CN100491528C - 与利培酮临床疗效相关的核酸序列 - Google Patents
与利培酮临床疗效相关的核酸序列 Download PDFInfo
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- CN100491528C CN100491528C CNB2006100283294A CN200610028329A CN100491528C CN 100491528 C CN100491528 C CN 100491528C CN B2006100283294 A CNB2006100283294 A CN B2006100283294A CN 200610028329 A CN200610028329 A CN 200610028329A CN 100491528 C CN100491528 C CN 100491528C
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- risperidone
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- 229960001534 risperidone Drugs 0.000 title claims abstract description 44
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 230000000694 effects Effects 0.000 title claims abstract description 26
- 150000007523 nucleic acids Chemical group 0.000 title abstract description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 6
- 230000000295 complement effect Effects 0.000 claims abstract description 5
- 239000002773 nucleotide Substances 0.000 claims description 15
- 125000003729 nucleotide group Chemical group 0.000 claims description 15
- 102100020756 D(2) dopamine receptor Human genes 0.000 claims description 8
- 101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 claims description 8
- 108020004414 DNA Proteins 0.000 abstract description 12
- 108090000623 proteins and genes Proteins 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 8
- 101150049660 DRD2 gene Proteins 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 102000053602 DNA Human genes 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000164 antipsychotic agent Substances 0.000 description 5
- 229940005529 antipsychotics Drugs 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
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- 238000011337 individualized treatment Methods 0.000 description 3
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- 238000005516 engineering process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- MPUPANILEFVXCD-UHFFFAOYSA-N C1=CC=C2C(=C1)C=NO2.C1=CON=C1 Chemical class C1=CC=C2C(=C1)C=NO2.C1=CON=C1 MPUPANILEFVXCD-UHFFFAOYSA-N 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000027776 Extrapyramidal disease Diseases 0.000 description 1
- 108091092584 GDNA Proteins 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229960004170 clozapine Drugs 0.000 description 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
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- 239000012153 distilled water Substances 0.000 description 1
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- 239000003550 marker Substances 0.000 description 1
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- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
- 229940054010 other antipsychotics in atc Drugs 0.000 description 1
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2006100283294A CN100491528C (zh) | 2006-06-29 | 2006-06-29 | 与利培酮临床疗效相关的核酸序列 |
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CNB2006100283294A CN100491528C (zh) | 2006-06-29 | 2006-06-29 | 与利培酮临床疗效相关的核酸序列 |
Publications (2)
Publication Number | Publication Date |
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CN1884528A CN1884528A (zh) | 2006-12-27 |
CN100491528C true CN100491528C (zh) | 2009-05-27 |
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CNB2006100283294A Active CN100491528C (zh) | 2006-06-29 | 2006-06-29 | 与利培酮临床疗效相关的核酸序列 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109234383A (zh) * | 2018-11-07 | 2019-01-18 | 上海康黎医学检验所有限公司 | 与抗精神疾病药相关的试剂盒、目标基因及其制备、snp标记、snp识别和应用 |
CN111440861B (zh) * | 2020-04-01 | 2022-11-04 | 上海市精神卫生中心(上海市心理咨询培训中心) | 甲基化的miR-124基因在制备用于诊断抑郁症的标志物中的用途 |
-
2006
- 2006-06-29 CN CNB2006100283294A patent/CN100491528C/zh active Active
Non-Patent Citations (6)
Title |
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AF148806. Murakami N., et al.EMBL. 2006 |
AF148806. Murakami N., et al.EMBL. 2006 * |
Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia. Shitij Kapur, M.D., et al.Am J Psychiatry,Vol.156 No.2. 1999 |
Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia. Shitij Kapur, M.D., et al.Am J Psychiatry,Vol.156 No.2. 1999 * |
X53502. Gandelman,K.Y., et al.GenBank. 1994 |
X53502. Gandelman,K.Y., et al.GenBank. 1994 * |
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