino acid chelate according to claim 2 is characterized in that: above-mentioned inorganic calcium is a calcium chloride.
4, the preparation method of calcium amino acid chelate according to claim 1 is characterized in that: above-mentioned Zeo-karb is 732 type strongly acidic cation-exchanges.
5, the preparation method of calcium amino acid chelate according to claim 1 is characterized in that: above-mentioned amino acid is leucine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100962399A CN100516026C (en) | 2006-09-29 | 2006-09-29 | preparation process of amino acid-calcium chelate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100962399A CN100516026C (en) | 2006-09-29 | 2006-09-29 | preparation process of amino acid-calcium chelate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931828A CN1931828A (en) | 2007-03-21 |
| CN100516026C true CN100516026C (en) | 2009-07-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100962399A Expired - Fee Related CN100516026C (en) | 2006-09-29 | 2006-09-29 | preparation process of amino acid-calcium chelate |
Country Status (1)
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| CN (1) | CN100516026C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274099B (en) * | 2007-03-27 | 2011-03-23 | 醒能生物制品开发股份有限公司 | Method for preparing polymer matrix with transfer function |
| CN103922949A (en) * | 2014-04-29 | 2014-07-16 | 吉林大学 | Calcium leucine chelate powder and processing method thereof |
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2006
- 2006-09-29 CN CNB2006100962399A patent/CN100516026C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 氨基酸螯合钙的研制. 陈睿妍等.制剂技术，第13卷第10期. 2004 |
| 氨基酸螯合钙的研制. 陈睿妍等.制剂技术，第13卷第10期. 2004 * |
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| Publication number | Publication date |
|---|---|
| CN1931828A (en) | 2007-03-21 |
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Assignee: Wuhan Vital Pharmaceutical Co., Ltd. Assignor: Huaqiao University Contract record no.: 2011420000126 Denomination of invention: Prepn process of amino acid-calcium chelate Granted publication date: 20090722 License type: Exclusive License Open date: 20070321 Record date: 20110620 |
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