CN100457133C - Application of Qiannianai in preparing medicine for treating chronic viral hepatitis B - Google Patents
Application of Qiannianai in preparing medicine for treating chronic viral hepatitis B Download PDFInfo
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- CN100457133C CN100457133C CNB200610017215XA CN200610017215A CN100457133C CN 100457133 C CN100457133 C CN 100457133C CN B200610017215X A CNB200610017215X A CN B200610017215XA CN 200610017215 A CN200610017215 A CN 200610017215A CN 100457133 C CN100457133 C CN 100457133C
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- viral hepatitis
- chinese mugwort
- chronic viral
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Abstract
The present invention relates to Chinese medicine technology, and is especially the application of Qiannianai in preparing medicine for treating chronic viral hepatitis B. The composition of Qiannianai and clover fern possesses even higher effect of treating chronic viral hepatitis B. The Qiannianai decoction has obvious ALT recovering rate, HbeAg negative conversion rate and HBV-DNA negative conversion rate.
Description
Technical field
The invention belongs to the new medicinal usage field of Chinese crude drug and water extract thereof.
Background technology
Chinese mugwort in thousand, different name Chinese mugwort, Coagulum Opuntiae sucus, Folium Crossostephii Chinensis, white Chinese mugwort, Limonium wrightii Kuntz, rock head are white, are the leaf of Compositae Chinese mugwort platymiscium Hibisci Mutabilis chrysanthemum.Hibisci Mutabilis chrysanthemum Crossostephium chinense (L.) Makinoex Cham.et Schltr.[Artemisia chinensis L.] fruticuli, high 10～40 centimetres.Stem is upright, multi-branched, the branch, the close life of leaf tool white fine hair and be celadon.The leaf alternate, tightly poly-end of the branch, narrow cochlear or obovate, top 3-5 fissure or division, no sawtooth, base portion are gradually narrow.The head inflorescence yellow green has stalk, and most head inflorescences are lined up total shape at the branch end, 2～3 layers of phyllarys, and the outer phyllary food value of leaf is outward by the canescence pubescence; The floral tube shape, peripheral spending is female, corolla tip 2～3 fissures, the colored both sexes of central authorities, corolla tip 5 short splitting.Achene has 5 corner angle, and tip has lacerated scale.Spring at florescence.Be born in roadside, hillside, the stone crack, seabeach.Be distributed in ground such as Fujian, Guangdong, Guangxi, there is cultivation all parts of the country.Nature and flavor: hot, little hardship, temperature, nontoxic.Effect with cure mainly: relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, wind-expelling pain-stopping.Be used for anemofrigid cold, measles, rheumatic arthralgia, stomachache, bronchitis, pertussis, furuncle swelling toxin, mastitis.
TIANZICAO, the dry herb of Marsileaceae plant Herba Marsileae Quadrifoliae Marsilea quadrifolia L. claims field word duckweed, silk tree grass, Herba Pistiae, Radix Pesudostellariae again, the 5-9 month gathers.Remove silt particle, dry.Get together more agglomerating, elongated horizontal walk of rhizome, pale brown color.Lobule 4, del is arranged in crosswise, petiole is long 5～20 centimetres, light green, base portion sometimes give birth to the cystocarp of tool handle.Cystocarp square circle kidney shape, brown, wide about 3 millimeters, be about 5 millimeters, thick about 1 millimeter, in numerous Sporangiums are arranged.Feeble QI, it is little sweet to distinguish the flavor of.Nature and flavor: sweet, cold.Function with cure mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema is calmed the nerves.Be used for the neurasthenia, dysphoria and insomnia, acute nephritis, acute hepatitis and furuncle, Serpentis stings.
Chronic viral hepatitis B is a kind of infectious disease of serious harm people's health, and course of disease delay is difficult.
Summary of the invention
The invention provides the application of Chinese mugwort in the medicine of preparation treatment chronic viral hepatitis B in a kind of thousand, the effect of this Drug therapy chronic viral hepatitis B is obvious, its water extract also has the effect of treatment chronic viral hepatitis B, the preparation method of Ai Shui extract in thousand is: Chinese mugwort 10 grams in thousand, decoct with water 3 times, and be respectively 2 hours, 1 hour, 1 hour, amount of water is respectively 200 milliliters, 100 milliliters, 100 milliliters, filter, merging filtrate is concentrated into 100 milliliters.
Ended in thousand and the compositions of TIANZICAO and the effect that both water extracts can both obviously improve the treatment chronic viral hepatitis B.
Chinese mugwort in thousand is 1: 1 by weight percentage with the proportioning of the compositions of TIANZICAO.Chinese mugwort with the preparation method of TIANZICAO water extract was in these thousand: get Chinese mugwort 10 grams in thousand, TIANZICAO 10 grams, merge, decoct with water 3 times, be respectively 2 hours, 1 hour, 1 hour, amount of water is respectively 200 milliliters, 100 milliliters, 100 milliliters, filters, merging filtrate is concentrated into 100 milliliters.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, injection.
Chinese mugwort in thousand and water extract thereof have the effect of treatment chronic viral hepatitis B, and Chinese mugwort in thousand is used with TIANZICAO can improve the effect for the treatment of chronic viral hepatitis B.Oral, every day 2～3 times, take 200 milliliters～300 milliliters of Ai Shui extracts in thousand altogether, contain crude drug amount 20 grams～30 grams, 6 months courses of treatment.Or oral, every day 2～3 times, take Chinese mugwort in thousand and 200 milliliters～300 milliliters of TIANZICAO water extracts altogether, contain crude drug amount 40 grams～60 grams, 6 months courses of treatment.
Below by concrete clinical research further confirm thousand the Chinese mugwort and the water extract have the treatment chronic viral hepatitis B effect.
Experimental example Chinese mugwort in thousand and Chinese mugwort in thousand have treatment chronic viral hepatitis B effect research with the TIANZICAO compositions.
One, the case selection meets the diagnostic criteria of " viral hepatitis is prevented and treated scheme " middle chronic hepatitis of the 10th national viral hepatitis in JIUYUE, 2000 Xi'an and hepatopathy academic conference discussion revision.All cases are: (1) HBV-DNA positive 〉.(2) the HbsAg positive, HbeAg are more than positive and lasting 24 weeks.(3) anti--HBc feminine gender.(4) screening preceding 12 all ALT continue or repeatedly (more than 2 times) increase, screen ALT and double between 10 times greater than upper limits of normal.Chinese mugwort was organized 18 examples in thousand, male 15 examples, women 3 examples, age 18---67 year.Chinese mugwort in thousand and TIANZICAO group 36 examples, male 31 examples, women 5 examples, age 20---50 year.All cases all adopt random fashion to divide into groups, and all there is comparability two groups of aspects such as patient age, sex, the state of an illness and stadium.
Two, test method
Chinese mugwort in thousand group: oral, take 100 milliliters of Ai Shui extracts in thousand every day altogether every day 3 times, contain crude drug amount 10 grams, 6 months courses of treatment.
Chinese mugwort in thousand and TIANZICAO group: oral, take Chinese mugwort in thousand and 100 milliliters of TIANZICAO water extracts every day altogether every day 3 times, contain crude drug amount 20 grams, 6 months courses of treatment.
Three, observation item and index detect ALT, HBsAg, the HBV-DNA before the treatment respectively, the 4th week of treatment beginning back and treat ALT, HBsAg, HBV-DNA and relevant hepatopathy symptom and sign when finished the course of treatment in 6 months.
When four, efficacy determination treatment finishes with serum HBV-DNA cloudyly change, HbeAg cloudyly changes, ALT＜40IU/L is effective improvement index.
Five, result
Two groups of ALT natural rate of interest and HbeAg, HBV-DNA negative conversion rate are relatively
As seen from the above table, Chinese mugwort treatment in thousand makes ALT normalization rate and HbeAg negative conversion rate, HBV-DNA negative conversion rate all effective in cure.Chinese mugwort was better than Chinese mugwort group therapeutic effect in thousand with TIANZICAO prescription therapeutic effect in thousand.
The specific embodiment
The preparation of embodiment 1 the present invention Chinese mugwort in thousand oral liquid
Get Chinese mugwort 10 grams in thousand, decoct with water 3 times, be respectively 2 hours, 1 hour, 1 hour, amount of water is respectively 200 milliliters, 100 milliliters, 100 milliliters, filters, and merging filtrate is concentrated into 100 milliliters.
The preparation of the oral liquid that embodiment 2 the present invention thousand Chinese mugwort and TIANZICAO prescription use
Get Chinese mugwort 10 grams, TIANZICAO 10 in thousand and restrain, merge, decoct with water 3 times, be respectively 2 hours, 1 hour, 1 hour, amount of water is respectively 200 milliliters, 100 milliliters, 100 milliliters, filters, and merging filtrate is concentrated into 100 milliliters.
Claims (3)
1, the application of Ai Shui extract in the medicine of preparation treatment chronic viral hepatitis B in thousand.
2, Chinese mugwort in thousand and the application in the medicine of preparation treatment chronic viral hepatitis B of the composition water extract of TIANZICAO.
3, Chinese mugwort in as claimed in claim 2 thousand with the proportioning of the composition water extract of TIANZICAO is:
Chinese mugwort in thousand and TIANZICAO 1: 1 by ratio of weight and the number of copies.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610017215XA CN100457133C (en) | 2006-09-29 | 2006-09-29 | Application of Qiannianai in preparing medicine for treating chronic viral hepatitis B |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610017215XA CN100457133C (en) | 2006-09-29 | 2006-09-29 | Application of Qiannianai in preparing medicine for treating chronic viral hepatitis B |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931209A CN1931209A (en) | 2007-03-21 |
| CN100457133C true CN100457133C (en) | 2009-02-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610017215XA Expired - Fee Related CN100457133C (en) | 2006-09-29 | 2006-09-29 | Application of Qiannianai in preparing medicine for treating chronic viral hepatitis B |
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| CN (1) | CN100457133C (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772094A (en) * | 2005-10-29 | 2006-05-17 | 四川泰华堂制药有限公司 | Hepatitis treating Chinese medicine prepn and its prepn process |
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2006
- 2006-09-29 CN CNB200610017215XA patent/CN100457133C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772094A (en) * | 2005-10-29 | 2006-05-17 | 四川泰华堂制药有限公司 | Hepatitis treating Chinese medicine prepn and its prepn process |
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| Publication number | Publication date |
|---|---|
| CN1931209A (en) | 2007-03-21 |
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| SE01 | Entry into force of request for substantive examination | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090204 Termination date: 20100929 |