CN100430080C - Medicine for treating femoral head necrosis and femur head fracture and its preparation method - Google Patents
Medicine for treating femoral head necrosis and femur head fracture and its preparation method Download PDFInfo
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Abstract
The present invention discloses a medicine for treating osteonecrosis of the femoral head and fracture of neck of femur, which is mainly prepared from the raw medicinal materials of fortune's drynaria rhizome, Chinese eaglewood wood, olibanum, myrrh, garden balsam stem, yam, rhizoma, fossilizid, common curculigo rhizome, himalayan teasel root, sappanwood, sandalwood, ground beetle, calcined dogbone, etc. according to a certain proportion by weight. The medicine can be prepared into any medicine for external application. The medicine of the present invention has the functions of reunion of the fractured tendons and bones, elimination of stagnation and generation of new bones. The present invention has obvious effect and high cure rate on treating ischemic necrosis of head of femur, fracture of neck of femur and traumatic injury.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of femur head necrosis, fracture of femoral neck and preparation method thereof, belong to the field of Chinese medicines.
Background technology:
Femur head necrosis, fracture of femoral neck are the common skeletal diseases of middle-aged and elderly people.There is quite a few patient to occur that bone does not connect connects or ischemic necrosis of femoral head after skeleton is ill, causes permanent disbility.And present Therapeutic Method mostly is traction and operation is main, not only has a big risk, the expense height, and the operation meeting brings certain misery to patient, therefore, at the initial stage of femoral head disease, should be based on Traditional Chinese Medicine for external application, be used in conjunction with Chinese medicine for oral administration, to improve the cure rate of disease.
Summary of the invention:
Therefore, there is demand in people's Traditional Chinese Medicine for external application that curative effect is better treated fracture of femoral neck.Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, and having found finally has the external application of Chinese medicine of the treatment of better curative effect femur head necrosis and fracture of femoral neck medication, thereby has finished the present invention.
Purpose of the present invention just provides a kind of a kind of Traditional Chinese Medicine for external application compositions of more effectively treating femur head necrosis and fracture of femoral neck.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Rhizoma Drynariae, Lignum Aquilariae Resinatum, Olibanum, Myrrha, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Nipponicae, Rhizoma Paridis, Os Draconis (calcined), Rhizoma Curculiginis, Radix Dipsaci, Lignum Sappan, Lignum Santali Albi, eupolyphoge sinensis, forge Os Canitis, forge Eriocheir sinensis and Pyritum (calcined) makes up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat femur head necrosis, fracture of femoral neck.Wherein selecting Rhizoma Drynariae for use is because of its nature and flavor hardship, temperature, goes into liver, kidney channel, is used for the kidney invigorating, invigorates blood circulation, stops blooding, and controls suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.Select for use Lignum Aquilariae Resinatum to be because its nature and flavor are arduous, temperature is gone into kidney, spleen, stomach warp, is used for the sending down the abnormal ascending QI warming middle-JIAO, and the warming the kidney improving inspiration by invigorating kidney-QI is controlled QI rising in reverse order and panted, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.Select for use Olibanum to be because its nature and flavor are arduous, warm, go into the heart, liver, spleen channel, be used for regulating qi and activating blood, analgesic therapy chases after poison, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select for use Myrrha to be because its nature and flavor hardship, flat is gone into Liver Channel, be used for loose blood blood stasis removing, subduing swelling and relieving pain, control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, amenorrhea, carbuncle is swollen painful, anal fistula, diseases of the eye.Select for use Herba speranskiae tuberculatae be because its nature and flavor sweet, nontoxic, be used to dispel the wind, dehumidifying, Shujin, invigorate blood circulation, pain relieving, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, skin ulcer tinea toxic swelling.Select for use Rhizoma Dioscoreae Nipponicae to be because its nature and flavor are flat, bitter in the mouth, be used for relaxing muscles and tendons to promote blood circulation, eat diuretic clearly, eliminate the phlegm that it is cruel to wear, control anemofrigid-damp arthralgia, chronic tracheitis, dyspepsia, strain is sprained, malaria, carbuncle.Select for use Rhizoma Paridis to be because its nature and flavor toil, cold, poisonous is gone into the heart, Liver Channel, heat-clearing and toxic substances removing, antiasthmatic-antitussive, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is used to relieving asthma, cough-relieving, and is antibiotic, controls carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, the infantile convulsion tic, snakeworm bites, snake bite and insect sting.Select for use Os Draconis (calcined) to be because its property sweet-puckery flavor is flat, go into the heart, liver, kidney, large intestine channel, be used for tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Selecting Rhizoma Curculiginis for use is because of its property suffering, temperature, poisonous, goes into kidney, Liver Channel, is used for the kidney warming sun, and strengthening bone and muscle is controlled the sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Selecting Radix Dipsaci for use is because of its nature and flavor toil, tepor, goes into liver, kidney channel, is used for invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating, controls aching pain in waist and back, the foot and knee being feeble, and vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, the carbuncle skin ulcer is swollen.Select for use Lignum Sappan to be because Lignum Sappan property sweet-salty is flat, the GUIXIN Liver Channel has removing blood stasis with potent drugs, promoting the circulation of blood, swollen clearly analgesic function is controlled married woman's vim and vigour cardiac and abdominal pain, the postnatal blood stasis distending pain, dysentery, tetanus, carbuncle and puerperal deteriorated blood.Selecting Lignum Santali Albi for use is because of Lignum Santali Albi nature and flavor suffering, temperature, returns spleen, stomach, lung meridian, and the energy regulating qi-flowing for harmonizing stomach is controlled trusted subordinate's pain, dysphagic vomiting, and chest and diaphragm does not relax.Selecting for use and forging Os Canitis is that it is active to be used for spleen invigorating because nature and flavor are sweet, warm, blood activating and promoting tissue regeneration, and the dispelling the wind and dampness pathogens pain, lumbago is unable, numb limbs and tense tendons, chronic dysentery, skin ulcer fistula, chilblain.Select for use Pyritum (calcined) to be because its nature and flavor are arduous, flat, go into kidney meridian, liver channel of foot-Jueyin is used for eliminating stasis to stop pain, and reunion of bone is controlled traumatic injury, the tendon breaking fracture, and blood stasis pain is gathered, goiter, skin infection is scalded.Forge the different name that Eriocheir sinensis is an Eriocheir sinensis, nature and flavor are salty-cold, are used for the diffusing blood of heat clearing away, control bones and muscles injury, scabies, and dermatitis rhus is scalded.Eupolyphoge sinensis also claims Eupolyphaga Seu Steleophaga, and is cold in nature, and salty in the mouth is poisonous, and the function of dissipating blood stasis to promote menstruationg is arranged, and cures mainly amenorrhea due to stagnation of blood, stomachache stasis of blood piece, and disease such as traumatic injury.
The consumption of drug component of the present invention carries out a large amount of practice summaries through the inventor and draws, and each amounts of components all has curative effect preferably in following weight range:
Rhizoma Drynariae 80-100 gram LIGNUM AQUILARIAE SINENSIS from Hainan of China 25-35 gram Olibanum 55-65 gram
Myrrha 55-65 gram Herba speranskiae tuberculatae 55-65 gram Rhizoma Dioscoreae Nipponicae 55-65 gram
Rhizoma Paridis 25-35 cron bone 55-65 gram Rhizoma Curculiginis 26-35 gram
Radix Dipsaci 80-100 gram Lignum Sappan 110-130 gram Lignum Santali Albi 170-190 gram
Pyritum (calcined) 80-100 gram is forged Os Canitis 110-130 gram and is forged Eriocheir sinensis 80-100 gram
Eupolyphoge sinensis 25-35 gram
Be preferably: Rhizoma Drynariae 90 grams, LIGNUM AQUILARIAE SINENSIS from Hainan of China 30 grams, Olibanum 60 grams, Myrrha 60 grams, Herba speranskiae tuberculatae 60 grams, Rhizoma Dioscoreae Nipponicae 60 grams, Rhizoma Paridis 30 grams, Os Draconis 60 grams, Rhizoma Curculiginis 30 grams, Radix Dipsaci 90 grams, Lignum Sappan 120 grams, Lignum Santali Albi 180 grams, Pyritum (calcined) 90 grams are forged Os Canitis 120 grams, forge Eriocheir sinensis 90 grams, eupolyphoge sinensis 30 grams.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the external preparation of any routine, for example can be with these crude drug pulverizes, and mix homogeneously makes unguentum or powder is used.
The preparation method of drug component of the present invention is as follows:
1, Rhizoma Drynariae: remove clean silt impurity, clean, soak slightly, run through section, dry;
2, Rhizoma Curculiginis: get clean Rhizoma Curculiginis and mix thoroughly, after running through, put interior little stir-fry of pot and do, take out, dry with yellow wine;
3, Radix Dipsaci: clean silt, remove the retained root head, run through the back section and dry, sieve anti-dandruff;
4, Lignum Santali Albi: be soaked in water pound sheet or split broken drying;
5, Os Draconis (calcined): with the Os Draconis of outwash, forge on smokeless stove fire or in the crucible and be popular in, taking-up cools, and pulverizes;
6, Pyritum (calcined): get Pyritum, put into and forge pot, forge to being popular in, take out and put into vinegar and soak quench (100 kilograms of Pyritums are with 25 kilograms of vinegar), take out, calcining again, quench in vinegar is dark brown to complexion changed, appearance embrittlement, gloss disappear, and quality is crisp to get final product;
7, forge Os Canitis: with the Os Canitis of outwash, in crucible, forge and be popular in, take out, cool, pulverize;
8, forge Eriocheir sinensis: Eriocheir sinensis is forged ash with fire;
9, with above-mentioned medicine by measuring foot, be ground into the end, mix homogeneously, bottling sealing.
The powder 200 of getting it filled during use restrains, 55 ° of Chinese liquor 100 grams, and warm water 100 grams, furnishing pasty state ointment spreads on around the affected part, wraps with plastic foil, twines binder outward, and change dressings once every day.
Medicine of the present invention has reunion of fractured tendons and bones, repercussive tissue regeneration promoting, the function of bactericidal antiphlogistic, treatment Avascular Necrosis Of Femur Head, traumatic injury, fracture of femoral neck instant effect, good effect.
The specific embodiment:
Below by testing the beneficial effect of further setting forth medicine of the present invention, these test examples comprise animal experiment and clinical observation on the therapeutic effect test.
[test example 1] animal toxicity test data:
Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and 10 every group, wherein one group is the treatment group, and another group is the treatment comparable group.Becoming mildewed of 10 rabbit back leg tops with the treatment group takes out earlier, and the scraping fine hair is got medicated powder of the present invention, Chinese liquor and warm water furnishing pasty state ointment and spread on back leg depilation position, use plastic film wrapped, twine binder outward, changed dressings once in 1st, continuous 7 days, observe medicining condition every day.
10 rabbit abdominal paries to treating comparable group again become mildewed and take out, and the scraping fine hair is got medicated powder of the present invention, Chinese liquor, warm water furnishing pasty state ointment and spread on abdominal part depilation place, use plastic film wrapped, twine binder outward, changed dressings once in 1st, continuous 7 days, observe rabbit medication reaction every day.
The result shows that medicine of the present invention all has no adverse reaction to the medication of two groups of rabbit.Duration of test, two groups of rabbit foraging activity are normal, and medicine of the present invention has no side effect.
The clinical observation material of [test example 2] Drug therapy fracture of femoral neck of the present invention and femur head necrosis:
1, physical data:
Accept out-patient's 52 examples for medical treatment, male 28 examples, women 24 examples, age 20-30 year 4 examples, 31-40 year 6 examples, 41-50 year 8 examples, 51-60 year 13 examples, 61-75 year 21 examples, femur head necrosis 22 examples wherein, fracture of femoral neck 30 examples.
2, diagnostic criteria:
1. slight femur head necrosis: the patient fell ill within half a year, and patient suffers from limb pain, stretch bend limited.
2. moderate femur head necrosis, the patient 1-2 that falls ill, the pain increased to suffer from limb, can not walk.
3. severe femur head necrosis: patient's medical history is more than 2 years, and the pain increased to suffer from limb, and bed can not be walked.
4. slight fracture of femoral neck: the X sheet shows slight crackle, and the patient has tenderness.
5. moderate fracture of femoral neck: the X sheet shows big crackle, patient skin swelling, and the pain increased.
6. severe fracture of femoral neck: the X sheet shows the serious dislocation phenomenon, and patient's pain unbearably.
3, Therapeutic Method:
1. femur head necrosis patient's treatment: with the ointment that mixes up spread on suffer from the limb position around, wrap with plastic foil, twine binder outward, changed dressings once in 1st, one month is a course of treatment, one to three course of treatment of logotype.
2. the treatment of fracture of femoral neck: a. allows the patient is flat to sleep on the tractive bed, as has dislocation the patient, and patient's tractive gently corrects and resets, but it is askew on one side to allow foot or body do; B. the drug of topical application will be at regular time and quantity, with the ointment that mixes up spread on suffer from the limb position around, wrap with plastic foil, twine binder outward, changed dressings once in 1st, be a course of treatment all around, two courses of treatment of logotype; C. note winter warmingly, can increase and decrease antiinflammatory, blood circulation promoting medicine, forbidding hormone drug with disease.
4, efficacy assessment standard:
Produce effects: all types of osteopathia are after treatment, and bone healing is good, and body constitution returns to one's perfect health, and observes 3 months no recidivists.
Take a turn for the better: healing time is accelerated, and pain degree alleviates, and body constitution is recovered substantially.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (see Table 1 and table 2)
Table 1 femur head necrosis observation of curative effect
Through slight femur head necrosis 9 examples of application Drug therapy of the present invention, produce effects 8 examples as a result, 1 example that takes a turn for the better, obvious effective rate is 88.88%, improvement rate 11.11%, total effective rate are 100%; Treatment moderate femur head necrosis 7 examples, produce effects 5 examples as a result, 1 example that takes a turn for the better, invalid 1 example, obvious effective rate is 71.42%, and improvement rate is 14.28%, and total effective rate is 85.71%; Treatment severe femur head necrosis patient 6 examples, produce effects 3 examples as a result, 1 example that takes a turn for the better, invalid 2 examples, obvious effective rate is 50%, improvement rate 16.66%, total effective rate are 66.66%.
Table 2 fracture of femoral neck observation of curative effect
Through slight fracture of femoral neck 12 examples of application Drug therapy of the present invention, produce effects 11 examples as a result, 1 example that takes a turn for the better, obvious effective rate 91.66%, improvement rate are 8.33%, total effective rate is 100%; Treatment moderate fracture of femoral neck 8 examples, produce effects 6 is imitated, 2 examples that take a turn for the better, obvious effective rate is 75%, improvement rate 25%, total effective rate are 100%; Treatment severe fracture of femoral neck 10 examples, produce effects 7 is imitated, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is 70%, improvement rate 20%, inefficiency is 10%, total effective rate is 90%.
Claims (3)
1, a kind of external used medicine for the treatment of femur head necrosis, fracture of femoral neck is characterized in that: it is to be made by following bulk drugs:
Rhizoma Drynariae 80-100 gram LIGNUM AQUILARIAE SINENSIS from Hainan of China 25-35 gram Olibanum 55-65 gram
Myrrha 55-65 gram Herba speranskiae tuberculatae 55-65 gram Rhizoma Dioscoreae Nipponicae 55-65 gram
Rhizoma Paridis 25-35 cron bone 55-65 gram Rhizoma Curculiginis 26-35 gram
Radix Dipsaci 80-100 gram Lignum Sappan 110-130 gram Lignum Santali Albi 170-190 gram
Pyritum (calcined) 80-100 gram is forged Os Canitis 110-130 gram and is forged Eriocheir sinensis 80-100 gram
Eupolyphaga Seu Steleophaga 25-35 gram.
2, the external used medicine of treatment femur head necrosis according to claim 1, femur neck fracture, wherein the consumption of each crude drug is: Rhizoma Drynariae 90 grams, LIGNUM AQUILARIAE SINENSIS from Hainan of China 30 grams, Olibanum 60 grams, Myrrha 60 grams, Herba speranskiae tuberculatae 60 grams, Rhizoma Dioscoreae Nipponicae 60 grams, Rhizoma Paridis 30 grams, Os Draconis 60 grams, Rhizoma Curculiginis 30 grams, Radix Dipsaci 90 grams, Lignum Sappan 120 grams, Lignum Santali Albi 180 grams, Pyritum (calcined) 90 grams are forged Os Canitis 120 grams, forge Eriocheir sinensis 90 grams, Eupolyphaga Seu Steleophaga 30 grams.
3, according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
(1) Rhizoma Drynariae: remove clean silt impurity, clean, soak slightly, run through section, dry;
(2) Rhizoma Curculiginis: get clean Rhizoma Curculiginis and mix thoroughly, after running through, put interior little stir-fry of pot and do, take out, dry with yellow wine;
(3) Radix Dipsaci: clean silt, remove the retained root head, run through the back section and dry, sieve anti-dandruff;
(4) Lignum Santali Albi: be soaked in water pound sheet or split broken drying;
(5) Os Draconis (calcined): with the Os Draconis of outwash, forge on smokeless stove fire or in the crucible and be popular in, taking-up cools, and pulverizes;
(6) Pyritum (calcined): get Pyritum, put into and forge pot, forge to being popular in, take out and put into vinegar and soak and quench
100 kilograms of Pyritums with 25 kilograms of vinegar, take out, reignition, and quench in vinegar is dark brown to complexion changed, appearance embrittlement, gloss disappear, and quality is crisp to get final product;
(7) forge Os Canitis: with the Os Canitis of outwash, in crucible, forge and be popular in, take out, cool, pulverize;
(8) forge Eriocheir sinensis: Eriocheir sinensis is forged ash with fire;
(9) with Rhizoma Drynariae, Rhizoma Curculiginis, Radix Dipsaci, Lignum Santali Albi, Os Draconis (calcined), Pyritum (calcined), forge Os Canitis, forge Eriocheir sinensis together with LIGNUM AQUILARIAE SINENSIS from Hainan of China, Olibanum, Myrrha, Herba speranskiae tuberculatae, Rhizoma Dioscoreae Nipponicae, Rhizoma Paridis, Lignum Sappan, Eupolyphaga Seu Steleophaga by measuring foot, be ground into the end, mix homogeneously, the bottling sealing.
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CN105106796A (en) * | 2015-08-26 | 2015-12-02 | 刘金 | Traditional Chinese medicine composition for treating fracture and preparation method of traditional Chinese medicine composition |
CN105708994A (en) * | 2016-01-29 | 2016-06-29 | 潍坊德善堂中医骨伤病研究所 | Traditional Chinese medicine composition for treating collum femoris fracture and preparation method thereof |
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CN1063639C (en) * | 1995-09-06 | 2001-03-28 | 浙江省苍南县骨伤科研究所 | Powder medicine for setting broken bone and its usage |
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CN1228072C (en) * | 2003-01-29 | 2005-11-23 | 沈海琦 | Medicine used for joining bone |
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CN1063639C (en) * | 1995-09-06 | 2001-03-28 | 浙江省苍南县骨伤科研究所 | Powder medicine for setting broken bone and its usage |
CN1228072C (en) * | 2003-01-29 | 2005-11-23 | 沈海琦 | Medicine used for joining bone |
CN1207051C (en) * | 2003-05-26 | 2005-06-22 | 李克成 | Jiegudan medicine for rejoining bone |
Non-Patent Citations (4)
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虫类药外治在骨伤科的应用. 欧伦.中医外治杂志,第2期. 1996 |
虫类药外治在骨伤科的应用. 欧伦.中医外治杂志,第2期. 1996 * |
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