CN100393371C - 含胆红素液体之体外照射装置 - Google Patents
含胆红素液体之体外照射装置 Download PDFInfo
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- CN100393371C CN100393371C CNB2004100426617A CN200410042661A CN100393371C CN 100393371 C CN100393371 C CN 100393371C CN B2004100426617 A CNB2004100426617 A CN B2004100426617A CN 200410042661 A CN200410042661 A CN 200410042661A CN 100393371 C CN100393371 C CN 100393371C
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- Prior art keywords
- circuit
- body fluid
- bilirubin
- patient
- illumination unit
- Prior art date
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Images
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Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
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- Biophysics (AREA)
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- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10324668A DE10324668A1 (de) | 2003-05-30 | 2003-05-30 | Vorrichtung zur extrakorporalen Bestrahlung einer Bilirubin enthaltenden Flüssigkeit und Verfahren hierfür |
| DE10324668.1 | 2003-05-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1572332A CN1572332A (zh) | 2005-02-02 |
| CN100393371C true CN100393371C (zh) | 2008-06-11 |
Family
ID=33103662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100426617A Expired - Fee Related CN100393371C (zh) | 2003-05-30 | 2004-05-31 | 含胆红素液体之体外照射装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7846121B2 (enExample) |
| EP (1) | EP1481700B1 (enExample) |
| JP (1) | JP4476023B2 (enExample) |
| KR (1) | KR101180591B1 (enExample) |
| CN (1) | CN100393371C (enExample) |
| DE (1) | DE10324668A1 (enExample) |
| ES (1) | ES2448569T3 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7207964B2 (en) * | 2003-03-17 | 2007-04-24 | Hemavation, Llc | Apparatus and method for down-regulating immune system mediators in blood |
| JP4899040B2 (ja) * | 2005-07-01 | 2012-03-21 | 国立大学法人 岡山大学 | ビリルビン変性器及びビリルビン透析装置 |
| US7527737B2 (en) * | 2006-05-09 | 2009-05-05 | Wang Xiangyu | Hemodialysis apparatus and methods |
| GB2438375A (en) * | 2006-05-27 | 2007-11-28 | Xiangyu Wang | Dialysis apparatus with blood irradiation means |
| JP5702777B2 (ja) * | 2009-07-09 | 2015-04-15 | コーニンクレッカ フィリップス エヌ ヴェ | Oled光治療装置 |
| DE102009034150A1 (de) * | 2009-07-20 | 2011-01-27 | Fresenius Medical Care Deutschland Gmbh | Adsorbens zur Adsorption von Hepcidin |
| DE102011078695A1 (de) * | 2011-07-05 | 2013-01-10 | Charité - Universitätsmedizin Berlin | Dialyseverfahren zur Entfernung proteingebundener Toxine aus dem Blut von Patienten unter Einsatz hochfrequenter elektromagnetischer Felder |
| US9399093B2 (en) | 2012-01-27 | 2016-07-26 | Fenwal, Inc. | Systems and methods for performing online extracorporeal photopheresis |
| US20130345614A1 (en) * | 2012-06-22 | 2013-12-26 | Viraj P. Mane | Device for extracorporeal photo-isomerization for hyperbilirubinemia, and method thereof |
| EP2735359B1 (en) | 2012-11-26 | 2017-02-08 | Gambro Lundia AB | Integrated device for liver support systems |
| PL2735360T3 (pl) | 2012-11-26 | 2017-09-29 | Gambro Lundia Ab | Urządzenie adsorbujące łączące granulki i membrany z włókien kanalikowych |
| ES2625510T3 (es) * | 2012-11-26 | 2017-07-19 | Gambro Lundia Ab | Sistema de soporte hepático |
| DE102012025052A1 (de) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
| DE102012025164A1 (de) * | 2012-12-21 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung zur Entfernung proteingebundener Toxine aus Blutplasma |
| DE102013100050A1 (de) * | 2013-01-04 | 2014-07-10 | Charité - Universitätsmedizin Berlin | Vorrichtung und Verfahren zur Entfernung proteingebundener Toxine aus dem Blut von Patienten unter Einsatz eines hochfrequenten, elektromagnetischen Feldes und eines elektrostatischen Gleichfeldes |
| CN104548233B (zh) * | 2013-10-23 | 2018-05-08 | 国医华科(深圳)医疗科技发展有限公司 | 一种血液辐照仪 |
| CN104225698B (zh) * | 2014-09-03 | 2016-04-13 | 西安交通大学 | 一种肝细胞微球循环生物人工肝支持系统 |
| US10434240B2 (en) | 2015-08-17 | 2019-10-08 | Fenwal, Inc. | Methods and systems for processing and washing a photopheresis mononuclear cell product |
| DE102016207398B3 (de) * | 2015-09-09 | 2016-08-18 | Koenig & Bauer Ag | Maschinenanordnung zum sequentiellen Bearbeiten mehrerer bogenförmiger jeweils eine Vorderseite und eine Rückseite aufweisender Substrate |
| CN106880881A (zh) * | 2017-03-06 | 2017-06-23 | 赵磊 | 一种体外血液光动力学治疗装置 |
| CN108211032B (zh) * | 2018-02-01 | 2023-11-17 | 南方医科大学珠江医院 | 组合型生物人工肝支持系统 |
| US11672898B2 (en) * | 2018-06-08 | 2023-06-13 | Oregon State University | Microfluidic removal of excess bilirubin from blood |
| CN110711278A (zh) * | 2019-10-17 | 2020-01-21 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 血循环式胆红素分解装置 |
| CN110711277A (zh) * | 2019-10-17 | 2020-01-21 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 血液胆红素分解装置 |
| CN116672533A (zh) | 2020-08-19 | 2023-09-01 | 上海心光生物医药有限责任公司 | 医疗设备 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275351A (ja) * | 1987-05-07 | 1988-11-14 | Kuraray Co Ltd | 血液浄化用装置 |
| US5744042A (en) * | 1993-03-19 | 1998-04-28 | Stange; Jan | Method for the separation of protein-bound substances from a protein-containing liquid by dialysis |
| WO2000059551A1 (en) * | 1999-04-01 | 2000-10-12 | Gerhard Saalmann | Photodynamic inactivation of viruses in biological fluids |
| WO2001094349A1 (en) * | 2000-06-02 | 2001-12-13 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5666262A (en) * | 1979-11-02 | 1981-06-04 | Nissho Kk | Method of treating circulatory body fluid of outside of body |
| US4398906A (en) * | 1979-12-11 | 1983-08-16 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
| US4350156A (en) * | 1980-05-29 | 1982-09-21 | Japan Foundation For Artificial Organs | Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid |
| DE3044184A1 (de) * | 1980-11-24 | 1982-06-16 | Mutzhas Maximilian F | Vorrichtung zur phototherapeutischen behandlung der hyperbilirubinaemie |
| US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US4737140A (en) * | 1984-10-29 | 1988-04-12 | Mcneilab, Inc. | Irradiation chamber for photoactivation patient treatment system |
| US5304113A (en) * | 1986-11-21 | 1994-04-19 | The Mcw Research Foundation, Inc. | Method of eradicating infectious biological contaminants |
| US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| DE4026022A1 (de) * | 1990-08-17 | 1992-02-20 | Mutzhas Maximilian F | Uv-bestrahlungsgeraet zur phototherapie der neurodermitis |
| US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
| US6156007A (en) * | 1992-09-04 | 2000-12-05 | Hemotherm, Inc. | Apparatus for whole-body hyperthermia |
| US5628727A (en) * | 1995-08-15 | 1997-05-13 | Hakky; Said I. | Extracorporeal virioncidal apparatus |
| US5925542A (en) * | 1997-05-05 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Nucleic acid encoding human phosphodiesterase regulatory subunit |
| BE1011522A3 (fr) * | 1997-10-30 | 1999-10-05 | Gysens Lucien | Dispositif de phototherapie multidirectionelle intensive. |
| US6277337B1 (en) | 1998-07-21 | 2001-08-21 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US6193681B1 (en) * | 1998-09-14 | 2001-02-27 | American Immuno Tech, Llc. | Septicemia prevention and treatment system |
| US6113566A (en) * | 1998-12-15 | 2000-09-05 | Foundation For Blood Irradiation Inc. | Ultraviolet blood irradiation method and apparatus |
| US7455771B2 (en) * | 2002-05-14 | 2008-11-25 | Hepa Wash Gmbh | Means for removing protein-bound substances |
-
2003
- 2003-05-30 DE DE10324668A patent/DE10324668A1/de not_active Ceased
-
2004
- 2004-05-26 JP JP2004155864A patent/JP4476023B2/ja not_active Expired - Fee Related
- 2004-05-27 EP EP04012654.2A patent/EP1481700B1/de not_active Expired - Lifetime
- 2004-05-27 ES ES04012654.2T patent/ES2448569T3/es not_active Expired - Lifetime
- 2004-05-28 US US10/856,087 patent/US7846121B2/en not_active Expired - Fee Related
- 2004-05-31 KR KR1020040038999A patent/KR101180591B1/ko not_active Expired - Fee Related
- 2004-05-31 CN CNB2004100426617A patent/CN100393371C/zh not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275351A (ja) * | 1987-05-07 | 1988-11-14 | Kuraray Co Ltd | 血液浄化用装置 |
| US5744042A (en) * | 1993-03-19 | 1998-04-28 | Stange; Jan | Method for the separation of protein-bound substances from a protein-containing liquid by dialysis |
| WO2000059551A1 (en) * | 1999-04-01 | 2000-10-12 | Gerhard Saalmann | Photodynamic inactivation of viruses in biological fluids |
| WO2001094349A1 (en) * | 2000-06-02 | 2001-12-13 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2448569T3 (es) | 2014-03-14 |
| CN1572332A (zh) | 2005-02-02 |
| JP4476023B2 (ja) | 2010-06-09 |
| KR20040103478A (ko) | 2004-12-08 |
| JP2004358243A (ja) | 2004-12-24 |
| KR101180591B1 (ko) | 2012-09-06 |
| EP1481700A1 (de) | 2004-12-01 |
| DE10324668A1 (de) | 2004-12-23 |
| EP1481700B1 (de) | 2014-01-22 |
| US20050015040A1 (en) | 2005-01-20 |
| US7846121B2 (en) | 2010-12-07 |
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