CN100415252C - Chinese medicinal composition for strengthening body and enriching blood - Google Patents
Chinese medicinal composition for strengthening body and enriching blood Download PDFInfo
- Publication number
- CN100415252C CN100415252C CNB2005100426062A CN200510042606A CN100415252C CN 100415252 C CN100415252 C CN 100415252C CN B2005100426062 A CNB2005100426062 A CN B2005100426062A CN 200510042606 A CN200510042606 A CN 200510042606A CN 100415252 C CN100415252 C CN 100415252C
- Authority
- CN
- China
- Prior art keywords
- parts
- fine powder
- chinese medicine
- medicine composition
- donkey
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a Chinese medicinal composition and a preparation method thereof for strengthening body and enriching blood. The Chinese medicinal composition comprises by weight: 32 to 48 parts of red stilbene, 16 to 24 parts of Chinese angelica, 16 to 24 parts of dogwood and 16 to 24 parts of donkey-hide gelatin; in the preparation method, (a), the red stilbene and the Chinese angelica are added with water for twice decoction, and decoction liquids are obtained by filtering; the twice decoction liquids are combined and are filtered; the filtered liquid is concentrated into an ointment; (b), the dogwood is taken and is percolated through a fluid extracted ointment and an extracted-ointment percolation method; a percolated liquid is collected, and alcohol is recovered; a clear ointment with the relative density of 1.28 to 1.32 at the temperature of 55 DEG C. through concentration; (c), the two clear ointments are uniformly mixed and are pulverized into fine powder through drying; the donkey-hide gelatin is parched into donkey-hide gelatin balls which are pulverized into fine powder; the extracted ointment fine powder and the donkey-hide gelatin fine powder are uniformly mixed, and are made into granules; extracted ointment fine powder and the donkey-hide gelatin fine powder ar dried. The present invention has the functions of benefiting qi, nourishing blood and strengthening energy; the curative effect is significant; clinical symptoms of vitality and strength fatigue, dizziness, palpitation, etc., of radiotherapy and chemotherapy patients with tumors can be obviously improved; hemogram is raised, immunity is improved, and radiotherapy and chemotherapy of patients can be successfully completed.
Description
Affiliated field
The present invention relates to set upright the Chinese medicine composition of enriching blood, particularly a kind of Chinese medicine composition of enriching blood of setting upright that contains Radix Hedysari, Radix Angelicae Sinensis, Fructus Corni, Colla Corii Asini.
Background technology
Tumour patient often descends because of radiotherapy, chemotherapy cause immunity of organism, and hemopoietic suppresses, and clinical multilist reveals the symptom of QI and blood deficiency, and wherein the main cause of radiotherapy, chemotherapy is interrupted in a large amount of minimizings of leukocyte often.Use leucogen, batilol, vitamin B at present clinically
4Deng the medicine treatment, effect is not satisfactory.Chinese medicine " ZHENQI FUZHENG KELI " and " FUFANG EJIAO JIANG " respectively have biased though certain curative effect is arranged.Tradition ancient prescription " Radix Angelicae Sinensis decoction for tonifying blood " (Ming Dynasty Lee Dong Yuan " interior wound debate puzzled opinion ") is reused the gas of the big spleen reinforcing lung of the Radix Astragali, as a means of the source of hemopoietic, is equipped with Chinese Angelica blood replonishing and battalion, reaches the effect of qi-supplementing, blood-engendering; " ZHENQI FUZHENG KELI " also has the effect of qi-supplementing, blood-engendering, but these two kinds of medicines are all a little less than improving aspect the cellular immune function; " FUFANG EJIAO JIANG " has the effect that promotes hemopoietic, but its leukocyte increasing function a little less than.
Summary of the invention
The objective of the invention is to utilize the qi-supplementing, blood-engendering effect of traditional ancient prescription " Radix Angelicae Sinensis decoction for tonifying blood ", add Fructus Corni again with enrich blood key medicine Colla Corii Asini and the kidney invigorating and essence nourishing, provide that a kind of double spleen reinforcing, lung, liver, kidney are gentle, blood, essence, and have improve cellular immune function a kind of and be used to set upright Chinese medicine composition of enriching blood and preparation method thereof
The objective of the invention is to realize by following technical proposals:
A kind ofly be used to set upright the Chinese medicine composition of enriching blood, its raw material and weight proportion are:
32～48 parts of Radix Hedysari, 16～24 parts of Radix Angelicae Sinensis, 16～24 parts of Fructus Corni, 16～24 parts in Colla Corii Asini
Preparation method comprises the following steps:
A) get Radix Hedysari, Radix Angelicae Sinensis decocts with water twice, for the first time amount of water is 7～12 times of raw material, decocts the leaching decocting liquid 1.5～3 hours; For the second time amount of water is 5～9 times of raw material, decocts the leaching decocting liquid 1～2 hour; Twice decocting liquid merged, filter, filtrate clear paste of 1.28～1.32 when to be concentrated into relative density be 55 ℃ of temperature under 0.03～0.06MPa negative pressure;
B) get Fructus Corni and adopt fluid extract and extractum percolation, ethanol with 7～12 times of amounts 65%～75% of raw material is made solvent, carry out percolation, percolation speed is 1～3ml/ minute, the collection liquid of filtering, reclaim ethanol, 1.28～1.32 clear paste when being concentrated into relative density under negative pressure 0.03～0.06Mpa and being 55 ℃;
C) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder mixing, make granule, drying is promptly made Chinese medicine composition of the present invention.
The present invention reuses the Radix Hedysari QI invigorating for monarch from QI invigorating, blood, the legislation of smart three aspects, is equipped with Colla Corii Asini nourishing blood, Chinese Angelica blood replonishing, and the Fructus Corni benefit is smart, the function that gather QI invigorating altogether, nourishes blood, sets upright.After the patient takes, generally reflect this medication effect significantly, can obviously improve tumor radiotherapy, chemotherapy patients's spiritlessness and weakness, clinical symptoms such as dizzy cardiopalmus, the rising hemogram improves immunity, guarantees that the patient finishes radiotherapy, chemotherapy smoothly.Simultaneously take better effects if for a long time, and without any side effects, characteristics such as the low and taking convenience of treatment cost.
The present invention has advantage at the aspects such as competitiveness of product curative effect, scientific and technological content, produce market.To differentiate in this quality standard that item formulated the thin layer chromatography of medical material Radix Hedysari, Fructus Corni and differentiated that specificity, reliability be all good; Donkey-hide gelatin fine powder directly is used as medicine, and guarantees that effective ingredient is not destroyed, and measures control with nitrogen content, lists in and checks item; And increased the assay item, adopt the HPLC method to measure effective ingredient content of ferulic acid in the Radix Angelicae Sinensis.
Clinical 255 routine tumors are put, patients undergoing chemotherapy is divided into three groups at random, and 193 examples are organized in " setting upright the granule of enriching blood " treatment, " FUFANG EJIAO JIANG " matched group 30 examples, " ZHENQI FUZHENG KELI " matched group 32 examples.Show by observation indexs such as clinical symptoms, peripheral hemogram and cellular immunization, humoral immunization, " set upright the granule of enriching blood " and can obviously improve the clinical symptoms of tumor patient, obvious effective rate and total effective rate are respectively 59.6% and 96.9%, and wherein obvious effective rate is apparently higher than " FUFANG EJIAO JIANG " (p＜0.01); The energy raising is put, the hemopoietic function and the immunologic function of patients undergoing chemotherapy, to the raising of WBC and Tc esterase, Th, IgG and IgA particularly evident (p＜0.01).
" set upright the granule of enriching blood " and have QI invigorating, nourish blood, set upright function; Can improve tumor chemoradiotherapy patient's QI and blood deficiency symptom, improve immunologic function, its effect that improves cellular immunization is excellent than " ZHENQI FUZHENG KELI "; Can promote hemopoietic, leukocyte increasing, erythrocyte, platelet, the curative effect of its leukocyte increasing " FUFANG EJIAO JIANG " are remarkable.Consumption each 15 restrains " to set upright the granule of enriching blood ", and every day 3 times, be advisable with 2 weeks the course of treatment, can take 1-2 the course of treatment according to the state of an illness.This medicine safety, nontoxic is not found untoward reaction clinical taking in the process, be the Chinese medicine of a kind of ideal adjuvant drug for tumor therapy and treatment QI and blood deficiency.
The specific embodiment
Below in conjunction with embodiment the present invention is explained in further detail:
Embodiment 1:
With " setting upright the granule of enriching blood " is example
Get Radix Hedysari 400g, Radix Angelicae Sinensis 200g, Fructus Corni 200g, Colla Corii Asini 200g, soluble starch 100g.
(1) Radix Hedysari, Radix Angelicae Sinensis are decocted with water twice, add the water that accounts for 7 times of amounts of raw material for the first time, decocted the leaching decocting liquid 1.5 hours; For the second time add 9 times of amounts of water, decocted the leaching decocting liquid 2 hours; Collecting decoction filters, and (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to the filtrate negative pressure.
(2) get Fructus Corni and adopt " the 13rd page of appendix IO fluid extract of 2000 editions Chinese pharmacopoeia and extractum percolation, make solvent with accounting for 7 times of amounts of crude drug, 65% ethanol, carry out percolation, percolation speed is 1ml/ minute, the collection liquid of filtering, reclaim ethanol, (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to negative pressure.
(3) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder mixing, make granule, drying, promptly.
Embodiment 2:
Get Radix Hedysari 320g, Radix Angelicae Sinensis 240g, Fructus Corni 240g, Colla Corii Asini 240g, soluble starch 80g.
(1) weight ratio is got Radix Hedysari, Radix Angelicae Sinensis decocts with water twice, adds 12 times of amounts of water for the first time, decocts the leaching decocting liquid 3 hours; For the second time add 5 times of amounts of water, decocted the leaching decocting liquid 1 hour; Collecting decoction filters, and (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.30 (55 ℃) to the filtrate negative pressure;
(2) get Fructus Corni and adopt " the 13rd page of appendix IO fluid extract of 2000 editions Chinese pharmacopoeia and extractum percolation, make solvent with 12 times of amount 75% ethanol, carry out percolation, percolation speed is 3ml/ minute, the collection liquid of filtering, reclaim ethanol, (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to negative pressure;
(3) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder and adjuvant sucrose 530g, dextrin 50g mixing, make the sugar-containing type granule, drying, promptly.
Embodiment 3:
Get Radix Hedysari 480g, Radix Angelicae Sinensis 160g, Fructus Corni 160g, Colla Corii Asini 160g, soluble starch 80g.
(1) get Radix Hedysari by weight, Radix Angelicae Sinensis decocts with water twice by proportioning, for the first time adds 10 times of amounts of water, decocts the leaching decocting liquid 2 hours; For the second time add 7 times of amounts of water, decocted the leaching decocting liquid 1.5 hours; Collecting decoction filters, and (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.30 (55 ℃) to the filtrate negative pressure;
(2) get Fructus Corni by weight ratio and adopt " the 13rd page of appendix IO fluid extract of 2000 editions Chinese pharmacopoeia and extractum percolation, make solvent with 10 times of amount 70% ethanol, carry out percolation, percolation speed is 2ml/ minute, the collection liquid of filtering, reclaim ethanol, (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.30 (55 ℃) to negative pressure;
(3) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder and adjuvant soluble starch 120g, mixing is made granule (Sugarless type), drying, promptly.
Embodiment 4:
With " setting upright blood enriching capsule " is example
Get Radix Hedysari 400g, Radix Angelicae Sinensis 200g, Fructus Corni 200g, Colla Corii Asini 200g, soluble starch 100g.
(1) Radix Hedysari, Radix Angelicae Sinensis are decocted with water twice, add the water that accounts for 7 times of amounts of raw material for the first time, decocted the leaching decocting liquid 1.5 hours; For the second time add 9 times of amounts of water, decocted the leaching decocting liquid 2 hours; Collecting decoction filters, and (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to the filtrate negative pressure.
(2) get Fructus Corni and adopt " the 13rd page of appendix IO fluid extract of 2000 editions Chinese pharmacopoeia and extractum percolation, make solvent with accounting for 7 times of amounts of crude drug, 65% ethanol, carry out percolation, percolation speed is 1ml/ minute, the collection liquid of filtering, reclaim ethanol, (0.03 ~ 0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to negative pressure.
(3) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder mixing, make granule, drying is dressed up capsule, promptly.
Embodiment 5:
With " setting upright the tablet of enriching blood " is example
Get Radix Hedysari 320g, Radix Angelicae Sinensis 240g, Fructus Corni 240g, Colla Corii Asini 240g, soluble starch 80g.
(1) weight ratio is got Radix Hedysari, Radix Angelicae Sinensis decocts with water twice, adds 12 times of amounts of water for the first time, decocts the leaching decocting liquid 3 hours; For the second time add 5 times of amounts of water, decocted the leaching decocting liquid 1 hour; Collecting decoction filters, and (0.03～0.06MPa) is concentrated into the clear paste that relative density is 1.30 (55 ℃) to the filtrate negative pressure;
(2) get Fructus Corni and adopt " the 13rd page of appendix IO fluid extract of 2000 editions Chinese pharmacopoeia and extractum percolation, make solvent with 12 times of amount 75% ethanol, carry out percolation, percolation speed is 3ml/ minute, the collection liquid of filtering, reclaim ethanol, (0.03 ~ 0.06MPa) is concentrated into the clear paste that relative density is 1.28 (55 ℃) to negative pressure;
(3) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder and dextrin 50g mixing, make granule, drying, tabletting, promptly.
Pharmaceutical composition of the present invention adopts the pharmaceutical preparation technology on the pharmaceutics can make granule and capsule formulation.
Claims (10)
1. one kind is used to set upright the Chinese medicine composition of enriching blood, and it is characterized in that its raw material and weight proportion are:
32～48 parts of Radix Hedysari, 16～24 parts of Radix Angelicae Sinensis, 16～24 parts of Fructus Corni, 16～24 parts in Colla Corii Asini.
2. a kind of Chinese medicine composition of enriching blood that is used to set upright according to claim 1 is characterized in that the weight proportion of above-mentioned raw materials is:
40 parts of Radix Hedysari, 20 parts of Radix Angelicae Sinensis, 20 parts of Fructus Corni, 20 parts in Colla Corii Asini.
3. a kind of Chinese medicine composition of enriching blood that is used to set upright according to claim 1 and 2 is characterized in that the above-mentioned raw materials Radix Hedysari substitutes with the Radix Astragali.
4. a kind of Chinese medicine composition of enriching blood that is used to set upright according to claim 1 and 2 is characterized in that wherein adding adjuvant: 43～63 parts of sucrose, 4～6 parts in dextrin.
5. a kind of Chinese medicine composition of enriching blood that is used to set upright according to claim 4 is characterized in that adjuvant wherein: 53 parts of sucrose, 5 parts in dextrin.
6. claim 1 or 2 described a kind of Chinese medicine compositions of enriching blood that are used to set upright is characterized in that wherein adding adjuvant: 8～12 parts of soluble starches.
7. a kind of Chinese medicine composition of enriching blood that is used to set upright according to claim 6 is characterized in that adjuvant soluble starch wherein is 10 parts.
8. the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that it comprises the following steps:
A) get Radix Hedysari, Radix Angelicae Sinensis decocts with water twice, for the first time amount of water is 7～12 times of raw material, decocts the leaching decocting liquid 1.5～3 hours; For the second time amount of water is 5～9 times of raw material, decocts the leaching decocting liquid 1～2 hour; Twice decocting liquid merged, filter, filtrate clear paste of 1.28～1.32 when to be concentrated into relative density be 55 ℃ of temperature under 0.03～0.06MPa negative pressure;
B) get Fructus Corni and adopt fluid extract and extractum percolation, ethanol with 7～12 times of amounts 65%～75% of raw material is made solvent, carry out percolation, percolation speed is 1～3ml/ minute, the collection liquid of filtering, reclaim ethanol, 1.28～1.32 clear paste when being concentrated into relative density under negative pressure 0.03～0.06Mpa and being 55 ℃;
C) with behind above-mentioned two kinds of clear paste mixings, be dried and crushed into fine powder; Get Colla Corii Asini and fry into Colla Corii Asini bead, be ground into fine powder; With extractum fine powder, donkey-hide gelatin fine powder mixing, make granule, drying is promptly made Chinese medicine composition of the present invention.
9. the preparation method of Chinese medicine composition according to claim 8 is characterized in that in step c) extractum fine powder, donkey-hide gelatin fine powder and auxiliary materials and mixing are made granule, and drying is promptly made Chinese medicine composition of the present invention.
10. the preparation method of Chinese medicine composition according to claim 8 is characterized in that the pharmaceutical composition that step c) is made adopts the pharmaceutical preparation technology on the pharmaceutics to make granule or capsule formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100426062A CN100415252C (en) | 2005-04-28 | 2005-04-28 | Chinese medicinal composition for strengthening body and enriching blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100426062A CN100415252C (en) | 2005-04-28 | 2005-04-28 | Chinese medicinal composition for strengthening body and enriching blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1853668A CN1853668A (en) | 2006-11-01 |
| CN100415252C true CN100415252C (en) | 2008-09-03 |
Family
ID=37194321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100426062A Expired - Fee Related CN100415252C (en) | 2005-04-28 | 2005-04-28 | Chinese medicinal composition for strengthening body and enriching blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100415252C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688996A (en) * | 2015-03-04 | 2015-06-10 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition for perfecting anemia and preparation method thereof |
| CN105477352A (en) * | 2016-01-25 | 2016-04-13 | 湖北妙莲天香生物科技有限公司 | Dietary therapy stewed food for female physiological accommodation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165676A (en) * | 1997-03-07 | 1997-11-26 | 讷志芳 | Instant powder for nourishing blood and its prepn. method |
| CN1562272A (en) * | 2004-04-05 | 2005-01-12 | 陕西郝其军制药有限责任公司 | Medication for curing secondary anemia, iron deficiency anemia and preparation method |
-
2005
- 2005-04-28 CN CNB2005100426062A patent/CN100415252C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165676A (en) * | 1997-03-07 | 1997-11-26 | 讷志芳 | Instant powder for nourishing blood and its prepn. method |
| CN1562272A (en) * | 2004-04-05 | 2005-01-12 | 陕西郝其军制药有限责任公司 | Medication for curing secondary anemia, iron deficiency anemia and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1853668A (en) | 2006-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112972547B (en) | Traditional Chinese medicine composition for treating qi and blood deficiency syndrome and preparation method and application thereof | |
| CN102846846A (en) | Donkey-hide gelatin paste and preparation method thereof | |
| CN103251856B (en) | Traditional Chinese medicine preparation for benefiting Qi and nourishing blood and preparation method of traditional Chinese medicine preparation | |
| CN101623313B (en) | Method for preparing traditional Chinese medicine preparation for tonifying blood | |
| CN103340841A (en) | Chinese medicine film as well as preparation method and application thereof | |
| CN101371915A (en) | Method for preparing minor decoction of Bupleurum formulation | |
| CN100415252C (en) | Chinese medicinal composition for strengthening body and enriching blood | |
| CN102600281B (en) | Traditional Chinese medicine composition for promoting digestion as well as preparation method and use | |
| CN101264154A (en) | Preparation of Chinese medicine oral preparation | |
| CN100500183C (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN104922295A (en) | Blood-nourishing and blood-enriching traditional Chinese medicine composition | |
| CN101371875B (en) | Method for extracting and preparing total saponin of compound abnormal savda mature agent | |
| CN103301245A (en) | Medicament for reinforcing qi, nourishing blood and nourishing liver and kidney | |
| CN100423738C (en) | Chinese medicine preparation for treating cardio-cerebral vascular disease and its preparing method | |
| CN103494894A (en) | Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof | |
| CN100500189C (en) | Medicament for treating ulcerative colitis and preparation process thereof | |
| CN105943701B (en) | Application of qi-tonifying and blood-activating medicine in preparation of insomnia medicine | |
| CN100352471C (en) | Medication for curing secondary anemia, iron deficiency anemia and preparation method | |
| CN102836315A (en) | Chinese medicinal composition for preventing and conditioning prognosis tumors and preparation method thereof | |
| CN103494916A (en) | Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof | |
| CN103230456A (en) | Traditional Chinese medicine extract and preparation method thereof | |
| CN103417906A (en) | Applications of compound mylabris traditional Chinese medicine composition and preparations thereof in preparing drugs for curing depression | |
| CN101347446B (en) | Medicament composition containing astragalus polysaccharide and ginseng bud saponin and uses thereof | |
| CN100391528C (en) | Chinese traditional medicine composition for treating infant anorexia and preparation and quality controlling method thereof | |
| CN101219201B (en) | Traditional Chinese medicine liquid capsule and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080903 Termination date: 20170428 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |