CN100384400C - Small golden pellets and preparation method - Google Patents
Small golden pellets and preparation method Download PDFInfo
- Publication number
- CN100384400C CN100384400C CNB2005100211925A CN200510021192A CN100384400C CN 100384400 C CN100384400 C CN 100384400C CN B2005100211925 A CNB2005100211925 A CN B2005100211925A CN 200510021192 A CN200510021192 A CN 200510021192A CN 100384400 C CN100384400 C CN 100384400C
- Authority
- CN
- China
- Prior art keywords
- parts
- moschus
- pellet
- present
- small
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active - Reinstated
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a small golden pellet which is prepared from the raw materials of musk, cochinchina momordica seed, radix aconiti kusnezoffii preparata, beautiful sweetgum resin, olibanum, myrrh, excrementum pteropi, angelica, earthworm and ink. The bulk density of the pellet is from 0.64 g/cm<3> to 0.67 g/cm<3>. The present invention also provides a preparation method for the small golden pellet. The diameter of the pellet of the present invention is smaller than 2.5mm. The pellet has the advantages of smaller weight, small pill diameter and good clinical adaptability and is favorable to the swallow by patients. When the pellet of the present invention is encapsulated or compressed into tablets, dispensing package is used, and the subpackage dose error is small; the amount of each encapsulated particle is large and the dose is small. By ultrafine pulverizing technology, the pellet of the present invention has the advantages of small loss, sufficient dissolution, sufficient digestion, sufficient absorption, enhanced biological availability and shorter dissolving time. The pellet can be dissolved and disintegrated within 7 to 15 minutes in general and quickly takes effect; the present invention provides a new quick acting preparation for clinical operation.
Description
Technical field
The invention provides a kind of small golden pellets, particularly, it is the micropill that the feedstock production by " XIAOJIN WAN " forms, and belongs to drug world.
Background technology
" XIAOJIN WAN ", record in " Chinese pharmacopoeia 2000 editions, preparation method is: above ten flavors, except that Moschus, all the other Semen Momordicaes etc. nine flavor is ground into fine powder, just the Moschus porphyrize with above-mentioned powder facing-up, sieves.Every 100g powder adds starch 25g, mixing, and in addition with starch 5g system magma, general ball, cold drying, promptly.Function cures mainly: mass dissipating and swelling eliminating, blood-activating analgetic.Be used for carbuncle of yin nature from the beginning of, color of the leather is constant, swollen has a pain multiple abscess, goiter, breast carcinoma, nodules of the breast firmly.Dosage form commonly used at present is pill, capsule, tablet.Wherein pill is a paste pill, and its taking dose is: the 3g/ bottle, and for oral administration, 1.5-3g/ time, 2 times/day.Because paste pill is bigger, the divided dose error is bigger, the patient of the clinical inconvenience of taking, especially dysphagia.Other dosage form, as capsule, tablet, because former powder directly is used as medicine, the granule of preparation is inhomogeneous, tabletting is specification not, and presentation quality is poor than pill, and mobile low, in the time of encapsulated dose, the content granule is irregular, and content uniformity is big, and every granule capsule loading amount is about 0.3g, and the dose of capsule is big.
Summary of the invention
In order to address the above problem, technical scheme of the present invention has provided a kind of pellet, and it is the dosage form that the feedstock production by " XIAOJIN WAN " forms.The present invention also provides the preparation method and the purposes of this micropill.
The invention provides a kind of small golden pellets, it is that feedstock production forms by Moschus, Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Resina Liquidambaris, Olibanum, Myrrha, Oletum Trogopterori, Radix Angelicae Sinensis, Pheretima, XIANGMO(sic), and wherein, described micropill bulk density is: 0.64～0.67g/cm
3
With the micropill of the present invention capsule of packing into No. 0, charge weight is 0.55～0.6g in every capsules.
Small golden pellets of the present invention is to be prepared from by following method:
A, take by weighing the following weight proportion raw material:
20～40 parts in Moschus, 140～160 parts of Semen Momordicaes, 140～160 parts of Radix Aconiti Kusnezoffii Preparatas, 140～160 parts of Resina Liquidambarises, 65～85 parts of Olibanums, 65～85 parts of Myrrhas, 140～160 parts of Oletum Trogopteroris, 65～85 parts of Radix Angelicae Sinensis, 140～160 parts of Pheretimas, 6～18 parts of XIANGMO(sic);
B, with the above-mentioned raw materials medical material except that Moschus, be dried to water content below 2.0%, be ground into the above impalpable powder of 180 orders again;
C, get starch and add water, boil into pasty state, as binding agent;
D, molding: adopt artificial molding or mechanical molding, the ball mode diameter is 0.1～1.8mm;
E, be rolled into ball;
F, Moschus is dissolved in the 95% above ethanol, sprays in the piller of step, ethanol volatilizees naturally;
G, add medicinal powder or salad oil, enclose once more;
H, polishing promptly get micropill of the present invention.
Wherein, the weight proportion of described raw material is: 30 parts in Moschus, 150 parts of Semen Momordicaes, 150 parts of Radix Aconiti Kusnezoffii Preparatas, 150 parts of Resina Liquidambarises, 75 parts of Olibanums, 75 parts of Myrrhas, 150 parts of Oletum Trogopteroris, 75 parts of Radix Angelicae Sinensis, 150 parts of Pheretimas, 12 parts of XIANGMO(sic).
Micropill diameter of the present invention is below 2.5mm, and single ball weight is less, and the ball footpath is little, is beneficial to the patient and swallows, and clinical compliance is good; Micropill of the present invention during encapsulated or tabletting, is utilized weight packaging, and the packing dose error is little, and it is big to incapsulate every loading amount, and dose is little; Adopt superfine communication technique, make drug loss of the present invention few, fully stripping, digestion, absorption, raising bioavailability, the molten diffusing time is shorter, just can moltenly loose in general 7-15 minute, and drug effect is brought into play in disintegrate rapidly, provides a kind of new quick-effective preparation for clinical.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 micropill of the present invention
A, take by weighing the following weight proportion raw material:
Moschus 30g, Semen Momordicae 150g, Radix Aconiti Kusnezoffii Preparata 150g, Resina Liquidambaris 150g, Olibanum 75g, Myrrha 75g, Oletum Trogopterori 150g, Radix Angelicae Sinensis 75g, Pheretima 150g, XIANGMO(sic) 12g;
B, with the above-mentioned raw materials medical material except that Moschus, be dried to water content below 2.0%, be ground into the above impalpable powder of 180 orders again;
C, get starch and add water, boil into pasty state, as binding agent;
D, molding: adopt artificial molding or mechanical molding, the ball mode diameter is 0.1～1.8mm; The method of molding has multiple, can be in coating pan powder-stuck, molding; Rubbing by hand, the cutting molding; With maple tool extruding slivering, cutting molding.If the ball mould is too small, it is low to be rolled into the ball yield rate, and excessive again through being rolled into ball, the ball footpath can surpass 2.5mm;
E, be rolled into ball; Be the correction operation that pill prepares molding, the ball operation, no matter large and small ball is all necessary owing to adopt superfine communication technique, it is more even to use the former powder of Chinese medicine to decompose in encapsulation process, one-tenth ball better effects if.
F, Moschus is dissolved in the 95% above ethanol, sprays in the piller of step e, ethanol volatilizees naturally;
G, add medicinal powder or salad oil, enclose once more;
H, polishing adopt the food grade Cera Flava to carry out the polishing of pill, promptly get micropill of the present invention.
The preparation of embodiment 2 medicament pellets of the present invention
Take by weighing the raw material of following weight: Moschus 20g, Semen Momordicae 140g, Radix Aconiti Kusnezoffii Preparata 140g, Resina Liquidambaris 140g, Olibanum 65g, Myrrha 65g, Oletum Trogopterori 140g, Radix Angelicae Sinensis 65g, Pheretima 140g, XIANGMO(sic) 6g; Press the method preparation of embodiment 1.
The preparation of embodiment 3 medicament pellets of the present invention
Take by weighing the raw material of following weight: Moschus 40g, Semen Momordicae 160g, Radix Aconiti Kusnezoffii Preparata 160g, Resina Liquidambaris 160g, Olibanum 85g, Myrrha 85g, Oletum Trogopterori 160g, Radix Angelicae Sinensis 85g, Pheretima 160g, XIANGMO(sic) 18g; The method preparation of embodiment 1.
The assay method of embodiment 4 micropill bulk densities of the present invention
By " pharmaceutics " chief editor: Cui Fude, People's Health Publisher in May, 1980, P295 the 3rd joint: the density of powder body and voidage, the assay method of bulk density (or bulk density), the bulk density of measuring micropill of the present invention is 0.64～0.67g/cm
3
The physical and chemical index of embodiment 5 medicament pellets of the present invention
1, ball footpath: 1.2～2.5mm;
2, single ball weight: 0.010～0.050g;
3, single is taken the pill number: the 120-24 ball;
4, dissolve scattered time limit: 7-15 minute.
The molten diffusing time ratio of embodiment 3 micropills of the present invention and ordinary pill
XIAOJIN WAN: by " 2000 editions preparations of Chinese pharmacopoeia
Above-mentioned test explanation, micropill bulk density of the present invention is big, and taking dose is little, and volatile ingredient is difficult lost, and dissolve scattered time limit is big, is a kind of reliable quick-effective preparation.
Claims (5)
1. small golden pellets, it is made up of the following weight proportion raw material, with starch, salad oil is the micropill that adjuvant is prepared from: 20～40 parts in Moschus, 140～160 parts of Semen Momordicaes, 140～160 parts of Radix Aconiti Kusnezoffii Preparatas, 140～160 parts of Resina Liquidambarises, 65～85 parts of Olibanums, 65～85 parts of Myrrhas, 140～160 parts of Oletum Trogopteroris, 65～85 parts of Radix Angelicae Sinensis, 140～160 parts of Pheretimas, 6～18 parts of XIANGMO(sic) is characterized in that described micropill bulk density is: 0.64～0.67g/cm
3
2. small golden pellets according to claim 1 is characterized in that: it is to be prepared from by following method:
A, take by weighing the following weight proportion raw material:
20～40 parts in Moschus, 140～160 parts of Semen Momordicaes, 140～160 parts of Radix Aconiti Kusnezoffii Preparatas, 140～160 parts of Resina Liquidambarises, 65～85 parts of Olibanums, 65～85 parts of Myrrhas, 140～160 parts of Oletum Trogopteroris, 65～85 parts of Radix Angelicae Sinensis, 140～160 parts of Pheretimas, 6～18 parts of XIANGMO(sic);
B, with the above-mentioned raw materials medical material except that Moschus, be dried to water content below 2.0%, be ground into the above impalpable powder of 180 orders again;
C, get starch and add water, boil into pasty state, as binding agent;
D, molding: adopt artificial molding or mechanical molding, the ball mode diameter is 0.1～1.8mm;
E, be rolled into ball;
F, Moschus is dissolved in the 95% above ethanol, sprays in the piller of step, ethanol volatilizees naturally;
G, adding salad oil, enclose;
H, polishing promptly get micropill of the present invention.
3. small golden pellets according to claim 2 is characterized in that: the weight proportion of described raw material is: 30 parts in Moschus, 150 parts of Semen Momordicaes, 150 parts of Radix Aconiti Kusnezoffii Preparatas, 150 parts of Resina Liquidambarises, 75 parts of Olibanums, 75 parts of Myrrhas, 150 parts of Oletum Trogopteroris, 75 parts of Radix Angelicae Sinensis, 150 parts of Pheretimas, 12 parts of XIANGMO(sic).
4. a preparation method for preparing the described small golden pellets of claim 1 comprises the steps:
A, take by weighing the following weight proportion raw material:
20～40 parts in Moschus, 140～160 parts of Semen Momordicaes, 140～160 parts of Radix Aconiti Kusnezoffii Preparatas, 140～160 parts of Resina Liquidambarises, 65～85 parts of Olibanums, 65～85 parts of Myrrhas, 140～160 parts of Oletum Trogopteroris, 65～85 parts of Radix Angelicae Sinensis, 140～160 parts of Pheretimas, 6～18 parts of XIANGMO(sic);
B, with the above-mentioned raw materials medical material except that Moschus, be dried to water content below 2.0%, be ground into the above impalpable powder of 180 orders again;
C, get starch and add water, boil into pasty state, as binding agent;
D, molding: adopt artificial molding or mechanical molding, the ball mode diameter is 0.1～1.8mm;
E, be rolled into ball;
F, Moschus is dissolved in the 95% above ethanol, sprays in the piller of step, ethanol volatilizees naturally;
G, adding salad oil, enclose;
H, polishing promptly get micropill of the present invention.
5. the preparation method of small golden pellets according to claim 4, it is characterized in that: step a takes by weighing the following weight proportion raw material:
30 parts in Moschus, 150 parts of Semen Momordicaes, 150 parts of Radix Aconiti Kusnezoffii Preparatas, 150 parts of Resina Liquidambarises, 75 parts of Olibanums, 75 parts of Myrrhas, 150 parts of Oletum Trogopteroris, 75 parts of Radix Angelicae Sinensis, 150 parts of Pheretimas, 12 parts of XIANGMO(sic).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100211925A CN100384400C (en) | 2005-06-30 | 2005-06-30 | Small golden pellets and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100211925A CN100384400C (en) | 2005-06-30 | 2005-06-30 | Small golden pellets and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1726969A CN1726969A (en) | 2006-02-01 |
| CN100384400C true CN100384400C (en) | 2008-04-30 |
Family
ID=35926607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100211925A Active - Reinstated CN100384400C (en) | 2005-06-30 | 2005-06-30 | Small golden pellets and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100384400C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306170B (en) * | 2007-05-20 | 2011-08-31 | 于恒君 | Traditional Chinese medicinal preparation for fracture setting |
| CN101417020B (en) * | 2007-10-23 | 2012-04-25 | 北京亚东生物制药有限公司 | Medicine composition capable of eliminating the mass and relieving swelling, absorbing clots and alleviating pain, preparation method and quality control method thereof |
| CN102114090A (en) * | 2009-12-30 | 2011-07-06 | 成都永康制药有限公司 | Preparation and medical use of minor gold pills for male testicular nodular lesions |
| CN104306474B (en) * | 2014-10-29 | 2017-05-17 | 成都中医药大学 | Process for preparing xiaojin pill |
| CN108185415B (en) * | 2018-01-11 | 2021-11-26 | 刘言周 | Preparation method of gel beads containing volatile substances |
| CN108244511B (en) * | 2018-01-11 | 2021-09-03 | 刘言周 | Preparation method of rubber beads |
| CN111135213A (en) * | 2020-01-15 | 2020-05-12 | 安徽汇喻科技服务有限公司 | Processing and preparation method of Xiaojin pills |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082887A (en) * | 1992-08-25 | 1994-03-02 | 北京同仁堂制药厂药品研究所 | The preparation technology of Bezoar Sedative Pills novel form |
-
2005
- 2005-06-30 CN CNB2005100211925A patent/CN100384400C/en active Active - Reinstated
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082887A (en) * | 1992-08-25 | 1994-03-02 | 北京同仁堂制药厂药品研究所 | The preparation technology of Bezoar Sedative Pills novel form |
Non-Patent Citations (4)
| Title |
|---|
| 中华人民共和国药典一部. 国家药典委员会，378，化学工业出版社. 2000 |
| 中华人民共和国药典一部. 国家药典委员会，378，化学工业出版社. 2000 * |
| 制备微丸两种方法的比较. 陈梅新等.中国药师，第6卷第2期. 2003 |
| 制备微丸两种方法的比较. 陈梅新等.中国药师，第6卷第2期. 2003 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1726969A (en) | 2006-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100384400C (en) | Small golden pellets and preparation method | |
| TW586941B (en) | Quickly disintegratable pharmaceutical composition | |
| CN108969490A (en) | Rapid dispersion particle, oral disnitegration tablet and method | |
| CN104271339B (en) | The method for manufacturing solid dosage forms | |
| WO2016205923A1 (en) | Ingestible plant source pill and method | |
| CN101360493A (en) | Levetiracetam formulations and methods for their manufacture | |
| CN106068120A (en) | Use the method that radio frequency and lossy coated bead manufacture tablet | |
| CN107708737A (en) | The outer layer composition of solid pharmaceutical preparation and the easy taking solid pharmaceutical preparation containing the outer layer composition | |
| CN103006750B (en) | Preparation method of heat-clearing, cholagogic and digestant medicament | |
| CN101204394A (en) | Composite containing pioglitazone HCL and repaglinide | |
| CN101401796A (en) | Pramipexole orally disintegrating tablets and preparation method thereof | |
| JP2002097130A (en) | Method of producing powdery herb medicine, and/or granulated herb medicine and tablet comprising the powdery herb medicine | |
| CN102018801B (en) | Novel digestion promoting tablets and preparation method thereof | |
| CN100515471C (en) | Liver kidney nourishing fast dispersion solid preparation and its preparation method | |
| CN106880611A (en) | A kind of tolvaptan preparation of tolvaptan and water soluble adjuvant containing micronizing | |
| CN106456640A (en) | Ceritinib formulation | |
| CN107854671A (en) | A Na series anaesthetic intragastric floating sustained-release preparations and preparation method thereof | |
| JPS6346726B2 (en) | ||
| JP2017137315A (en) | Solid pharmaceutical | |
| CN109512790A (en) | A kind of prescription and preparation process of oral disnitegration tablet | |
| CN107028909A (en) | Burst drug release compositions | |
| CN103432082A (en) | Glucosamine composition and preparation method thereof | |
| CN100370969C (en) | Chinese materia medica preparation for treating dysmenorrhea of women | |
| CN107412175A (en) | Glipizide oral cavity disintegrating piece and preparation method thereof | |
| CN103285050B (en) | The preparation method of ginkgo biloba armillaria oral solid preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080430 |
|
| RR01 | Reinstatement of patent right |
Former decision: cessation of patent right due to non-payment of the annual fee Former decision publication date: 20100901 |