CN100464737C - 同载尼莫司汀及其增效剂的药物组合物 - Google Patents
同载尼莫司汀及其增效剂的药物组合物 Download PDFInfo
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- CN100464737C CN100464737C CNB2006102008978A CN200610200897A CN100464737C CN 100464737 C CN100464737 C CN 100464737C CN B2006102008978 A CNB2006102008978 A CN B2006102008978A CN 200610200897 A CN200610200897 A CN 200610200897A CN 100464737 C CN100464737 C CN 100464737C
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Abstract
Description
肿瘤细胞 | 抑制率(%) |
肝癌肺癌食管癌胃癌乳腺癌胰腺癌甲状腺癌鼻咽癌卵巢癌子宫内膜癌子宫颈癌肾癌前列腺癌膀胱癌结肠癌直肠癌皮肤癌睾丸癌 | 908080868692908866808468708288808688 |
试验组(n) | ACNU治疗量(mg/kg) | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | 对照 | 62±10 | |
2(6) | 0.5 | 58±8.2 | >0.05 |
3(6) | 1.0 | 52±6.6 | <0.01 |
4(6) | 2.0 | 44±6.0 | <0.01 |
5(6) | 4.0 | 32±4.8 | <0.01 |
6(6) | 8.0 | 18±2.8 | <0.01 |
7(6) | 16.0 | 12±2.0 | <0.001 |
瘤细胞 | 尼莫司汀 | 丝裂霉素C | 美法仑 | 长春瑞滨 | 尼莫司汀+丝裂霉素C | 尼莫司汀+美法仑 | 尼莫司汀+长春瑞滨 |
胰腺癌 | 48% | 30% | 42% | 40% | 80% | 82% | 86% |
食道癌 | 60% | 22% | 52% | 50% | 88% | 84% | 82% |
SA | 48% | 32% | 60% | 42% | 84% | 84% | 82% |
BC | 52% | 32% | 44% | 60% | 86% | 86% | 88% |
BA | 54% | 34% | 52% | 42% | 82% | 90% | 84% |
LH | 52% | 44% | 48% | 48% | 66% | 84% | 84% |
PAT | 46% | 44% | 46% | 48% | 88% | 84% | 92% |
试验组(n) | 治疗量 | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | 对照 | 54±12 | |
2(6) | 尼莫司汀(5%) | 46±8.0 | <0.05 |
3(6) | 尼莫司汀(10%) | 38±6.0 | <0.01 |
4(6) | 尼莫司汀(15%) | 28±4.4 | <0.001 |
5(6) | 尼莫司汀(30) | 24±4.2 | <0.01 |
6(6) | 长春瑞滨(10%) | 46±10.0 | <0.001 |
7(6) | 尼莫司汀(5%)+长春瑞滨 | 28±4.4 | <0.01 |
8(6) | 尼莫司汀(10%)+长春瑞滨 | 22±4.0 | <0.001 |
9(6) | 尼莫司汀(15%)+长春瑞滨 | 14±2.0 | <0.01 |
10(6) | 尼莫司汀(30%)+长春瑞滨 | 10±1.4 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | ||
2(6) | 尼莫司汀(5%) | 48 | <0.05 |
3(6) | 尼莫司汀(10%) | 56 | <0.01 |
4(6) | 尼莫司汀(15%) | 62 | <0.01 |
5(6) | 尼莫司汀(20%) | 70 | <0.01 |
6(6) | 美法仑(10%) | 60 | <0.01 |
7(6) | 尼莫司汀(5%)+美法仑 | 78 | <0.001 |
8(6) | 尼莫司汀(10%)+美法仑 | 84 | <0.001 |
9(6) | 尼莫司汀(15%)+美法仑 | 92 | <0.001 |
10(6) | 尼莫司汀(20%)+美法仑 | 98 | <0.001 |
试验组(n) | 所受治疗 | 肿瘤抑制率(%) | P值 |
1(6) | 对照 | ||
2(6) | 尼莫司汀(5%) | 48 | <0.05 |
3(6) | 尼莫司汀(10%) | 56 | <0.01 |
4(6) | 尼莫司汀(15%) | 62 | <0.01 |
5(6) | 尼莫司汀(20%) | 70 | <0.01 |
6(6) | 丝裂霉素C(15%) | 60 | <0.01 |
7(6) | 尼莫司汀(5%)+丝裂霉素C | 72 | <0.001 |
8(6) | 尼莫司汀(10%)+丝裂霉素C | 82 | <0.001 |
9(6) | 尼莫司汀(15%)+丝裂霉素C | 88 | <0.001 |
10(6) | 尼莫司汀(20%)+丝裂霉素C | 96 | <0.001 |
试验组(n) | 治疗量 | 肿瘤体积(cm<sup>3</sup>) | P值 |
1(6) | 对照 | 52±12 | |
2(6) | 美法仑(5%) | 46±8.2 | <0.05 |
3(6) | 美法仑(10%) | 34±6.6 | <0.01 |
4(6) | 美法仑(15%) | 26±4.0 | <0.001 |
5(6) | 美法仑(30) | 20±3.2 | <0.01 |
6(6) | 尼莫司汀(10%) | 24±4.0 | <0.001 |
7(6) | (5%)美法仑+尼莫司汀 | 16±3.2 | <0.01 |
8(6) | (10%)美法仑+尼莫司汀 | 14±3.2 | <0.001 |
9(6) | (15%)美法仑+尼莫司汀 | 8±1.4 | <0.01 |
10(6) | (30%)美法仑+尼莫司汀 | 4±1.0 | <0.001 |
Claims (3)
- 【权利要求1】一种同载尼莫司汀及其增效剂的药物组合物,为缓释注射剂,所述的缓释注射剂的组分为下列组合之一:(1)抗癌有效成分为10%尼莫司汀和20%美法仑,缓释辅料为分子量为20000-40000的聚乳酸,溶媒为含1.5%羧甲基纤维素钠的生理盐水;(2)抗癌有效成分为10%尼莫司汀和10%美法仑,缓释辅料为对羧苯基丙烷:癸二酸为50:50的聚苯丙生,溶媒为含2.5%羧甲基纤维素钠的生理盐水。
- 【权利要求2】一种同载尼莫司汀及其增效剂的药物组合物,其特征在于其抗癌有效成分制成缓释植入剂,所述的缓释植入剂的组分为下列组合之一:(1)抗癌有效成分为5%尼莫司汀和15%美法仑,缓释辅料为分子量为25000-40000的聚乳酸;(2)抗癌有效成分为10%尼莫司汀和20%美法仑,缓释辅料为分子量为35000-55000的乙烯乙酸乙烯酯共聚物;(3)抗癌有效成分为10%尼莫司汀和20%美法仑,缓释辅料为分子量为20000-40000的聚乳酸;以上均为重量百分比。
- 【权利要求3】如权利要求1所述之一种同载尼莫司汀及其增效剂的药物组合物,用于制备治疗包括脑肿瘤、肝癌、肺癌、食管癌、胃癌、乳腺癌、胰腺癌、甲状腺癌、鼻咽癌、卵巢癌、子宫内膜癌、子宫颈癌、肾癌、前列腺癌、膀胱癌、结肠癌、直肠癌、睾丸癌、头颈部肿瘤和源于胆囊、口腔、外周神经系统、眼睛的原发或继发的癌、肉瘤或癌肉瘤的实体肿瘤的药物。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1824314A (zh) * | 2005-12-20 | 2006-08-30 | 济南康泉医药科技有限公司 | 一种含激素类抗癌药物缓释剂 |
CN1824319A (zh) * | 2005-12-20 | 2006-08-30 | 济南康泉医药科技有限公司 | 一种激素类抗癌药物缓释剂 |
CN1887265A (zh) * | 2006-07-25 | 2007-01-03 | 济南帅华医药科技有限公司 | 一种抗癌缓释剂 |
CN1887268A (zh) * | 2006-07-25 | 2007-01-03 | 济南帅华医药科技有限公司 | 一种新的抗癌缓释注射剂 |
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CN1824314A (zh) * | 2005-12-20 | 2006-08-30 | 济南康泉医药科技有限公司 | 一种含激素类抗癌药物缓释剂 |
CN1824319A (zh) * | 2005-12-20 | 2006-08-30 | 济南康泉医药科技有限公司 | 一种激素类抗癌药物缓释剂 |
CN1887265A (zh) * | 2006-07-25 | 2007-01-03 | 济南帅华医药科技有限公司 | 一种抗癌缓释剂 |
CN1887268A (zh) * | 2006-07-25 | 2007-01-03 | 济南帅华医药科技有限公司 | 一种新的抗癌缓释注射剂 |
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